Neurodegenerative disorders like Parkinson＇s disease （PD） or atypi- cal Parkinsonian syndromes including the different synucleinopa- thies and tauopathies are an important burden for patients, rela- tives, care pro...Neurodegenerative disorders like Parkinson＇s disease （PD） or atypi- cal Parkinsonian syndromes including the different synucleinopa- thies and tauopathies are an important burden for patients, rela- tives, care providers and incur mounting costs for the health care system in our aging society.展开更多
采用无电镀Pd的方法,在硅纳米线上制备了一层Pd.首次制备出了能够在室温下工作的Pd/SiNWs肖特基氢气传感器.SEM(Scanning Electron Microscopy)(扫描电子显微镜)表征结果表明,硅纳米线表面Pd层是由Pd纳米颗粒组成.Pd/SiNWs肖特基二极管...采用无电镀Pd的方法,在硅纳米线上制备了一层Pd.首次制备出了能够在室温下工作的Pd/SiNWs肖特基氢气传感器.SEM(Scanning Electron Microscopy)(扫描电子显微镜)表征结果表明,硅纳米线表面Pd层是由Pd纳米颗粒组成.Pd/SiNWs肖特基二极管I-V测试结果表明,该传感器可以在室温下进行氢气(H2)浓度的检测,且可检测的浓度范围很大,同时给出了Pd/SiNWs/p-Si肖特基二极管在常温下进行检测H_2的敏感机理.实验表明,这种新型传感器可以在室温下进行H2检测,且具有很大的发展潜力,可以应用于燃料电池等诸多领域.展开更多
Geometric and electronic properties of Pdn–1Pb and Pdn （n≤8） clusters have been studied by using density functional theory with effective core potentials, focusing on the differences between mono- and bimetallic c...Geometric and electronic properties of Pdn–1Pb and Pdn （n≤8） clusters have been studied by using density functional theory with effective core potentials, focusing on the differences between mono- and bimetallic clusters. The average bond length of Pdn–1Pb （n≤8） bimetallic clusters is longer than that of pure palladium clusters except for n = 2 and 3. The most stable structure of Pdn–1Pb （n≤7） is the singlet where there is at least a Pd or Pb atom on its excited state. The energy gaps of Pd–Pb binary clusters are narrower than those of Pdn clusters, and then the chemical activity is strengthened when Pdn clusters are doped with Pb.展开更多
帕金森病(Parkinson’s disease,PD)主要症状是由中脑黑质致密部(substantia nigra compact,SNc)的多巴胺(dopamine,DA)神经元死亡引起。帕金森病发病过程中,路易小体病理(Lewy pathology,LP)和线粒体功能障碍最为突出,但SNc多巴胺神经...帕金森病(Parkinson’s disease,PD)主要症状是由中脑黑质致密部(substantia nigra compact,SNc)的多巴胺(dopamine,DA)神经元死亡引起。帕金森病发病过程中,路易小体病理(Lewy pathology,LP)和线粒体功能障碍最为突出,但SNc多巴胺神经元为什么特别易遭受这两种病理损害尚不清楚。研究表明,与脑内其他神经元相比,SNc多巴胺神经元具有特殊的解剖形态、生理和生化表型。SNc多巴胺神经元具有高分支无髓鞘轴突和众多的突触终端,突触末梢物质和能量代谢的高要求需要大量的线粒体,巨大突触终端增加了突触蛋白质的表达、转运和降解的负担。SNc多巴胺神经元具有独特的自主起搏电活动和缓慢钙振荡特性,Cav1. 3钙通道活动及后续的级联反应增加了SNc多巴胺神经元线粒体负担,增加了基础氧化应激、线粒体损伤和自噬,降低了处理错误折叠蛋白质的能力。SNc多巴胺神经元特有的神经递质--多巴胺易被氧化成为反应性醌,具有潜在毒性,可破坏葡糖脑苷脂酶导致其活性降低,引起线粒体氧化应激和溶酶体功能障碍。总之,SNc多巴胺神经元具有的这些内在因素综合起来,可能导致了其对线粒体功能障碍和路易小体病理损伤的易感性,并且SNc多巴胺神经元所处的神经网络障碍也促使了帕金森病的进展。认识到这些特征会对研究帕金森病相关病理学机制和阻止疾病进展创造新的机会。展开更多
基金funded by the TRANSMED Kolleg Gottingen,which was supported by the Ministerium für Wissenschaft und Kultur,Niedersachsenfunded by the DFG-Center for Nanoscale Microscopy and Molecular Physiology of the Brain(CNMPB),Gottingen,Germany
文摘Neurodegenerative disorders like Parkinson＇s disease （PD） or atypi- cal Parkinsonian syndromes including the different synucleinopa- thies and tauopathies are an important burden for patients, rela- tives, care providers and incur mounting costs for the health care system in our aging society.
文摘采用无电镀Pd的方法,在硅纳米线上制备了一层Pd.首次制备出了能够在室温下工作的Pd/SiNWs肖特基氢气传感器.SEM(Scanning Electron Microscopy)(扫描电子显微镜)表征结果表明,硅纳米线表面Pd层是由Pd纳米颗粒组成.Pd/SiNWs肖特基二极管I-V测试结果表明,该传感器可以在室温下进行氢气(H2)浓度的检测,且可检测的浓度范围很大,同时给出了Pd/SiNWs/p-Si肖特基二极管在常温下进行检测H_2的敏感机理.实验表明,这种新型传感器可以在室温下进行H2检测,且具有很大的发展潜力,可以应用于燃料电池等诸多领域.
文摘Geometric and electronic properties of Pdn–1Pb and Pdn （n≤8） clusters have been studied by using density functional theory with effective core potentials, focusing on the differences between mono- and bimetallic clusters. The average bond length of Pdn–1Pb （n≤8） bimetallic clusters is longer than that of pure palladium clusters except for n = 2 and 3. The most stable structure of Pdn–1Pb （n≤7） is the singlet where there is at least a Pd or Pb atom on its excited state. The energy gaps of Pd–Pb binary clusters are narrower than those of Pdn clusters, and then the chemical activity is strengthened when Pdn clusters are doped with Pb.
