Observations of PKS 1510-089 indicate the existence of a deep flux minimum with a timescale of -35 min and an interval of about 336 ± 14 d. A binary black hole system is proposed to be at the nucleus of this obje...Observations of PKS 1510-089 indicate the existence of a deep flux minimum with a timescale of -35 min and an interval of about 336 ± 14 d. A binary black hole system is proposed to be at the nucleus of this object. The secondary black hole orbits around the primary black hole. The minimum is caused by the periodic eclipse of the primary black hole by the secondary black hole. Based on the observations of PKS 1510-089, we estimate the parameters of the binary black hole system. The masses for the primary and secondary black holes are 1.37 × 10^9M⊙（M⊙ is the solar mass） and 1.37 × 10^7M⊙, and the major axis for this pair being about 0.1 parsec（pc）.展开更多
目的介绍美罗培南在危重症、脓毒症及脓毒症休克、肾功能不全、病态肥胖、烧伤等特殊机体状态下的PK/PD及给药方案研究进展,为其临床合理应用提供参考。方法查阅国内外相关文献,进行系统的文献整理和综合分析。结果患者特殊的病理生理状...目的介绍美罗培南在危重症、脓毒症及脓毒症休克、肾功能不全、病态肥胖、烧伤等特殊机体状态下的PK/PD及给药方案研究进展,为其临床合理应用提供参考。方法查阅国内外相关文献,进行系统的文献整理和综合分析。结果患者特殊的病理生理状态,可使美罗培南的PK和PD发生重要改变,其中最重要的改变是Vd和CL。多个研究报道,增大美罗培南给药剂量,延长输注时间,可提高目标获得概率(Probability of target attainment,PTA)或累积反应分数(Cumulative fraction of response,CFR),但对于敏感的致病菌常规给药方案仍可得到良好的治疗效果。药物对治疗靶部位的组织穿透力也是影响PD的重要指标。研究发现,美罗培南可以很好的渗透到脑脊液、腹腔、肺部、软组织、前列腺、胰腺等。结论临床医生在使用美罗培南前,应了解患者的病理生理状态,明确病原菌、感染部位,根据PK/PD制定合理的给药方案。展开更多
基金Project supported by State Key Development Program for Basic Research of China （Grant No 19990754）, the National Science Foundation for 0utstanding Young Scientists of China （Grant No 10125313）, the National Natural Science Foundation of China （Grant No 10573005）, and the Fund for Top Scholars of Guangdong Province, China （Grant No 02114）. Acknowledgments The authors wish to thank the referee for the comments and suggestions, and are also grateful for useful discussion to Dr Wang Hong-Guang, Liu Yi, Zhou Ji- Liang, Chen Jian-Ling and Xu Shou-Xi.
文摘Observations of PKS 1510-089 indicate the existence of a deep flux minimum with a timescale of -35 min and an interval of about 336 ± 14 d. A binary black hole system is proposed to be at the nucleus of this object. The secondary black hole orbits around the primary black hole. The minimum is caused by the periodic eclipse of the primary black hole by the secondary black hole. Based on the observations of PKS 1510-089, we estimate the parameters of the binary black hole system. The masses for the primary and secondary black holes are 1.37 × 10^9M⊙（M⊙ is the solar mass） and 1.37 × 10^7M⊙, and the major axis for this pair being about 0.1 parsec（pc）.
文摘目的介绍美罗培南在危重症、脓毒症及脓毒症休克、肾功能不全、病态肥胖、烧伤等特殊机体状态下的PK/PD及给药方案研究进展,为其临床合理应用提供参考。方法查阅国内外相关文献,进行系统的文献整理和综合分析。结果患者特殊的病理生理状态,可使美罗培南的PK和PD发生重要改变,其中最重要的改变是Vd和CL。多个研究报道,增大美罗培南给药剂量,延长输注时间,可提高目标获得概率(Probability of target attainment,PTA)或累积反应分数(Cumulative fraction of response,CFR),但对于敏感的致病菌常规给药方案仍可得到良好的治疗效果。药物对治疗靶部位的组织穿透力也是影响PD的重要指标。研究发现,美罗培南可以很好的渗透到脑脊液、腹腔、肺部、软组织、前列腺、胰腺等。结论临床医生在使用美罗培南前,应了解患者的病理生理状态,明确病原菌、感染部位,根据PK/PD制定合理的给药方案。
