Research Progress on Mechanism of Ovulation Disorder in Polycystic Ovary Syndrome

Polycystic ovary syndrome(PCOS)is a reproductive endocrine disease characterized by ovulation disorder,hyperandrogenism and/or polycystic ovary.Follicular development disorder caused by PCOS accounts for up to 75%of anovulatory infertility,which is a common cause of infertility and affects up to 15%of reproductive aged women worldwide.Oxidative stress,chronic inflammation,endoplasmic reticulum stress and other pathological conditions coexist in the ovarian microenvironment of PCOS,which are further aggravated under the action of high levels of androgens,synergistically deteriorating the follicular microenvironment,leading to ovulation disorders in PCOS patients.This paper briefly reviewed the research on the mechanism of PCOS ovulation disorder in recent years.

Efficacy observation on 40 cases of anovulatory infertility treated by acupuncture and moxibustion

Objective To observe clinical effect of acupuncture and moxibustion on inducing ovulation. Methods Forty cases of anovulatory infertility were treated with electroacupuncture and moxibustion at Zigong （子宫 EX-CA 1）, Guanyuan （元关 CV 4） and Zhongji （中极 CV 3） as well as Linggui Bafa therapy, 30 min each time, once a day for 15 days. One menstrual cycle made a session, and totally 3 sessions were required. The level of follicle stimulating hormone （FSH）, luteinizing hormone （LH） and estradiol （E2）, the growth and development situation of follicle and endometrium before and after treatment, spontaneous pregnancy rate during follow-up visit were observed and compared. Results After the treatment, the level of FSH, LH and Ez were signifiacntly increased （all P〈0.05）, the thickness of endometrium and diameter of follicle were obviously increased （both P〈0.05）. As for the spontaneous pregnancy rate during follow- up visit, 9 cases were cured, 25 cases were effective, 6 cases were failed and the total effective rate was 85.0%. Conclusion The acupuncture and moxibustion has better clinical efficacy for anovulatory infertility.

Review on studies of acupuncture treatment for luteinized unruptured follicle syndrome

Luteinized unruptured follicle syndrome（LUFS）, a specific type of ovulation disorder, is for a cause of female infertility. Acupuncture therapy has a good effect for LUFS. In order to understand the clinical effects and research situation of acupuncture therapy for LUFS, the author analyzed and reviewed the relevant literature. It was indicated by the findings that acupuncture therapy and integrative therapy of acupuncture and Chinese herbs have good therapeutic effect for this disease. Acupuncture therapy has the effect to promote ovulation. By the therapeutic principle to tonify the kidney and circulate blood, acupuncture therapy mostly was adopted in the period of ovulation. The acupoints are mostly selected from the lower abdomen and lower limbs, possibly based upon syndrome differentiation at the same time. The needling techniques are of certain characteristics. But, the issues of low quality, un-standardized inclusive, exclusive criteria and effective criteria still exist in the current clinical study.