[Objectives]To investigate the effects of propolis extract on HeLa cells to provide theoretical guidance for facilitating clinical treatment.[Methods]The effects of propolis on inflammation,and proliferation were anal...[Objectives]To investigate the effects of propolis extract on HeLa cells to provide theoretical guidance for facilitating clinical treatment.[Methods]The effects of propolis on inflammation,and proliferation were analyzed based on the levels of DNA transcriptional regulation and mRNA and protein expression levels.[Results]Propolis water extract(PWE)could inhibit the cell proliferation and production of DNA damage in a dosedependent manner.Moreover,the propolis water extract could significantly downregulate the expression of iNOS-Luc,PTGS-2-Luc,and IL-8-Luc,and that it was related to the expression of the NF-κB family protein.After the induction of HeLa cells by propolis,the expression of the cell cycle inhibitor gene p21 was increased,while that of the cell proliferation gene Ki67 was decreased.[Conclusions]Propolis water extract could significantly inhibit the cell proliferation and production of DNA damage,suggesting propolis as a potential candidate for the development of adjunctive therapy against cervical cancer.展开更多
随着电力通信业务IP化趋势的不断发展,分组传送网(Packet Transfer Network,PTN)逐渐被广泛采用,但是对于分组传送网对E1业务的承载性能,目前仍存在较大争议。文章以分析、评估PTN网络对E1业务的承载能力为出发点,通过原理分析、实验室...随着电力通信业务IP化趋势的不断发展,分组传送网(Packet Transfer Network,PTN)逐渐被广泛采用,但是对于分组传送网对E1业务的承载性能,目前仍存在较大争议。文章以分析、评估PTN网络对E1业务的承载能力为出发点,通过原理分析、实验室测试等方式,验证了PTN网络对E1业务的优良承载性能,为未来电力通信网络建设和工程设计提供了新的参考和可靠的依据。展开更多
基金Supported by the Modern Agricultural Technology Industry System of ShandongProvince(SDAIT-24-05)。
文摘[Objectives]To investigate the effects of propolis extract on HeLa cells to provide theoretical guidance for facilitating clinical treatment.[Methods]The effects of propolis on inflammation,and proliferation were analyzed based on the levels of DNA transcriptional regulation and mRNA and protein expression levels.[Results]Propolis water extract(PWE)could inhibit the cell proliferation and production of DNA damage in a dosedependent manner.Moreover,the propolis water extract could significantly downregulate the expression of iNOS-Luc,PTGS-2-Luc,and IL-8-Luc,and that it was related to the expression of the NF-κB family protein.After the induction of HeLa cells by propolis,the expression of the cell cycle inhibitor gene p21 was increased,while that of the cell proliferation gene Ki67 was decreased.[Conclusions]Propolis water extract could significantly inhibit the cell proliferation and production of DNA damage,suggesting propolis as a potential candidate for the development of adjunctive therapy against cervical cancer.
文摘随着电力通信业务IP化趋势的不断发展,分组传送网(Packet Transfer Network,PTN)逐渐被广泛采用,但是对于分组传送网对E1业务的承载性能,目前仍存在较大争议。文章以分析、评估PTN网络对E1业务的承载能力为出发点,通过原理分析、实验室测试等方式,验证了PTN网络对E1业务的优良承载性能,为未来电力通信网络建设和工程设计提供了新的参考和可靠的依据。
