AIM： To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers. METHODS： In a mouse model of gastric bleeding with high dose of indo...AIM： To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers. METHODS： In a mouse model of gastric bleeding with high dose of indomethacin （20 mg/kg）, an EP4-selective agonist was administered orally. Stomach lesions and gastric mucous regeneration were monitored. In a mouse model of chronic gastric ulcer induced by acetic acid, EP4 agonist effect on the healing of chronic gastric ulcer was evaluated in the presence or absence of low dose indomethadn （3 mg/kg）. In cultured human gastric mucous cells, EP4 agonist effect on indomethacin- induced apoptosis was assessed by flow cytometry. RESULTS： The EP4-selective agonist reduced high dose indomethacin-induced acute hemorrhagic damage and promoted mucous epithelial regeneration. Low-dose indomethacin aggravated ulcer bleeding and inflammation, and delayed the healing of the established chronic gastric ulcer. The EP4 agonist, when applied locally, not only offset indomethacin-induced gastric bleeding and inflammation, but also accelerated ulcer healing. In the absence of indomethacin, the EP4 agonist even accelerated chronic gastric ulcer healing and suppressed inflammatory cell infiltration in the granulation tissue. In vitro, the EP4 agonist protected human gastric mucous cells from indomethacin-induced apoptosis.CONCLUSION： EP4-selective agonist may prevent indomethacin-induced gastric lesions and promote healing of existing and i ulcers, via promoting mucous epithelial cells. proliferation and survival of mucous epithelial cells.展开更多
目的:探讨老年人鼻腔后部难治性出血的鼻内镜下治疗疗效。方法:2016年1月～2017年12月期间我科收治146例老年鼻腔后部难治性出血的鼻内镜下处理患者,将鼻内镜下单极电凝止血治疗作为观察组,鼻内镜下鼻腔填塞治疗作为对照组,每组各73例,...目的:探讨老年人鼻腔后部难治性出血的鼻内镜下治疗疗效。方法:2016年1月～2017年12月期间我科收治146例老年鼻腔后部难治性出血的鼻内镜下处理患者,将鼻内镜下单极电凝止血治疗作为观察组,鼻内镜下鼻腔填塞治疗作为对照组,每组各73例,比较两组患者一次性治疗总有效率、并发症发生率、复发率、VAS评分和其对治疗的满意度。结果:两组患者一次性治疗总有效率差异比较均无统计学意义(P>0.05);两组患者均未见粘连和穿孔并发症及再次复发出血;观察组手术结束时和术后24 h VAS评分低于对照组,但对治疗的满意率却高于对照组,差异比较有统计学意义(P<0.05)。结论:鼻内镜下探查鼻腔后部的出血点具有重要意义;对出血部位进行准确电凝和对无法电凝部位行局部填塞,是成功的关键,且安全性和患者满意度也更受肯定。展开更多
文摘AIM： To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers. METHODS： In a mouse model of gastric bleeding with high dose of indomethacin （20 mg/kg）, an EP4-selective agonist was administered orally. Stomach lesions and gastric mucous regeneration were monitored. In a mouse model of chronic gastric ulcer induced by acetic acid, EP4 agonist effect on the healing of chronic gastric ulcer was evaluated in the presence or absence of low dose indomethadn （3 mg/kg）. In cultured human gastric mucous cells, EP4 agonist effect on indomethacin- induced apoptosis was assessed by flow cytometry. RESULTS： The EP4-selective agonist reduced high dose indomethacin-induced acute hemorrhagic damage and promoted mucous epithelial regeneration. Low-dose indomethacin aggravated ulcer bleeding and inflammation, and delayed the healing of the established chronic gastric ulcer. The EP4 agonist, when applied locally, not only offset indomethacin-induced gastric bleeding and inflammation, but also accelerated ulcer healing. In the absence of indomethacin, the EP4 agonist even accelerated chronic gastric ulcer healing and suppressed inflammatory cell infiltration in the granulation tissue. In vitro, the EP4 agonist protected human gastric mucous cells from indomethacin-induced apoptosis.CONCLUSION： EP4-selective agonist may prevent indomethacin-induced gastric lesions and promote healing of existing and i ulcers, via promoting mucous epithelial cells. proliferation and survival of mucous epithelial cells.
文摘目的:探讨老年人鼻腔后部难治性出血的鼻内镜下治疗疗效。方法:2016年1月～2017年12月期间我科收治146例老年鼻腔后部难治性出血的鼻内镜下处理患者,将鼻内镜下单极电凝止血治疗作为观察组,鼻内镜下鼻腔填塞治疗作为对照组,每组各73例,比较两组患者一次性治疗总有效率、并发症发生率、复发率、VAS评分和其对治疗的满意度。结果:两组患者一次性治疗总有效率差异比较均无统计学意义(P>0.05);两组患者均未见粘连和穿孔并发症及再次复发出血;观察组手术结束时和术后24 h VAS评分低于对照组,但对治疗的满意率却高于对照组,差异比较有统计学意义(P<0.05)。结论:鼻内镜下探查鼻腔后部的出血点具有重要意义;对出血部位进行准确电凝和对无法电凝部位行局部填塞,是成功的关键,且安全性和患者满意度也更受肯定。
