AIM: To study the systemic anti-inflammatory actions of interleukin-1 (IL-1) blockers, OB-101 and OB-186. METHODS: Prevention of palm swelling induced by carrageenin injection was used as an animal model of systemic a...AIM: To study the systemic anti-inflammatory actions of interleukin-1 (IL-1) blockers, OB-101 and OB-186. METHODS: Prevention of palm swelling induced by carrageenin injection was used as an animal model of systemic anti-inflammation efficacy. RESULTS: Both OB-101 and OB-186 (10 - 30 mg· kg-1) were approximately 10 - 30-fold more potent than aspirin (300 mg·kg-1) to inhibit carrageenin-induced systemic inflammation. The LD50 of OB-101 and OB-186 were at least 20 g · kg-1 ig, indicating that they were extremely safe agents with a therapeutic index (LD50/ ED50) of at least 2000. CONCLUSION: These IL-1 blockers are extremely safe systemically and are useable for the treatment of systemic inflammation such as rheumatoid arthritis.展开更多
文摘AIM: To study the systemic anti-inflammatory actions of interleukin-1 (IL-1) blockers, OB-101 and OB-186. METHODS: Prevention of palm swelling induced by carrageenin injection was used as an animal model of systemic anti-inflammation efficacy. RESULTS: Both OB-101 and OB-186 (10 - 30 mg· kg-1) were approximately 10 - 30-fold more potent than aspirin (300 mg·kg-1) to inhibit carrageenin-induced systemic inflammation. The LD50 of OB-101 and OB-186 were at least 20 g · kg-1 ig, indicating that they were extremely safe agents with a therapeutic index (LD50/ ED50) of at least 2000. CONCLUSION: These IL-1 blockers are extremely safe systemically and are useable for the treatment of systemic inflammation such as rheumatoid arthritis.
