Abdominal pain related to adulterated opium:An emerging issue in drug addicts

Lead may contaminate opium,heroin and illicit opiates and is particularly observed in Iran.Lead,a natural heavy metal is able to interfere with several organ functions after ingestion or inhalation.Lead poisoning manifestations are non-specific and thus lead poisoning remains difficult to diagnose.Among the manifestations,abdominal pain is almost the most frequent symptom causing patients to seek medical care.In patients with a history of opium addiction presenting with moderate-to-severe abdominal pain,lack of diagnosis of lead toxicity may thus result in time-consuming and unnecessary medical work-ups that can end up in invasive surgery.This paper aims to briefly review abdominal pain as an emergency issue and the leading symptom of lead poisoning that brings most of the patients to healthcare facilities.All published adult cases and case series of opium addicts admitted with abdominal pain due to leadadulterated opium consumption have been reviewed.A trend of increasing numbers of lead poisoning cases has recently emerged among opium addicts in Iran.Due to the non-specific manifestations and hazardous effects,psychiatrists and emergency physicians should consider lead poisoning in patients with a past or present history of opium addiction referred for acute abdominal pain,particularly in case of colicky abdominal pain.

opium的历史文化解读与中文名

opium一词受到不同的历史文化影响,从而产生了不同的解读。在新的历史时期,正确翻译并解读opium对于全面正确理解马克思"宗教是人民的opium"这一论述,对于中国崛起背景下,包括宗教文化在内的中国文化的国际传播有着重要意义。

Preparation and Application of an Immunoaffinity Column for Direct Extraction of Morphine and its Analogs from Opium

A rapid, simple and accurate method using an immunoaffinity column (IAC) and capillary electrophoresis (CE) for the analysis of the major alkaloids in opium is developed. The IAC was synthesized by coupling specific morphine polyclonal antibodies to CNBr-actived Sepharose 4B. The IAC showed high selectivity and obvious enrichment to morphine, codeine, dionin and thebaine. The extraction solution was analyzed by CE with β-cyclodextrin as an additive. Recoveries of the four alkaloids from PBS were between 93%-105% with RSD value less than 5.0%. The result showed that this method was practical for the determination of morphine analogs in opium.

Outcomes and long-term survival of coronary artery surgery:The controversial role of opium as risk marker

AIM To study survival in isolated coronary artery bypass graft(CABG) patients and to evaluate the impact of preoperative chronic opium consumption on long-term outcome.METHODS Cohort of 566 isolated CABG patients as Tehran Heart Center cardiac output measurement was conducted. Daily evaluation until discharge as well as 4- and 12-mo and 6.5-year follow-up information for survival status were fulfilled for all patients. Long-term 6.5-year overall and opium-stratified survival, adjusted survival curves based on opium consumption as well as possible predictors of all-cause mortality using multiple cox regression were determined by statistical analysis.RESULTS Six point five-year overall survival was 91.8%; 86.6% in opium consumers and 92.7% in non-opium consumers(P=0.035). Patients with positive history of opium consumption significantly tended to have lower ejection fraction(EF), higher creatinine level and higher prevalence of myocardial infarction. Multiple predictors of all-cause mortality included age, body mass index, EF, diabetes mellitus and cerebrovascular accident. The hazard ratio(HR) of 2.09 for the risk of mortality in opium addicted patients with a borderline P value(P=0.052) was calculated in this model. Further adjustment with stratification based on smoking and opium addiction reduced the HR to 1.20(P=0.355).CONCLUSION Simultaneous impact of smoking as a confounding variable in most of the patients prevents from definitive judgment on the role of opium as an independent contributing factor in worse long-term survival of CABG patients in addition to advanced age, low EF, diabetes mellitus and cerebrovascular accident. Meanwhile, our findings do not confirm any cardio protective role for opium to improve outcome in coronary patients with the history of smoking. Further studies are needed to clarify pure effect of opium and warrant the aforementioned findings.

Effect of Opium on Lipid Profile and Expression of Liver X Receptor Alpha (LXR<i>α</i>) in Normolipidemic Mouse

Many people believe that opium has beneficial effects on lipid profile which results in reduced atherosclerosis. Opium contains several alkaloids and biological active components, which some of them are used for atherosclerosis treatment. The liver X receptor α (LXRα) is an important regulator of cholesterol and glucose homeostasis that belongs to the nuclear receptor superfamily. This study aimed to investigate the effects of opium on glucose, lipid profile and LXRα expression. Sixteen N-mary mice randomly were divided into two groups (control and addict), and were studied for one month. Serum lipid profile, Fasting blood sugar (FBS), Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) were determined. Also LXR mRNA and protein levels were determined by Reverse Transcription PCR and western blotting. This study showed that opium significantly reduced total cholesterol (P < 0.05), While the difference in blood glucose, triglyceride (TG), High-density lipoprotein cholesterol (HDL-c), Low-density lipoprotein cholesterol(LDL-c) and Very low-density lipoprotein cholesterol(VLDL-c), as well as AST and ALT between addict and control groups were not significant. More importantly, LXR protein and mRNA levels significantly increased (P < 0.05) in intestine of addict group in comparison with control, while the change in LXR protein and mRNA in the liver were not significant compared with control. The results of this study showed that opium addiction reduced total cholesterol and increased LXR expression in intestine. Further researches need to determine effective components.

Opium withdrawal and some blood biochemical factors in addicts' individuals

Objective: One of the common misinterpretation be- liefs in some societies (especially eastern communities) is the using of opium can reduce serum glucose and lipids. Opium is a derivative from a plant family called Papaveracea and contains almost 80 types of alkaloids. Drug addiction causes physiological dependency and its withdrawal lead to some disorders. The aim of this study was to determine the effects of opium consumption and its withdrawal on some blood biochemical factors in addicted people. Methods: We enrolled fifty-six opium addicted people according to the especial criteria to this study. Biochemical blood parameter levels such as fasting blood sugar (FBS), urea, Creatinine (Cr), Aspartate transaminase (AST), Alanine transaminase (ALT) and Alkaline phosphatase (ALP) enzymes levels were measured and urine analysis was also performed before and 3 months after withdrawal. Data were analyzed by using SPSS software version 18 and a P < 0.05 was considered as significant. Results: our finding showed that opium withdrawal reduces FBS and increases AST but these changes were not significant. Nevertheless opium withdrawal significantly increased blood urea level (P < 0.0001). We didn’t find any significant difference in Cr, ALP, AST and Urea specific gravity (SG). Conclusion: According to the results of the current study we can concluded that opium increases FBS, which is in contrast to the most previous studies and withdrawal has opposite effects.

近代日本对鸦片问题的认识及对中国台湾鸦片殖民特权的构建

继以英国为首的西方殖民列强向中国倾销鸦片,并以坚船利炮促使国门洞开进而催生鸦片问题后,作为后发的帝国主义国家,日本对鸦片战争的经验教训及鸦片本身的认识不断发生变化,一方面为免遭鸦片毒害,通过颁布禁止鸦片进口的法令规避鸦片威胁,另一方面又难掩对鸦片利润的贪婪及对扩大资本市场的追逐。日本对鸦片问题这种由“危机”到“获利”的认识转变,促使其于甲午战争后在中国台湾建立鸦片殖民特权,不仅通过聚敛大量财富巩固其殖民统治,而且成为其进一步扩大对中国鸦片侵略的恶例。

中医外治疗法改善癌症患者阿片类药物相关性便秘的网状Meta分析

目的使用网状meta分析评价不同中医外治疗法改善癌症患者阿片类药物相关性便秘(opioid-induced constipation,OIC)的效果。方法计算机检索PubMed、Web of Science、The Cochrane Library、EMbase、中国生物医学文献数据库、中国知网、万方期刊数据库及维普数据库,检索时间为建库至2023年8月28日。由2名研究者独立进行文献的筛选、质量评价、数据提取,运用Stata MP 17.0软件实施数据分析。结果共纳入53项研究,涉及15种中医外治疗法,共5263例患者。网状meta分析结果显示:针刺、穴位敷贴、低频电针、穴位注射、中药灌肠、穴位热熨、耳穴压贴、灸法、针灸、揿针、超声药透均优于常规治疗,差异均有统计学意义(P<0.05);穴位敷贴、穴位注射、穴位热熨均优于经皮穴位电刺激,差异均有统计学意义(P<0.05)。疗效排序结果显示:在治疗肿瘤患者OIC的效果上,穴位注射效果最佳的可能性最大。结论中医外治疗法能够有效改善癌症患者OIC,其中穴位注射疗法效果最佳,其次为针灸、揿针、穴位热熨,但未来仍需要大样本、高质量的研究进一步证实。

Citizenship, the Nation and the Race： China and the International Opium System, 1912-1931

This article analyzes China＇s attempts to participate in and use the negotiations about reforming the international opium control system in the interwar period. China had a contentious relationship with the international opium control system from its creation in the International Opium Convention of 1912 through the League of Nations opium control system of the 1920s and 1930s. The Chinese government wanted to gain acceptance for China as a modern state no longer in need of tutelage from the international community. They also wanted to portray the Chinese people as a modern race as a way of undermining colonial opium monopolies, which made a disproportionate amount of their profits from sales to Overseas Chinese. While they were not fully successful in either of these efforts, China did manage to win some support, drawing the United States into closer agreement with China＇s positions. Engagement with the international system also had a considerable impact on China＇s domestic opium politics and its broader diplomatic relationship with the major powers.

Mining, Bridges, Opium, and Guns： Chinese Investment and State Power in a Late Qing Frontier

In the last three decades of its rule, the Qing government attempted to establish Chinese-style administration in many of the empire＇s non-Hart territories, and, in conjunction with non-government actors, foster land cultivation, Han migration, Chinese education, and industries such as mining. This paper investigates these processes in Liangshan, in upland Southwest China. Here, attempts to establish Chinese administration came only in 1907, after a period of substantial private and state investment in mining, transport infrastructure, and, to a lesser extent, land cultivation. Government officials often assumed that such things would aid the political integration in China, but as this paper argues, the consequences were more complicated than that. Although better transport simplified the logistics of government military campaigns, increased commercial activity in the region also allowed its indigenes to acquire firearms for the first time.

Spatial risk assessment of opium poppy cultivation in Afghanistan: integrating environmental and socio-economic drivers

Recently the cultivation of opium poppy in Afghanistan reached unprecedented levels.It is agreed that the complex and coupled interactions of social,economic and environmental drivers are crucial for understanding the spatial and temporal dynamics of opium poppy cultivation in Afghanistan.In this context,we present an integrated risk concept,which considers environmental and socio-economic drivers of opium poppy cultivation.A set of spatially explicit indicators for the environmental suitability and socio-economic vulnerability was established and populated from a variety of databases.Subsequently,novel methods of modelling homogeneous and spatially explicit regions of opium poppy cultivation suitability,socio-economic vulnerability and risk are developed and applied.The risk assessment results demonstrate the complex nature of the illicit crops production in Afghanistan and prompt a more profound examination of the drivers of opium poppy cultivation in a spatial context.The study also confirms what has already been widely discussed in literature:that reasons for cultivation are spatially diverse and often distinct,meaning that any formulation of generalized explanations cannot be drawn without ignoring a more complex reality.Thus,an integrative spatial view of risk,which integrates the social dimension as well as environmental parameters,is required to better identify context-specific intervention measures.

The medieval Persian manuscript of Afyunieh:the first individual treatise on the opium and addiction in history

According to historical evidence, the abuse of opium has been reported all over the globe-specifically throughout Eastern nations-since the sixteenth century. Before that, opium had mostly been applied as medication. Reference has been made in traditional Persian medical literature to the method of cultivation, properties, side effects and toxicity. In sixteenth century Iran, during the reign of the Safavids, opium abuse began. It was from then that prominent Persian scholars started to think of solutions to this societal problem. One of the most famous scholars was Imad al-Din Mahmud ibn Mas＇ud Shirazi, who composed a book concerning addiction-Afyunieh, a comprehensive book on the topic of opium and all issues of opium. Furthermore, he recommended methods for reducing opium dose as well as substitution with other medications that had a narrower range of side effects, in order to eradicate dependency upon opium and opium-derived materials. This is most likely the first book that comprehensively addressed opium and discussed drug rehabilitation methodology, in traditional Persian medical literature. In this historical review, the authors have introduced the book Afyunieh, which presents methods for treating addiction to and giving up opium; the text comprises a synthesis of the author＇s opinions, professional experience and references to the work of other famous physicians.

关于史实真相与历史真实问题的辨析——以镇江之战的海龄殉难事件为例

在鸦片战争时期的镇江之战中,守将海龄殉难事件一时竟成聚讼之谜。在史实真相查实后,朝廷对海龄的嘉赏赐典,却遭到士民抵制。镇江民众抵拒的关键问题并不在其死亡之细故末节上,而依然聚焦于“尽忠殉国”大节方面。海龄悲剧性地自杀或自焚的史实真相,并不能成就其“尽节尽忠”的人生定评。时人在日常生活中琐碎片段的场景记录,已经立体地呈现了他原本鲜活而真实的形象。镇江失陷及其失陷后的惨剧与海龄“误国殃民,莫此为甚”的行为有着密切关联。海龄殉难的史实真相无法遮蔽历史的真实。

鸦片战争爆发前林则徐的禁烟举措与对外认知

林则徐受命前赴广东禁烟,不仅是一项政治使命,也是一项经济、社会使命。抵达广州后的林则徐采取疾风暴雨式的禁烟举措,重治吸食、强令缴烟、力催英方交凶、驱离英人出澳、断绝与英商贸易,禁烟力度逐步加大;而英国驻华商务监督义律由最初的缴烟妥协到反对具结、拒交凶手、海上炮击,态度越发强硬。林则徐断定义律的各种操作是想方设法支持私售鸦片,意在建立有利于英方的贸易体制。双方沟通上的障碍与不断叠加的矛盾,刺激了战事的爆发。林则徐对外认知也随禁烟进程发生渐变,但唯一不变的是他始终相信清朝有能力、有办法击败“英夷”,彰显了不惧强敌的斗争精神以及高尚的民族气节。

1927—1937年间的铁路犯罪及治理——以运输毒品罪为中心的考察

毒贩利用铁路运输毒品是铁路引入中国后出现的新型贩毒手段。在南京国民政府统治时期,借助铁路贩运毒品的群体包括职业毒贩与铁路职工、日韩浪人等。就运毒方法而言,毒贩通常使用随身携带毒货与铁路联运等多项手段运输烟毒。国民政府与铁路当局为在铁路运输业中开展禁运毒品工作,采取了颁布禁毒法规及严惩运毒者等措施,对于遏制烟毒流通起到了积极作用。但来自烟毒利益集团的抵制和执法力量腐败以及渎职等问题使国民政府整治运输毒品犯罪收效甚微,并终因日本发动全面侵华战争而失败。

鸦片战争浙东海上反击战考实——以侵华英军文献为中心

1841年8月,英军发动鸦片战争第二次侵华行动,10月,英军相继占领浙江定海、镇海、宁波。清军计划于三地同日举兵以收复失地,但以岱山为策源地的浙东海上反击战未能如期展开,其因成谜。清人贝青乔在其《咄咄吟》一书中称驻岱山清军畏惧英军,不敢出战。此论对后人正确认识及评价这段历史造成较大影响。据英军文献记载,英军在侦知情报后,数次对岱山展开围剿,打乱了清军海上作战计划;但清军依旧在敌严密防范下展开各项准备,并于1842年4月14日发动大规模海上反击战,影响了英军进攻杭州的作战计划,彰显了中国军民反抗侵略的坚强意志。

Occupied Space, Occupied Time： Food Hawking and the Central Market in Hong Kong＇s Victoria City during the Opium War

This article explains British measures against food hawking in the emergent city of Victoria, Hong Kong during the Opium War. It argues that British interest in the long-term development ofHong Kong can be traced back to the establishment in May 1842 of the Central Market in Victoria specifically to prevent food peddling. It was a time when Hong Kong was still under military occupation and its status as a British colony was uncertain. Although Hong Kong＇s public markets were associated with many of the problems that came with early British rule in the territory, the British administrators of Opium War Hong Kong intended that the Central Market, the first public market in Victoria, benefit both the Western and Chinese communities. This article also argues that the founding of the Central Market to eliminate food hawking exemplifies the overall manner that the British authorifes took in dealing with the urban Chinese population. In addition to strictly prohibiting Chinese peddling, which often obstructed roads and streets, the authorities encouraged Chinese food hawkers to move to the orderly Central Market. While the British authorities exercised some direct control to maintain social order inside the Central Market, the government appointed a better-off Chinese person to oversee its routine operation. The 1842 Central Market was one of the earliest urban Chinese ＂elite organizations＂ in British Hong Kong where Chinese elites managed the affairs of the Chinese community of Victoria city.

Changing Conceptions of the Opium War as History and Experience

Academic and popular accounts of the Opium War have gone through nearly two centuries of change in focus, view, and scope. My study probes this extensive historiography by tracing the evolvement of our understanding of the war through various phases among which we saw the rise of the ＂China-centered approach＂ and the beginning of a new trend towards combining government archives with personal records such as memoirs, personal correspondence, and private journals in research. Based on the observation, I will indicate, despite their undeniable achievements, most of the existing scholarships have paid little attention to the ordinary people in China whose lives were deeply affected by the war. It is high time that we pay more attention to human experience of the Chinese people in order to understand not only the war itself but also the history it helped shape.

Fidelity and Sacrifice: The Gender Discourse of Traders in Pre- and Post-Opium War Canton

This article examines the discourse of two American couples in the China trade regarding fidelity and sacrifice during the period in which the spatial confines of the Canton system gave way to the intensified interactions of the Treaty Port era.Before the Opium War,when the Qing court had mandated that Western husbands conducting business in Canton live apart from their wives,marital tension was accentuated by the separation from absentee husbands.In the subsequent Treaty Port era,enhanced spatial mobility of the couples did not assuage their concerns.Instead,intensified cross-cultural encounters allowed them to project their feelings and expectations on the foreign other,'as racial categories developed and their imperial proclivities began to escalate.Bringing the Western women in contact with elite Chinese and other Western women only aggravated their agitation as they faced their Chinese counterparts,whom they readily construed as competitors.The socio-political and spatial reconfigurations provided new dimensions to the discourse of fidelity and sacrifice.The voices of the American couples recorded here are those of individuals,but the underlying anxiety they articulated represented the growing pains of more intimate Sino-Western encounters.

The Genome of Opium Poppy Reveals Evolutionary History of Morphinan Pathway

Plants, as primary producers, have been playing an indispensable role in other organisms’ survival and the balance of whole ecosystem on Earth. Especially, they provide the main source of energy, food, and medicine for human beings, some of which are derived from the primary or secondary metabolites