Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previo...Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple ampli- fication of peripheral nerve regeneration using small gap sleeve bridging of small donor nerves to repair large receptor nerves in rodents. The present study sought to observe multiple ampli- fication of myelinated nerve fiber regeneration in the primate peripheral nerve. Rhesus monkey models of distal ulnar nerve defects were established and repaired using muscular branches of the right forearm pronator teres. Proximal muscular branches of the pronator teres were su- tured into the distal ulnar nerve using the small gap sleeve bridging method. At 6 months after suture, two-finger flexion and mild wrist flexion were restored in the ulnar-sided injured limbs of rhesus monkey. Neurophysiological examination showed that motor nerve conduction veloc- ity reached 22.63 _＋ 6.34 m/s on the affected side of rhesus monkey. Osmium tetroxide staining demonstrated that the number of myelinated nerve fibers was 1,657 ＋ 652 in the branches of pronator teres of donor, and 2,661 ~ 843 in the repaired ulnar nerve. The rate of multiple amplification of regenerating myelinated nerve fibers was 1.61. These data showed that when muscular branches of the pronator teres were used to repair ulnar nerve in primates, effective regeneration was observed in regenerating nerve fibers, and functions of the injured ulnar nerve were restored to a certain extent. Moreover, multiple amplification was subsequently detected in ulnar nerve axons.展开更多
In this paper, an algorithm is proposed to solve the 0（2） symmetric positive solutions to the boundary value problem of the p-Henon equation. Taking 1 in the p- Henon equation as a bifurcation parameter, the symmetr...In this paper, an algorithm is proposed to solve the 0（2） symmetric positive solutions to the boundary value problem of the p-Henon equation. Taking 1 in the p- Henon equation as a bifurcation parameter, the symmetry-breaking bifurcation point on the branch of the O（2） symmetric positive solutions is found via the extended systems. The other symmetric positive solutions are computed by the branch switching method based on the Liapunov-Schmidt reduction.展开更多
基金supported by grants from the National Program on Key Basic Research Project of China(973 Program),No.2014CB542200the National Natural Science Foundation of China,No.31271284,81171146,31100860+1 种基金Program for Innovative Research Team in University of Ministry of Education of China,No.IRT1201the Natural Science Foundation of Beijing of China,No.7142164
文摘Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple ampli- fication of peripheral nerve regeneration using small gap sleeve bridging of small donor nerves to repair large receptor nerves in rodents. The present study sought to observe multiple ampli- fication of myelinated nerve fiber regeneration in the primate peripheral nerve. Rhesus monkey models of distal ulnar nerve defects were established and repaired using muscular branches of the right forearm pronator teres. Proximal muscular branches of the pronator teres were su- tured into the distal ulnar nerve using the small gap sleeve bridging method. At 6 months after suture, two-finger flexion and mild wrist flexion were restored in the ulnar-sided injured limbs of rhesus monkey. Neurophysiological examination showed that motor nerve conduction veloc- ity reached 22.63 _＋ 6.34 m/s on the affected side of rhesus monkey. Osmium tetroxide staining demonstrated that the number of myelinated nerve fibers was 1,657 ＋ 652 in the branches of pronator teres of donor, and 2,661 ~ 843 in the repaired ulnar nerve. The rate of multiple amplification of regenerating myelinated nerve fibers was 1.61. These data showed that when muscular branches of the pronator teres were used to repair ulnar nerve in primates, effective regeneration was observed in regenerating nerve fibers, and functions of the injured ulnar nerve were restored to a certain extent. Moreover, multiple amplification was subsequently detected in ulnar nerve axons.
基金Project supported by the National Natural Science Foundation of China (No. 10901106)the Shanghai Leading Academic Discipline Project (No. S30405)+2 种基金the Shanghai Normal University Academic Project (No. SK200936)the Natural Science Foundation of Shanghai (No. 09ZR1423200)the Innovation Program of Shanghai Municipal Education Commission (No. 09YZ150)
文摘In this paper, an algorithm is proposed to solve the 0（2） symmetric positive solutions to the boundary value problem of the p-Henon equation. Taking 1 in the p- Henon equation as a bifurcation parameter, the symmetry-breaking bifurcation point on the branch of the O（2） symmetric positive solutions is found via the extended systems. The other symmetric positive solutions are computed by the branch switching method based on the Liapunov-Schmidt reduction.
