Objective: To observe the effects of Xin'an capsule (XAC) on experimental ventricular arrhythmia (EVA) in animals and to explore the possible mechanism. Methods: Three types of animal arrhythmic model (ventricula...Objective: To observe the effects of Xin'an capsule (XAC) on experimental ventricular arrhythmia (EVA) in animals and to explore the possible mechanism. Methods: Three types of animal arrhythmic model (ventricular arrythmia in guinea pigs induced by Ouabin, in rats caused by reperfusion after ligation of descending anterior branch of coronary artery and by CaCl 2) were used to study the effects of XAC on ventricular arrhythmia (VA). Results: After XAC treatment, the dosage of Ouabin needed for inducing ventricular premature beat (VPB), ventricular tachycardia (VT) and ventricular fibrillation (VF) increased in guinea pigs. The sustaining time of reperfusion induced VT and total occurrence of ventricular arrhythmias decreased. XAC also showed an effect in increasing CaCl 2 dosage needed to cause VA, and decreased the occurrence of VF and death in rats. Conclusion: XAC is effective in the treatment of above mentioned experimental VA. The therapeutic mechanism may be multiple sided.展开更多
文摘Objective: To observe the effects of Xin'an capsule (XAC) on experimental ventricular arrhythmia (EVA) in animals and to explore the possible mechanism. Methods: Three types of animal arrhythmic model (ventricular arrythmia in guinea pigs induced by Ouabin, in rats caused by reperfusion after ligation of descending anterior branch of coronary artery and by CaCl 2) were used to study the effects of XAC on ventricular arrhythmia (VA). Results: After XAC treatment, the dosage of Ouabin needed for inducing ventricular premature beat (VPB), ventricular tachycardia (VT) and ventricular fibrillation (VF) increased in guinea pigs. The sustaining time of reperfusion induced VT and total occurrence of ventricular arrhythmias decreased. XAC also showed an effect in increasing CaCl 2 dosage needed to cause VA, and decreased the occurrence of VF and death in rats. Conclusion: XAC is effective in the treatment of above mentioned experimental VA. The therapeutic mechanism may be multiple sided.
