Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells（MSC） to secrete brain-derived neurotrophic factor（BDNF） supports our plan to submit an Investigational N...Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells（MSC） to secrete brain-derived neurotrophic factor（BDNF） supports our plan to submit an Investigational New Drug application to the Food and Drug Administration for the future planned Phase 1 safety and tolerability trial of MSC/BDNF in patients with Huntington＇s disease（HD）. There are also potential applications of this approach beyond HD. Our biological delivery system for BDNF sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis（ALS）, spinocerebellar ataxia（SCA）, Alzheimer＇s disease, and some forms of Parkinson＇s disease. The MSC/BDNF product could also be considered for studies of regeneration in traumatic brain injury, spinal cord and peripheral nerve injury. This work also provides a platform for our future gene editing studies, since we will again use MSCs to deliver the needed molecules into the central nervous system.展开更多
Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database ma...Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database management system (EDBMS). Through studying and analyzing the database security, to draw a series of securi ty rules, which reach B1, level security standard. Which includes discretionary access control (DAC), mandatory access control (MAC) and audit. The EDBMS implem ents functions of DAC, MAC and multigranularity audit. DAC solves the problems o f role inheritance, right contain, authorization identify and cascade revoke, et c; MAC includes subject and object security setup rule, security modify rule and multilevel relation access operation rule, etc; Audit allows making the sub ject, object or operation type as different audit object to implement flexible a nd multigranularity audit method. The model is designed act as a security agent to access daemon database. At present, the model is implemented which runs on th e Windows 2000 environments.展开更多
In order to gain practical experience and hands-on skills,full-time professional master degree postgraduate in mineral processing engineering should engage in professional practices.Nonetheless,a series of problems,in...In order to gain practical experience and hands-on skills,full-time professional master degree postgraduate in mineral processing engineering should engage in professional practices.Nonetheless,a series of problems,including insufficient time for practice,low management level,inadequate implementation of the double-supervisor system,and poor results of professional practice,has reduced the effectiveness of professional practice.In view of the aforementioned problems and the characteristics of the discipline,this paper proposes several strategies for improving the effectiveness of professional practice for postgraduates in mineral processing engineering.展开更多
The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. T...The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. The preparation temperature and reaction time have great influence on the photocatalytic activity of SnIn4S8, and the optimal preparation temperature and reaction time are 70℃ and 3 h, respectively.The SnIn4S8 shows good reusability and high stability with no observable decrease of photocatalytic activity in five consecutive cycles.展开更多
Software engineering(SE) courses are confronted with predicaments how to cultivate students' engineering concept and how to abridge the distance between the academy and industry.The "Computing and Software En...Software engineering(SE) courses are confronted with predicaments how to cultivate students' engineering concept and how to abridge the distance between the academy and industry.The "Computing and Software Engineering,III(CSE III)" helps students mimic a real-world software development and broaden realworld SE view.With the spiral model as the main development model,the CSE III course includes not only the SE theory knowledge,but also quick learning,team cooperation,development management and risk management skills which meet the real-world industry requirements.Our contribution is providing an introductory course for multiple dimensions of knowledge,creating a real-world software development circumstance for students under quantitative control and designing a systematic and practical evaluation mechanism which stimulates the interests of students.CSE III has been executed from 2009 and obtains a valuable teaching and learning effects among our teachers,TAs and students;and we add refinements to the course according to feedbacks of participants.This paper will describe the design and practice of the CSE III course.展开更多
During the early days of New China, to support the domestic construction of those projects aided by the former Soviet Union, the design institution formed a chemical engineering production installation design team. Du...During the early days of New China, to support the domestic construction of those projects aided by the former Soviet Union, the design institution formed a chemical engineering production installation design team. During the 1950s, this team designed an ammonia synthesis unit with an annual capacity of 75000 tons, set up the Sichuan Chemical Plant and worked out a展开更多
Software product lines have recently been presented as one of the best promis-ing improvements for the efficient software development. Different research works contribute supportive parameters and negotiations regardi...Software product lines have recently been presented as one of the best promis-ing improvements for the efficient software development. Different research works contribute supportive parameters and negotiations regarding the prob-lems of producing a perfect software scheme. Traditional approaches or recy-cling software are not effective to solve the problems concerning software competence. Since fast developments with software engineering in the past few years, studies show that some approaches are getting extensive attention in both industries and universities. This method is categorized as the software product line improvement;that supports reusing of software in big organizations. Different industries are adopting product lines to enhance efficiency and reduce operational expenses by way of emerging product developments. This research paper is formed to offer in-depth study regarding the software engineering issues such as complexity, conformity, changeability, invisibility, time constraints, budget constraints, and security. We have conducted various research surveys by visiting different professional software development organizations and took feedback from the professional software engineers to analyze the real-time problems that they are facing during the development process of software systems. Survey results proved that complexity is a most occurring issue that most software developers face while developing software applications. Moreover, invisibility is the problem that rarely happens according to the survey.展开更多
The origin,formation and evolution of the systems engineering theory accompanied QIAN Xuesen's whole life.The systems engineering theory is the concentrated reflection of QIAN's achievements and theory in all ...The origin,formation and evolution of the systems engineering theory accompanied QIAN Xuesen's whole life.The systems engineering theory is the concentrated reflection of QIAN's achievements and theory in all aspects.From returning to China to pioneer China's space industry,creating a new management mode of "one overall design department,two command lines",publishing Organization and Management Technology:Systems Engineering,to proposing the theory of Open Complex Giant System(OCGS) and the theory of Metasynthetic Wisdom,all these mark the formation of the Chinese school of systems engineering.Guided by QIAN's academic ideas,various major Chinese space programs have been implemented successfully which verified the fact that the systems engineering is scientific.The systems engineering has been applied to different fields of the national economy and has a development process with the distinguished characteristics of Chinese systems science.On one hand,the systems engineering is put forward deeply along the traditional systems engineering thought and theory;on the other hand,a batch of innovations that break the traditional shackles have occurred,making the Chinese systems engineering unique and outstanding compared with foreign counterparts.展开更多
ECO-88D Double Rope High Speed Dyeing Machine ECO-88D Double Rope High Speed Dyeing Machine is suitable for the processing of light to medium weight fabric made from synthetic ber. Fabric structure suitable for the dy...ECO-88D Double Rope High Speed Dyeing Machine ECO-88D Double Rope High Speed Dyeing Machine is suitable for the processing of light to medium weight fabric made from synthetic ber. Fabric structure suitable for the dyeing process inside the ECO-88D includes woven,展开更多
This article expounds that China’s higher engineering education is facing both challenges and opportunities. Some special difficulties and problems rise in the course of economic transition, and exhort us that it has...This article expounds that China’s higher engineering education is facing both challenges and opportunities. Some special difficulties and problems rise in the course of economic transition, and exhort us that it has been of great urgency to carry out a reform of higher engineering education. Here are put forward six measures: to explore training patterns of such an education suited to China’s national conditions; to improve university system: to transform educational ideology, and reform educational contents and methods; to establish a system of cooperation of engineering universities and colleges with industries; to strengthen construction of teacher contingent in engineering universities and colleges; and to carry out testing work of continuing engineering education and training education.展开更多
The author puts forward a proposal for developing chemistry and chemical engineering of China’s salt lakes on the basis of an investigation into exploitation and utilization of salt lake resources all over the world....The author puts forward a proposal for developing chemistry and chemical engineering of China’s salt lakes on the basis of an investigation into exploitation and utilization of salt lake resources all over the world. It contains the subjects of setting up an engineering research center, mainly developing leading products, giving priority to the development of a chemical industry by using Qinghai salt lake resources, actively popularizing results, stressing basic research and systematic management.展开更多
The problem of associating the agricultural market names on web sites with their locations is essential for geographical analysis of the agricultural products. In this paper, an algorithm which employs the administrat...The problem of associating the agricultural market names on web sites with their locations is essential for geographical analysis of the agricultural products. In this paper, an algorithm which employs the administrative ontology and the statistics from the search results were proposed. The experiments with 100 market names collected from web sites were conducted. The experimental results demonstrate that the algorithm proposed obtains satisfactory performance in resolving the problem above, thus the effectiveness of the method is verified.展开更多
FlexRay bus has become the standard of similar products and it will lead the direction of the development of auto- motive electronics control system for a long time. This paper proposes a design of automobile engine c...FlexRay bus has become the standard of similar products and it will lead the direction of the development of auto- motive electronics control system for a long time. This paper proposes a design of automobile engine control system based on FlexRay bus. In order to improve the network rate, reliability and flexibility, it adopts high-performance MC9S12XF512 microcontroller of Freescale and FlexRay bus driver TJA1080 of NXP company, and it gives the overall circuit design and software design process of automobile engine control system. The design has the characteristics of simple hardware circuit, high reliability and good real-time performance. It offers a certain reference value for the development of FlexRay bus node of engine control system.展开更多
Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable ac...Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable achievements, and liquid rocket engine technology has also been effectively developed. In this article, the development processes of China’s liquid rocket engines are discussed. Then, the performance features of China’s new generation liquid rocket engines as well as the flight tests of the new-generation launch vehicles are introduced. Finally, the development direction and the most recent progress of the next generation large-thrust liquid rocket engine is presented.展开更多
基金provided by a NIH NIGMS Predoctoral Fellowship T32GM099608(Deng)NIH NRSA Postdoctoral Fellowship F32NS090722(Fink)+2 种基金a NIH Director’s transformative award 1R01GM099688(Nolta)A Stewart’s and Dake Family Gift(Fink),California Institute for Regenerative Medicine(CIRM)DR2-05415(Wheelock/Nolta)philanthropic donors from the HD community,including the Roberson family and Team KJ
文摘Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells（MSC） to secrete brain-derived neurotrophic factor（BDNF） supports our plan to submit an Investigational New Drug application to the Food and Drug Administration for the future planned Phase 1 safety and tolerability trial of MSC/BDNF in patients with Huntington＇s disease（HD）. There are also potential applications of this approach beyond HD. Our biological delivery system for BDNF sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis（ALS）, spinocerebellar ataxia（SCA）, Alzheimer＇s disease, and some forms of Parkinson＇s disease. The MSC/BDNF product could also be considered for studies of regeneration in traumatic brain injury, spinal cord and peripheral nerve injury. This work also provides a platform for our future gene editing studies, since we will again use MSCs to deliver the needed molecules into the central nervous system.
文摘Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database management system (EDBMS). Through studying and analyzing the database security, to draw a series of securi ty rules, which reach B1, level security standard. Which includes discretionary access control (DAC), mandatory access control (MAC) and audit. The EDBMS implem ents functions of DAC, MAC and multigranularity audit. DAC solves the problems o f role inheritance, right contain, authorization identify and cascade revoke, et c; MAC includes subject and object security setup rule, security modify rule and multilevel relation access operation rule, etc; Audit allows making the sub ject, object or operation type as different audit object to implement flexible a nd multigranularity audit method. The model is designed act as a security agent to access daemon database. At present, the model is implemented which runs on th e Windows 2000 environments.
基金This work was supported by The Graduate Education and Teaching Reform Project of CUMTB(YJG202200301)The Yueqi Outstanding Scholar Award of CUMTB and Science and Technology Major Project of Ordos City-Iconic Innovation Team(202204).
文摘In order to gain practical experience and hands-on skills,full-time professional master degree postgraduate in mineral processing engineering should engage in professional practices.Nonetheless,a series of problems,including insufficient time for practice,low management level,inadequate implementation of the double-supervisor system,and poor results of professional practice,has reduced the effectiveness of professional practice.In view of the aforementioned problems and the characteristics of the discipline,this paper proposes several strategies for improving the effectiveness of professional practice for postgraduates in mineral processing engineering.
基金supported by Natural Science Foundation of China (51741806, 51238002, 51720105001)Science Fund for Excellent Young Scholars of Jiangxi Province (20162BCB23038)Natural Science Foundation of Jiangxi Province (20161BAB206117)
文摘The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. The preparation temperature and reaction time have great influence on the photocatalytic activity of SnIn4S8, and the optimal preparation temperature and reaction time are 70℃ and 3 h, respectively.The SnIn4S8 shows good reusability and high stability with no observable decrease of photocatalytic activity in five consecutive cycles.
文摘Software engineering(SE) courses are confronted with predicaments how to cultivate students' engineering concept and how to abridge the distance between the academy and industry.The "Computing and Software Engineering,III(CSE III)" helps students mimic a real-world software development and broaden realworld SE view.With the spiral model as the main development model,the CSE III course includes not only the SE theory knowledge,but also quick learning,team cooperation,development management and risk management skills which meet the real-world industry requirements.Our contribution is providing an introductory course for multiple dimensions of knowledge,creating a real-world software development circumstance for students under quantitative control and designing a systematic and practical evaluation mechanism which stimulates the interests of students.CSE III has been executed from 2009 and obtains a valuable teaching and learning effects among our teachers,TAs and students;and we add refinements to the course according to feedbacks of participants.This paper will describe the design and practice of the CSE III course.
文摘During the early days of New China, to support the domestic construction of those projects aided by the former Soviet Union, the design institution formed a chemical engineering production installation design team. During the 1950s, this team designed an ammonia synthesis unit with an annual capacity of 75000 tons, set up the Sichuan Chemical Plant and worked out a
文摘Software product lines have recently been presented as one of the best promis-ing improvements for the efficient software development. Different research works contribute supportive parameters and negotiations regarding the prob-lems of producing a perfect software scheme. Traditional approaches or recy-cling software are not effective to solve the problems concerning software competence. Since fast developments with software engineering in the past few years, studies show that some approaches are getting extensive attention in both industries and universities. This method is categorized as the software product line improvement;that supports reusing of software in big organizations. Different industries are adopting product lines to enhance efficiency and reduce operational expenses by way of emerging product developments. This research paper is formed to offer in-depth study regarding the software engineering issues such as complexity, conformity, changeability, invisibility, time constraints, budget constraints, and security. We have conducted various research surveys by visiting different professional software development organizations and took feedback from the professional software engineers to analyze the real-time problems that they are facing during the development process of software systems. Survey results proved that complexity is a most occurring issue that most software developers face while developing software applications. Moreover, invisibility is the problem that rarely happens according to the survey.
文摘The origin,formation and evolution of the systems engineering theory accompanied QIAN Xuesen's whole life.The systems engineering theory is the concentrated reflection of QIAN's achievements and theory in all aspects.From returning to China to pioneer China's space industry,creating a new management mode of "one overall design department,two command lines",publishing Organization and Management Technology:Systems Engineering,to proposing the theory of Open Complex Giant System(OCGS) and the theory of Metasynthetic Wisdom,all these mark the formation of the Chinese school of systems engineering.Guided by QIAN's academic ideas,various major Chinese space programs have been implemented successfully which verified the fact that the systems engineering is scientific.The systems engineering has been applied to different fields of the national economy and has a development process with the distinguished characteristics of Chinese systems science.On one hand,the systems engineering is put forward deeply along the traditional systems engineering thought and theory;on the other hand,a batch of innovations that break the traditional shackles have occurred,making the Chinese systems engineering unique and outstanding compared with foreign counterparts.
文摘ECO-88D Double Rope High Speed Dyeing Machine ECO-88D Double Rope High Speed Dyeing Machine is suitable for the processing of light to medium weight fabric made from synthetic ber. Fabric structure suitable for the dyeing process inside the ECO-88D includes woven,
文摘This article expounds that China’s higher engineering education is facing both challenges and opportunities. Some special difficulties and problems rise in the course of economic transition, and exhort us that it has been of great urgency to carry out a reform of higher engineering education. Here are put forward six measures: to explore training patterns of such an education suited to China’s national conditions; to improve university system: to transform educational ideology, and reform educational contents and methods; to establish a system of cooperation of engineering universities and colleges with industries; to strengthen construction of teacher contingent in engineering universities and colleges; and to carry out testing work of continuing engineering education and training education.
文摘The author puts forward a proposal for developing chemistry and chemical engineering of China’s salt lakes on the basis of an investigation into exploitation and utilization of salt lake resources all over the world. It contains the subjects of setting up an engineering research center, mainly developing leading products, giving priority to the development of a chemical industry by using Qinghai salt lake resources, actively popularizing results, stressing basic research and systematic management.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences
文摘The problem of associating the agricultural market names on web sites with their locations is essential for geographical analysis of the agricultural products. In this paper, an algorithm which employs the administrative ontology and the statistics from the search results were proposed. The experiments with 100 market names collected from web sites were conducted. The experimental results demonstrate that the algorithm proposed obtains satisfactory performance in resolving the problem above, thus the effectiveness of the method is verified.
基金National Natural Science Foundation of China(No.61262007)Guizhou Science and Technology Department School Cooperation Project(Qian Bureau No.[2013]7001)
文摘FlexRay bus has become the standard of similar products and it will lead the direction of the development of auto- motive electronics control system for a long time. This paper proposes a design of automobile engine control system based on FlexRay bus. In order to improve the network rate, reliability and flexibility, it adopts high-performance MC9S12XF512 microcontroller of Freescale and FlexRay bus driver TJA1080 of NXP company, and it gives the overall circuit design and software design process of automobile engine control system. The design has the characteristics of simple hardware circuit, high reliability and good real-time performance. It offers a certain reference value for the development of FlexRay bus node of engine control system.
文摘Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable achievements, and liquid rocket engine technology has also been effectively developed. In this article, the development processes of China’s liquid rocket engines are discussed. Then, the performance features of China’s new generation liquid rocket engines as well as the flight tests of the new-generation launch vehicles are introduced. Finally, the development direction and the most recent progress of the next generation large-thrust liquid rocket engine is presented.
