Structures and Properties of Three Solvent-Dependent Chiral Compounds Based on N-Benzoyl-L-glutamic Acid

Three solvent-dependent chiral copper（II） compounds, {[Cu2（bzgluO）2（HzO）2]-4HzO}n （1）, {[Cu2（bzgluO）2-（DMSO）2].H2O}, （2） and [Cuz（bzgluO）2（DMF）2], （3） （H2bzgluO=N-benzoyl-L-glutamic acid） have been synthe-sized under ambient temperature conditions and characterized by elemental analysis, IR spectra, UV spectra, ther- mogravimetric analysis, powder X-ray diffraction （PXRD） and single-crystal X-ray diffraction. Compounds 1 and 2 both crystallize in the orthorhombic space group P212121. Compound 3 crystallizes in the tetragonal space group P43. Compound 1 exhibits a ladder-like 1D chain structure, which is extended by hydrogen-bonding interactions to form a 3D supramolecular network. Compounds 2 and 3 both give a diamond-like 3D structure. Besides, there are hydrogen-bonding interactions in 2. The structural difference indicates that the solvent system plays a crucial role in modulating structures of coordination compounds. Circular dichroism （CD） and the magnetic properties of the compounds have also been investigated.

反相高效液相色谱法测定叶酸及其相关物质

建立了反相高效液相色谱法对叶酸及其相关物质的分离测定方法。对叶酸原料药进行了测定,色谱柱为JASCO C18柱(250mm×4.6mmi.d.,5μm),流动相为V(0.05mol LKH2PO4):V(0.1mol LKOH)∶V(甲醇)=78∶2∶20,流速为1.0mL min,柱温为30℃。叶酸检出限为1.0ng,叶酸的质量分数为98.52%～99 87%;加标回收率为95.22%～100.83%。该法快速简捷,精密度高,重现性好,可用于叶酸的质量控制。

催化加氢合成对氨基苯甲酰谷氨酸新工艺

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