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Characteristic fragmentation behavior of the analogs of endomorphin-2 with phenylglycine in position 3 or 4 by ESI-FT tandem mass spectrometry
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作者 Chang Feng Hu Chuan Jun Zhu +3 位作者 Yan Feng Gao Xuan Shao Rui Wang Yu Xin Cui 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第12期1479-1482,共4页
A series of analogs of endomorphin-2 (EM-2) with phenylglycine (Phg) in position 3 or 4 were synthesized. In electrospray ionization Fourier transform ion cyclotron resonance (ESI-Fr-ICR) MS/MS spectra of these ... A series of analogs of endomorphin-2 (EM-2) with phenylglycine (Phg) in position 3 or 4 were synthesized. In electrospray ionization Fourier transform ion cyclotron resonance (ESI-Fr-ICR) MS/MS spectra of these compounds, some b, y, a, and internal ions were observed and slight mass differences between the calculated and observed results are obtained. Their sequences were derived successfully. However, the MS/MS patterns of these analogs with Dphg and Lphg were very similar. It is hard to distinguish them by MS/MS spectra. Moreover, if the third position was substituted by phenylglycine (L or D), a rearrangement could occur in MS/MS experiment to lose proline residue. 展开更多
关键词 Endomorphin-2 opioid peptide analogs PHENYLGLYCINE ESI-FT MS
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