ON 01910.Na联合紫杉醇对人宫颈癌Hela细胞增殖的影响

目的探讨ON 01910.Na单药及联合紫杉醇对Hela宫颈癌细胞增殖的影响。方法以不同浓度的ON 01910.Na和紫杉醇处理Hela宫颈癌细胞,采用MTT法测定药物作用不同时间对检测细胞的增殖抑制率。取ON 01910.Na和紫杉醇作用48 h的IC50值的半量作为药物浓度,单独应用或者联合作用于宫颈癌细胞,采用MTT法以及流式细胞仪检测不同用药方案的抗肿瘤作用。结果 ON 01910.Na和紫杉醇均可抑制Hela细胞的增殖,该抑制作用呈剂量依赖性,且随着用药时间的延长,药物对宫颈癌细胞增殖的抑制效应更明显(P<0.05);紫杉醇主要是将细胞阻滞在S期,而ON 01910.Na可将细胞阻滞在G0/G1期;ON 01910.Na与紫杉醇联用对Hela细胞增殖的抑制率和细胞的凋亡率明显高于单独用药组(P<0.01)。结论 ON 01910.Na对宫颈癌Hela细胞的增殖具有抑制作用,该抑制作用呈时间和剂量依赖性。ON 01910.Na还可增强紫杉醇抑制宫颈癌Hela细胞增殖的效应。

高效液相色谱法测定生物样品中ON01910.Na的含量

目的探索高效液相色谱法测定大鼠生物样品中ON 01910.Na的含量的可行性及条件。方法采用高效液相色谱法测定大鼠生物样品中ON 01910.Na的含量,检测该方法的特异性和选择性、线性范围、检测限(LOD)、定量限(LOQ)、精密度、准确度、回收率及稳定性。结果 ON 01910.Na HPLC定量检测方法采用的流动相为0.01 mol磷酸二氢钾缓冲液(pH 8.0)∶乙腈=70∶30(V/V),流速恒定为1.0 mL/min。保留时间内未见干扰峰;检测限(LOD)约为0.023μg/mL,灌流液、胆汁和大鼠血浆中,LOQ分别为0.100、3.000和1.000μg/mL;该方法准确度高,回收率及稳定性好。结论 HPLC方法能够高效检测灌流液、胆汁和大鼠血浆等基质中ON 01910.Na含量。

Manipulating Na occupation and constructing protective film of P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2) as long-term cycle stability cathode for sodium-ion batteries

P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2)(NNMO)is promising cathode material for sodium-ion batteries(SIBs)due to its high specific capacity and fast Na+diffusion rate.Nonetheless,the irreversible P2-O_(2)phase transformation,Na+/vacancy ordering,and transition metal(TM)dissolution seriously damage its cycling stability and restrict its commercialization process.Herein,Na occupation manipulation and interface stabilization are proposed to strengthen the phase structure of NNMO by synergistic Zn/Ti co-doping and introducing lithium difluorophosp(LiPO_(2)F_(2))film-forming electrolyte additive.The Zn/Ti co-doping regulates the occupancy ratio of Nae/Nafat Na sites and disorganizes the Na+/vacancy ordering,resulting in a faster Na+diffusion kinetics and reversible P2-Z phase transition for P2-Na_(0.67)Ni_(0.28)Zn_(0.05)Mn_(0.62)Ti_(0.05)O_(2)(NNZMTO).Meanwhile,the LiPO_(2)F_(2)additive can form homogeneous and ultrathin cathode-electrolyte interphase(CEI)on NNZMTO surface,which can stabilize the NNZMTO-electrolyte interface to prevent TM dissolution,surface structure transformation,and micro-crack generation.Combination studies of in situ and ex situ characterizations and theoretical calculations were used to elucidate the storage mechanism of NNZMTO with Li PO_(2)F_(2)additive.As a result,the NNZMTO displays outstanding capacity retention of 94.44%after 500 cycles at 1C with 0.3 wt%Li PO_(2)F_(2),excellent rate performance of 92.5 mA h g^(-1)at 8C with 0.1 wt%Li PO_(2)F_(2),and remarkable full cell capability.This work highlights the important role of manipulating Na occupation and constructing protective film in the design of layered materials,which provides a promising direction for developing high-performance cathodes for SIBs.

抗肿瘤药ON 01910.Na

Polo样激酶（PLK）为一种高度保守的丝氨酸／苏氨酸蛋白激酶，广泛存在于各种真核生物中，在细胞有丝分裂进程中发挥着重要作用；其中，PLK1的高度表达与肿瘤的发生和发展密切相关，作为抗肿瘤药物的潜在靶点极具开发价值。

Natural Lignin:A Sustainable and Cost-Effective Electrode Material for High-Temperature Na-Ion Battery

Rechargeable sodium-ion batteries usually suffer from accelerated electrode destruction at high temperatures and high synthesis costs of electrode materials.Therefore,it is highly desirable to explore novel organic electrodes considering their cost-effectiveness and large adaptability to volume changes.Herein,natural biomass,pristine lignin,is employed as the sodium-ion battery anodes,and their sodium storage performance is investigated at room temperature and 60℃.The lignin anodes exhibit excellent high-temperature sodium-ion battery performance.This mainly results from the generation of abundant reactive sites(C=O)due to the high temperature-induced homogeneous cleavage of the C_(β)-O bond in the lignin macromolecule.This work can inspire researchers to explore other natural organic materials for large-scale applications and high-value utilization in advanced energy storage devices.

Facile in situ synthesis and characterization of Fe@Si/zeolite Na composites with magnetic core–shell structures from natural materials for enhanced curcumin loading capacity

Curcumin is a natural polyphenol that is used in various traditional medicines.However,its inherent properties,such as its rapid degradation and metabolism,low bioavailability,and short half-life,are serious problems that must be resolved.To this end,a drug carrier incorporating natural magnetic cores in a zeolite framework was developed and applied to the loading of curcumin in ethanol solutions.In this system,curcumin is encapsulated in a zeolite Na(ZNA)magnetic core–shell structure(Fe@Si/ZNA),which can be easily synthesized using an in situ method.Synthesis of Fe_(3)O_(4) nanoparticles was carried out from natural materials using a co-precipitation method.Analysis of the prepared magnetic core–shell structures and composites was carried out using vibrating-sample magnetometery,Fourier transform infrared spectroscopy,transmission electron microscopy,and x-ray diffraction.The cumulative loading of curcumin in the ZNA composite with 9%nanoparticles was found to reach 90.70%with a relatively long half-life of 32.49 min.Stability tests of curcumin loading in the composite showed that adding magnetic particles to the zeolite framework also increased the stability of the composite structure.Adsorption kinetics and isotherm studies also found that the system follows the pseudo-second-order and Langmuir isotherm models.

Designing Conformal Electrode-electrolyte Interface by Semi-solid NaK Anode for Sodium Metal Batteries

Solid-state Na metal batteries(SSNBs),known for its low cost,high safety,and high energy density,hold a significant position in the next generation of rechargeable batteries.However,the urgent challenge of poor interfacial contact in solid-state electrolytes has hindered the commercialization of SSNBs.Driven by the concept of intimate electrode-electrolyte interface design,this study employs a combination of NaK alloy and carbon nanotubes to prepare a semi-solid NaK(NKC)anode.Unlike traditional Na anodes,the paintable paste-like NKC anode exhibits superior adhesion and interface compatibility with both current collectors and gel electrolytes,significantly enhancing the intimate contact of electrode-electrolyte interface.Additionally,the filling of SiO_(2)nanoparticles improves the wettability of NaK alloy on gel polymer electrolytes,further achieving a conformal interface contact.Consequently,the overpotential of the NKC symmetric cell is markedly lower than that of the Na symmetric cell when subjected to a long cycle of 300 h.The full cell coupled with Na_(3)V_(3)(PO_(4))_(2)cathodes had an initial discharge capacity of 106.8 mAh·g^(-1)with a capacity retention of 89.61%after 300 cycles,and a high discharge capacity of 88.1 mAh·g^(-1)even at a high rate of 10 C.The outstanding electrochemical performance highlights the promising application potential of the NKC electrode.

Designing ultrastable P2/O3-type layered oxides for sodium ion batteries by regulating Na distribution and oxygen redox chemistry

P2/O3-type Ni/Mn-based layered oxides are promising cathode materials for sodium-ion batteries(SIBs)owing to their high energy density.However,exploring effective ways to enhance the synergy between the P2 and 03 phases remains a necessity.Herein,we design a P2/O3-type Na_(0.76)Ni_(0.31)Zn_(0.07)Mn_(0.50)Ti_(0.12)0_(2)(NNZMT)with high chemical/electrochemical stability by enhancing the coupling between the two phases.For the first time,a unique Na*extraction is observed from a Na-rich O3 phase by a Na-poor P2 phase and systematically investigated.This process is facilitated by Zn^(2+)/Ti^(4+)dual doping and calcination condition regulation,allowing a higher Na*content in the P2 phase with larger Na^(+)transport channels and enhancing Na transport kinetics.Because of reduced Na^(+)in the O3 phase,which increases the difficulty of H^(+)/Na^(+) exchange,the hydrostability of the O3 phase in NNZMT is considerably improved.Furthermore,Zn^(2+)/Ti^(4+)presence in NNZMT synergistically regulates oxygen redox chemistry,which effectively suppresses O_(2)/CO_(2) gas release and electrolyte decomposition,and completely inhibits phase transitions above 4.0 V.As a result,NNZMT achieves a high discharge capacity of 144.8 mA h g^(-1) with a median voltage of 3.42 V at 20 mA g^(-1) and exhibits excellent cycling performance with a capacity retention of 77.3% for 1000 cycles at 2000 mA g^(-1).This study provides an effective strategy and new insights into the design of high-performance layered-oxide cathode materials with enhanced structure/interface stability forSIBs.

Outstanding proton conductivity over wide temperature and humidity ranges and enhanced mechanical, thermal stabilities for surface-modified MIL-101-Cr-NH_(2)/Nafion composite membranes

High-performance proton exchange membranes are of great importance for fuel cells.Here,we have synthesized polycarboxylate plasticizer modified MIL-101-Cr-NH_(2)(PCP-MCN),a kind of hybrid metal-organic framework,which exhibits a superior proton conductivity.PCP-MCN nanoparticles are used as additives to fabricate PCP-MCN/Nafion composite membranes.Microstructures and characteristics of PCP-MCN and these membranes have been extensively investigated.Significant enhancement in proton conduction for PCP-MCN around 55℃ is interestingly found due to the thermal motion of the PCP molecular chains.Robust mechanical properties and higher thermal decomposition temperature of the composite membranes are directly ascribed to strong intermolecular interactions between PCP-MCN and Nafion side chains,i.e.,the formation of substantial acid–base pairs(-SO_(3)^(-)…^(+)H–NH-),which further improves compatibility between additive and Nafion matrix.At the same humidity and temperature condition,the water uptake of composite membranes significantly increases due to the incorporation of porous additives with abundant functional groups and thus less crystallinity degree in comparison to pristine Nafion.Proton conductivity(σ)over wide ranges of humidities(30-100%RH at 25℃)and temperatures(30-98℃ at 100%RH)for prepared membranes is measured.The s in PCPMCN/Nafion composite membranes is remarkably enhanced,i.e.0.245 S/cm for PCP-MCN-3wt.%/Nafion is twice that of Nafion membrane at 98℃ and 100%RH,because of the establishment of well-interconnected proton transport ionic water channels and perhaps faster protonation–deprotonation processes.The composite membranes possess weak humidity-dependence of proton transport and higher water uptake due to excellent water retention ability of PCP-MCN.In particular,when 3 wt.%PCP-MCN was added to Nafion,the power density of a single-cell fabricated with this composite membrane reaches impressively 0.480,1.098 W/cm^(2) under 40%RH,100%RH at 60℃,respectively,guaranteeing it to be a promising proton exchange membrane.

Dual-Functional Electrode Promoting Dendrite-Free and CO_(2) Utilization Enabled High-Reversible Symmetric Na-CO_(2) Batteries

Sodium-carbon dioxide(Na-CO_(2))batteries are regarded as promising energy storage technologies because of their impressive theoretical energy density and CO_(2)reutilization,but their practical applications are restricted by uncontrollable sodium dendrite growth and poor electrochemical kinetics of CO_(2)cathode.Constructing suitable multifunctional electrodes for dendritefree anodes and kinetics-enhanced CO_(2)cathodes is considered one of the most important ways to advance the practical application of Na-CO_(2)batteries.Herein,RuO2 nanoparticles encapsulated in carbon paper(RuCP)are rationally designed and employed as both Na anode host and CO_(2)cathode in Na-CO_(2)batteries.The outstanding sodiophilicity and high catalytic activity of RuCP electrodes can simultaneously contribute to homogenous Na+distribution and dendrite-free sodium structure at the anode,as well as strengthen discharge and charge kinetics at the cathode.The morphological evolution confirmed the uniform deposition of Na on RuCP anode with dense and flat interfaces,delivering enhanced Coulombic efficiency of 99.5%and cycling stability near 1500 cycles.Meanwhile,Na-CO_(2)batteries with RuCP cathode demonstrated excellent cycling stability(>350 cycles).Significantly,implementation of a dendrite-free RuCP@Na anode and catalytic-site-rich RuCP cathode allowed for the construction of a symmetric Na-CO_(2)battery with long-duration cyclability,offering inspiration for extensive practical uses of Na-CO_(2)batteries.

Seasonal Sodium Percentage (%NA), Absorption Ratio (SAR) and Irrigation Water Quality Index (IWQI) Determination for Irrigation Purposes Along River Ethiope, Southern Nigeria

The improvement of agriculture through irrigation farming is now of great need in the country Nigeria and Delta State. The country is going through a phase of famine and food insecurity caused by climate change and rain dependent agricultural practices. The aim of the study therefore, was to evaluate the quality of water from River Ethiope in Southern Nigeria for irrigation agriculture purposes using the percentage sodium (%Na), sodium-adsorption ratio (SAR) and irrigation-water quality index (IWQ1) techniques. The study deployed the experimental design and water samples were collected from different segments of the Ethiope River. A total of 144 water samples were collected and analysed for physicochemical parameters quality (EC, HCO3, Cl−, Na+, Mg2+, Ca2+ and K+) from January to December, 2022. The results showed that all the calculated values for %Na were within the classified rating of 20 < N ≤ 40 and 60 < Na ≤ 80;while SAR were within the range of 0 < SAR ≤ 10. The recorded values of IWQI were within the range of 70 - 55 and 55 - 40. This implies that the water is good to doubtful for %Na, excellent for SAR and of moderate and high restrictions for IWQI. Water was adjudged to be good for irrigation activities, and should be applicable in areas with moderate and high soil permeability. The routine testing of the water to ascertain physicochemical parameters quality regularly, in order not to affect its use for irrigation was among the recommendations. This finding herein shall be of use to Water Resources and Agriculture ministries in Nigeria.

Evaluation of the Level of Pollution by Heavy Metals of Market Garden Soils along the Chari River in Ndjamena: Case of the 9th and 7th Districts

The main aim of this study was to characterize the metal content of soils used for market gardening along the Chari river: the 7th and 9th districts of NDjaména. To achieve this, two sites were selected: Gassi and Walia, and two control sites (Gassi and Walia). A total of fifty (50) soil samples were taken (24 from the Gassi site, 24 from the Walia site and 2 as control soils) and then analyzed to determine a number of physico-chemical parameters (pH, OM and electrical conductivity) and heavy metal concentrations in the various soils. The TME content (As, Cd, Cu, Cr, Ni, Pb, Hg and Zn) of the soils was determined by plasma-coupled Atomic Emission Spectrometry. In order to assess the level of contamination in Gassi and Walia soils, the geoaccumulation index (GeoIndex), contamination factor and degree of contamination were calculated. Results for physico-chemical parameters revealed that pH ranged from acidic (4.6) to moderately neutral (6.5), electrical conductivity was higher in cultivated soils (mean 292.14 μs/cm) than in control soils (mean 149.33 μs/cm), and soils were rich in organic matter. Overall, heavy metal concentrations in cultivated soils were higher than in control soils. The pollution estimate shows that soils in the area have no moderate contamination. The increase in TME concentrations in cultivated soils is thought to be due to the input of agricultural inputs to the soil. However, these levels are below the Average shale reference and Canadian guidelines for agricultural soil quality. Principal component analysis shows that metals are positively and significantly correlated with each other, and negatively and moderately significantly correlated with each other.

Unraveling the incompatibility mechanism of ethylene carbonate-based electrolytes in sodium metal anodes

Ethylene carbonate(EC)is widely used in lithium-ion batteries due to its optimal overall performance with satisfactory conductivity,relatively stable solid electrolyte interphase(SEI),and wide electrochemical window.EC is also the most widely used electrolyte solvent in sodium ion batteries.However,compared to lithium metal,sodium metal(Na)shows higher activity and reacts violently with EC-based electrolyte(NaPF_(6)as solute),which leads to the failure of sodium metal batteries(SMBs).Herein,we reveal the electrochemical instability mechanism of EC on sodium metal battery,and find that the com-bination of EC and NaPF_(6) is electrically reduced in sodium metal anode during charging,resulting in the reduction of the first coulombic efficiency,and the continuous consumption of electrolyte leads to the cell failure.To address the above issues,an additive modified linear carbonate-based electrolyte is provided as a substitute for EC based electrolytes.Specifically,ethyl methyl carbonate(EMC)and dimethyl carbon-ate(DMC)as solvents and fluoroethylene carbonate(FEC)as SEI-forming additive have been identified as the optimal solvent for NaFP_(6)based electrolyte and used in Na_(4)Fe_(3)(PO_(4))_(2)(P_(2)O_(7))/Na batteries.The batter-ies exhibit excellent capacity retention rate of about 80%over 1000 cycles at a cut-off voltage of 4.3 V.

Enhancing Na^(+) diffusion dynamics and structural stability of O3-NaMn_(0.5)Ni_(0.5)O_(2)cathode by Sc and Zn dual-substitution

Sc and Zn were introduced into O3-NaMn_(0.5)Ni_(0.5)O_(2)(NaMN)using the combination of solution combustion and solid-state method.The effect of Sc and Zn dual-substitution on Na^(+) diffusion dynamics and structural stability of NaMN was investigated.The physicochemical characterizations suggest that the introduction of Sc and Zn broaden Na^(+) diffusion channels and weaken the Na—O bonds,thereby facilitating the diffusion of sodium ions.Simulations indicate that the Sc and Zn dual-substitution decreases the diffusion barrier of Na-ions and improves the conductivity of the material.The dual-substituted NaMn_(0.5)Ni_(0.4)Sc_(0.04)Zn_(0.04)O_(2)(Na MNSZ44)cathode delivers impressive cycle stability with capacity retention of 71.2%after 200 cycles at 1C and 54.8%after 400 cycles at 5C.Additionally,the full cell paired with hard carbon anode exhibits a remarkable long-term cycling stability,showing capacity retention of 64.1%after 250 cycles at 1C.These results demonstrate that Sc and Zn dual-substitution is an effective strategy to improve the Na^(+) diffusion dynamics and structural stability of NaMN.

Preparation of Na specific absorbent and application of sodium removal from ammonium tungstate solution

An adsorbent, Na1.6Al0.6Ti1.4（PO4）3 （or NATP）, was prepared by controlled crystallization of glasses in the Na2O-Al2O3-CaO-TiO2-P2O5 system. The crystalline phases characterized by X-ray diffraction （XRD） show that the sample glasses crystallizes into two phases, i.e. NATP and Ca9Al（PO4）7, while the Ca9Al（PO4）7 phase can be leached selectively with HCl, leaving a massive number of pores in the material. Through the experimental research, the effects of contact time, solution pH, and the initial concentration of Na＋on the cation exchange properties were investigated. The batch sorption kinetics and equilibria can be described by Pseudo-second-order kinetic equations and Langmuir isotherm equations respectively. Furthermore, the experiments with an industrial solution show that the removal rate of sodium from industrial （NH4）2WO4 is higher than 97%. Cycle experiment also shows that the NATP has a good cyclic performance.

同分布NA列Jamison型加权和强稳定的充要条件

本文将Ｊａｍｉｓｏｎ等（１９６５）关于ｉｄ列加权和强稳定的充分性结果推广到ＮＡ列的场合。

Oxidation process of low-grade vanadium slag in presence of Na_(2)CO_3

The oxidation process of low-grade vanadium slag in the presence of Na2CO3 was investigated by XRD,SEM/EDS and TG-DSC techniques.The results show that the vanadium slag is oxidized in a temperature range from 273 to 700 °C.Olivine phases and spinel phases are completely decomposed at 500 and 600 °C,respectively.Most of water-soluble sodium vanadates are formed between 500 and 600 °C.When roasting temperature reaches above 700 °C,the vanadium-rich phases of sodium vanadates can be obviously observed.However,at temperature above 800 °C,the samples are sintered.Most of the vanadium is enwrapped by glassy phase compounds which lead to the decrease of the leaching rate of vanadium.At the same time,the effect of roasting temperature on extraction of vanadium and characterization of leach residues were discussed.

Screening an Na^+/H^+ Antiporter Gene from the Halophiles Colonizing in the Dagong Ancient Brine Well of Zigong City,China

[Objective] This study aimed to screen an Na＋/H＋ antiporter gene from the halophiles colonizing in the Dagong Ancient Brine Well in Zigong City, China, and then analyze the gene structure and properties of the protein encoded by this gene. [Method] Metagenomic DNA libraries of halophiles from the Dagong Ancient Brine Well were used for screening genes with Na＋/H＋ antiporter activity in antiporter-defi- cient E. coil KNabc strain by functional complementation. Then the start codon, stop codon, ORF, -35 region, -10 region and SD sequence of Na~/H＋ antiporter gene, as well as the molecular weight, isoelectric point, hydrophobic region, transmembrane domain, phyletic evolution and salt resistance of protein encoded by the gene were investigated. [Result] A new Na＋/H＋ antiporter gene m-nha was obtained, which ,ren- dered the antiporter-negative mutant E. coil KNabc cells with both the resistance to Na＋ and the ability to grow under alkaline conditions. [Conclusion] The structure and amino acid sequence of M-Nha was different from the previously reported Na＋/H~ antiporters, and the m-nha gene disclosed from the Dagong Ancient Brine Well was identified as a novel Na＋/H＋ antiporter gene. This study was significant not only in helping us understand the salt tolerance of halophiles in ancient brine wells and develop and utilize the genes resource, but also in exploring new salt-tolerant genes.

Selective recovery of lead from zinc oxide dust with alkaline Na_2EDTA solution

The selective recovery of lead from the zinc oxide dust using an alkaline Na2EDTA solution was investigated. The effects of temperature, leaching time, Na2EDTA concentration and initial NaOH concentration on the leaching rates of lead and zinc were studied. The following optimized leaching conditions were obtained： liquid-to-solid ratio 5：1 mL/g, stirring speed 650 r/min, Na2EDTA concentration 0.12 mol/L, initial NaOH concentration 0.5 mol/L, leaching temperature 70 ℃, leaching time 120 min. Under the optimized conditions, the average leaching rates of lead, zinc, fluoride and chloride are 89.92%, 0.94%, 62.84% and 90.02%, respectively. The filtrate was used to electrowin lead powders. The average current efficiency of electrowinning is about 93% and lead content is higher than 98% under the conditions of temperature of 60 ℃, current density of 200 A/m2, H3PO4 concentration of 1.5 g/L, and lead ion concentration of above 5 g/L. The consumption of Na2EDTA and the direct current are about respectively 0.218 kg and 0.958 kW·h for per kilogram of lead powder.

Effect of Na_2O on alumina leaching property and phase transformation of MgO-containing calcium aluminate slags

In order to remove or reduce the negative effect of MgO in calcium aluminate slags, the method of adding Na2O into calcium aluminate slags was studied and its effect on leaching mechanism was also analyzed. The results show that the alumina leaching efficiency of the calcium aluminate slag increases from 68.73% to 80.86% with Na2O content increasing from 0 to 4% when MgO content is 3%. The XRD results show that the quaternary compound C20A13M3S3 disappears when Na2O content increases to 4%. The addition of Na2O cannot remove the negative effect of MgO on leachability completely. XRD and EDS results indicate that Na2O can come into the lattice of 12CaO·7Al2O3 and promote the formation of 12CaO·7Al2O3