经皮椎体成形术(PVP)是治疗骨质疏松性脊柱骨折的常用方法,主要穿刺方式有两种,一种是单侧经椎弓根入路或者椎弓根外侧入路穿刺,另一种为双侧经椎弓根入路穿刺。本研究旨在探讨这两种穿刺方式在治疗骨质疏松性脊柱骨折中的效能差异,包...经皮椎体成形术(PVP)是治疗骨质疏松性脊柱骨折的常用方法,主要穿刺方式有两种,一种是单侧经椎弓根入路或者椎弓根外侧入路穿刺,另一种为双侧经椎弓根入路穿刺。本研究旨在探讨这两种穿刺方式在治疗骨质疏松性脊柱骨折中的效能差异,包括手术相关指标、治疗效果、并发症等方面,以便为临床抉择提供依据。通过对相关文献的综合分析,发现单侧穿刺具有手术时间短、骨水泥用量少等优点,双侧穿刺在骨水泥弥散和疼痛缓解方面可能更具优势。术者可根据个人喜好以及患者的具体情况选择合适的穿刺方式。Percutaneous vertebroplasty (PVP) is a commonly used method for treating osteoporotic spinal fractures. There are two main puncture methods, one is unilateral transpedicular or lateral approach, and the other is bilateral transpedicular approach. This study aims to explore the difference in efficacy between these two puncture methods in the treatment of osteoporotic spinal fractures, including surgical indicators, treatment effects, complications, etc., in order to provide a basis for clinical decision-making. Through comprehensive analysis of relevant literature, it was found that unilateral puncture has the advantages of short operation time and less bone cement usage, and bilateral puncture may have more advantages in bone cement diffusion and pain relief. The surgeon can choose the appropriate puncture method according to personal preferences and the specific situation of the patient.展开更多
目的研究在没有对照品的情况下鉴定检材中1-(4-氟苯基)-2-(N-吡咯烷基)-1-戊酮[1-(4-fluorophenyl)-2-(1-pyrrolidinyl)pentan-1-one,4-F-α-PVP]类似物1-(4-氟-3甲基苯基)-2-(N-吡咯烷基)-1-戊酮[1-(4-fluoro-3-methyl phenyl)-2-(1-py...目的研究在没有对照品的情况下鉴定检材中1-(4-氟苯基)-2-(N-吡咯烷基)-1-戊酮[1-(4-fluorophenyl)-2-(1-pyrrolidinyl)pentan-1-one,4-F-α-PVP]类似物1-(4-氟-3甲基苯基)-2-(N-吡咯烷基)-1-戊酮[1-(4-fluoro-3-methyl phenyl)-2-(1-pyrrolidinyl)pentan-1-one,4-F-3-Methyl-α-PVP]盐酸盐的方法。方法综合利用直接进样电子电离-质谱(electron ionization-mass spectrometry,EI-MS)、GCMS、电喷雾离子化-高分辨质谱(electrospray ionization-high resolution mass spectrometry,ESI-HRMS)、超高效液相色谱-高分辨串联质谱(ultra-high performance liquid chromatography-high resolution tandem mass spectrometry,UPLC-HRMS/MS)、核磁共振(nuclear magnetic resonance,NMR)、离子色谱和傅里叶变换红外光谱法(Fourier transform infrared spectroscopy,FTIR),实现对检材中未知化合物的结构解析与表征,并对该化合物在EI-MS和UPLC-HRMS/MS两种质谱分析方式下生成碎片离子的裂解机制进行推导。结果通过对检材中化合物的直接进样EI-MS、GC-MS、ESI-HRMS和UPLC-HRMS/MS分析,推断出未知化合物为4-F-α-PVP的结构类似物,可能苯环中多了1个甲基。根据核磁共振氢谱(1H-nuclear magnetic reso⁃nance,1 H-NMR)、核磁共振碳谱(13C-nuclear magnetic resonance,13C-NMR)等分析结果,进一步证明了甲基的位置在苯环的3-位。由于1H-NMR分析中实际氢的个数比4-F-3-Methyl-α-PVP中性分子多1个,推断该化合物以盐形式存在。离子色谱法分析结果表明该化合物含氯离子(含量11.14%~11.16%),结合FTIR对主要官能团信息的结构分析,最终确定该未知化合物为4-F-3-Methyl-α-PVP盐酸盐。结论建立了综合利用EI-MS、GC-MS、ESI-HRMS、UPLC-HRMS/MS、NMR、离子色谱和FTIR鉴定检材中4-F-3-Methyl-α-PVP盐酸盐的方法,将有助于法庭科学实验室在案件中鉴定该物质或其他具有类似结构的化合物。展开更多
文摘经皮椎体成形术(PVP)是治疗骨质疏松性脊柱骨折的常用方法,主要穿刺方式有两种,一种是单侧经椎弓根入路或者椎弓根外侧入路穿刺,另一种为双侧经椎弓根入路穿刺。本研究旨在探讨这两种穿刺方式在治疗骨质疏松性脊柱骨折中的效能差异,包括手术相关指标、治疗效果、并发症等方面,以便为临床抉择提供依据。通过对相关文献的综合分析,发现单侧穿刺具有手术时间短、骨水泥用量少等优点,双侧穿刺在骨水泥弥散和疼痛缓解方面可能更具优势。术者可根据个人喜好以及患者的具体情况选择合适的穿刺方式。Percutaneous vertebroplasty (PVP) is a commonly used method for treating osteoporotic spinal fractures. There are two main puncture methods, one is unilateral transpedicular or lateral approach, and the other is bilateral transpedicular approach. This study aims to explore the difference in efficacy between these two puncture methods in the treatment of osteoporotic spinal fractures, including surgical indicators, treatment effects, complications, etc., in order to provide a basis for clinical decision-making. Through comprehensive analysis of relevant literature, it was found that unilateral puncture has the advantages of short operation time and less bone cement usage, and bilateral puncture may have more advantages in bone cement diffusion and pain relief. The surgeon can choose the appropriate puncture method according to personal preferences and the specific situation of the patient.
文摘目的研究在没有对照品的情况下鉴定检材中1-(4-氟苯基)-2-(N-吡咯烷基)-1-戊酮[1-(4-fluorophenyl)-2-(1-pyrrolidinyl)pentan-1-one,4-F-α-PVP]类似物1-(4-氟-3甲基苯基)-2-(N-吡咯烷基)-1-戊酮[1-(4-fluoro-3-methyl phenyl)-2-(1-pyrrolidinyl)pentan-1-one,4-F-3-Methyl-α-PVP]盐酸盐的方法。方法综合利用直接进样电子电离-质谱(electron ionization-mass spectrometry,EI-MS)、GCMS、电喷雾离子化-高分辨质谱(electrospray ionization-high resolution mass spectrometry,ESI-HRMS)、超高效液相色谱-高分辨串联质谱(ultra-high performance liquid chromatography-high resolution tandem mass spectrometry,UPLC-HRMS/MS)、核磁共振(nuclear magnetic resonance,NMR)、离子色谱和傅里叶变换红外光谱法(Fourier transform infrared spectroscopy,FTIR),实现对检材中未知化合物的结构解析与表征,并对该化合物在EI-MS和UPLC-HRMS/MS两种质谱分析方式下生成碎片离子的裂解机制进行推导。结果通过对检材中化合物的直接进样EI-MS、GC-MS、ESI-HRMS和UPLC-HRMS/MS分析,推断出未知化合物为4-F-α-PVP的结构类似物,可能苯环中多了1个甲基。根据核磁共振氢谱(1H-nuclear magnetic reso⁃nance,1 H-NMR)、核磁共振碳谱(13C-nuclear magnetic resonance,13C-NMR)等分析结果,进一步证明了甲基的位置在苯环的3-位。由于1H-NMR分析中实际氢的个数比4-F-3-Methyl-α-PVP中性分子多1个,推断该化合物以盐形式存在。离子色谱法分析结果表明该化合物含氯离子(含量11.14%~11.16%),结合FTIR对主要官能团信息的结构分析,最终确定该未知化合物为4-F-3-Methyl-α-PVP盐酸盐。结论建立了综合利用EI-MS、GC-MS、ESI-HRMS、UPLC-HRMS/MS、NMR、离子色谱和FTIR鉴定检材中4-F-3-Methyl-α-PVP盐酸盐的方法,将有助于法庭科学实验室在案件中鉴定该物质或其他具有类似结构的化合物。
