The new title compound N-（2-hydroxy ethyl） tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine hydrochloride.The structure of the product was confirmed by 1H NMR,MS（ESI） and single-cr...The new title compound N-（2-hydroxy ethyl） tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine hydrochloride.The structure of the product was confirmed by 1H NMR,MS（ESI） and single-crystal X-ray diffraction.The title compound crystallizes in the triclinic system,space group P1 with a = 10.5887（11）,b = 10.8652（9）,c = 12.0914（12） ,β = 84.808（9）o,V = 1253.3（2） A^3,Z = 2,Dc = 1.355 g/cm^3,F（000） = 530,μ = 1.680 mm-1,the final R = 0.0833 and w R = 0.2371 for 5112 observed reflections（I 〉 2A（I））.X-ray analysis indicates that the two planar parts（C（2） C（3） C（4） C（5） C（6） C（7） N（1） C（20） C（21） C（21）） and（C（7） C（8） C（9） C（10） C（12） C（14） N（15） C（16） C（17）） are not coplanar,with the dihedral angles to be 67.9°.Weak interactions mainly between O（5）–H（5）···O from two water molecules and O（5）···Br are observed.展开更多
The determination method of L-phenylalartine （LPA） by fluorescence quenching was developed. The assay was based on the combination of the cucurbit[7]uril （CB [7]） with palmatine hydrochloride （PAL） reaction. In ...The determination method of L-phenylalartine （LPA） by fluorescence quenching was developed. The assay was based on the combination of the cucurbit[7]uril （CB [7]） with palmatine hydrochloride （PAL） reaction. In the presence of CB [7], the fluorescence of PAL was quenched by LPA which can be employed to detect LPA. Under the optimal conditions, a linear range 3.63 ×10^-8- 9.68 ×10^-6 mol/L and a detection limit 1.27 ×10^-8 mol/L of LPA were obtained. The relative standard deviation （R.S.D） was 1.8% obtained from a series of 11 standards each containing 6.05 ×10^-6 mol/L of LPA. This paper also discusses the mechanism of fluorescence indicator probe.展开更多
基金Supported by the National Natural Science Foundation of China(No.51263002)Natural Science Foundation of Guangxi Province(No.2014GXNSFBA118182)+1 种基金the Scientific Research Fund of Guangxi Provincial Education Department(No.YB2014181)subject for Guangxi University of Chinese Medicine(No.QN14017)
文摘The new title compound N-（2-hydroxy ethyl） tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine hydrochloride.The structure of the product was confirmed by 1H NMR,MS（ESI） and single-crystal X-ray diffraction.The title compound crystallizes in the triclinic system,space group P1 with a = 10.5887（11）,b = 10.8652（9）,c = 12.0914（12） ,β = 84.808（9）o,V = 1253.3（2） A^3,Z = 2,Dc = 1.355 g/cm^3,F（000） = 530,μ = 1.680 mm-1,the final R = 0.0833 and w R = 0.2371 for 5112 observed reflections（I 〉 2A（I））.X-ray analysis indicates that the two planar parts（C（2） C（3） C（4） C（5） C（6） C（7） N（1） C（20） C（21） C（21）） and（C（7） C（8） C（9） C（10） C（12） C（14） N（15） C（16） C（17）） are not coplanar,with the dihedral angles to be 67.9°.Weak interactions mainly between O（5）–H（5）···O from two water molecules and O（5）···Br are observed.
基金supported by the Research Fund for the Doctoral Program of Higher Education of China(No. 20091404110001)the foundation of Shanxi Normal University(No.ZR1007)
文摘The determination method of L-phenylalartine （LPA） by fluorescence quenching was developed. The assay was based on the combination of the cucurbit[7]uril （CB [7]） with palmatine hydrochloride （PAL） reaction. In the presence of CB [7], the fluorescence of PAL was quenched by LPA which can be employed to detect LPA. Under the optimal conditions, a linear range 3.63 ×10^-8- 9.68 ×10^-6 mol/L and a detection limit 1.27 ×10^-8 mol/L of LPA were obtained. The relative standard deviation （R.S.D） was 1.8% obtained from a series of 11 standards each containing 6.05 ×10^-6 mol/L of LPA. This paper also discusses the mechanism of fluorescence indicator probe.
