Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has b...Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last decades.However,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic strategies.Increasing evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s disease.These receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s disease.This review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.展开更多
随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境...随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境效益的社会福利函数,研究分布式电能产消者通过合作联盟形式实现社会福利最大化的途径。设计一种依据产消者对联盟社会福利贡献值分配合作剩余的机制,激励产消者合作的积极性以维持联盟的稳定。算例分析表明:相较于P2G(peer-to-grid)交易和非合作P2P交易,产消者以合作联盟方式参与电力P2P交易的社会福利分别提升了62.62%、33.79%。因此,以市场化的方式组建合作联盟参与电力P2P交易并合理分配利益,可挖掘分布式清洁能源就地消纳的潜力,促进能源消费的绿色低碳转型。展开更多
在碳达峰碳中和的政策方针背景下,北方地区的冬季由于需要供热,使得热电联产机组(combined heat and power,CHP)强迫出力,限制了新能源的消纳与碳减排的能力。利用碳捕集与封存(carbon capture and storage,CCS)技术将热电联产机组产生...在碳达峰碳中和的政策方针背景下,北方地区的冬季由于需要供热,使得热电联产机组(combined heat and power,CHP)强迫出力,限制了新能源的消纳与碳减排的能力。利用碳捕集与封存(carbon capture and storage,CCS)技术将热电联产机组产生的CO_(2)捕捉并封存,将新能源发电通过电转气(power to gas,P2G)产生氢能并与捕集到的CO_(2)反应生成CH_(4),热电联产的燃气轮机使用合成的CH_(4)并掺入一定比例的H_(2)进行燃烧,循环使用CO_(2),减少碳排放并增加收益,进一步提高虚拟电厂参与电力市场的经济性与低碳性,促进新能源消纳,并保障北方冬季的供热量。建立了考虑P2G及碳捕集的热电联产虚拟电厂的数学模型,并通过MATLAB调用CPLEX求解器进行求解,仿真结果验证了所建模型的有效性。展开更多
文摘Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last decades.However,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic strategies.Increasing evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s disease.These receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s disease.This review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.
文摘随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境效益的社会福利函数,研究分布式电能产消者通过合作联盟形式实现社会福利最大化的途径。设计一种依据产消者对联盟社会福利贡献值分配合作剩余的机制,激励产消者合作的积极性以维持联盟的稳定。算例分析表明:相较于P2G(peer-to-grid)交易和非合作P2P交易,产消者以合作联盟方式参与电力P2P交易的社会福利分别提升了62.62%、33.79%。因此,以市场化的方式组建合作联盟参与电力P2P交易并合理分配利益,可挖掘分布式清洁能源就地消纳的潜力,促进能源消费的绿色低碳转型。
文摘在碳达峰碳中和的政策方针背景下,北方地区的冬季由于需要供热,使得热电联产机组(combined heat and power,CHP)强迫出力,限制了新能源的消纳与碳减排的能力。利用碳捕集与封存(carbon capture and storage,CCS)技术将热电联产机组产生的CO_(2)捕捉并封存,将新能源发电通过电转气(power to gas,P2G)产生氢能并与捕集到的CO_(2)反应生成CH_(4),热电联产的燃气轮机使用合成的CH_(4)并掺入一定比例的H_(2)进行燃烧,循环使用CO_(2),减少碳排放并增加收益,进一步提高虚拟电厂参与电力市场的经济性与低碳性,促进新能源消纳,并保障北方冬季的供热量。建立了考虑P2G及碳捕集的热电联产虚拟电厂的数学模型,并通过MATLAB调用CPLEX求解器进行求解,仿真结果验证了所建模型的有效性。
