Two novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone （1）, phlomistetraol A （2）, were isolated from the roots of Phlomis umbrosa. Their structures were elucidated ...Two novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone （1）, phlomistetraol A （2）, were isolated from the roots of Phlomis umbrosa. Their structures were elucidated by spectroscopic methods, including 1D, 2D nuclear magnetic resonance （NMR）, high-resolution mass spectrometry （HR-MS）.展开更多
The flower buds of Lonicera macranthoides(Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranth...The flower buds of Lonicera macranthoides(Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids(1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid(1) and 2α, 4α-dihydroxy-23-nor-ursolic acid(2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L^(-1).展开更多
基金the fund for Doctor of Henan University of Science and Technology.
文摘Two novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone （1）, phlomistetraol A （2）, were isolated from the roots of Phlomis umbrosa. Their structures were elucidated by spectroscopic methods, including 1D, 2D nuclear magnetic resonance （NMR）, high-resolution mass spectrometry （HR-MS）.
基金supported by the National Natural Science Foundation of China(Nos.81602984 and 81630097)Science and Technology Planning Project of Guangdong Province(No.2015B030301005)
文摘The flower buds of Lonicera macranthoides(Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids(1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid(1) and 2α, 4α-dihydroxy-23-nor-ursolic acid(2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L^(-1).
