Inhibition of Albendazole and Oxfendazole on the Activity of Fumaric Reductase in Cysticercus cellulosae

The activity of fumaric reductase in Cysticercus cellulosae tissue homogenate with albendazole and oxfendazole individually was detected. Results showed that the two kinds of drugs both could inhabite the activity of fumaric reductase. The results indicate that the mechanism of action of benzimidazole carbamate drugs is probably inhabiting the complex of fumaric reductase noncompetently, thus lead to the exhaostion of energy and death.

Control trial of porcine cysticercosis in Uganda using a combination of the TSOL18 vaccination and oxfendazole

Background:Neurocysticercosis caused by Taenio solium when the parasite lodges in the central nervous system,is an important cause of human seizures and mortality in sub-Saharan Africa.The parasite is prevalent in many regions of Uganda.Pigs are intermediate hosts for T.solium,and we evaluated a T.solium control program in pigs,involving vaccination of pigs with the TSOL18 vaccine and treatment with oxfendazole.Methods:The study was conducted in two districts of Eastern Uganda involving the rural village communities of Bukedea(intervention area)and Kumi(control area)during 2016-2017.Seven hundred and thirty-four households were enrolled in the study.

The Target of Benzimidazole Carbamate Against Cysticerci cellulosae

To study the target of benzimidazole carbamate drugs against Cysticerci cellulosae and give a theoretical basis for type evolution and new drug design, the changes of key enzyme activities and metabolite contents in the pathway of energy metabolism in C. cellulosae in vitro and in vivo were tested with albendazole and oxfendazole, respectively. Both albendazole and oxfendazole inhibited the pathways of anaerobic glycolysis, partial inversed tricarboxylic acid cycle of Taenia Solium oncosphere, immature and mature Cysticerci in vitro, and immature and mature Cysticerci in vivo to a certain degree, and enhanced fat decomposing, amino acid decomposing, xanthine decomposing metabolism, and on the other hand, the absorption of glucose was hindered; furthermore, both albendazole and oxfendazole inhibited the activities of the fumaric reductase （FR） complex noncompetently in vitro. Benzimidazole carbamate drugs could inhibit the activities of FR complex noncompetently and hinder the absorption of glucose.

Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine cysticercosis.Methods:Eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals each.The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management conditions.The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups.Results:All pigs treated with oxfendazole had only degenerated cysts in their carcasses.In contrast,TCBZ had very little effect against the parasitic cysts.Cysts from pigs in the TCBZ group looked apparently normal after treatment.However,histological evaluation showed a mild to moderate degree of inflammation.Conclusions:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.