Oxidative stress(OS)is intimately associated with tumorigenesis and has been considered a potential therapeutic strategy.However,the OS-associated therapeutic target for esophageal squamous cell carcinoma(ESCC)remains...Oxidative stress(OS)is intimately associated with tumorigenesis and has been considered a potential therapeutic strategy.However,the OS-associated therapeutic target for esophageal squamous cell carcinoma(ESCC)remains unconfirmed.In our study,gene expression data of ESCC and clinical information from public databases were downloaded.Through LASSO-Cox regression analysis,a risk score(RS)signature map of prognosis was constructed and performed external verification with the GSE53625 cohort.The ESTIMATE,xCell,CIBERSORT,TIMER,and ImmuCellAI algorithms were employed to analyze infiltrating immune cells and generate an immune microenvironment(IM).Afterward,functional enrichment analysis clarified the underlying mechanism of the model.Nomogram was utilized for forecasting the survival rate of individual ESCC cases.As a result,we successfully constructed an OS-related genes(OSRGs)model and found that the survival rate of high-risk groups was lower than that of low-risk groups.The AUC of the ROC verified the strong prediction performance of the signal in these two cohorts further.According to independent prognostic analysis,the RS was identified as an independent risk factor for ESCC.The nomogram and follow-up data revealed that the RS possesses favorable predictive value for the prognosis of ESCC patients.qRT-PCR detection demonstrated increased expression of MPC1,COX6C,CYB5R3,CASP7,and CYCS in esophageal cancer patients.In conclusion,we have constructed an OSRGs model for ESCC to predict patients’prognosis,offering a novel insight into the potential application of the OSRGs model in ESCC.展开更多
Malcolm Baldrige National Quality Award-BNQA-SA was introduced in 1987 in US companies to create overall excellence in all parts of an organisation, leading to “integrated companies” as the ultimate goal for sustain...Malcolm Baldrige National Quality Award-BNQA-SA was introduced in 1987 in US companies to create overall excellence in all parts of an organisation, leading to “integrated companies” as the ultimate goal for sustained performance by using the Baldrige Excellence Framework (BEF). The “Balanced Score Cards” (BSC) methodology, as an instrument of designing, cascading and communicating strategy, was introduced in 1992. Operations excellence is an outcome of a well-designed, monitored and implemented operations strategy (OS). This paper traces the evolution of an “OS Wheel” model of operations strategy, for continuous manufacturing industries (CMI), deployed using the BEF, using BSC’s, to achieve performance excellence and sustained competitive advantage. The model was applied in a large scale, CMI company in India, over a period of fifteen years (a longitudinal study), the description of which will demonstrate its utility.展开更多
基金Natural Science Foundation of Ningbo(Grant No.2021J261).
文摘Oxidative stress(OS)is intimately associated with tumorigenesis and has been considered a potential therapeutic strategy.However,the OS-associated therapeutic target for esophageal squamous cell carcinoma(ESCC)remains unconfirmed.In our study,gene expression data of ESCC and clinical information from public databases were downloaded.Through LASSO-Cox regression analysis,a risk score(RS)signature map of prognosis was constructed and performed external verification with the GSE53625 cohort.The ESTIMATE,xCell,CIBERSORT,TIMER,and ImmuCellAI algorithms were employed to analyze infiltrating immune cells and generate an immune microenvironment(IM).Afterward,functional enrichment analysis clarified the underlying mechanism of the model.Nomogram was utilized for forecasting the survival rate of individual ESCC cases.As a result,we successfully constructed an OS-related genes(OSRGs)model and found that the survival rate of high-risk groups was lower than that of low-risk groups.The AUC of the ROC verified the strong prediction performance of the signal in these two cohorts further.According to independent prognostic analysis,the RS was identified as an independent risk factor for ESCC.The nomogram and follow-up data revealed that the RS possesses favorable predictive value for the prognosis of ESCC patients.qRT-PCR detection demonstrated increased expression of MPC1,COX6C,CYB5R3,CASP7,and CYCS in esophageal cancer patients.In conclusion,we have constructed an OSRGs model for ESCC to predict patients’prognosis,offering a novel insight into the potential application of the OSRGs model in ESCC.
文摘Malcolm Baldrige National Quality Award-BNQA-SA was introduced in 1987 in US companies to create overall excellence in all parts of an organisation, leading to “integrated companies” as the ultimate goal for sustained performance by using the Baldrige Excellence Framework (BEF). The “Balanced Score Cards” (BSC) methodology, as an instrument of designing, cascading and communicating strategy, was introduced in 1992. Operations excellence is an outcome of a well-designed, monitored and implemented operations strategy (OS). This paper traces the evolution of an “OS Wheel” model of operations strategy, for continuous manufacturing industries (CMI), deployed using the BEF, using BSC’s, to achieve performance excellence and sustained competitive advantage. The model was applied in a large scale, CMI company in India, over a period of fifteen years (a longitudinal study), the description of which will demonstrate its utility.
