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MISCIBILITY, THERMAL STABILITY AND RETENTION OF PVP FOR CROSSLINKED PVA/PVP BLENDS
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作者 梁国眉 张堃 冯榕荫 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1994年第3期201-209,共9页
The thermal behavior, miscibility, crystallite conformation and thermal stability ofcrosslinked(CL-) PVA/PVP blends were studied by DSC and TG methods, respectively. DSCresults showed that in the blend, the crystallin... The thermal behavior, miscibility, crystallite conformation and thermal stability ofcrosslinked(CL-) PVA/PVP blends were studied by DSC and TG methods, respectively. DSCresults showed that in the blend, the crystallinity,T_m and T_c of PVA were obviously lower thanthose of pure PVA; the crystal growth changed from three dimensional to two dimensional andonly a single T_g was detected. These facts demonstrated that this crystalline and amorphousblend have good miscibility. TG curves showed that providing the quantity of K_2S_2O_8 added ismore than 3 wt%,in the blends PVA will form a stable CL-network, whose thermal degradationtemperature was near to that of PVP. But crosslinking reaction will not take place for PVP. Theprocesses of thermal degradation of CL-blends are based on combining both the thermaldegradation of PVP and that of PVA crosslinked with corresponding quantity of K_2S_2O_8 CL-agent, respectively. The UV measurements showed that 75 wt% of PVP may be remained in CL-blend hydrogelscrosslinked by adding (3--5 wt% )K_2S_2O_8. This is mainly due to the stable CL-network formed and the good compatibility and properentanglement between the composites in the CL-blends. 展开更多
关键词 Crosslinked pva/PVP blends MISCIBILITY Thermal stability hydrogel network
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纤维素改性PVA水凝胶的制备及其性能研究 被引量:2
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作者 钱程 《嘉兴学院学报》 2012年第6期80-85,共6页
为弥补PVA水凝胶性能存在的缺陷与不足,选用纤维素对PVA水凝胶进行改性.对PVA和纤维素的质量比、增塑剂交联剂的种类和用量分别进行实验筛选,得出以聚乙二醇为增塑剂,硼酸为交联剂,最佳制备条件为:PVA、纤维素、聚乙二醇和硼酸的质量比... 为弥补PVA水凝胶性能存在的缺陷与不足,选用纤维素对PVA水凝胶进行改性.对PVA和纤维素的质量比、增塑剂交联剂的种类和用量分别进行实验筛选,得出以聚乙二醇为增塑剂,硼酸为交联剂,最佳制备条件为:PVA、纤维素、聚乙二醇和硼酸的质量比为20︰10︰1︰10时,可获得具有优良强度、吸水速率快、吸水和保水性能好,且具多孔结构的纤维素改性PVA水凝胶. 展开更多
关键词 聚乙烯醇 纤维素 聚乙二醇 硼酸 共混改性
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聚乙烯醇/葡聚糖复合凝胶的制备及药物释放规律的研究 被引量:5
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作者 窦学文 杨泗兴 袁伟恩 《现代生物医学进展》 CAS 2009年第8期1469-1471,共3页
目的:采用冷冻-解冻物理交联方法制备聚乙烯醇(PVA)和葡聚糖(Dextran)混合凝胶。并考察复合凝胶药物释放规律。方法:含有胰岛素的PVA/Dextran溶液置于-20℃条件下冷冻8h,在室温下解冻4h,反复冷冻-解冻数次制备得到胰岛素PVA/Dextran复... 目的:采用冷冻-解冻物理交联方法制备聚乙烯醇(PVA)和葡聚糖(Dextran)混合凝胶。并考察复合凝胶药物释放规律。方法:含有胰岛素的PVA/Dextran溶液置于-20℃条件下冷冻8h,在室温下解冻4h,反复冷冻-解冻数次制备得到胰岛素PVA/Dextran复合凝胶,反相高效液相色谱法考察了胰岛素的体外释放行为。结果:胰岛素复合凝胶体外释放模式符合Higuchi扩散方程。当PVA/Dextran比例从100/0降到80/20,胰岛素释放速率明显增加,最大释放率从45%增加到65%。当冷冻-解冻循环次数从2增加到6,胰岛素达到最大释放的时间从24h增加到45h,最大释放率从70%降到50%。释放介质的温度的升高能显著增加胰岛素的释放速率。结论:PVA/Dextran制备的胰岛素复合凝胶具有良好的缓释效果。PVA/Dextran复合凝胶是一种较有前景的水凝胶药物载体。 展开更多
关键词 胰岛素 聚乙烯醇/葡聚糖复合凝胶 冷冻-解冻交联
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