A 44 year-old women with persistent back and irradiate pain after discectomy in L5-S1 lumbar level presented a osteoblastoma in L4-L5 level. The osteoblastoma mimic a failed back surgery. She was successfully treated ...A 44 year-old women with persistent back and irradiate pain after discectomy in L5-S1 lumbar level presented a osteoblastoma in L4-L5 level. The osteoblastoma mimic a failed back surgery. She was successfully treated by removing the tumour with instrumented posteroalateral fusion. This case warns people that a new disease (such as a tumour in this case), irrelevant to the original one, may happen simultaneously even if the original one has been successfully treated and should be differentiated from the previous disease or surgical failure and complications.展开更多
Background: Osteoblastoma, a rare osteoblastic tumor, constitutes approximately 1% of all primary bone tu- mors. Aim: The purpose of this report is to present an osteoblastoma of the mandible, with particular emphasis...Background: Osteoblastoma, a rare osteoblastic tumor, constitutes approximately 1% of all primary bone tu- mors. Aim: The purpose of this report is to present an osteoblastoma of the mandible, with particular emphasis on the differential diagnosis of this rare tu- mor. Methods-Results: the lesion showed osteoblast- like cells, stromal cells, osteoclast-like cells and inter- lacing trabeculae of osteoid. Because of the high cel- lularity of the tumor, immunohistochemical analysis was performed using the cell proliferation marker Ki-67, the p53 and the anti-apoptotic protein Bcl-2. The lesion demonstrated low to moderate prolifera- tive activity and no immunoreactivity was detected for p53. An interesting finding was the Bcl-2 expres- sion by the multinucleated osteoclast-like giant cells, in contrast to the lack of Bcl-2 expression from osteo- blast-like and stromal tumor cells. Conclusion: To our knowledge the Bcl-2 expression has not yet been in- vestigated in benign or malignant osteoblastic tumors. This finding may be related to the molecular mecha- nisms regulating the apoptosis of osteoclast-like tu- mor cells or their function.展开更多
Osteoblastoma is an uncommon benign tumor which commonly affects the vertebrae and the long bones. It occasionally arises in the maxilla. It is important to do differential diagnoses which include osteoid osteoma, gia...Osteoblastoma is an uncommon benign tumor which commonly affects the vertebrae and the long bones. It occasionally arises in the maxilla. It is important to do differential diagnoses which include osteoid osteoma, giant cell bone tumour, aneurysmal bone cyst and fibrous dysplasia giant cell tumor and osteogenic sarcoma. The current study presents the case of a 14-year-old boy with a tumor in the ethmoid cell and maxillary sinus. Previous literature was reviewed and discussed.展开更多
文摘A 44 year-old women with persistent back and irradiate pain after discectomy in L5-S1 lumbar level presented a osteoblastoma in L4-L5 level. The osteoblastoma mimic a failed back surgery. She was successfully treated by removing the tumour with instrumented posteroalateral fusion. This case warns people that a new disease (such as a tumour in this case), irrelevant to the original one, may happen simultaneously even if the original one has been successfully treated and should be differentiated from the previous disease or surgical failure and complications.
文摘Background: Osteoblastoma, a rare osteoblastic tumor, constitutes approximately 1% of all primary bone tu- mors. Aim: The purpose of this report is to present an osteoblastoma of the mandible, with particular emphasis on the differential diagnosis of this rare tu- mor. Methods-Results: the lesion showed osteoblast- like cells, stromal cells, osteoclast-like cells and inter- lacing trabeculae of osteoid. Because of the high cel- lularity of the tumor, immunohistochemical analysis was performed using the cell proliferation marker Ki-67, the p53 and the anti-apoptotic protein Bcl-2. The lesion demonstrated low to moderate prolifera- tive activity and no immunoreactivity was detected for p53. An interesting finding was the Bcl-2 expres- sion by the multinucleated osteoclast-like giant cells, in contrast to the lack of Bcl-2 expression from osteo- blast-like and stromal tumor cells. Conclusion: To our knowledge the Bcl-2 expression has not yet been in- vestigated in benign or malignant osteoblastic tumors. This finding may be related to the molecular mecha- nisms regulating the apoptosis of osteoclast-like tu- mor cells or their function.
文摘Osteoblastoma is an uncommon benign tumor which commonly affects the vertebrae and the long bones. It occasionally arises in the maxilla. It is important to do differential diagnoses which include osteoid osteoma, giant cell bone tumour, aneurysmal bone cyst and fibrous dysplasia giant cell tumor and osteogenic sarcoma. The current study presents the case of a 14-year-old boy with a tumor in the ethmoid cell and maxillary sinus. Previous literature was reviewed and discussed.
