Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to tra...Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to traditional therapies.Faced with the obstacles of insufficient adhesive strength and ensuing short drug retention time,conventional oral therapeutic agents often have difficulty in achieving their desired efficacy.Oral and maxillofacial wet-adhesive materials have the advantages of excellent wet environment retention,internal stability,plasticity,and clinical potential,thus have become a significant research direction in the field of oral related disorders healing.In the past decade,the development of oral adhesive materials with good wet adhesion has accelerated based on the chemical molecular interaction,physical interlocking,and biological adhesion mechanisms,including biomimetic-inspired materials,naturally derived polymer–based materials and adhesive electrospun fiber films.These fancy wet-adhesive materials can be used for oral mucosal drug delivery,oral vaccination,wound healing,and bone defects treatments.Despite their numerous novel applications,wet-adhesive materials in stomatology still face unresolved challenges from material and biological aspects.Here,advances in designs of oral and maxillofacial wetadhesive materials are reviewed in terms of design backgrounds,attachment mechanisms,and common classifications.Recent demonstrations of wet-adhesive materials for oral and maxillofacial region medical applications from drug delivery to multifunctional tissue treatments are presented.To conclude,current challenges and prospects on potential applications of oral and maxillofacial wet-adhesive materials are also briefly discussed.展开更多
Objective: To investigate the cl inical effect of electro￣acupuncture (EA) in treating maxillofacial hemangiom a (MFH). Methods:Platinum needles (electrode) were inserted into t he MFH in 405 patients, the locations ...Objective: To investigate the cl inical effect of electro￣acupuncture (EA) in treating maxillofacial hemangiom a (MFH). Methods:Platinum needles (electrode) were inserted into t he MFH in 405 patients, the locations of which were found with the guidance of B￣ultrasonography or CT, and the number of needles was decided by the size of the MFH, the distance between needles was about 1.5cm, and the peri￣lesional health tissues were protected with plastic insulating canulae. The electrodes, i.e. the cathodes and anodes, were linked to the EA apparatus for EA treatment, and the usually applied voltage was 5.0-7.0V, the current 60-80mA and the quanti ty about 100 coulombs/cm of MFH's diameter. B￣ultrasonography was used for mo nitoring during EA, and the treatment was finished when B￣ultrasonography sho wed disappearance of blood flow in the MFH. Results: Evaluation ac cording to WHO's standard for therapeutic efficacy evaluation of tumor showed th at, after treatment, 345 patients (85.2%) were completely remitted (CR), 39 (9.6 %) partially remitted (PR), 12 (3.0%) improved pathologically, and 9 (2.2%) show ing no improvement, the effective rate (CR+PR) being 94.8%. Conclusion: EA, as a creative technique for treatment of MFH, has made a breakthrough in clinical practice,showing high efficacy. It also has such superiorities as be ing simple, causing less injury, and enabling the patients to recover quickly, w ith no scar left and easily to popularize, and therefore, it provides an effecti ve method for curing MFH.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82101076,81771122,81970985)Key Research Program of Sichuan Science and Technology Department(No.2019YJ0147)Postdoctoral Research Foundation of China(No.2020M683334)。
文摘Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to traditional therapies.Faced with the obstacles of insufficient adhesive strength and ensuing short drug retention time,conventional oral therapeutic agents often have difficulty in achieving their desired efficacy.Oral and maxillofacial wet-adhesive materials have the advantages of excellent wet environment retention,internal stability,plasticity,and clinical potential,thus have become a significant research direction in the field of oral related disorders healing.In the past decade,the development of oral adhesive materials with good wet adhesion has accelerated based on the chemical molecular interaction,physical interlocking,and biological adhesion mechanisms,including biomimetic-inspired materials,naturally derived polymer–based materials and adhesive electrospun fiber films.These fancy wet-adhesive materials can be used for oral mucosal drug delivery,oral vaccination,wound healing,and bone defects treatments.Despite their numerous novel applications,wet-adhesive materials in stomatology still face unresolved challenges from material and biological aspects.Here,advances in designs of oral and maxillofacial wetadhesive materials are reviewed in terms of design backgrounds,attachment mechanisms,and common classifications.Recent demonstrations of wet-adhesive materials for oral and maxillofacial region medical applications from drug delivery to multifunctional tissue treatments are presented.To conclude,current challenges and prospects on potential applications of oral and maxillofacial wet-adhesive materials are also briefly discussed.
文摘Objective: To investigate the cl inical effect of electro￣acupuncture (EA) in treating maxillofacial hemangiom a (MFH). Methods:Platinum needles (electrode) were inserted into t he MFH in 405 patients, the locations of which were found with the guidance of B￣ultrasonography or CT, and the number of needles was decided by the size of the MFH, the distance between needles was about 1.5cm, and the peri￣lesional health tissues were protected with plastic insulating canulae. The electrodes, i.e. the cathodes and anodes, were linked to the EA apparatus for EA treatment, and the usually applied voltage was 5.0-7.0V, the current 60-80mA and the quanti ty about 100 coulombs/cm of MFH's diameter. B￣ultrasonography was used for mo nitoring during EA, and the treatment was finished when B￣ultrasonography sho wed disappearance of blood flow in the MFH. Results: Evaluation ac cording to WHO's standard for therapeutic efficacy evaluation of tumor showed th at, after treatment, 345 patients (85.2%) were completely remitted (CR), 39 (9.6 %) partially remitted (PR), 12 (3.0%) improved pathologically, and 9 (2.2%) show ing no improvement, the effective rate (CR+PR) being 94.8%. Conclusion: EA, as a creative technique for treatment of MFH, has made a breakthrough in clinical practice,showing high efficacy. It also has such superiorities as be ing simple, causing less injury, and enabling the patients to recover quickly, w ith no scar left and easily to popularize, and therefore, it provides an effecti ve method for curing MFH.
