Within the framework of the Usdpf(16) interacting boson model (IBM), the effects of strong correlations of the dipole (p--boson) and the octupole (f--boson) degree of freedom on the positive-parity states of even-even...Within the framework of the Usdpf(16) interacting boson model (IBM), the effects of strong correlations of the dipole (p--boson) and the octupole (f--boson) degree of freedom on the positive-parity states of even-even nuclei in SU(3) limit are discussed. It is shown that configurations of an even number of many p- and f-bosons can not only be incorporated into the usual low-lying collective rotational bands, such as the ground state band, β- and γ-vibrational bands, but also naturally form the Kπ＝ 1+, 3+ rotational bands, etc. These results are similar to that of Usdg (15)-IBM and in agreement well with the experimental data of the 176 72 Hf 104 nucleus. Besides, several intraband E2 transition probabilities are given, which are consistent with that of Usd(6)-IBM.展开更多
Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and af...Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.展开更多
文摘Within the framework of the Usdpf(16) interacting boson model (IBM), the effects of strong correlations of the dipole (p--boson) and the octupole (f--boson) degree of freedom on the positive-parity states of even-even nuclei in SU(3) limit are discussed. It is shown that configurations of an even number of many p- and f-bosons can not only be incorporated into the usual low-lying collective rotational bands, such as the ground state band, β- and γ-vibrational bands, but also naturally form the Kπ＝ 1+, 3+ rotational bands, etc. These results are similar to that of Usdg (15)-IBM and in agreement well with the experimental data of the 176 72 Hf 104 nucleus. Besides, several intraband E2 transition probabilities are given, which are consistent with that of Usd(6)-IBM.
基金supported by American Diabetes Association,American Heart Association,NIH NIEHS,NIH NIA,NIH NINDS,and NIH ARRA
文摘Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.
