The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFK-2/FBPase 3,PFKFB3)has advanced considerably since its initial identification in human macrophages in the mid-1990s.As a vital regulator of...The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFK-2/FBPase 3,PFKFB3)has advanced considerably since its initial identification in human macrophages in the mid-1990s.As a vital regulator of glycolysis,accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer,including carcinogenesis,cancer cell proliferation,vessel aggressiveness,drug resistance and tumor microenvironment.In this review,we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues.Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy.展开更多
基金This work was supported by the National Natural Science Foundation of China(81372621,81572361,81502398 and 81602635)the Zhejiang Province Preeminence Youth Fund(LR16H160001)the Zhejiang Natural Sciences Foundation Grant(Q16H160019).
文摘The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFK-2/FBPase 3,PFKFB3)has advanced considerably since its initial identification in human macrophages in the mid-1990s.As a vital regulator of glycolysis,accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer,including carcinogenesis,cancer cell proliferation,vessel aggressiveness,drug resistance and tumor microenvironment.In this review,we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues.Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy.
