Objective To determine the prognostic significance of MIBl proliferation marker expression on ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of the breast. Methods By means of histological and imm...Objective To determine the prognostic significance of MIBl proliferation marker expression on ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of the breast. Methods By means of histological and immunohis tochemical techniques, MIB1 labelling index (LI) was determined in 31 pathologic specimens (DIal 6, IDC 22 and 3 benign breast lesions as control ). Results Significantly higher (P< 0. 05) MIB1 expression wus noted in breast carcinomas in contrast with benign breast lesions. MIBl LI increased with increasing tumor invasion from DCIS to IDC (P< 0. 05). Increased tendency of MIB1 LI had been also noted in according with the increased nuclear grabing (NG) of IDC. Conclusion MIBI ex- pression can faithfully reflect the proliferative activity of the breast lesions, where the breast cancers with both high MIBl LI and NG seem to have a poor prognosis.展开更多
Mesothelioma is a rare malignant tumor of the serosal membranes that can be challenging to diagnose,especially on small biopsy specimens.There are updated guidelines on the diagnosis and classification of mesothelioma...Mesothelioma is a rare malignant tumor of the serosal membranes that can be challenging to diagnose,especially on small biopsy specimens.There are updated guidelines on the diagnosis and classification of mesothelioma,which incorporate advancements in understanding mesothelioma biology published in the literature over recent years.This review will discuss marked developments and/or improvements that have been made,including:(1)to the histologic classifications of mesothelioma;(2)the use of such classifications and nuclear grading in prognosis;(3)the indispensability of ancillary studies in the diagnosis of mesothelioma;(4)the application of these pleural based classifications and diagnostic schemes in peritoneal mesothelioma;and(5)the potential for diagnosis of mesothelioma in situ.展开更多
文摘Objective To determine the prognostic significance of MIBl proliferation marker expression on ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of the breast. Methods By means of histological and immunohis tochemical techniques, MIB1 labelling index (LI) was determined in 31 pathologic specimens (DIal 6, IDC 22 and 3 benign breast lesions as control ). Results Significantly higher (P< 0. 05) MIB1 expression wus noted in breast carcinomas in contrast with benign breast lesions. MIBl LI increased with increasing tumor invasion from DCIS to IDC (P< 0. 05). Increased tendency of MIB1 LI had been also noted in according with the increased nuclear grabing (NG) of IDC. Conclusion MIBI ex- pression can faithfully reflect the proliferative activity of the breast lesions, where the breast cancers with both high MIBl LI and NG seem to have a poor prognosis.
文摘Mesothelioma is a rare malignant tumor of the serosal membranes that can be challenging to diagnose,especially on small biopsy specimens.There are updated guidelines on the diagnosis and classification of mesothelioma,which incorporate advancements in understanding mesothelioma biology published in the literature over recent years.This review will discuss marked developments and/or improvements that have been made,including:(1)to the histologic classifications of mesothelioma;(2)the use of such classifications and nuclear grading in prognosis;(3)the indispensability of ancillary studies in the diagnosis of mesothelioma;(4)the application of these pleural based classifications and diagnostic schemes in peritoneal mesothelioma;and(5)the potential for diagnosis of mesothelioma in situ.
