The aim of this study was to investigate the effects of varieties sources of omega-3 on diabetic rats. Fifty six male albi-no rats were divided into 7 group: first group was fed on normal basal diet (maintained at neg...The aim of this study was to investigate the effects of varieties sources of omega-3 on diabetic rats. Fifty six male albi-no rats were divided into 7 group: first group was fed on normal basal diet (maintained at negative control group), group 2 diabetic group fed on 60% fructose, group 3 fed on 60% fructose + 8% fish oil, group 4 fed on 60% fructose + 8% flaxseed oil, group 5 fed on 60% fructose + 4% corn oil + 4% fish oil, group 6 fed on 60% fructose + 4% corn oil + 4% flaxseed oil and group 7 fed on 60% fructose + 4% fish oil + 4% flaxseed oil. Fatty acid composition of investigated oils show that the corn oil contained high levels of omega-6 fatty acid (LA: 56.95%), flaxseed oil contained high level of short chain omega-3 fatty acid (ALA: 56.31%), meanwhile fish oil only has high concentration of long chain omega-3 fatty acid 39.20% (23.98% of EPA and 15.22% of DHA). After 8 week feeding of fish oil, flaxseed oil, corn oil + fish oil, corn oil + flaxseed oil and fish oil + flaxseed oil show reduces levels of glucose by 49.09%, 44.0%, 43.4%. 43.6% and 44.9% respectively. Data revealed significant decrease (P < 0.05%) was observed of TC, TG, LDL and VLDL of all treatment. Urea and creatinine in diabetic rats was increase, in contrast the glutathione reduced was decrease compared to the control group. Fish oil show the highest decrease in urea and creatinene and the highest increase in glutathione levels and insulin compared to other sources of omega-3. Omega-3 fatty acids have potential effect to protect pancreas from up normality changes which induced in diabetic disease. The data suggest that omega-3 fatty acid and fish oil especially may be effective in the prevention of diabetic disease.展开更多
目的探讨ω3鱼油脂肪酸能否通过改善淋巴细胞免疫功能来降低肠功能障碍患者的病死率。方法选择48例存在肠功能障碍的严重脓毒症并多脏器功能障碍患者,随机将其为对照组与观察组,每组24例,对照组采用胸腺肽α1及乌司他丁等常规治疗,观察...目的探讨ω3鱼油脂肪酸能否通过改善淋巴细胞免疫功能来降低肠功能障碍患者的病死率。方法选择48例存在肠功能障碍的严重脓毒症并多脏器功能障碍患者,随机将其为对照组与观察组,每组24例,对照组采用胸腺肽α1及乌司他丁等常规治疗,观察组在此基础上加用ω3鱼油脂肪酸治疗,比较两组患者的死亡率、ICU住院日、急性生理与慢性健康评分(APACHEⅡ)、Marshall评分、T淋巴细胞亚群(CD3+、CD4+、CD8+及CD4+/CD8+)及超敏C反应蛋白(hs-CRP)水平。结果 28 d随访中,对照组死亡10例,占41.7%,观察组死亡3例,占12.5%,两组患者病死率比较差异有统计学意义(P<0.05);观察组ICU住院日短于对照组(P<0.05);观察组治疗第7 d APACHEⅡ和Marshall评分均低于对照组,差异均有统计学意义(P<0.05);观察组血清CD3+、CD4+、CD4+/CD8+均明显高于对照组,hs-CRP低于对照组,差异均有统计学意义(P<0.05)。结论ω3鱼油脂肪酸可能通过改善淋巴细胞免疫功能从而降低肠功能障碍患者的病死率。展开更多
目的研究ω-3鱼油对胃肠道恶性肿瘤术后患者在营养及免疫功能恢复上的作用。方法以我院从2010年5月到2013年5月收治的60例胃肠道恶性肿瘤患者作为研究对象,将60例患者随机分为实验组和对照组,每组患者30例。患者在术后均使用等氮、等热...目的研究ω-3鱼油对胃肠道恶性肿瘤术后患者在营养及免疫功能恢复上的作用。方法以我院从2010年5月到2013年5月收治的60例胃肠道恶性肿瘤患者作为研究对象,将60例患者随机分为实验组和对照组,每组患者30例。患者在术后均使用等氮、等热量的肠外营养(PN)支持常规治疗的基础上,实验组添加ω-3鱼油辅助治疗,观察添加与不渗加ω-3鱼油的患者在术前、术后1 d、6 d的肝功能、血脂、血红蛋白(Hb)、白蛋白(ALB)、转铁蛋白(TRF)、淋巴细胞计数(TLC)、B淋巴细胞亚群(B1、B2)、免疫球蛋白(IgG、IgM、IgA)和补体(C3、C4)水平。结果实验组患者在肝功能、TRF及血脂水平与对照组无显著差异,但是实验组在术后6 d TLC、IgG、IgM、C3上却有着显著的差异(P<0.05)。结论ω-3鱼油对于胃肠道恶性肿瘤患者术后营养虽然没有明显的效果,但是却能提高患者的免疫力。展开更多
文摘The aim of this study was to investigate the effects of varieties sources of omega-3 on diabetic rats. Fifty six male albi-no rats were divided into 7 group: first group was fed on normal basal diet (maintained at negative control group), group 2 diabetic group fed on 60% fructose, group 3 fed on 60% fructose + 8% fish oil, group 4 fed on 60% fructose + 8% flaxseed oil, group 5 fed on 60% fructose + 4% corn oil + 4% fish oil, group 6 fed on 60% fructose + 4% corn oil + 4% flaxseed oil and group 7 fed on 60% fructose + 4% fish oil + 4% flaxseed oil. Fatty acid composition of investigated oils show that the corn oil contained high levels of omega-6 fatty acid (LA: 56.95%), flaxseed oil contained high level of short chain omega-3 fatty acid (ALA: 56.31%), meanwhile fish oil only has high concentration of long chain omega-3 fatty acid 39.20% (23.98% of EPA and 15.22% of DHA). After 8 week feeding of fish oil, flaxseed oil, corn oil + fish oil, corn oil + flaxseed oil and fish oil + flaxseed oil show reduces levels of glucose by 49.09%, 44.0%, 43.4%. 43.6% and 44.9% respectively. Data revealed significant decrease (P < 0.05%) was observed of TC, TG, LDL and VLDL of all treatment. Urea and creatinine in diabetic rats was increase, in contrast the glutathione reduced was decrease compared to the control group. Fish oil show the highest decrease in urea and creatinene and the highest increase in glutathione levels and insulin compared to other sources of omega-3. Omega-3 fatty acids have potential effect to protect pancreas from up normality changes which induced in diabetic disease. The data suggest that omega-3 fatty acid and fish oil especially may be effective in the prevention of diabetic disease.
文摘目的探讨ω3鱼油脂肪酸能否通过改善淋巴细胞免疫功能来降低肠功能障碍患者的病死率。方法选择48例存在肠功能障碍的严重脓毒症并多脏器功能障碍患者,随机将其为对照组与观察组,每组24例,对照组采用胸腺肽α1及乌司他丁等常规治疗,观察组在此基础上加用ω3鱼油脂肪酸治疗,比较两组患者的死亡率、ICU住院日、急性生理与慢性健康评分(APACHEⅡ)、Marshall评分、T淋巴细胞亚群(CD3+、CD4+、CD8+及CD4+/CD8+)及超敏C反应蛋白(hs-CRP)水平。结果 28 d随访中,对照组死亡10例,占41.7%,观察组死亡3例,占12.5%,两组患者病死率比较差异有统计学意义(P<0.05);观察组ICU住院日短于对照组(P<0.05);观察组治疗第7 d APACHEⅡ和Marshall评分均低于对照组,差异均有统计学意义(P<0.05);观察组血清CD3+、CD4+、CD4+/CD8+均明显高于对照组,hs-CRP低于对照组,差异均有统计学意义(P<0.05)。结论ω3鱼油脂肪酸可能通过改善淋巴细胞免疫功能从而降低肠功能障碍患者的病死率。
文摘目的研究ω-3鱼油对胃肠道恶性肿瘤术后患者在营养及免疫功能恢复上的作用。方法以我院从2010年5月到2013年5月收治的60例胃肠道恶性肿瘤患者作为研究对象,将60例患者随机分为实验组和对照组,每组患者30例。患者在术后均使用等氮、等热量的肠外营养(PN)支持常规治疗的基础上,实验组添加ω-3鱼油辅助治疗,观察添加与不渗加ω-3鱼油的患者在术前、术后1 d、6 d的肝功能、血脂、血红蛋白(Hb)、白蛋白(ALB)、转铁蛋白(TRF)、淋巴细胞计数(TLC)、B淋巴细胞亚群(B1、B2)、免疫球蛋白(IgG、IgM、IgA)和补体(C3、C4)水平。结果实验组患者在肝功能、TRF及血脂水平与对照组无显著差异,但是实验组在术后6 d TLC、IgG、IgM、C3上却有着显著的差异(P<0.05)。结论ω-3鱼油对于胃肠道恶性肿瘤患者术后营养虽然没有明显的效果,但是却能提高患者的免疫力。
