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Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage 被引量:1
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作者 Yue-Ying Wang Ke Li +5 位作者 Jia-Jun Wang Wei Hua Qi Liu Yu-Lan Sun Ji-Ping Qi Yue-Jia Song 《World Journal of Diabetes》 SCIE 2024年第9期1979-2001,共23页
BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie... BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain. 展开更多
关键词 Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1
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Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis
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作者 Ke NI Zi-li LI +1 位作者 Zhi-yong HU Li HONG 《Current Medical Science》 SCIE CAS 2024年第3期623-632,共10页
Objective Endometrial carcinoma(EC)is a prevalent gynecological malignancy characterized by increasing incidence and mortality rates.This underscores the critical need for novel therapeutic targets.One such potential ... Objective Endometrial carcinoma(EC)is a prevalent gynecological malignancy characterized by increasing incidence and mortality rates.This underscores the critical need for novel therapeutic targets.One such potential target is cell division cycle 20(CDC20),which has been implicated in oncogenesis.This study investigated the effect of the CDC20 inhibitor Apcin on EC and elucidated the underlying mechanism involved.Methods The effects of Apcin on EC cell proliferation,apoptosis,and the cell cycle were evaluated using CCK8 assays and flow cytometry.RNA sequencing(RNA-seq)was subsequently conducted to explore the underlying molecular mechanism,and Western blotting and coimmunoprecipitation were subsequently performed to validate the results.Animal studies were performed to evaluate the antitumor effects in vivo.Bioinformatics analysis was also conducted to identify CDC20 as a potential therapeutic target in EC.Results Treatment with Apcin inhibited proliferation and induced apoptosis in EC cells,resulting in cell cycle arrest.Pathways associated with apoptosis and the cell cycle were activated following treatment with Apcin.Notably,Apcin treatment led to the upregulation of the cell cycle regulator p21,which was verified to interact with CDC20 and consequently decrease the expression of downstream cyclins in EC cells.In vivo experiments confirmed that Apcin treatment significantly impeded tumor growth.Higher CDC20 expression was observed in EC tissue than in nonmalignant tissue,and increased CDC20 expression in EC patients was associated with shorter overall survival and progress free interval.Conclusion CDC20 is a novel molecular target in EC,and Apcin could be developed as a candidate antitumor drug for EC treatment. 展开更多
关键词 endometrial carcinoma CDC20 ApOpTOSIS cell cycle arrest p21 BBC3
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Evaluation of working fluids for organic Rankine cycles using group-contribution methods and second-law-based models 被引量:1
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作者 MA Wei-wu WANG Lin +1 位作者 LIU Tao LI Min 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第8期2234-2243,共10页
The group-contribution (GC) methods suffer from a limitation concerning to the prediction of process-related indexes, e.g., thermal efficiency. Recently developed analytical models for thermal efficiency of organic Ra... The group-contribution (GC) methods suffer from a limitation concerning to the prediction of process-related indexes, e.g., thermal efficiency. Recently developed analytical models for thermal efficiency of organic Rankine cycles (ORCs) provide a possibility of overcoming the limitation of the GC methods because these models formulate thermal efficiency as functions of key thermal properties. Using these analytical relations together with GC methods, more than 60 organic fluids are screened for medium-low temperature ORCs. The results indicate that the GC methods can estimate thermal properties with acceptable accuracy (mean relative errors are 4.45%-11.50%);the precision, however, is low because the relative errors can vary from less than 0.1% to 45.0%. By contrast, the GC-based estimation of thermal efficiency has better accuracy and precision. The relative errors in thermal efficiency have an arithmetic mean of about 2.9% and fall within the range of 0-24.0%. These findings suggest that the analytical equations provide not only a direct way of estimating thermal efficiency but an accurate and precise approach to evaluating working fluids and guiding computer-aided molecular design of new fluids for ORCs using GC methods. 展开更多
关键词 organic Rankine cycles (ORCs) group contribution methods working fluids property estimation computer-aided molecular design
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抗毁网状WDM网络中的光纤级P-Cycles优化设计
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作者 虞红芳 吴冬凌 +2 位作者 李乐民 林然 陈天罡 《电子科技大学学报》 EI CAS CSCD 北大核心 2007年第2期161-163,216,共4页
为降低保护切换代价和提高故障恢复时间,提出了以光纤级P-Cycle来实现网络保护;研究了工作路由与光纤级P-Cycle放置联合优化的设计问题,给出了ILP数学模型。为降低计算的复杂度,采用了一种简单有效的方法:根据跳数预先选择工作路由候选... 为降低保护切换代价和提高故障恢复时间,提出了以光纤级P-Cycle来实现网络保护;研究了工作路由与光纤级P-Cycle放置联合优化的设计问题,给出了ILP数学模型。为降低计算的复杂度,采用了一种简单有效的方法:根据跳数预先选择工作路由候选集及环的有效性和长度预先选择P-Cycle候选集。仿真结果表明光纤级P-Cycle设计相比于波长级P-Cycle设计保护切换代价大大降低。 展开更多
关键词 光纤级p-cycle 联合优化 预先选择 保护切换代价
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血清HMGA2、P-gp与老年进展性脑梗死患者预后相关研究
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作者 孙一鸣 王翠 +2 位作者 尹文超 徐晓琳 付煜颖 《疑难病杂志》 CAS 2024年第5期542-547,共6页
目的探讨血清高迁移率族蛋白A2(HMGA2)、P-糖蛋白(P-gp)在老年进展性脑梗死患者中的表达水平及其与预后的关系。方法收集2020年2月—2023年2月大连市中心医院神经内科收治老年进展性脑梗死患者67例为进展组,老年非进展性脑梗死患者79例... 目的探讨血清高迁移率族蛋白A2(HMGA2)、P-糖蛋白(P-gp)在老年进展性脑梗死患者中的表达水平及其与预后的关系。方法收集2020年2月—2023年2月大连市中心医院神经内科收治老年进展性脑梗死患者67例为进展组,老年非进展性脑梗死患者79例为非进展组;进展组根据治疗后3个月神经功能恢复情况分为预后良好亚组(n=39,mRS评分0~2分)和预后不良亚组(n=28,mRS评分3~6分)。采用酶联免疫吸附法检测血清HMGA2、P-gp水平,Pearson积矩相关分析血清HMGA2、P-gp与NIHSS评分的关系,Logistic回归分析进展性脑梗死患者预后不良的影响因素,受试者工作特征曲线(ROC)评估血清HMGA2、P-gp对预后不良的预测价值。结果进展组血清HMGA2、P-gp水平及NIHSS评分高于非进展组(t/P=13.672/<0.001,8.095/<0.001,8.226/<0.001)。进展性脑梗死患者血清HMGA2、P-gp与NIHSS评分均呈正相关(r/P=0.732/<0.001、0.708/<0.001);预后不良亚组患者年龄大于预后良好亚组,血清HMGA2、P-gp水平及NIHSS评分高于预后良好亚组(t/P=5.092/<0.001、5.103/<0.001、4.449/<0.001、2.357/0.021)。多因素Logistic回归结果显示,高龄和血清HMGA2、P-gp水平及NIHSS评分升高是进展性脑梗死患者预后不良独立危险因素[OR(95%CI)=1.429(1.093~1.869),1.288(1.082~1.533),1.586(1.161~2.165),1.483(1.120~1.963)];血清HMGA2、P-gp及二者联合预测进展性脑梗死患者预后不良的AUC分别为0.738、0.740、0.895,二者联合优于各自单独预测效能(Z/P=2.031/0.002、2.006/0.003)。结论血清HMGA2、P-gp在老年进展性脑梗死患者中异常升高,并与病情严重程度以及预后不良有关,早期联合检测两项指标可预测患者预后不良风险发生。 展开更多
关键词 进展性脑梗死 高迁移率族蛋白A2 p-糖蛋白 神经功能缺损评分 预后 老年人
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静态p-cycles双链路故障保护配置准则 被引量:4
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作者 侯林 周煜 顾畹仪 《北京邮电大学学报》 EI CAS CSCD 北大核心 2006年第4期57-60,共4页
提出并证明了如果一个网络拓扑中的每个链路都可以配置2个仅边相交于该链路的p-cycles,则该网络中的任意2个链路故障均能得到完全保护.同时提出了基于此准则的启发式算法,并进行了仿真。结果表明,在该配置准则中,采用共享p-cycles能减... 提出并证明了如果一个网络拓扑中的每个链路都可以配置2个仅边相交于该链路的p-cycles,则该网络中的任意2个链路故障均能得到完全保护.同时提出了基于此准则的启发式算法,并进行了仿真。结果表明,在该配置准则中,采用共享p-cycles能减少所需的保护容量. 展开更多
关键词 双链路故障 p-cycles静态配置 保护
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Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway 被引量:1
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作者 Tong-Tong Lin Chun-Yi Jiang +10 位作者 Lei Sheng Li Wan Wen Fan Jin-Can Li Xiao-Di Sun Chen-Jie Xu Liang Hu Xue-Feng Wu Yuan Han Wen-Tao Liu Yin-Bing Pan 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第9期2067-2074,共8页
Opioids,such as morphine,are the most potent drugs used to treat pain.Long-term use results in high tolerance to morphine.High mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory p... Opioids,such as morphine,are the most potent drugs used to treat pain.Long-term use results in high tolerance to morphine.High mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory pain,but its role in morphine tolerance is unclear.In this study,we established rat and mouse models of morphine tolerance by intrathecal injection of morphine for 7 consecutive days.We found that morphine induced rat spinal cord neurons to release a large amount of HMGB1.HMGB1 regulated nuclear factor κB p65 phosphorylation and interleukin-1β production by increasing Toll-like receptor 4receptor expression in microglia,thereby inducing morphine tolerance.Glycyrrhizin,an HMGB1 inhibito r,markedly attenuated chronic morphine tole rance in the mouse model.Finally,compound C(adenosine 5’-monophosphate-activated protein kinase inhibitor) and zinc protoporphyrin(heme oxygenase-1 inhibitor)alleviated the morphine-induced release of HMGB1 and reduced nuclear factor κB p65 phosphorylation and interleukin-1β production in a mouse model of morphine tolerance and an SH-SY5Y cell model of morphine tole rance,and alleviated morphine tolerance in the mouse model.These findings suggest that morphine induces HMGB1 release via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 signaling pathway,and that inhibiting this signaling pathway can effectively reduce morphine tole rance. 展开更多
关键词 adenosine 5’-monophosphate-activated protein kinase heme oxygenase-1 high mobility group box-1 INTERLEUKIN-1Β MICROGLIA morphine tolerance NEUROINFLAMMATION neuron nuclear factor-κB p65 Toll-like receptor 4
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CSCO_3 CYCLES IN SALAWUSU RIVER BASINSINCE 150KA B.P. 被引量:4
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作者 LUO Kai-li1,2, LI Bao-sheng1,2, ZHU Yi-zhi2, JIN He-ling3, ZHANG David Dian4, YAN Man-cun5, LI Hou-xin1, YAO Chun-xia1, ZHANG Yu-hong1f 1. Department of Geography, South China Normal University, Guangzhou 510631, P. R. China 2. State Key Labor 《Chinese Geographical Science》 SCIE CSCD 2001年第4期50-56,共7页
ABSTRACT: This paper, with Milanggouwan stratigraphic section as a typical section of the Salawusu River Basin, explores the relation between CaCO3 content distribution and climate change since 150 ka B. P. and conclu... ABSTRACT: This paper, with Milanggouwan stratigraphic section as a typical section of the Salawusu River Basin, explores the relation between CaCO3 content distribution and climate change since 150 ka B. P. and concludes that: 1) The low-high changes of CaCO3 content in the section has a remarkable corresponding relation with the sedimentary cycles of ancient aeolian sand and overlying fluviolacustrine facies or palaeosols. 2) CaCO3 distribution in aeolian sand is relatively meagre, ranging from 0. 8% - 7. 18%, or on an average 2. 50% but relatively enriches in the fluviolacustrine faceis and palaeosols, ranging from 2. 20% - 14. 9% , or on an average 5. 74%. This implies that they have different climatic backgrounds. The former was the product of erosion, transport and deposition by wind under arid and cold climatic conditions, whereas the latter was related to its special low-lying geomorphic position between the Ordos Plateau and Loess Plateau and warm-humid climatic environment. When the climatic became warm and humid, fluviolacustrine and swamp facies developed, soil-forming action strengthened, and low-lying catchment condition was favorable to CaCO3 accumulation. 3) The basic cause responsible for the multicycle of CaCO3 migration and accumulation in the Milanggouwan section may be the multiple alterations of winter and summer monsoons over the Mu Us Desert under the influences of climatic fluctuation of glacial and interglacial periods in the Northern Hemisphere since 150ka B. P. . 展开更多
关键词 Milanggouwan section 150ka B. p. CaCO3 27 sediment-climatic cycles
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MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss 被引量:1
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作者 Xiang-li PANG Jie LI +2 位作者 Jing WANG Si-si YAN Jing YANG 《Current Medical Science》 SCIE CAS 2024年第1期195-211,共17页
Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target... Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related diseases.Furthermore,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling pathway.This study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling pathway.Methods Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different groups.The targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were investigated.In addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,respectively.Furthermore,changes of the NF-κB signaling pathway in ILC1s were examined in the different groups.For the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling pathway.Results The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion miR-142-3p can regulate ILC1s by targeting HMGB1 via the NF-κB signaling pathway,and attenuate the inflammation at the maternal-fetal interface in abortive mice. 展开更多
关键词 maternal-fetal interface group 1 innate lymphoid cells(ILCis) high mobility group box 1(HMGB1) miR-142-3p ABORTION
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格网中p-cycles重配置的快速实现算法
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作者 侯林 周煜 顾畹仪 《高技术通讯》 CAS CSCD 北大核心 2007年第8期789-792,共4页
提出了一种用于双链路故障恢复和为动态业务提供保护的p-cycles重配置启发式算法.该算法可以提供网络生存性设计和网络管理的高效性和简洁性,并能提供快速的恢复操作.仿真结果表明,这种算法用于双链路故障恢复的重配置容量冗余度可达74%... 提出了一种用于双链路故障恢复和为动态业务提供保护的p-cycles重配置启发式算法.该算法可以提供网络生存性设计和网络管理的高效性和简洁性,并能提供快速的恢复操作.仿真结果表明,这种算法用于双链路故障恢复的重配置容量冗余度可达74%,平均计算时间为48ms;用于增量重配置的双故障冗余度为118%,计算时间为81ms.基于该算法的业务恢复可以满足大多数业务的最低可中断时间要求.分析表明该算法亦适用于动态业务的p-cycles重配置. 展开更多
关键词 p-cycles 重配置 快速 算法
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静态p-Cycles双链路故障保护策略的研究 被引量:1
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作者 侯林 徐美玉 顾畹仪 《现代有线传输》 2005年第6期72-75,共4页
p-Cycles应用在WDM格网中可以得到高的容量利用率和快速保护倒换时间,本文给出了一种格网生存性有关容量问题的 研究方法,即孤立节点分析法,提出了p-Cycles在双链路故障情况下的保护策略,并建立了以保护容量需求作为优化目 标的p-Cycle... p-Cycles应用在WDM格网中可以得到高的容量利用率和快速保护倒换时间,本文给出了一种格网生存性有关容量问题的 研究方法,即孤立节点分析法,提出了p-Cycles在双链路故障情况下的保护策略,并建立了以保护容量需求作为优化目 标的p-Cycles优化设计模型。 展开更多
关键词 生存性 格网 双故障 p-cycles 保护策略 整数线性规划
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GI.5和GII.4诺如病毒P蛋白的克隆表达及与长牡蛎类HBGAs的结合特性
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作者 佟利惠 杨敏 +3 位作者 王珊珊 王大军 王明丽 周德庆 《食品科学》 EI CAS CSCD 北大核心 2024年第2期113-119,共7页
为明确人诺如病毒(human norovirus,HuNoV)与长牡蛎类组织血型抗原(histo-blood group antigens,HBGAs)的结合特性,本实验运用大肠杆菌表达系统,克隆表达了基因簇I.5(genogroup I.5,GI.5)和GII.4 HuNoV P蛋白,采用酶联免疫吸附测定研究H... 为明确人诺如病毒(human norovirus,HuNoV)与长牡蛎类组织血型抗原(histo-blood group antigens,HBGAs)的结合特性,本实验运用大肠杆菌表达系统,克隆表达了基因簇I.5(genogroup I.5,GI.5)和GII.4 HuNoV P蛋白,采用酶联免疫吸附测定研究HuNoV P蛋白与唾液HBGAs和长牡蛎类HBGAs的结合特性。结果表明,GII.4 HuNoV与唾液A型、B型、AB型和O型HBGAs均有较好的结合,而GI.5 HuNoV与B型HBGAs结合较弱,与O型HBGAs具有明显的结合优势。GI.5和GII.4 HuNoV在长牡蛎鳃、消化腺和外套膜中均可富集,其中在消化腺中富集最多,二者主要与类A型和H1型HBGAs结合,GII.4HuNoV与类Lea型、Leb型、Lex型和Ley型HBGAs有不同程度的结合,而GI.5 HuNoV与类Leb型HBGAs仅微弱结合,与类H1型HBGAs具有明显结合优势。综上,不同型别HuNoV与HBGAs的结合特性不尽相同,GII.4HuNoV具有广谱结合特性,GI.5HuNoV具有选择结合特性。 展开更多
关键词 人诺如病毒 p蛋白 长牡蛎 组织血型抗原 结合特性
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极大类p群的非线性非忠实不可约特征标个数
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作者 王雪 李亚利 《云南民族大学学报(自然科学版)》 CAS 2024年第2期266-270,共5页
利用极大类p群的性质以及有限群的特征标理论探究了极大类p群G的非线性非忠实不可约特征标的个数.证明了p^(n)阶的极大类p群G的非线性非忠实不可约特征标的个数等于p^(n-1)阶的极大类p群G/Z(G)的非线性不可约特征标的个数.特别地,分析... 利用极大类p群的性质以及有限群的特征标理论探究了极大类p群G的非线性非忠实不可约特征标的个数.证明了p^(n)阶的极大类p群G的非线性非忠实不可约特征标的个数等于p^(n-1)阶的极大类p群G/Z(G)的非线性不可约特征标的个数.特别地,分析了只有3个非线性非忠实不可约特征标的有限p群的性质. 展开更多
关键词 极大类p 非线性不可约特征标 非忠实不可约特征标
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Atmospheric nitrogen deposition affects forest plant and soil system carbon:nitrogen:phosphorus stoichiometric flexibility:A meta-analysis
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作者 Xiyan Jiang Xiaojing Wang +7 位作者 Yaqi Qiao Yi Cao Yan Jiao An Yang Mengzhou Liu Lei Ma Mengya Song Shenglei Fu 《Forest Ecosystems》 SCIE CSCD 2024年第3期307-317,共11页
Background:Nitrogen(N)deposition affects forest stoichiometric flexibility through changing soil nutrient availability to influence plant uptake.However,the effect of N deposition on the flexibility of carbon(C),N,and... Background:Nitrogen(N)deposition affects forest stoichiometric flexibility through changing soil nutrient availability to influence plant uptake.However,the effect of N deposition on the flexibility of carbon(C),N,and phosphorus(P)in forest plant-soil-microbe systems remains unclear.Methods:We conducted a meta-analysis based on 751 pairs of observations to evaluate the responses of plant,soil and microbial biomass C,N and P nutrients and stoichiometry to N addition in different N intensity(050,50–100,>100 kg·ha^(-1)·year^(-1)of N),duration(0–5,>5 year),method(understory,canopy),and matter(ammonium N,nitrate N,organic N,mixed N).Results:N addition significantly increased plant N:P(leaf:14.98%,root:13.29%),plant C:P(leaf:6.8%,root:25.44%),soil N:P(13.94%),soil C:P(10.86%),microbial biomass N:P(23.58%),microbial biomass C:P(12.62%),but reduced plant C:N(leaf:6.49%,root:9.02%).Furthermore,plant C:N:P stoichiometry changed significantly under short-term N inputs,while soil and microorganisms changed drastically under high N addition.Canopy N addition primarily affected plant C:N:P stoichiometry through altering plant N content,while understory N inputs altered more by influencing soil C and P content.Organic N significantly influenced plant and soil C:N and C:P,while ammonia N changed plant N:P.Plant C:P and soil C:N were strongly correlated with mean annual precipitation(MAT),and the C:N:P stoichiometric flexibility in soil and plant under N addition connected with soil depth.Besides,N addition decoupled the correlations between soil microorganisms and the plant.Conclusions:N addition significantly increased the C:P and N:P in soil,plant,and microbial biomass,reducing plant C:N,and aggravated forest P limitations.Significantly,these impacts were contingent on climate types,soil layers,and N input forms.The findings enhance our comprehension of the plant-soil system nutrient cycling mechanisms in forest ecosystems and plant strategy responses to N deposition. 展开更多
关键词 C:N:p stoichiometry META-ANALYSIS Forest ecosystem Nitrogen addition form Nutrient cycles
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Biological function of miRNA-145-5p in angiotensin II induced renal inflammation
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作者 BIN LI YUCHENG SHENG +7 位作者 XIAOYING XU SHENGCUN WANG HONGYAN SONG JINGYUAN LI HAONAN JI QINGHUA WANG XIAODI ZHOU LONGJU QI 《BIOCELL》 SCIE 2024年第4期601-611,共11页
Objective:Chronic kidney disease(CKD)is a progressive disorder characterized by intricate structural and functional alterations in the kidneys,attributable to diverse causative factors.Notably,the therapeutic promise ... Objective:Chronic kidney disease(CKD)is a progressive disorder characterized by intricate structural and functional alterations in the kidneys,attributable to diverse causative factors.Notably,the therapeutic promise of miR-145-5p in addressing renal pathologies has been discerned.This investigation seeks to elucidate the functional role of miR-145-5p in injured kidneys by subjecting human glomerular mesangial cells(HGMCs)to stimulation with Angiotensin II(AngII).Materials and Methods:Cellular viability and the levels of inflammatory mediators were evaluated utilizing Cell Counting Kit-8(CCK-8),quantitative real-time polymerase chain reaction(qRT-PCR),and western blot methodologies,both in the presence of AngII incubation and in scenarios of miR-145p overexpression and downregulation.Furthermore,the cell cycle dynamics were elucidated through Fluorescence-activated Cell Sorting(FACS)analysis.Results:AngII incubation induced an upregulation of miR-145-5p and inflammatory factors including Intercellular Adhesion Molecule 1(ICAM-1),Interleukin 6(IL-6),Interleukin 8(IL-8),and Interleukin 1β(IL-1β).Additionally,it elevated the expression of Cyclin A2,Cyclin D1,and the G2/M cell cycle ratio.Conversely,inhibition of miR-145-5p heightened the levels of inflammatory factors and cell cycle regulators induced by AngII incubation.Reduced expression of miR-145-5p correlated with a downregulation of Interleukin 10(IL-10)expression,concurrently promoting HGMC proliferation under AngII stimulation.Moreover,ectopic miR-145-5p expression demonstrated a reduction in inflammatory factors,cell cyclin regulators,G2/M cell cycle ratio,and overall proliferation.Conclusion:MiR-145-5p exhibited inhibitory effects on the inflammatory response and proliferation induced by Angiotensin II in HGMCs,showcasing its potential as a therapeutic avenue for the treatment of kidney injury. 展开更多
关键词 miR-145-5p KIDNEY Angiotensin II Cell cycle INFLAMMATION
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PDCA在医学成人高等教育学院实习病历质量管理中的应用
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作者 贺雪黛 刘晓清 张冰 《中国卫生产业》 2024年第11期24-27,共4页
目的探讨基于PDCA循环理论的病历书写管理对成人高等教育学员实习质量的应用效果。方法选取2021年6月—2022年6月南京中医药大学继续教育学院医学类的65名实习学员和708份病历,根据管理时间分为两组,将2021年6—12月的351份病历采用常... 目的探讨基于PDCA循环理论的病历书写管理对成人高等教育学员实习质量的应用效果。方法选取2021年6月—2022年6月南京中医药大学继续教育学院医学类的65名实习学员和708份病历,根据管理时间分为两组,将2021年6—12月的351份病历采用常规病历管理,为常规病历管理组;将2022年1—6月的357份病历采用PDCA循环法管理,为PDCA循环组。对比两组病历常规质控情况(病历书写评分、病历缺陷指数评分)、首页完整率、首页填写准确率及学员对病历质量管理满意度。结果PDCA循环组病历书写评分高于常规病历管理组,病历缺陷指数评分低于常规病历管理组,差异有统计学意义(P均<0.05)。PDCA循环组病案首页完整率、首页准确率、学员对病历质量管理满意度高于常规病历管理组,差异有统计学意义(P均<0.05)。结论PDCA循环法的应用不仅规范了实习生的病历质量管理,提升了实习学员对病历管理满意度,且对成人高等教育的改革与发展亦起到较好的推动作用。 展开更多
关键词 pDCA循环 病历书写 质量管理 按疾病诊断相关分类
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c-正规性对有限群p-可解性的影响
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作者 贾蕾 雒晓良 《吉首大学学报(自然科学版)》 CAS 2024年第4期11-14,共4页
利用c-正规性给出了有限群是p-幂零群的充要条件,并通过分析Sylow子群及其极大子群在G中的c-正规性,给出了有限群G是p-超可解群的2个充分条件.
关键词 C-正规子群 p-幂零群 p-可解群 p-超可解群
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SS-拟正规子群对有限群p-超可解性的影响
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作者 高建玲 毛月梅 曹陈辰 《西北师范大学学报(自然科学版)》 CAS 2024年第2期1-5,共5页
设G为有限群,若存在B≤G使得G=HB,且对任意p∈π(B),P∈Sy1_( p)(B),都有HP=PH,则称子群H在G中SS-拟正规.利用极小阶反例法,讨论某些p-子群SS-拟正规的有限群结构,得到p-超可解群的若干充分条件,推广了p-超可解性的部分结果.
关键词 p-子群 SS-拟正规子群 p-超可解群 极小阶反例
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p-超可解群的新判定
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作者 谢凤艳 李保军 刘倩 《安徽大学学报(自然科学版)》 CAS 北大核心 2024年第4期10-14,共5页
设p是有限群G的一个素因子,P是G的p-子群且t是正整数满足|P|>p^(t).通过P的任意pt阶子群和4阶循环子群(P为非交换2-群且t=1)在G中c-正规或者Φ-可补,得到p-超可解群的一些新判定方法.
关键词 有限群 p-超可解子x群 C-正规子群 Φ-可补子群
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具有指数p的子群的双循环群
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作者 杨梅 苏映梅 《新乡学院学报》 2024年第6期16-18,共3页
研究了当有限群G是具有指数p的子群(即极大子群)的双循环群时的另一种结构,利用群G的2阶子群对循环子群的共轭作用导出了24阶双循环群的结构。
关键词 Sylow p子群 循环群 双循环群
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