Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many stud...Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention.We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids(PFBS,PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell(hMSC) system.Our results demonstrate significant cyto-and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity.Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA.展开更多
Egg hatching of the soil collembolan Folsomia candida and the effects of per-and polyfluoroalkyl substances were investigated.New and effective laboratory methods for egg hatching studies with soil collembolans were e...Egg hatching of the soil collembolan Folsomia candida and the effects of per-and polyfluoroalkyl substances were investigated.New and effective laboratory methods for egg hatching studies with soil collembolans were established.Per-and polyfluoroalkyl compounds(PFASs)have been used industrially worldwide and are persistent organic pollutants in many soils.Twenty eggs laid by synchronized adults of the collembolan Folsomia candida were added to each Petri dish containing compressed soil substrate mixed with perfluorooctanoic acid(PFOA),heptafluorobutyric acid(PFBA),or 6:2 chlorinated polyfluoroalkyl ether sulfonic acid(F-53B),and after 25 d of exposure the number hatched declined on average by 6.9%−49.7%,10.3%−24.1%,and 3.4%−18.6%,respectively.PFASs delayed the peak of hatching by one day,and at different concentrations reduced the number of eggs hatched during the peak by 16.7%−30%and 23.3%−43.2%in PFOA and PFBA treatments,respectively.In the presence of F-53B the number of eggs hatched declined by 73.3%but the number of individuals increased by 29.3%at higher concentrations.The characteristics of egg hatching were stable and sensitive to PFASs,and may be suitable for use as indicators in the screening of contaminated soils for environmental risk assessment.展开更多
基金supported by the National Natural Science Foundation of China (Nos.21876197, 21577166, 21707160)the Chinese Academy of Sciences (Nos.XDB14040301, 29[2015]30, QYZDJ-SSW-DQC017)the K.C.Wong Education Foundation.
文摘Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention.We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids(PFBS,PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell(hMSC) system.Our results demonstrate significant cyto-and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity.Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA.
基金funded by the National Natural Science Foundation of China(Grant Nos.41977136 and 41991334).
文摘Egg hatching of the soil collembolan Folsomia candida and the effects of per-and polyfluoroalkyl substances were investigated.New and effective laboratory methods for egg hatching studies with soil collembolans were established.Per-and polyfluoroalkyl compounds(PFASs)have been used industrially worldwide and are persistent organic pollutants in many soils.Twenty eggs laid by synchronized adults of the collembolan Folsomia candida were added to each Petri dish containing compressed soil substrate mixed with perfluorooctanoic acid(PFOA),heptafluorobutyric acid(PFBA),or 6:2 chlorinated polyfluoroalkyl ether sulfonic acid(F-53B),and after 25 d of exposure the number hatched declined on average by 6.9%−49.7%,10.3%−24.1%,and 3.4%−18.6%,respectively.PFASs delayed the peak of hatching by one day,and at different concentrations reduced the number of eggs hatched during the peak by 16.7%−30%and 23.3%−43.2%in PFOA and PFBA treatments,respectively.In the presence of F-53B the number of eggs hatched declined by 73.3%but the number of individuals increased by 29.3%at higher concentrations.The characteristics of egg hatching were stable and sensitive to PFASs,and may be suitable for use as indicators in the screening of contaminated soils for environmental risk assessment.
