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The First Global Map of Atmospheric Ammonia(NH_(3)) as Observed by the HIRAS/FY-3D Satellite
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作者 Minqiang ZHOU Zhili DENG +6 位作者 Charles ROBERT Xingying ZHANG Lu ZHANG Yapeng WANG Chengli QI Pucai WANG Martine De MAZIÈRE 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第3期379-390,共12页
Atmospheric ammonia(NH_(3)) is a chemically active trace gas that plays an important role in the atmospheric environment and climate change. Satellite remote sensing is a powerful technique to monitor NH_(3) concentra... Atmospheric ammonia(NH_(3)) is a chemically active trace gas that plays an important role in the atmospheric environment and climate change. Satellite remote sensing is a powerful technique to monitor NH_(3) concentration based on the absorption lines of NH_(3) in the thermal infrared region. In this study, we establish a retrieval algorithm to derive the NH_(3)column from the Hyperspectral Infrared Atmospheric Sounder(HIRAS) onboard the Chinese Feng Yun(FY)-3D satellite and present the first atmospheric NH_(3) column global map observed by the HIRAS instrument. The HIRAS observations can well capture NH_(3) hotspots around the world, e.g., India, West Africa, and East China, where large NH_(3) emissions exist. The HIRAS NH_(3) columns are also compared to the space-based Infrared Atmospheric Sounding Interferometer(IASI)measurements, and we find that the two instruments observe a consistent NH_(3) global distribution, with correlation coefficient(R) values of 0.28–0.73. Finally, some remaining issues about the HIRAS NH_(3) retrieval are discussed. 展开更多
关键词 AMMONIA HIRAS/FY-3d satellite thermal-infrared observation remote sensing optimal estimation method
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SAR regional all-azimuth observation orbit design for target 3D reconstruction
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作者 WANG Yanan ZHOU Chaowei +1 位作者 LIU Aifang MAO Qin 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期609-618,共10页
Three-dimensional(3D) synthetic aperture radar(SAR)extends the conventional 2D images into 3D features by several acquisitions in different aspects. Compared with 3D techniques via multiple observations in elevation, ... Three-dimensional(3D) synthetic aperture radar(SAR)extends the conventional 2D images into 3D features by several acquisitions in different aspects. Compared with 3D techniques via multiple observations in elevation, e.g. SAR interferometry(InSAR) and SAR tomography(TomoSAR), holographic SAR can retrieve 3D structure by observations in azimuth. This paper focuses on designing a novel type of orbit to achieve SAR regional all-azimuth observation(AAO) for embedded targets detection and holographic 3D reconstruction. The ground tracks of the AAO orbit separate the earth surface into grids. Target in these grids can be accessed with an azimuth angle span of360°, which is similar to the flight path of airborne circular SAR(CSAR). Inspired from the successive coverage orbits of optical sensors, several optimizations are made in the proposed method to ensure favorable grazing angles, the performance of 3D reconstruction, and long-term supervision for SAR sensors. Simulation experiments show the regional AAO can be completed within five hours. In addition, a second AAO of the same area can be duplicated in two days. Finally, an airborne SAR data process result is presented to illustrate the significance of AAO in 3D reconstruction. 展开更多
关键词 synthetic aperture radar(SAR) orbit design all-azimuth observation(AAO) three-dimensional(3d)reconstruction successive coverage
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Application of 3D stereoscopic visualization technology in casting aspect 被引量:1
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作者 Kang Jinwu Zhang Xiaopeng +1 位作者 Zhang Chi Liu Baicheng 《China Foundry》 SCIE CAS 2014年第4期308-313,共6页
3D stereoscopic visualization technology is coming into more and more common use in the field of entertainment,and this technology is also beginning to cut a striking figure in casting industry and scientific research... 3D stereoscopic visualization technology is coming into more and more common use in the field of entertainment,and this technology is also beginning to cut a striking figure in casting industry and scientific research.The history,fundamental principle,and devices of 3D stereoscopic visualization technology are reviewed in this paper.The authors’research achievements on the 3D stereoscopic visualization technology in the modeling and simulation of the casting process are presented.This technology can be used for the observation of complex 3D solid models of castings and the simulated results of solidification processes such as temperature,fluid flow,displacement,stress strain and microstructure,as well as the predicted defects such as shrinkage/porosity,cracks,and deformation.It can also be used for other areas relating to 3D models,such as assembling of dies,cores,etc.Several cases are given to compare the illustration of simulated results by traditional images and red-blue 3D stereoscopic images.The spatial shape is observed better by the new method.The prospect of3D stereoscopic visualization in the casting aspect is discussed as well.The need for aided-viewing devices is still the most prominent problem of 3D stereoscopic visualization technology.However,3D stereoscopic visualization represents the tendency of visualization technology in the future;and as the problem is solved in the years ahead,great breakthroughs will certainly be made for its application in casting design and modeling and simulation of the casting processes. 展开更多
关键词 3d stereoscopic visualization technology CASTING modeling and simulation observation and analysis
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3D Confocal Raman Imaging of Oil-Rich Emulsion from Enzyme-Assisted Aqueous Extraction of Extruded Soybean Powder
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作者 Wu Longkun Wang Limin +5 位作者 Qi Baokun Zhang Xiaonan Chen Fusheng Li Yang Sui Xiaonan Jiang Lianzhou 《大豆科技》 2019年第S01期76-83,96,共9页
The understanding of the structure morphology of oil-rich emulsion from enzyme-assisted extraction processing(EAEP)was a critical step to break the oil-rich emulsion structure in order to recover oil.Albeit EAEP metho... The understanding of the structure morphology of oil-rich emulsion from enzyme-assisted extraction processing(EAEP)was a critical step to break the oil-rich emulsion structure in order to recover oil.Albeit EAEP method has been applied as an alternative way to conventional solvent extraction method,the structure morphology of oil-rich emulsion was still unclear.The current study aimed to investigate the structure morphology of oil-rich emulsion from EAEP using 3 D confocal Raman imaging technique.With increasing the enzymatic hydrolysis duration from 1 to 3 h,the stability of oil-rich emulsion was decreased as visualized in the 3 D confocal Raman images that the protein and oil were mixed together.The subsequent Raman spectrum analysis further revealed that the decreased stability of oil-rich emulsion was due to the protein aggregations via SS bonds or protein-lipid interactions.The conformational transfer in protein indicated the formation of a compact structure. 展开更多
关键词 Enzyme-assisted extraction process Oil-rich emulsion 3d confocal Raman imaging technique Raman spectrum analysis
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3-D velocity structure in the central-eastern part of Qilianshan 被引量:30
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作者 张元生 周民都 +2 位作者 荣代潞 张立光 许中秋 《地震学报》 CSCD 北大核心 2004年第3期247-255,共9页
The 3-D velocity tomography image of the central-eastern part of Qilianshan is obtained by the joint inversion of 3-D velocity structure and focal parameters based on the S-P data of micro-earthquakes recorded by the ... The 3-D velocity tomography image of the central-eastern part of Qilianshan is obtained by the joint inversion of 3-D velocity structure and focal parameters based on the S-P data of micro-earthquakes recorded by the digital seismic network set up for a Sino-French cooperation program since 1996. The inversed velocity structure does primarily reflect some important features of the deep structure in the region and provide the scientific background for the further study of active tectonic structure and the calculation of earthquake parameters. 展开更多
关键词 祁连山中东段 微震观测 三维速度结构 震源参数 联合反演
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Parametric formation control of multiple nanosatellites for cooperative observation of China Space Station
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作者 Hao Zhou Bohan Jiao +1 位作者 Zhaohui Dang Jianping Yuan 《Astrodynamics》 EI CSCD 2024年第1期77-95,共19页
This study proposes a parametric formation control method for the cooperative observation of the China Space Station(CSS)using multiple nanosatellites.First,a simplified geometrical model of the CSS is constructed usi... This study proposes a parametric formation control method for the cooperative observation of the China Space Station(CSS)using multiple nanosatellites.First,a simplified geometrical model of the CSS is constructed using fundamental solids,such as the capsule body and cuboid.Second,the spacecraft formation configuration for the observation mission is characterized by a three-dimensional(3D)Lissajous curve using related design parameters under the full-coverage observation requirements of specific parts,such as the CSS connecting section and collision avoidance constraints.Third,a double-layer control law is designed for each nanosatellite,in which the upper layer is a distributed observer for recognizing the target formation configuration parameters,and the lower layer is a trajectory-tracking controller to make the nanosatellite converge to its temporary target position calculated from the upper layer’s outputs.The closed-loop control stability is proven under the condition that the communication network topology of the nanosatellite cluster contains a directed spanning tree.Finally,the control method is verified by numerical simulation,where the CSS connecting section is selected as the observation target,and ten small nanosatellites are assumed to perform the cooperative observation mission.The simulation results demonstrate that the double-layer control law is robust to single-point communication failures and suitable for the accompanying missions of large space objects with multiple nanosatellites. 展开更多
关键词 China Space Station(CSS) cooperative observation parametric formation 3d Lissajous curve double-layer system
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3-D velocity structure in the central-eastern part of Qilianshan 被引量:8
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作者 ZHANG Yuan-sheng(张元生) +7 位作者 ZHOU Min-du(周民都) RONG Dai-lu(荣代潞) ZHANG Li-guang(张立光) XU Zhong-qiu(许中秋) 《Acta Seismologica Sinica(English Edition)》 CSCD 2004年第3期272-281,共10页
The 3-D velocity tomography image of the central-eastern part of Qilianshan is obtained by the joint inversion of 3-D velocity structure and focal parameters based on the S-P data of micro-earthquakes recorded by the ... The 3-D velocity tomography image of the central-eastern part of Qilianshan is obtained by the joint inversion of 3-D velocity structure and focal parameters based on the S-P data of micro-earthquakes recorded by the digital seismic network set up for a Sino-French cooperation program since 1996. The inversed velocity structure does primarily reflect some important features of the deep structure in the region and provide the scientific background for the further study of active tectonic structure and the calculation of earthquake parameters. 展开更多
关键词 central-eastern Qilianshan micro-earthquake observation 3-D velocity structure focal pa-rameters joint inversion
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SAR tomography imaging via higher-order spectrum analysis 被引量:2
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作者 Wang Jinfeng Pi Yiming 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第4期748-754,共7页
To deal with the non-Caussian noise in standard 2-D SAR images, the deramped signal in imaging plane, and the possible symmetric distribution of complex noise, the fourth-order cumulant of complex process is introduce... To deal with the non-Caussian noise in standard 2-D SAR images, the deramped signal in imaging plane, and the possible symmetric distribution of complex noise, the fourth-order cumulant of complex process is introduced into SAR tomography. With the estimated AR parameters of ARMA model of noise through Yule-Walker equation, the signal series of height is pre-filtered. Then, through ESPRIT, the spectrum is obtained and the aperture in height direction is synthesized. Finally, the SAR tomography imaging of scene is achieved. The results of processing on signal with non-Gaussian noise demonstrate the robustness of the proposed method. The tomography imaging of the scenes shows that the higher-order spectrum analysis is feasible in the application. 展开更多
关键词 synthetic aperture radar 3-D imaging TOMOGRAPHY high-order spectrum analysis nongaussian
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Spectrum Illumination for 3-D Surface Imaging System
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作者 XUZhi-hai FENGHua-jun 《Semiconductor Photonics and Technology》 CAS 2001年第2期70-75,共6页
A method using spectrum illumination to reconstruct 3-D object image is a new concept in the field of computer vision. The design of optical illumination system is crucial in this method. Several ways to achieve multi... A method using spectrum illumination to reconstruct 3-D object image is a new concept in the field of computer vision. The design of optical illumination system is crucial in this method. Several ways to achieve multi-color spectrum illumination are discussed. A prism illumination system is designed by means of aligning symmetrically the prism at the mid-wavelength (n d=1.806 274) of light path and using reflection collimating lens, cylindrical expending lens and two optical shutters. The relations between deviation angles and light wavelengths are given, and some 3-D reconstruction results are presented. 展开更多
关键词 三维图像 亮度光谱 计算机视觉
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孤独症谱系障碍患儿维生素D及叶酸水平与病情程度的相关性研究 被引量:1
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作者 夏建锋 纪建兵 +2 位作者 吴霞 缪伶伶 陈晚琴 《徐州医科大学学报》 CAS 2023年第6期459-462,共4页
目的分析维生素D(VitD)及叶酸水平与孤独症谱系障碍(ASD)患儿病情程度的相关性。方法选择2017年3月—2022年3月如皋市人民医院确诊为ASD的55例患儿作为ASD组,同时选择于我院同期体检的55例健康儿童作为对照组。清晨空腹采集受试者外周... 目的分析维生素D(VitD)及叶酸水平与孤独症谱系障碍(ASD)患儿病情程度的相关性。方法选择2017年3月—2022年3月如皋市人民医院确诊为ASD的55例患儿作为ASD组,同时选择于我院同期体检的55例健康儿童作为对照组。清晨空腹采集受试者外周静脉血检测血清25-羟基维生素D 3[25(OH)D 3]及叶酸水平。采用儿童孤独症评定量表(CARS)评估ASD患儿病情程度,采用Pearson相关分析ASD患儿血清25(OH)D 3及叶酸与CARS评分的关系,并通过受试者工作特征曲线(ROC)分析血清25(OH)D 3与ASD患儿病情危重程度的关系。结果ASD组患儿血清中25(OH)D 3及叶酸水平明显低于对照组(P<0.05),2组VitD不足率及叶酸缺乏率比较差异均有统计学意义(P<0.05)。55例ASD患儿经CARS量表评估确定重度19例,轻中度36例,重度患儿VitD缺乏率明显高于轻中度患儿(P<0.05)。Pearson相关分析显示ASD患儿25(OH)D 3与CARS评分呈负相关(r=-0.606,P=0.000)。ROC曲线分析显示当25(OH)D 3取15.8μg/L(最佳截点值)时,重度ASD患儿的敏感度、特异度分别为73.80%、91.4%,曲线下面积为0.85。结论ASD患儿体内血清25(OH)D 3及叶酸水平均明显降低,且ASD与VitD存在相关性。25(OH)D 3可作为预测重度ASD患儿病情程度的辅助指标。 展开更多
关键词 维生素D 25-羟基维生素D 3 叶酸 孤独症谱系障碍 儿童
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基于面向对象技术的3D量测系统
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作者 杨韫澜 张保明 杨喆 《测绘科学与工程》 2007年第1期37-40,共4页
本文主要阐述可量测立体像对的3D坐标量测系统的设计与实现。由于现存的全数字摄影测量产品要么是价格非常高昂的高端专业设备(一般为具有高端图像卡的工作站),要么是功能受约束的简单设备。本文将说明如何在非高端图形PC设备上,运... 本文主要阐述可量测立体像对的3D坐标量测系统的设计与实现。由于现存的全数字摄影测量产品要么是价格非常高昂的高端专业设备(一般为具有高端图像卡的工作站),要么是功能受约束的简单设备。本文将说明如何在非高端图形PC设备上,运用面向对象程序设计、软件模块化和硬件无关性等技术实现所要求的立体量测系统功能。 展开更多
关键词 数字摄影测量 3d量测 立体观测
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三维荧光等高线特征谱及其应用研究 被引量:14
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作者 徐永群 彭翠红 +2 位作者 徐坦 黄冬兰 陈小康 《分析测试学报》 CAS CSCD 北大核心 2008年第11期1151-1156,共6页
用图像信息统计法,得到了三维荧光等高线指纹图谱在发射波长方向和激发波长方向的1对特征谱以及1个沿发射波长方向并带有激发波长信息的特征谱。基于3种特征谱,对花生油、调和油和芝麻油的29个食用植物油样本进行了模式识别,结果表明:3... 用图像信息统计法,得到了三维荧光等高线指纹图谱在发射波长方向和激发波长方向的1对特征谱以及1个沿发射波长方向并带有激发波长信息的特征谱。基于3种特征谱,对花生油、调和油和芝麻油的29个食用植物油样本进行了模式识别,结果表明:3种特征谱均能以数值集的形式描述物质的荧光性质,具有特征性和可计算性;数据客观,识别结果准确。将现代的数值分析技术与3种特征谱结合,不仅可实现物质的分类与鉴别,还可揭示化学变化过程中物质结构变化的客观规律。 展开更多
关键词 三维荧光光谱 等高线特征谱 模式识别 食用油
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准噶尔盆地隐蔽油气藏的识别方法 被引量:8
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作者 蔡刚 姚清洲 +2 位作者 李双文 吕锡敏 龚洪林 《石油地球物理勘探》 EI CSCD 北大核心 2006年第6期692-696,共5页
本文将频谱分解技术、全三维可视化技术和全三维体解释技术应用于准噶尔盆地中的多个三维工区,有效地预测出了河道及储层岩性体的空间展布,并识别出了岩性圈闭的边界和幅度。通过这三项技术的成功应用,发现了S31井大型岩性油气藏,为准... 本文将频谱分解技术、全三维可视化技术和全三维体解释技术应用于准噶尔盆地中的多个三维工区,有效地预测出了河道及储层岩性体的空间展布,并识别出了岩性圈闭的边界和幅度。通过这三项技术的成功应用,发现了S31井大型岩性油气藏,为准噶尔盆地的隐蔽油气藏勘探提供了新思路。值得注意的是,在研究隐蔽油气藏时,一定要选用合适的解释方法,方能收到成效。 展开更多
关键词 准噶尔盆地 隐蔽油气藏 频谱 分解 全三维可视化 全三维体解释
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海洋微藻生长过程藻液三维荧光特征 被引量:18
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作者 任保卫 赵卫红 +1 位作者 王江涛 王璐 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2008年第5期1130-1134,共5页
利用三维荧光光谱技术监测了中肋骨条藻(Skeletonema costatum),塔玛亚历山大藻(Alexandriumtamarense),微小亚历山大藻(Alexandrium mimntum),锥状斯氏藻(Scrippsiella trochoidea),东海原甲藻(Prorocentrum donghaiense)及海洋原甲藻(... 利用三维荧光光谱技术监测了中肋骨条藻(Skeletonema costatum),塔玛亚历山大藻(Alexandriumtamarense),微小亚历山大藻(Alexandrium mimntum),锥状斯氏藻(Scrippsiella trochoidea),东海原甲藻(Prorocentrum donghaiense)及海洋原甲藻(Prorocentrum micans)实验室培养过程中产生的荧光溶解有机物。中肋骨条藻为代表的硅藻主要产生类腐殖质荧光物质,而甲藻在指数增长期主要产生类蛋白荧光物质。进入消亡期后类蛋白荧光和类腐殖质荧光强度迅速增大,原因可能是衰老、死亡藻细胞的破碎释放出大量的荧光有机物质所致,此外还有细菌对非荧光有机物进一步降解。塔玛亚历山大藻、微小亚历山大藻、东海原甲藻及海洋原甲藻的类蛋白荧光强度在消亡后期由于细菌降解或光降解等因素而降低。同属微藻产生的荧光物质相似,例如塔玛亚历山大藻与微小亚历山藻、东海原甲藻与海洋原甲藻,但具体荧光峰位置有所不同。 展开更多
关键词 海洋微藻 溶解有机物 三维荧光光谱 类蛋白荧光 类腐殖质荧光
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基于加速度信号全谱分析的转子碰摩故障特征提取实验研究 被引量:9
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作者 吴峰崎 孟光 荆建平 《振动与冲击》 EI CSCD 北大核心 2006年第2期44-47,共4页
转子在运行过程中的振动加速度信号包含了转子运行状态大量信号,瞬态过程中故障加速度信号特征的提取及其识别对于旋转机械故障诊断是十分重要的。旋转机械振动的全谱分析是一种使一些典型故障尤其是碰摩故障能被很清楚检测出来的有效方... 转子在运行过程中的振动加速度信号包含了转子运行状态大量信号,瞬态过程中故障加速度信号特征的提取及其识别对于旋转机械故障诊断是十分重要的。旋转机械振动的全谱分析是一种使一些典型故障尤其是碰摩故障能被很清楚检测出来的有效方法,本文在对旋转机械转子中的一些典型碰摩故障进行了模拟试验,以及对故障发生过程中的加速度信号进行采集的基础上,对转子故障加速度信号的全谱特性进行了分析,提取和总结出由故障造成的加速度信号突变和对应的谱特征。分析结果表明:采用转子振动加速度信号对转子的碰摩故障进行诊断是有效的。加速度信号全谱图可以丰富旋转机械碰摩故障诊断系统知识库中的特征信息,对于更准确地诊断转子中的碰摩故障具有重要意义。 展开更多
关键词 加速度信号 全谱 故障诊断 转子
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基于Matlab的不规则海浪三维仿真 被引量:33
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作者 李晖 郭晨 李晓方 《系统仿真学报》 CAS CSCD 2003年第7期1057-1059,共3页
讨论了二维不规则长峰波海浪和三维不规则短峰波海浪的模型的建立,并在海浪谱分析的基础上进行了仿真研究。在Matlab仿真系统中为了得到较为真实理想的海浪模拟效果,作者提出了对仿真图形进行了波面细化,海浪颜色和光照等加工处理的方法。
关键词 海浪模型 频谱分析 三维仿真 MATLAB语言
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地球同步轨道圆迹SAR研究 被引量:10
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作者 洪文 林赟 +2 位作者 谭维贤 王彦平 向茂生 《雷达学报(中英文)》 CSCD 2015年第3期241-253,共13页
该文介绍了地球同步轨道圆迹合成孔径雷达(Geosynchronous Circular SAR,Geo-CSAR)的概念,通过设计同步轨道的轨道参数,可以形成近圆的卫星相对地球轨迹,使SAR载荷的凝视成像模式成为可能,实现对地的大面积定点连续观测以及真3维信息获... 该文介绍了地球同步轨道圆迹合成孔径雷达(Geosynchronous Circular SAR,Geo-CSAR)的概念,通过设计同步轨道的轨道参数,可以形成近圆的卫星相对地球轨迹,使SAR载荷的凝视成像模式成为可能,实现对地的大面积定点连续观测以及真3维信息获取;研究分析了Geo-CSAR的成像能力,指出其在瞬时覆盖度、连续观测范围及3维精确定位方面,具有现有低轨星载SAR无法比拟的优势,是实现全球不间断覆盖的有效途径之一,在军事侦察、灾害监测方面具有重要的应用前景。 展开更多
关键词 对地观测 地球同步轨道 合成孔径雷达 圆迹SAR 大面积定点连续观测 3维成像
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石油馏分荧光光谱等高线特征谱分析研究 被引量:9
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作者 赵友全 路雪峰 +1 位作者 梁瑛 房彦军 《仪器仪表学报》 EI CAS CSCD 北大核心 2012年第6期1275-1280,共6页
相对色谱或色质联用分析,荧光分析法具有灵敏度高、选择性好、取样量少、分析结果快速等优点。三维荧光光谱是有机物种类鉴别领域的新技术,可应用于石油馏分的分类,且具有准备过程简单、信息量丰富和费用低的优点。分析了柴油、汽油、... 相对色谱或色质联用分析,荧光分析法具有灵敏度高、选择性好、取样量少、分析结果快速等优点。三维荧光光谱是有机物种类鉴别领域的新技术,可应用于石油馏分的分类,且具有准备过程简单、信息量丰富和费用低的优点。分析了柴油、汽油、混合油3类石油馏分的三维荧光光谱特征,应用图像信息统计原理,提出了基于三维荧光等高线特征谱分析技术的一种新方法,研究了同一馏分和不同馏分之间特征谱的相关特性,并给出了利用等高线特征谱相关系数鉴别油品的新方法,对3类馏分的分析结果表明,此方法数据客观,识别结果准确。 展开更多
关键词 石油馏分 三维荧光光谱 等高线 分类识别
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基于医学图像的交互式三维测量技术研究与实现 被引量:7
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作者 林晓梅 魏巍 +1 位作者 张超 李琎 《长春工业大学学报》 CAS 2006年第1期24-26,共3页
介绍了交互式三维测量技术在医学图像中的应用。在平行投影透视图中,将用户指定的屏幕二维坐标点转化为需要的物体坐标系下的空间三维坐标,并用取点法实现了特征点的选取。对病人的颅面部进行实际测量,得到了较为满意的结果。
关键词 三维观察 三维交互 三维测量 拾取
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维生素D联合ω-3脂肪酸治疗儿童孤独症的疗效 被引量:6
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作者 方乐 蒋雪明 +3 位作者 黄彦科 孙彦香 谢雨芳 王鹭 《药学服务与研究》 CAS 2018年第5期347-350,共4页
目的:观察服用维生素D(VD)联合ω-3脂肪酸治疗孤独症(autism spectrum disorder,ASD)患儿的疗效。方法:本研究为48名年龄在5~12岁、新诊断的ASD患儿参与的随机双盲临床试验。患儿分成4组,每组12例。对照组患儿服用安慰剂,VD组患儿服用V... 目的:观察服用维生素D(VD)联合ω-3脂肪酸治疗孤独症(autism spectrum disorder,ASD)患儿的疗效。方法:本研究为48名年龄在5~12岁、新诊断的ASD患儿参与的随机双盲临床试验。患儿分成4组,每组12例。对照组患儿服用安慰剂,VD组患儿服用VD 800U/d,ω-3脂肪酸组患儿服用ω-3脂肪酸900mg/d,联合用药组患儿联合服用VD 800U/d及ω-3脂肪酸900mg/d。用药同时所有患儿针对症状进行结构化训练,地点为医院,时间为4h/d,每周5d。在用药12个月后采用儿童孤独症评定量表(Childhood Autism Rating Scale,CARS)评估治疗后的临床症状改善情况。结果:治疗12个月后,与对照组比较,VD组及联合用药组患儿大部分CARS评分明显降低(P<0.05)。联合用药组患儿视觉反应及听觉反应评分较VD组下降更明显(P<0.05),且联合用药组焦虑反应评分较ω-3脂肪酸组下降更明显(P<0.05)。结论:在结构化训练的同时补充VD或VD联合ω-3脂肪酸可有效改善ASD患儿的症状。VD联合ω-3脂肪酸有望成为治疗儿童ASD的有效辅助方法。 展开更多
关键词 孤独症 儿童 维生素D Ω-3脂肪酸
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