A glutathione-disulfide-ended poly（ethylene glycol）（GSSG-PEG-GSSG） was designed. It is a much more efficient accelerator than glutathione disulfide（GSSG） for the gelation of an 8arm-PEG-SH polymer solution, and ...A glutathione-disulfide-ended poly（ethylene glycol）（GSSG-PEG-GSSG） was designed. It is a much more efficient accelerator than glutathione disulfide（GSSG） for the gelation of an 8arm-PEG-SH polymer solution, and the gelation time can be tuned from hours to minutes at the physiological p H and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also showed interesting swelling behavior.展开更多
基金financially supported by the National Natural Science Foundation of China(No.21004038)
文摘A glutathione-disulfide-ended poly（ethylene glycol）（GSSG-PEG-GSSG） was designed. It is a much more efficient accelerator than glutathione disulfide（GSSG） for the gelation of an 8arm-PEG-SH polymer solution, and the gelation time can be tuned from hours to minutes at the physiological p H and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also showed interesting swelling behavior.
