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Combination treatment of bisphosphonate(pamidronate) and Quercus infectoria semipurified fraction promotes proliferation and differentiation of osteoblast cell via expression of Osterix and Runx2 marker
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作者 Abdullah Amira Raudhah Hapidin Hermizi Abdullah Hasmah 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2018年第5期261-267,共7页
Objective:To understand the effects of combination treatment of pamidronate with isolated Quercus infectoria semi-purified fraction(Qlsm-F)on human foetal osteoblast cell model(hFOB1.19 cell line)through assessment of... Objective:To understand the effects of combination treatment of pamidronate with isolated Quercus infectoria semi-purified fraction(Qlsm-F)on human foetal osteoblast cell model(hFOB1.19 cell line)through assessment of Runt related transcription fraction-2(Runx2)and Osterix(Osx).Methods:The isolation and purification of QIsm-F were conducted by chromatographic technique.In order to assess relative efficacy of QIsm-F to the osteoblast model,the determination of half maximal effective concentration(EC_(50))was performed by MTT assay.hFOB 1.19 cells were cultured in DMEM F-12 and supplemented with 10%fetal bovine serum along with 1%penicillin-streptomycin incubated in 5%CO_2 at 37℃.Expression of Runx2 and Osx was assessed through western blotting and confirmed with immunofluorescence staining.Results:Results of western blot analysis and immunofluorescence staining demonstrated that compared to hFOB 1.19 cells treated with single individual treatment of QIsm-F and control groups,levels of Runx2 and Osx were elevated with higher fluorescence intensity and more rapid proliferation in hFOB 1.19 cells treated with combined treatment of QIsm-F and pamidronate.Conclusions:The finding demonstrates the synergistic effect between osteoporotic drug pamidronate and established QIsm-F.The combination treatment helps increase the efficiency of pamidronate acting on osteoblast cells by stimulating osteoblast proliferation and differentiation via expression of Runx2 and Osx. 展开更多
关键词 pamidronate RUNX2 OSTERIX OSTEOBLAST Quercus infectoria semi-purified fraction
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Long-term Efficacy and Safety of Pamidronate Disodium in Treatment of Bone Metastases in Breast Cancer
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作者 Li-jun Di Jun Ren Ying Yan Feng-ling Wan Guo-gong Song Jing Yu 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2009年第2期109-114,共6页
Objective: To evaluate the long-term efficacy and safety of pamidronate disodium in patients with bone lesions secondary to advanced breast carcinoma. Methods: A retrospective chart review was conducted of 62 patie... Objective: To evaluate the long-term efficacy and safety of pamidronate disodium in patients with bone lesions secondary to advanced breast carcinoma. Methods: A retrospective chart review was conducted of 62 patients receiving intravenous pamidronate disodium for metastatic breast cancer. The proportion of patients experiencing at least one skeletal related event (SRE) after 12 months of therapy was determined. Results: The proportion of patients who had an SRE was 29.00% (18 individuals) and the median time to first event was greater than 350 days. Radiotherapy(ll individuals)and pathologic fracture(6 individuals)were the most frequent type of SRE, while cord compression(1 individuals) and hypercalcaemia(0 individuals) were rare. A total of 37 individuals had transient hypocalcaemia without any clinical symptom. No significant creatinine abnormalities were encountered. There were no clinically relevant changes of calcium ,phosphate and creatinine before and after therapy. Conclusion: Long-term treatment with pamidronate disodium significantly reduces and delays skeletal morbidity from osteolytic metastases . Prolonged therapy was well tolerated. This study suggests that the rate of clinically relevant SREs is substantially lower than the event rate observed in phase llI clinical trials. 展开更多
关键词 pamidronate disodium Skeletal related event Bone metastases Breast cancer
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新生儿严重甲状旁腺功能亢进症:基因型/表现型间相关性和应用pamidronate作为抢救措施
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作者 Waller S. Kurzawinski T. +2 位作者 Spitz L. W.G.Van’t Hoff 高蕊 《世界核心医学期刊文摘(儿科学分册)》 2005年第3期31-31,共1页
家族性低尿钙性高钙血症(FHH)是一种常染色体显性遗传性疾病。该病因钙敏感受体(CaSR)的基因发生杂合性突变引起。而在那些CaSR的基因纯合性突变的患儿则会罹患新生儿严重甲状旁腺功能亢进(NSHPT)症。与相对良性且无症状的:FHH不同,NSH... 家族性低尿钙性高钙血症(FHH)是一种常染色体显性遗传性疾病。该病因钙敏感受体(CaSR)的基因发生杂合性突变引起。而在那些CaSR的基因纯合性突变的患儿则会罹患新生儿严重甲状旁腺功能亢进(NSHPT)症。与相对良性且无症状的:FHH不同,NSHPT 者如果不进行甲状旁腺切除则有生命危险。笔者报道了3例NSHPT病例。 展开更多
关键词 pamidronate 高钙血症 甲状旁腺切除 钙敏感受体 生命危险 表现型 纯合性 无症状 杂合性 遗传性疾病
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接受静脉注射pamidronate治疗后Paget病患者骨密度增加
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《国外医学(内分泌学分册)》 2003年第4期287-287,共1页
关键词 PAGET病 骨密度 pamidronate 用药剂量
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Role of bisphosphonates in the management of acute Charcot foot 被引量:9
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作者 Harsh Durgia Jayaprakash Sahoo +3 位作者 Sadishkumar Kam-alanathan Rajan Palui Kalyani Sridharan Henith Raj 《World Journal of Diabetes》 SCIE CAS 2018年第7期115-126,共12页
Diabetes mellitus is the most common cause of Charcot neuropathy affecting foot and ankle. Acute Charcot foot(CF) presents with a red and swollen foot in co-ntrast to the painless deformed one of chronic CF. En-hanced... Diabetes mellitus is the most common cause of Charcot neuropathy affecting foot and ankle. Acute Charcot foot(CF) presents with a red and swollen foot in co-ntrast to the painless deformed one of chronic CF. En-hanced osteoclastogenesis plays a central role in the pathogenesis of acute CF. Many studies have shown elevated levels of bone turnover markers in patients with acute CF confirming it. These findings have led cl-inicians to use anti-resorptive agents [bisphosphonates(BP), calcitonin, and denosumab] along with immobi-lization and offloading in acute CF patients. The ma-ximum evidence among all anti-resorptive agents is available for BPs, although its quality is low. Pamidronate has been shown to reduce the markers of activity of CF like raised skin temperature, pain, edema, and bone turnover markers in the majority of studies. Intravenous BPs are known to cause acute phase reactions leading to flu-like illness following their first infusion, which can be ameliorated by oral acetaminophen. Alendronate is the only oral BP used in these patients. It needs to be taken on an empty stomach with a full glass of water to avoid esophagitis. The side-effects and contraindications to BPs should be kept in mind while treating acute CF patients with them. 展开更多
关键词 CHARCOT FOOT DIABETES MELLITUS CHARCOT neuroarthropathy BISPHOSPHONATES pamidronate
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Clinical research on zoledronic acid in treatment of pain caused by bone metastasis of malignant tumors
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作者 Zhuang Yu Jun Liang Ling Peng 《The Chinese-German Journal of Clinical Oncology》 CAS 2007年第4期399-401,共3页
Objective:To evaluate the efficacy and safety of zoledronic acid for the pain caused by metastatic tumor of bone.Methods:52 patients with metastatic tumor of bone were randomly divided into two groups.The zoledronic a... Objective:To evaluate the efficacy and safety of zoledronic acid for the pain caused by metastatic tumor of bone.Methods:52 patients with metastatic tumor of bone were randomly divided into two groups.The zoledronic acid group received 4 mg zoledronic acid infusion for 30 minutes and the control group received 90 mg pamidronate infusion for 6 hours. Results:The effective rates in zoledronic acid group and control group were 73.08%and 69.23%respectively.No significant difference was observed between the two groups.The median pain relief onset at days 5 and 7,respectively,and no significant difference was observed.The ECOG scores on the 7th day after medication:the differences in the zoledronic acid group before and after medication and between the two groups were both significant(P<0.001 and P=0.0448).The adverse reac- tion was no significant difference between the two groups.Conclusion:Zoledronic acid is efficient and safe in the treatment of pain caused by metastatic tumor of bone and it has low adverse reaction rate and convenient shorter using time. 展开更多
关键词 zoledronic acid pamidronate metastatic tumor of bone bone pain
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双膦酸盐类骨质疏松症药物
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作者 许关煜 Sherry(编译) 《中国处方药》 2008年第1期19-19,共1页
美国FDA近日发布公告,着重提示接受双膦酸盐类骨质疏松症药物(商品名和通用名分别为:Actonel/risedronate,利塞膦酸钠;Actonel+Ca/risedronate,利塞膦酸钠+钙;Aredia/pamidronate Disodium,帕米膦酸钠;Boniva/ibandronat... 美国FDA近日发布公告,着重提示接受双膦酸盐类骨质疏松症药物(商品名和通用名分别为:Actonel/risedronate,利塞膦酸钠;Actonel+Ca/risedronate,利塞膦酸钠+钙;Aredia/pamidronate Disodium,帕米膦酸钠;Boniva/ibandronate,伊拜膦酸钠;Didronel/Etridronatedisodium,依替膦酸钠;Fosamax。 展开更多
关键词 骨质疏松症 双膦酸盐类 RISEDRONATE pamidronate IBANDRONATE 药物 DISODIUM Didronel
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The curative effect of zoledronic acid and pamidronic acid on treating ostealgia in malignant tumor with bone metastases and its side effects on serum calcium and phosphorus 被引量:2
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作者 Yuedi Dai Meixing Wang Li Tao Anqi Li Haixia Wu Mi Xiao 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第6期344-348,共5页
Objective: Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of... Objective: Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of malignant tumor with bone metastases and serum calcium, phosphorus and alkaline phosphorus movement. Methods: One Hundred cancer patients with bone metastases were diagnosed according to pathological and imaging methods. After zoledronic acid or pamidronic acid intravenous infusion one and two months, ostealgia degree, serum calcium, serum phosphorus and alkaline phosphorus were observed before bisphosphonates treatment, one and two months after treatment, respectively. Results: Ostealgia degree did not change significantly after diphosphonates treatment from one to two months (P 〉 0.05). The linear correlation between serum calcium and serum phosphorus on bone metastases cancer patients before therapy was dismissed after bisphosphonates treatment one month and did not recover in two months. The incidence of hypo-calcium after diphosphonate treatment one month (54%) and two months (56%) were significantly increased than that before treatment (36%) (X2 = 6.55, P = 0.011; X2 = 8.05, P = 0.005). Serum calcium and serum phosphorus were both decreased after treatment one month (t = 4.39, P = 0.000; t = 2.50, P = 0.014) and two months (t = 4.32, P = 0.000; t = 2.49, P = 0.010). There had no difference between zoledronic acid and pamidronic acid on treating of ostealgia and serum calcium and phosphorus changing. Conclusion: Zoledronic acid and pamidronic acid can relief ostealgia of cancer patients with bone metastases and induce hypo-calcium, break the linear relationship between calcium and phosphorus. There have no difference between zoledronic acid and pamidronic acid on treating ostealgia and inducing hypo-calcium and hypo-phosphorus. 展开更多
关键词 zoledronic acid pamidronic acid ostealgia CALCIUM PHOSPHORUS
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第三代双磷酸酯YM529可能是非小细胞肺癌的另一个治疗选择
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作者 安芸(摘译) 《中华医学信息导报》 2007年第3期8-8,共1页
YM529是一种新发现的含氮双磷酸酯,属于第三代双磷酸酯(BP),其抗骨吸收活性比pamidronate高100倍(第二代BP)。因此YM529被用于治疗骨质疏松和高钙血症。近来的研究表明,YM529等第三代BP在体内和/或体外存在着对多种肿瘤的拮抗... YM529是一种新发现的含氮双磷酸酯,属于第三代双磷酸酯(BP),其抗骨吸收活性比pamidronate高100倍(第二代BP)。因此YM529被用于治疗骨质疏松和高钙血症。近来的研究表明,YM529等第三代BP在体内和/或体外存在着对多种肿瘤的拮抗作用。KoshimuneR等观察了YM529对非小细胞肺癌的作用,并发表于2007年1月的BMC Cancer上。 展开更多
关键词 非小细胞肺癌 磷酸酯 第三代 pamidronate 治疗 骨吸收活性 高钙血症 骨质疏松
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