Large-field objective lens for multi-wavelength microscopy at mesoscale and submicron resolution

Conventional microscopes designed for submicron resolution in biological research are hindered by a limited field of view,typically around 1 mm.This restriction poses a challenge when attempting to simultaneously analyze various parts of a sample,such as different brain areas.In addition,conventional objective lenses struggle to perform consistently across the required range of wavelengths for brain imaging in vivo.Here we present a novel mesoscopic objective lens with an impressive field of view of 8 mm,a numerical aperture of 0.5,and a working wavelength range from 400 to 1000 nm.We achieved a resolution of 0.74μm in fluorescent beads imaging.The versatility of this lens was further demonstrated through high-quality images of mouse brain and kidney sections in a wide-field imaging system,a confocal laser scanning system,and a two-photon imaging system.This mesoscopic objective lens holds immense promise for advancing multi-wavelength imaging of large fields of view at high resolution.

Distributed Stochastic Optimization with Compression for Non-Strongly Convex Objectives

We are investigating the distributed optimization problem,where a network of nodes works together to minimize a global objective that is a finite sum of their stored local functions.Since nodes exchange optimization parameters through the wireless network,large-scale training models can create communication bottlenecks,resulting in slower training times.To address this issue,CHOCO-SGD was proposed,which allows compressing information with arbitrary precision without reducing the convergence rate for strongly convex objective functions.Nevertheless,most convex functions are not strongly convex(such as logistic regression or Lasso),which raises the question of whether this algorithm can be applied to non-strongly convex functions.In this paper,we provide the first theoretical analysis of the convergence rate of CHOCO-SGD on non-strongly convex objectives.We derive a sufficient condition,which limits the fidelity of compression,to guarantee convergence.Moreover,our analysis demonstrates that within the fidelity threshold,this algorithm can significantly reduce transmission burden while maintaining the same convergence rate order as its no-compression equivalent.Numerical experiments further validate the theoretical findings by demonstrating that CHOCO-SGD improves communication efficiency and keeps the same convergence rate order simultaneously.And experiments also show that the algorithm fails to converge with low compression fidelity and in time-varying topologies.Overall,our study offers valuable insights into the potential applicability of CHOCO-SGD for non-strongly convex objectives.Additionally,we provide practical guidelines for researchers seeking to utilize this algorithm in real-world scenarios.

Effect of low-degree astigmatism on the objective visual quality

AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis System(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corrected-to-normal vision.The cylindrical lenses(0,0.5,0.75,1.0,and 1.25 D)were placed at the axial direction(180°,45°,90°,and 135°)in front of the eyes with the best correction to form 16 types of regular low-degree astigmatism.OQAS was used to detect the objective visual quality,recorded as the objective scattering index(OSI),OQAS values at contrasts of 100%,20%,and 9%predictive visual acuity(OV100%,OV20%,and OV9%),modulation transfer function cut-off(MTFcut-off)and Strehl ratio(SR).The mixed effect linear model was used to compare objective visual quality differences between groups and examine associations between astigmatic magnitude and objective visual quality parameters.RESULTS:Apparent negative relationships between the magnitude of low astigmatism and objective visual quality were observed.The increase of OSI per degree of astigmatism at 180°,45°,90°,and 135°axis were 0.38(95%CI:0.35,0.42),0.50(95%CI:0.46,0.53),0.49(95%CI:0.45,0.54)and 0.37(95%CI:0.34,0.41),respectively.The decrease of MTFcut-off per degree of astigmatism at 180°,45°,90°,and 135°axis were-10.30(95%CI:-11.43,-9.16),-12.73(95%CI:-13.62,-11.86),-12.75(95%CI:-13.79,-11.70),and-9.97(95%CI:-10.92,-9.03),respectively.At the same astigmatism degree,OSI at 45°and 90°axis were higher than that at 0°and 135°axis,while MTFcut-off were lower.CONCLUSION:Low astigmatism of only 0.50 D can significantly reduce the objective visual quality.

Objective Model Selection in Physics: Exploring the Finite Information Quantity Approach

Traditional methods for selecting models in experimental data analysis are susceptible to researcher bias, hindering exploration of alternative explanations and potentially leading to overfitting. The Finite Information Quantity (FIQ) approach offers a novel solution by acknowledging the inherent limitations in information processing capacity of physical systems. This framework facilitates the development of objective criteria for model selection (comparative uncertainty) and paves the way for a more comprehensive understanding of phenomena through exploring diverse explanations. This work presents a detailed comparison of the FIQ approach with ten established model selection methods, highlighting the advantages and limitations of each. We demonstrate the potential of FIQ to enhance the objectivity and robustness of scientific inquiry through three practical examples: selecting appropriate models for measuring fundamental constants, sound velocity, and underwater electrical discharges. Further research is warranted to explore the full applicability of FIQ across various scientific disciplines.

Research on the Relationship between the School-Running Characteristics of Private Colleges and Universities and the Development Objectives of the Government

The development objectives of the Chinese government have a guiding effect on the school-running characteristics of private colleges and universities.This paper explores the relationship between the characteristics of private colleges and universities and the development objectives of the provincial government,using Jiangsu Province as a case study.All the schools have the consciousness of fully considering the development objectives of Jiangsu Province when formulating the school-running characteristics.Their characteristics all contain some training methods,training courses,or institutional construction aiming at the development objectives.Most universities can support the government’s objectives on employment and innovation.Only a third of the schools provide government support for science research.Private colleges and universities should make full use of the free and flexible advantages of private education,combine them with the continuous changes of policies and markets,and create clear,scientific,and dynamic school-running characteristics,in order to achieve long-term development.

Multi Objective Decision Making Method Based on Evaluation Criterion for Problems with Linear Value Function

A class of interactive multi objective decision making method by means of evaluation criterion is proposed for problems with linear value function,in which case,the decision maker(DM) usually has only unwhole information of weights for objectives. The concept of fault measure of the evaluation criterion is proposed to measure the deviation of the evaluation criterion from the DMs preference structure.The approach to obtain an upper boundary of fault measure of an evaluation criterion,and the approach to modify the evaluation criterion to be one with smaller fault measure,and the approach to obtain a pre optimized objective set by evaluation criterion with certain fault measure are also proposed.

Objective and subjective measures for sleep disorders

Subjective and objective measures of sleep structure or quality could help to characterize the chronic sleep disturbances, with relation to patients＇ risk factor profiles and co-morbidities. Studies have shown that discrepancies can occur between subjective data regarding sleep disturbances and the impact of insomnia and objective assays, and surrogate markers of sleep and sleep disturbances. Both objective and subjective measures should be incorporated into clinic studies. It seems likely that sleep quality is represented by a combination of more than one subjective sleep parameter. Objective and subjective assessments of sleep quality may relate to different parameters. Future studies incorporated both subjective and objective measures could help to address the sleep disorders.

A multi-objective fuzzy optimization model for cropping structure and water resources and its method

Cropping structure has a close relationship with the optimal allocation of agricultural water resources. Based on the analysis of the relationship between agricultural water resources and sustainable development, this paper presents a multi objective fuzzy optimization model for cropping structure and water allocation, which overcomes the shortcoming of current models that only considered the economic objective,and ignored the social and environmental objectives. During the process, a new method named fuzzy deciding weight is developed to decide the objective weight. A case study shows that the model is reliable, the method is simple and objective, and the results are reasonable. This model is useful for agricultural management and sustainable development.

Objectives of and Approaches to Ecological City Construction

It has become a trend of the city development in the world to build up the ecological city with an ecological system that is balanced in structure,high-efficient in service function.Taking Suzhou as a case,the authors believe that the construction of an ecological city is a process of the progressive and well-organized systematic development and of the ecological function consummation,which will require five stages to complete,including ecological hygiene,ecological security,ecological industry,ecological landscape,and ecological culture.The problems presently encountered in the construction of ecological city in Suzhou can be solved through the following approaches:(1) To rebuild the relationship between man and nature when the planning is worked out;(2) To observe the principle of ecology in city design;(3) To choose the local plant species in city afforestation;(4) To choose those plantlets with vigorous growth,good shape,and high survival rate,observing the growth rule of plant and paying much attention to forest landscape,ecological system and biological diversity,rationally allocating the plant species resources;(5) To aim at the implementation of the less-labor management even the zero-labor management.

Hierarchical Algorithms of Large-Scale Systems with Nonseparable Multiobjective

A class of large-scale hierarchical control systems is considered, the overall objective function is a nonlinear and nonseparable function of multiple quadratic performance indices.The separation strategy of the multiobjective optimization technique and the three-level objective coordination method are applied to the large -sacle systems, and a four-level hierarchical algorithms of optimization control is obtained.

Overview of multi-objective optimization methods

To assist readers to have a comprehensive understanding, the classical and intelligent methods roundly based on precursory research achievements are summarized in this paper. First, basic conception and description about multi-objective (MO) optimization are introduced. Then some definitions and related terminologies are given. Furthermore several MO optimization methods including classical and current intelligent methods are discussed one by one succinctly. Finally evaluations on advantages and disadvantages about these methods are made at the end of the paper.

基于Stingray Objective Studio的防空C^3I显控系统界面开发

文中提出了用 Stingray Objective Studio 工具集来进行防空显控系统界面开发,使得开发人员将大量的时间和精力用于系统结构和数据处理算法上,这样不光降低了开发难度,也增强了系统的功能和稳定性。

Objective increment based metaheuristic for total flowtime minimization in no-wait flowshops

To solve the NP-complete no-wait flowshop problems, objective increment properties are analyzed and proved for fundamental operations of heuristics. With these properties, whether a new generated schedule is better or worse than the original one is only evaluated by objective increments, instead of completely calculating objective values as the traditional algorithms do, so that the computational time can be considerably reduced. An objective increment-based hybrid genetic algorithm （IGA） is proposed by integrating the genetic algorithm （GA） with an improved various neighborhood search （VNS）as a local search. An initial solution generation heuristic（ISG） is constructed to generate one individual of the initial population. An expectation value-based selection mechanism and a crossover operator are introduced to the mating process. The IGA is compared with the traditional GA and two best-so-far algorithms for the considered problem on 110 benchmark instances. An experimental results show that the IGA outperforms the others in effectiveness although with a little more time consumption.

MULTI OBJECTIVE OPTIMIZATION USING GENETIC ALGORITHM WITH LOCAL SEARCH

In this paper,we propose a hybrid algorithm for finding a set of non dominated solutions of a multi objective optimization problem.In the proposed algorithm,a local search procedure is applied to each solution generated by genetic operations.The aim of the proposed algorithm is not to determine a single final solution but to try to find all the non dominated solutions of a multi objective optimization problem.The choice of the final solution is left to the decision makers preference.High search ability of the proposed algorithm is demonstrated by computer simulation.

Two-Stage Interactive Multi-Objective Decision-Making Method Based on the Satisfactoriness Criterion

In this paper, for multi objective decision making, the defects on the commonly used interactive methods based on the satisfactoriness criterion is studied. Then a class of two stage interactive method based on the satisfactoriness criterion is proposed for improvement with the satisfactoriness criterion being determined through the collection of the decision makers preference information. An application example is presented for illustration of applicability of the method.

Eclipse计划系统MU Objective工具在鼻咽癌容积调强放射治疗计划中的应用研究

目的:探讨Varian Eclipse计划系统MU Objective工具在鼻咽癌容积调强放射治疗(VMAT)计划中的应用,旨在保证治疗计划质量的同时降低治疗计划的机器跳数(MU)。方法:选取已接受容积调强放射治疗技术的21例鼻咽癌患者,在未使用MU Objective工具的情况下给每例患者设计治疗参考计划(MU_(ref));将使用MU Objective工具对MU_(ref)进行重新优化,分别设置MU_(ref)的MU的30%、50%、70%、90%和120%,分别命名为MU_(30%)、MU_(50%)、MU_(70%)、MU_(90%)和MU_(120%)。将治疗计划MU_(30%)、MU_(50%)、MU_(70%)、MU_(90%)和MU_(120%)分别与MU_(ref)进行配对t检验统计分析,比较两种治疗计划的靶区、危及器官(OAR)剂量分布和计划的MU。结果:使用MU Objective工具对参考计划优化MU后,与参考计划相比部分靶区和OAR剂量体积参数差异虽有统计学意义,但无临床意义。治疗计划参数为MU_(30%)、MU_(50%)、MU_(70%)和MU_(90%)时,与MU_(ref)比较计划MU平均分别减少21.5%、19.5%、16.6%和8%,差异有统计学意义(t=9.652,t=8.843,t=8.963,t=11.323;P<0.05)。在MU_(120%)时,治疗计划MU平均增加1.7%,但未显著提高靶区剂量覆盖。结论:对于鼻咽癌VMAT计划,使用Eclipse计划系统的MU Objective工具在减少计划MU的同时可获得与参考计划相似的剂量分布。MU Objective工具可作为鼻咽癌或其他部位VMAT计划的常规使用工具,以保证计划质量同时减少放射治疗计划的MU。

Closed-loop supply chain network equilibrium strategy model with environmental protection objectives

With the increasing popularity of ecological civilization and sustainable development,enterprises should consider environmental protection measures in their operations in addition to pursue their economic interests.This paper establsihes a closed-loop supply chain network model composed of multiple suppliers,manufacturers,retailers,recyclers,and demand markets—regarding their dual goals of the profit maximization and the minimization of carbon emissions.The conditions necessary for establishing overall equilibrium and an equilibrium model of the entire closed-loop supply chain network are determined by applying variational inequality and dual theory.A modified projection contraction algorithm is used to design a model-solving program.Finally,using numerical examples,the paper conducts a comparative static analysis on important parameters such as the weight coefficients of environmental protection objectives and consumers'awareness of low-carbon environmental protection and attains some beneficial enlightenment on management.The results indicate that when the environmental protection objectives of a certain type of enterprise increases,both the economic benefits and environmental protection performance will improve;when the environmental protection objectives of all enterprises increases simultaneously,environmental protection performance improves significantly,but the changes in economic benefits of different enterprises are inconsistent and profit coordination is more complex.Although consumers’awareness of low-carbon preference could improve environmental performance,it reduces the overall profits of network members and the entire closed-loop supply chain network as a whole.The above conclusions can be used as a reference for the government in designing low-carbon environmental protection policy and in closed-loop supply chain research.

China English——An Objective Existence as a Performance Variety

China English is an objective existence as a performance variety used in China.It is based on standard English and possesses Chinese characteristics.The Chinese characteristics of China English are reflected in the phonology,vocabulary,syntax,rhetoric and text,particularly in the vocabulary.This essay will discuss the features of China English from the following three aspects: the development of English in China;the comparison between China English,Pidgin English and Chinese English and the Chinese words borrowed by English.

Multi-objective route planning approach for timely searching tasks of a supervised robot

To performance efficient searching for an operator-supervised mobile robot, a multiple objectives route planning approach is proposed considering timeliness and path cost. An improved fitness function for route planning is proposed based on the multi-objective genetic algorithm （MOGA） for multiple objectives traveling salesman problem （MOTSP）. Then, the path between two route nodes is generated based on the heuristic path planning method A ＊. A simplified timeliness function for route nodes is proposed to represent the timeliness of each node. Based on the proposed timeliness function, experiments are conducted using the proposed two-stage planning method. The experimental results show that the proposed MOGA with improved fitness function can perform the searching function well when the timeliness of the searching task needs to be taken into consideration.

Applications of Chemical Learning Evaluation Based on Bloom＇s Taxonomy of Educational Objectives

In this paper, Law of Conservation of Mass （＂The Law＂）, one content standard of junior middle school chemistry, was decomposed based on The Revision of Bloom＇s Taxonomy of Educational Objectives （＂The Revision＂） and placed in the classification table. In order to understand the teaching objectives more, the relationship between the related activities was studied. Teachers can design the teaching plans based on teaching objective, and determine different evaluations method according to different types of teaching objectives. It will raise students more cognitive activities and promote targeted objectives teaching.