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Transformation of French Governance Model for Oceanian Overseas Territories
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作者 Zhang Ying Yu Xinyang 《Contemporary International Relations》 2024年第5期86-107,共22页
The governance of France's overseas territories in Oceania has undergone a significant model transformation since the end of World War Ⅱ. In recent years, it has further highlighted its determination to pursue st... The governance of France's overseas territories in Oceania has undergone a significant model transformation since the end of World War Ⅱ. In recent years, it has further highlighted its determination to pursue strategic autonomy. Through strict governance and legal mechanisms, France has promoted local autonomy and economic transformation, and has shifted the governance of these territories from colonial control to political cooperation and from predatory development to localized sustainable development. France's overseas territories in Oceania have increasingly become the fulcrum of its foreign strategy, serving the overall interests of its country and its overseas security. In recent years, France's governance policies in the region have become increasingly diversified, such as promoting economic diversification, strengthening regional security cooperation, weakening its independence tendencies, and promoting changes in the regional situation and relevant national policies. 展开更多
关键词 FRANCE governance model overseas territories of Oceania strategic independence
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Doctor-patient Narrative Re-discovered from Overseas Traditional Chinese Medicine Practices
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作者 SHEN Chengju YANG Yidan LI Zhenyi 《Chinese Medicine and Culture》 2024年第4期327-334,共8页
The doctor-patient narrative has been revisited and appreciated in both the West and the East due to the negative impact of biochemical medicine in the past two centuries on healthcare.Biochemical medicine system simp... The doctor-patient narrative has been revisited and appreciated in both the West and the East due to the negative impact of biochemical medicine in the past two centuries on healthcare.Biochemical medicine system simply marginalized the roles of doctors and patients.More research and practice of“doctor's benevolence”and“humanistic medicine”have called for the return of the doctor-patient narrative.This paper draws on interviews with several non-Chinese overseas traditional Chinese medicine(TCM)practitioners,whose clients are also non-Chinese.We adopted discourse analysis to explore our data.We found that they actively engaged in doctor-patient narrative with localized interpretation of TCM.We believe such a return to basic doctor-patient narrative is caused by fundamental needs for doctor-patient narrative coinciding with loose control of TCM practices in the studied countries.This discovery may inspire further study on re-establishing doctor-patient narratives in healthcare institutions by re-positioning biochemical medicine. 展开更多
关键词 Doctor-patient narrative overseas practice Cross-cultural communication Traditional Chinese medicine
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Preliminary Study on Overseas Applicability of Chinese Architectural Design Standards:Taking China-Aided Construction Projects in Asia Since the Belt and Road Initiative as Examples
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作者 Wei Chang Yifan Gao +1 位作者 Xiaofeng Guo Yingjie Zhu 《Journal of Architectural Research and Development》 2024年第3期1-7,共7页
This research takes China-aided construction projects in Asia since the Belt and Road Initiative as examples to explore the applicability of Chinese architectural design standards in other Asian countries.So far,the s... This research takes China-aided construction projects in Asia since the Belt and Road Initiative as examples to explore the applicability of Chinese architectural design standards in other Asian countries.So far,the standards demonstrated the highest applicability in South Asia is the best followed by Southeast Asia.Chinese architectural design standards for educational buildings showed the highest applicability,followed by office,medical,and sports buildings.This study puts forward some strategies to improve the applicability of Chinese architectural design standards.These strategies include integrating regionalism and local cultural traditions,optimizing energy efficiency,and aligning designs with local usage habits.This study serves as a reference for similar projects in the future. 展开更多
关键词 Chinese building design standards overseas applicability China-aided construction Belt and Road Initiative
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Research on Localized English Education for Transnational Left-behind Children in the Context of English Global Localization: A Case Study of Wenzhou Overseas Chinese Hometown
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作者 Yujie Su Xueyan Li +4 位作者 Huili Ma Shuchang Dong Ruoruo Lin Lijuan Zou Qiaoqiao Lin 《教育技术与创新》 2024年第1期36-49,共14页
With the increasing development of English globalization,the trend of combining English with local cultures has become more evident.This research focuses on five schools in the Wenzhou overseas Chinese hometown to inv... With the increasing development of English globalization,the trend of combining English with local cultures has become more evident.This research focuses on five schools in the Wenzhou overseas Chinese hometown to investigate the current status of English education from the perspectives of teachers,students,and textbooks.The aim was to propose bilingual education strategies for the education of transnational left-behind children(TLC).By examining the situation of English education in this specific context,this study sought to address the unique challenges faced by TLC and provide effective educational approaches.Interviews,observations,and document analysis were employed to gather data by means of questionnaire research methods.The findings of this study settled on the improvement of bilingual education for TLC and insights into enhancing English education in multicultural settings. 展开更多
关键词 GLOCALIZATION transnational left-behind children(TLC) bilingual education Wenzhou overseas Chinese Hometown
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2023-08-23辽宁普兰店M 4.6地震震源参数测定及发震构造初判
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作者 戴盈磊 张文静 +2 位作者 杨晓东 索锐 王承伟 《大地测量与地球动力学》 北大核心 2025年第1期48-54,59,共8页
2023-08-2318:19辽宁省大连市普兰店区发生M 4.6地震,为准确描述本次地震的震源特征,探讨其孕育和发震机理,本文通过测定地震的震源深度,反演震源机制、矩张量及质心深度,给出震源机制中心解;同时分析震源机制与构造应力场的关系,根据... 2023-08-2318:19辽宁省大连市普兰店区发生M 4.6地震,为准确描述本次地震的震源特征,探讨其孕育和发震机理,本文通过测定地震的震源深度,反演震源机制、矩张量及质心深度,给出震源机制中心解;同时分析震源机制与构造应力场的关系,根据小震重定位结果对发震断层面进行拟合,初步确定了本次地震的发震断层。结果表明,普兰店M 4.6地震初始破裂深度为12.0 km,震源机制解参数为节面Ⅰ走向50°,倾伏角75°,滑动角-169°;节面Ⅱ走向317°,倾伏角80°,滑动角-15°,矩震级M W4.8,最优质心深度12 km;地震矩M_(0)为1.796×10^(16)Nm,矩张量解M_(rr)、M_(tt)、M_(pp)、M_(rt)、M_(rp)、M_(tp)分别为-0.004、0.946、-0.942、0.017、-0.305、-0.125;中心解参数为节面Ⅰ走向47.03°,倾伏角79.04°,滑动角-168.15°;节面Ⅱ走向314.75°,倾伏角78.37°,滑动角-11.19°。构造应力场作用在中心解节面Ⅰ上的相对剪应力为0.877,相对正应力为-0.544;投影于节面Ⅱ上的相对剪应力为0.911,相对正应力为0.161。拟合的断层面走向148.91°,倾伏角89.85°,其在构造应力体系下的滑动角为26.47°。综合分析认为,普兰店M 4.6地震发生在NW向普兰店-长海构造带,是沿应力场最优节面以左旋走滑为错动方式的天然地震。 展开更多
关键词 普兰店m 4.6地震 初至P震相定位法 gCAP 震源机制 构造应力场
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血浆m1A及其编码器基因对结肠腺癌诊断的综合分析
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作者 朱立强 孙金旗 +6 位作者 冀恒涛 吴亚丽 韩晶晶 彭仁佳 樊清波 马卫国 李庆华 《胃肠病学和肝病学杂志》 2025年第1期25-30,共6页
目的探讨m1A RNA甲基化相关基因和血浆m1A甲基化水平对结肠腺癌(colorectal adenocarcinoma,COAD)的诊断效能,为COAD早期诊断提供新的方案。方法通过UALCAN、The Human Protein Atlas和TCGA-GTEx数据库,分析COAD组织和正常结肠组织中m1... 目的探讨m1A RNA甲基化相关基因和血浆m1A甲基化水平对结肠腺癌(colorectal adenocarcinoma,COAD)的诊断效能,为COAD早期诊断提供新的方案。方法通过UALCAN、The Human Protein Atlas和TCGA-GTEx数据库,分析COAD组织和正常结肠组织中m1A相关基因mRNA和蛋白水平的差异表达。利用ELISA法检测收集于我院初诊的COAD患者和正常人血浆中m1A甲基化水平。结合COAD临床病理特征分析m1A甲基化对COAD的诊断效能。结果m1A编码器和读码器基因的蛋白水平和mRNA水平在COAD组织中的表达显著上调,其中以TRMT6和TRMT10C两个编码器表达升高最为显著。两个编码器基因均可作为COAD诊断,尤其是早期诊断标志物,且其AUC均达到0.9以上。m1A总体甲基化水平在COAD血浆中明显升高,并可作为早期COAD的诊断标志物。结论m1A编码器基因和血浆m1A在COAD中明显升高,有望成为一种新的早期COAD诊断标志物。 展开更多
关键词 结肠腺癌 m1A 诊断 血浆
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高糖环境通过抑制免疫反应基因1的表达诱导巨噬细胞促炎性 M1型极化
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作者 罗维 王宇航 +2 位作者 刘延松 王媛媛 艾磊 《南方医科大学学报》 北大核心 2025年第1期1-9,共9页
目的研究高糖环境对巨噬细胞极化的影响及其潜在分子机制。方法将离体培养的RAW264.7细胞随机分为过表达对照组(NC-OE组)、免疫反应基因1过表达组(IRG1 OE组)、沉默对照组(NC-siRNA组)和IRG1沉默组(IRG1 siRNA组),电穿孔进行质粒转染后... 目的研究高糖环境对巨噬细胞极化的影响及其潜在分子机制。方法将离体培养的RAW264.7细胞随机分为过表达对照组(NC-OE组)、免疫反应基因1过表达组(IRG1 OE组)、沉默对照组(NC-siRNA组)和IRG1沉默组(IRG1 siRNA组),电穿孔进行质粒转染后再组内随机分为对照组(Con组)和高糖组(HG组),60 mmol/L葡萄糖干预72 h后收集细胞进行检测。CCK-8检测细胞活性,相差显微镜观察细胞形态,Western blotting检测细胞中IRG1、iNOS、Arg-1、IL-1β和IL-10蛋白表达,免疫荧光染色检测细胞中iNOS和Arg-1蛋白荧光水平,ELISA法检测细胞培养基中IL-1β和IL-10蛋白水平。结果与对应Con组相比,HG组IRG1表达均下降(P<0.01),同时出现较多梭形和多突形细胞且两极可见伸展的伪足,iNOS表达升高(P<0.01)、Arg-1表达下降(P<0.05),IL-1β表达和分泌升高(P<0.05)、IL-10分泌下降(P<0.01)。转染IRG1过表达质粒后,与对应NC-OE组相比,IRG1 OE组IRG1水平均升高(P<0.01);高糖环境下,HG-IRG1 OE组梭形和多突形细胞明显减少、iNOS表达下降(P<0.01)、Arg-1表达升高(P<0.01)、IL-1β表达和分泌下降(P<0.01)、IL-10表达和分泌升高(P<0.05)。IRG1沉默后,与对应NC-siRNA组相比,IRG1 siRNA组IRG1水平降低(P<0.01);高糖环境下,HG-IRG1 siRNA组多突形细胞和伪足进一步增加、Arg-1表达降低(P<0.01)、IL-10表达和分泌减少(P<0.05)。结论高糖环境诱导巨噬细胞促炎性M1型极化进而诱发慢性炎症反应,其作用机制可能与抑制巨噬细胞中IRG1蛋白表达有关。 展开更多
关键词 巨噬细胞 m1型极化 炎症因子 高糖环境 免疫反应基因1
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Overseas Short-term Training Program for Chinese University Teacher Educators:Theoretical Basis and Course Design
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作者 袁刚 《海外英语》 2022年第4期238-240,共3页
Overseas three-month intra-university training program is rear in Yunnan,China.Using adult learning and social con-structivism as theoretical basis,the author,introduces the background of the program and the course de... Overseas three-month intra-university training program is rear in Yunnan,China.Using adult learning and social con-structivism as theoretical basis,the author,introduces the background of the program and the course design,highlighting the inten-tion for the program and similar programs. 展开更多
关键词 overseas short-term training program adult learning social constructivism
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Learner Factors and Contextual Influences of an Overseas Short-term Training Program for Chinese University Teacher Educators
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作者 袁刚 《海外英语》 2021年第20期292-294,共3页
The participants of an overseas three-month program in this paper were divided into 3 levels according to their English language competences,and classroom observation,and interview were conducted during the learning p... The participants of an overseas three-month program in this paper were divided into 3 levels according to their English language competences,and classroom observation,and interview were conducted during the learning process.Results show the English language competences,interpretation,learners’education and research background and motivation are determining factors affecting classroom behavioral performance and learning effectiveness. 展开更多
关键词 overseas training program English language competences diverse background
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Model of interval multi-attribute optimization for overseas oil-gas projects 被引量:3
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作者 Yong-Zhang Huang Bao-Sheng Zhang +1 位作者 Xin-Qiang Wei Ren-Jin Sun 《Petroleum Science》 SCIE CAS CSCD 2015年第2期345-354,共10页
Because of the incompleteness and uncertainty in the information on overseas oil-gas projects, project evaluation needs models able to deal with such problems. A new model is, therefore, presented in this paper based ... Because of the incompleteness and uncertainty in the information on overseas oil-gas projects, project evaluation needs models able to deal with such problems. A new model is, therefore, presented in this paper based on interval multi-attribute decision-making theory. Analysis was made on the important attributes (index) and the re- lationships affecting the basic factors to the project eco- nomic results were described. The interval numbers are used to describe the information on overseas oil and gas projects. On these bases, an improved TOPSIS model is introduced for the evaluation and ranking of overseas oil and gas projects. The practical application of the new model was carried out for an oil company in selecting some promising blocks from 13 oil and gas blocks in eight dif- ferent countries in the Middle East. Based on these inno- vative studies, some conclusions are given from theoretical and application aspects. The practical application shows that the introduction of interval numbers into the evaluation and ranking of the overseas oil and gas projects can lead to more reasonable decisions. The users can do the project evaluation based on the comprehensive values as well as based on some preferred index in the project evaluation and ranking. 展开更多
关键词 Interval data Improved TOPSIS modelmultiple attribute decision making overseas oil-gasproject Alternative ranking
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The Reform Scheme of Practice-Courses Cooperation Training Pattern of Software Engineering Major of Overseas Chinese Universities 被引量:2
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作者 Jin Gou Wei Luo +1 位作者 Kongjie Lin Yaxuan Zhang 《计算机教育》 2018年第12期147-154,共8页
How to improve the employment of software engineering graduates, especially, how to effectively enhance the employment competitiveness of relevant overseas students in the context of "One Belt and One Road" ... How to improve the employment of software engineering graduates, especially, how to effectively enhance the employment competitiveness of relevant overseas students in the context of "One Belt and One Road" is one of the core tasks of overseas Chinese universities. This paper proposes a reform plan for the practical training mode of school-enterprise cooperative project in the software engineering of overseas Chinese universities. The reform plan combines education concepts with practical research and development. It subdivides students and according to the characteristics of different types of students, and is carried out on campus, outside campus(in the province), and abroad(original area), which makes senior undergraduates fully understand the needs of enterprises, constantly improve their professional practice ability, and improve their competitiveness. Thus, the professional innovation and entrepreneurship ability of students is enhanced, and it also reduces the cost of employee entry. 展开更多
关键词 SOFTWARE engineering overseas students project training
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THE CONSTRUCTION AND ITS DEVELOPMENT OFTHE OVERSEAS TRANSPORT SYSTEM IN NORTHEAST CHINA 被引量:1
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作者 高莎丽 刘宁 孙丽华 《Chinese Geographical Science》 SCIE CSCD 1994年第1期19-30,共12页
THECONSTRUCTIONANDITSDEVELOPMENTOFTHEOVERSEASTRANSPORTSYSTEMINNORTHEASTCHINAGaoShali(高莎丽)(DepartmentofGeogra... THECONSTRUCTIONANDITSDEVELOPMENTOFTHEOVERSEASTRANSPORTSYSTEMINNORTHEASTCHINAGaoShali(高莎丽)(DepartmentofGeography,NortheastNorm... 展开更多
关键词 NORTHEAST China PORT CONSTRUCTION overseas TRANSPORT SYSTEm
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Study of evaluation method for the overseas oil and gas investment based on risk compensation 被引量:3
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作者 Zu-Xin Li Jian-Ye Liu +1 位作者 Dong-Kun Luo Jian-Jun Wang 《Petroleum Science》 SCIE CAS CSCD 2020年第3期858-871,共14页
The overseas oil and gas investment evaluation is one of the core tasks in overseas investment of oil and gas companies,among which risk evaluation and benefit evaluation are the most important.This paper sets forth t... The overseas oil and gas investment evaluation is one of the core tasks in overseas investment of oil and gas companies,among which risk evaluation and benefit evaluation are the most important.This paper sets forth transmission paths of risk factors to the investment benefit by identifying 14 overseas oil and gas investment risks in four categories.On the basis of the concept of risk compensation,different compensation mechanisms specific to each risk are designed.The risk and benefit are integrated objectively to develop a comprehensive evaluation model by correcting the recoverable reserve,adjusting benefit evaluation parameters such as investments on exploration and development,and compensating for the changes in risk factors with time through dynamic discount rate.Moreover,two cases studies,namely the evaluations of Project A in Sudan and comparison among Blocks A–G,are used to describe usage method and applicable scope of such evaluation model,respectively.According to the results,oil price is a key influencing factor for enterprise internal risk and industrial risk.Risk compensation reduces comprehensive benefit of overseas oil and gas investment and undermines the investment feasibility and priority of blocks.The research findings of this paper are free from the effects of some subject factors and avoid multi-objective decision making,and also avoid the undesired repeated calculation of risk factors. 展开更多
关键词 overseas oil and gas investment Investment evaluation Risk compensation Dynamic discount rate Comprehensive benefit
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5 m低净空工况基坑支护开挖施工与实测研究
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作者 黎兴望 詹炎培 +2 位作者 杨平 魏领先 张婷 《建筑技术》 2025年第1期74-79,共6页
以苏州市轨道交通某地铁车站基坑为例,阐述了5m低净空工况下采取钻孔灌注桩+MJS工法桩施作基坑围护结构与低净空基坑分区开挖的施工工艺。通过实测分析围护结构变形、邻近高架桥墩台沉降、地表沉降变化、支撑轴力变化、水位变化的发展... 以苏州市轨道交通某地铁车站基坑为例,阐述了5m低净空工况下采取钻孔灌注桩+MJS工法桩施作基坑围护结构与低净空基坑分区开挖的施工工艺。通过实测分析围护结构变形、邻近高架桥墩台沉降、地表沉降变化、支撑轴力变化、水位变化的发展规律。结果表明:盖板下基坑部分自开始开挖至坑底,钻孔灌注桩最大侧向位移值呈增大趋势,最大侧向位移点位置深度随开挖深度逐渐下移至开挖深度的1.1倍处。随着基坑开挖位置逐渐远离桥墩台,墩台竖向位移变化量逐渐减小,同时基坑背面一侧地表沉降未出现较大变化,显而易见,桥桩桩身周围的隔离桩有效隔离了坑外地表沉降,支撑轴力变化随基坑开挖深度增加显现即时性特点。此外,基坑东北角潜水位一直低于预警值,但未见明显渗漏情况。证明5 m低净空工况下基坑采取地下连续墙结合钻孔灌注桩围护结构及MJS止水帷幕的施工方案具有合理性。 展开更多
关键词 5 m净空 基坑开挖 沉降 水位变化
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The Overseas Reception of Chinese Science Fiction Works from a Perspective of Western Interpretation Preference——A Case Study of Reader's Reception of Liu Cixin's The Three-Body Problem in the USA 被引量:1
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作者 Liu Ge Li Yun Wu Lingwei 《Contemporary Social Sciences》 2018年第6期90-102,共13页
The Three-Body Problem, written by Liu Cixin, won the 2015 Hugo Award for Best Novel, with over 200,000 copies in English already sold. This gure is hundreds of times the average sales volume of Chinese novels in the ... The Three-Body Problem, written by Liu Cixin, won the 2015 Hugo Award for Best Novel, with over 200,000 copies in English already sold. This gure is hundreds of times the average sales volume of Chinese novels in the USA. Through qualitative and quantitative analyses of overseas readers' comments on The Three-Body Problem posted on the online platforms of Goodreads and Amazon, this paper concludes that the novel's success overseas lies in its catering to the concerns of overseas readers. The ThreeBody Problem is popular among overseas readership thanks to its re ection on the ultimate existence of mankind, science ction vision & imagination, literary familiarity & identi cation, ideological di erence-triggered cultural curiosity, and a good translation. This paper attempts to interpret Liu Cixin's work on the map of world literature from the perspective of overseas readers' preferences to provide references for contemporary Chinese science ction creation and overseas reception. 展开更多
关键词 LIU CIXIN The THREE-BODY Problem science ction novel overseas RECEPTION
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Technological progress and development directions of PetroChina overseas oil and gas field production 被引量:1
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作者 MU Longxin CHEN Yaqiang +1 位作者 XU Anzhu WANG Ruifeng 《Petroleum Exploration and Development》 2020年第1期124-133,共10页
This study reviews the development history of PetroChina’s overseas oil and gas field development technologies, summarizes the characteristic technologies developed, and puts forward the development goals and technol... This study reviews the development history of PetroChina’s overseas oil and gas field development technologies, summarizes the characteristic technologies developed, and puts forward the development goals and technological development directions of overseas business to overcome the challenges met in overseas oil and gas production. In the course of PetroChina’s overseas oil and gas field production practice of more than 20 years, a series of characteristic technologies suitable for overseas oil and gas fields have been created by combining the domestic mature oil and gas field production technologies with the features of overseas oil and gas reservoirs, represented by the technology for high-speed development and stabilizing oil production and controlling water rise for overseas sandstone oilfields, high efficiency development technology for large carbonate oil and gas reservoirs and foamy oil depletion development technology in use of horizontal wells for extra-heavy oil reservoirs. Based on in-depth analysis of the challenges faced by overseas oil and gas development and technological requirements, combined with the development trends of oil and gas development technologies in China and abroad, overseas oil and gas development technologies in the future are put forward, including artificial intelligence reservoir prediction and 3 D geological modeling, secondary development and enhanced oil recovery(EOR) of overseas sandstone oilfields after high speed development, water and gas injection to improve oil recovery in overseas carbonate oil and gas reservoirs, economic and effective development of overseas unconventional oil and gas reservoirs, efficient development of marine deep-water oil and gas reservoirs. The following goals are expected to be achieved: keep the enhanced oil recovery(EOR) technology for high water-cut sandstone oilfield at international advanced level, and make the development technology for carbonate oil and gas reservoirs reach the international advanced level, and the development technologies for unconventional and marine deep-water oil and gas reservoirs catch up the level of international leading oil companies quickly. 展开更多
关键词 overseas OIL and GAS FIELD PRODUCTION sandstone OILFIELD large carbonate OILFIELD unconventional OIL and GAS FIELD marine deep-water OIL and GAS technological progress development direction
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Localization and the Chinese Overseas: Acculturation, Assimilation, Hybridization, Creolization, and Identification 被引量:1
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作者 TAN Chee-Beng 《Cultural and Religious Studies》 2018年第2期73-87,共15页
Based on materials on the localized Chinese overseas, including the Melaka Babas, who are mostly Malay-speaking Chinese, this article reflects on the use of such terms as acculturation and assimilation, as well as hyb... Based on materials on the localized Chinese overseas, including the Melaka Babas, who are mostly Malay-speaking Chinese, this article reflects on the use of such terms as acculturation and assimilation, as well as hybridization and creolization, in relation to highly localized Chinese. All these concepts are seen as different ways of describing cultural formation in transcultural context. In particular, the relevance of using creolization to refer to the kind of creative process of cultural formation beyond its original usage in the Caribbean is discussed. This results in the identification of fragmented creolization as in the case of the Caribbean and a rooted creolization as in the case of the Babas. The author shall first discuss the issues of assimilation and integration, followed by hybridization and creolization. This is followed by the discussion on localization of Chinese overseas and identity. The concluding section provides some remarks on the concepts reviewed, and three main categories of acculturated Chinese are identified, namely, Chinese who are linguistically assimilated but still observe major Chinese traditions, Chinese who are so acculturated to the mainstream society that they hardly practice Chinese traditions, and Chinese who are both highly localized and highly mixed “racially”. 展开更多
关键词 acculturation and assimilation HYBRIDIZATION creolization localization and identity Baba Chinese overseas
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脂多糖和钛颗粒对种植体周围组织中巨噬细胞M1/M2极化的诱导作用
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作者 邓冉 魏怡 姬晓炜 《中国组织工程研究》 北大核心 2025年第34期7415-7422,共8页
背景:随着种植技术的普及,种植体周围炎的发病率逐年升高,但其病因机制尚不明确。而高度可塑的巨噬细胞在微环境刺激下可极化为M1型和M2型,分别发挥促炎和抗炎作用,在种植体周围组织中发挥宿主防御、免疫应答和维持内环境稳态的重要作用... 背景:随着种植技术的普及,种植体周围炎的发病率逐年升高,但其病因机制尚不明确。而高度可塑的巨噬细胞在微环境刺激下可极化为M1型和M2型,分别发挥促炎和抗炎作用,在种植体周围组织中发挥宿主防御、免疫应答和维持内环境稳态的重要作用,M1/M2巨噬细胞极化趋势与植体周围异物反应平衡息息相关。目的:脂多糖和钛颗粒是引起种植体周围炎的重要致病因素,文章探究其对种植体周围组织中巨噬细胞极化的诱导作用。方法:以“种植体周围炎、巨噬细胞极化、脂多糖和钛颗粒、macrophage polarization、peri-implant inflammation、peri-implantitis、LPS、TLRs、NF-κB等”为关键词在CNKI和PubMed数据库中分别进行检索,对相关文献进行筛选和整理,分析脂多糖、钛颗粒对种植体周围组织中巨噬细胞M1/M2极化的诱导作用和相关机制。结果与结论:①脂多糖和钛颗粒可能通过Toll样受体/核因子κB等相关信号通路诱导植周组织中巨噬细胞极化,引起M1/M2极化失衡从而影响种植体周围炎的发生和进展,部分药物也可通过Toll样受体/核因子κB信号通路调控巨噬细胞M1/M2极化来治疗相关炎性疾病。②通过分析脂多糖、钛颗粒对种植体周围组织中巨噬细胞M1/M2极化的诱导作用,进一步阐述其调控Toll样受体/核因子κB信号通路诱导巨噬细胞极化的作用机制,以期为种植体周围炎的免疫防治研究提供一些新的思路和策略。 展开更多
关键词 种植体周围炎 脂多糖 钛颗粒 TLRs/NF-κB m1/m2 巨噬细胞
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罗汉果苷V调控高糖状态巨噬细胞M1极化促进骨髓间充质干细胞的成骨分化
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作者 叶枝茂 惠久莹 +2 位作者 钟晓霞 麦昱颖 李昊 《中国组织工程研究》 CAS 北大核心 2025年第19期3968-3975,共8页
背景:糖尿病微环境会造成巨噬细胞过度M1极化,这种高糖炎症状态会抑制骨髓间充质干细胞的成骨分化,从而影响糖尿病骨缺损的愈合。研究表明罗汉果苷Ⅴ具有抗炎、抗氧化、降血糖的作用,但其能否调节高糖炎症状态下巨噬细胞M1极化及骨髓间... 背景:糖尿病微环境会造成巨噬细胞过度M1极化,这种高糖炎症状态会抑制骨髓间充质干细胞的成骨分化,从而影响糖尿病骨缺损的愈合。研究表明罗汉果苷Ⅴ具有抗炎、抗氧化、降血糖的作用,但其能否调节高糖炎症状态下巨噬细胞M1极化及骨髓间充质干细胞的成骨分化尚不清楚。目的:探讨罗汉果苷Ⅴ在高糖炎症状态下调节巨噬细胞M1型极化对骨髓间充质干细胞成骨分化的影响。方法:构建糖尿病C57BL/6小鼠模型,从正常和糖尿病小鼠分离骨髓来源巨噬细胞,分别培养于低糖和高糖培养基。使用脂多糖和干扰素γ作为炎症刺激诱导骨髓来源巨噬细胞的M1型极化,同时以160,320,640μmol/L罗汉果苷Ⅴ干预,用流式细胞术检测F4/80^(+)CD86^(+)细胞比例,qRT-PCR检测诱导型一氧化氮合酶、白细胞介素1β、白细胞介素6的mRNA表达水平,ELISA检测骨髓来源巨噬细胞上清液中肿瘤坏死因子α水平。分离C57BL/6小鼠骨髓间充质干细胞,分别使用低糖或高糖成骨诱导液诱导成骨分化,添加M1型巨噬细胞条件培养基作为炎症刺激,以及320μmol/L罗汉果苷Ⅴ干预,成骨诱导14 d后采用qRT-PCR检测碱性磷酸酶、Runt相关因子2、骨钙素、骨桥蛋白的mRNA表达水平,成骨诱导21 d后进行茜素红染色及定量分析。结果与结论:①流式细胞术结果显示320,640μmol/L罗汉果苷Ⅴ组的F4/80^(+)CD86^(+)细胞比例明显低于高糖炎症对照组(P<0.05);②qRT-PCR结果显示160,320,640μmol/L罗汉果苷Ⅴ组的诱导型一氧化氮合酶、白细胞介素6的mRNA相对表达量较高糖炎症对照组显著降低(P<0.05),320,640μmol/L罗汉果苷Ⅴ组白细胞介素1β的mRNA相对表达量较高糖炎症对照组显著降低(P<0.05);③ELISA结果显示160,320,640μmol/L罗汉果苷Ⅴ组的肿瘤坏死因子α分泌水平较高糖炎症对照组显著降低(P<0.05);④320μmol/L罗汉果苷Ⅴ干预后,高糖炎症状态下骨髓间充质干细胞的钙盐沉积增加(P<0.05),且碱性磷酸酶、Runt相关因子2和骨桥蛋白的mRNA相对表达量增加(P<0.05)。结果表明,罗汉果苷Ⅴ可通过抑制高糖炎症状态下骨髓来源巨噬细胞的M1型极化及炎症因子表达,促进骨髓间充质干细胞的成骨分化。 展开更多
关键词 罗汉果苷Ⅴ 巨噬细胞 m1型极化 骨髓间充质干细胞 炎症反应 成骨分化 高糖
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IS CHINA LEARNING FROM ITS NEIGHBORS? A COMPARISON OF OVERSEAS INVESTMENT BETWEEN CHINA AND OTHER EAST ASIAN ECONOMIES
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作者 WANG Mark Yao-lin (Department of Geography and Environmental Studies,University of Melbourne, Victoria 3010,Australia) 《Chinese Geographical Science》 SCIE CSCD 2000年第4期39-47,共9页
Twenty years’ economic reform and open door practice have made China not only an important host nation to foreign direct investment (FDI), but also the largest FDI home nation among the developing countries. In fact,... Twenty years’ economic reform and open door practice have made China not only an important host nation to foreign direct investment (FDI), but also the largest FDI home nation among the developing countries. In fact, since the late 1980s, the Chinese government has not simply put its effort into exporting  made-in-China" products to earn foreign currency or into encouraging foreign inward capital, but also actively encouraged its manufacturers to invest overseas. This paper examines China’s outward FDI and poses the question to what degree China is expected to follow the other East Asian economies or will it forge its own particular patterns. The first section of this paper reviews the characteristics of FDI of China’s neighbors and then it turns to examine the spatial patterns of and motivations for China’s FDI. Finally, this paper looks at potential of China’s outward investment in the near future. It concludes that China is not Japan but its potential for further outward FDI is huge. With its WTO membership and growing economy, China will become the second to Japan or USA. It will also use its financial power to further contain Taiwan’s independence. 展开更多
关键词 China overseas investment East ASIAN economi
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