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祛风清热定痛方对偏头痛大鼠镇痛效应及内皮素1及5-羟色胺含量的影响 被引量:2
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作者 李瑞杰 冀绪 +2 位作者 白杏强 张晓双 司宁宁 《河北中医》 2015年第8期1183-1186,共4页
目的观察祛风清热定痛方对偏头痛大鼠的镇痛效应及可能机制。方法将72只SD大鼠随机分为6组,即空白组、模型组、正天丸组和祛风清热定痛方大、中、小剂量组,每组各12只,分别予相应药液灌胃给药,连续7 d。除空白组外,其余5组大鼠通过热板... 目的观察祛风清热定痛方对偏头痛大鼠的镇痛效应及可能机制。方法将72只SD大鼠随机分为6组,即空白组、模型组、正天丸组和祛风清热定痛方大、中、小剂量组,每组各12只,分别予相应药液灌胃给药,连续7 d。除空白组外,其余5组大鼠通过热板法测定痛阈值,然后以硝酸甘油制备偏头痛大鼠模型,放免法检测各组大鼠血浆中内皮素1(ET-1)、5-羟色胺(5-HT)含量。结果与模型组同期比较,祛风清热定痛方大、中剂量组60、120、180 min痛阈值均显著提高(P<0.05),祛风清热定痛方小剂量组、正天丸组120、180 min痛阈值均显著提高(P<0.05)。与模型组比较,祛风清热定痛方大、中、小剂量组及正天丸组ET-1含量均明显降低,5-HT含量均明显增加,比较差异有统计学意义(P<0.05)。与正天丸组比较,祛风清热定痛方大、中剂量组ET-1含量明显降低,5-HT含量明显增加,差异有统计学意义(P<0.05),小剂量组ET-1和5-HT含量无统计学意义(P>0.05)。与祛风清热定痛方大剂量组相比,祛风清热定痛方中剂量组ET-1和5-HT含量比较差异有统计学意义(P<0.05),小剂量组无统计学意义(P>0.05)。结论祛风清热定痛方具有明显的镇痛作用,其调节偏头痛模型大鼠血浆5-HT、ET-1含量可能是治疗偏头痛的机制之一。 展开更多
关键词 偏头痛 祛风 清热 镇痛 中医药疗法 止痛剂(中药) 放射免疫测定 内皮缩血管肽类 血清素 疾病模型 动物 paregoric ( Chinese herbs)
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Factors related to compliance with oral analgesic treatment of inpatients with chronic pain
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作者 Hong Zhu Yuzhu Zheng +2 位作者 Hui Gao Li Liu Lie Yang 《Frontiers of Medicine》 SCIE CAS CSCD 2015年第3期374-379,共6页
This study aimed to determine the relationship between the different factors of analgesic therapy and the compliance of chronic pain inpatients. We prospectively investigated 100 consecutive inpatients with non- cance... This study aimed to determine the relationship between the different factors of analgesic therapy and the compliance of chronic pain inpatients. We prospectively investigated 100 consecutive inpatients with non- cancer chronic pain who were hospitalized to receive oral analgesic treatment in the Pain Department of West China Hospital from May 2013 to October 2013. Patients who completed the treatment plan were recorded as good compliance, whereas patients who partly completed or even refused the treatment were recorded as moderate or non-compliance, respectively. A total of 73 (73.7%), 17 (17.1%), and 9 (9.2%) patients showed good, moderate, and non-compliance, respectively. Univariate analyses showed significantly better compliance among farmers, patients educated in college or above, with family income of 〈 3000 CNY, and with severe or moderate pain than those employed and unemployed (P= 0.02), patients educated below college (P= 0.013), with family income of ≥ 3000 CNY (P = 0.025), and with mild pain (P 〈 0.001), respectively. Logistic regression analysis showed that the family income of≥ 3000 CNY (OR: 2.50, 95%CI: 1.65-4.51, P= 0.021) and mild pain (OR: 1.27, 95%CI: 1.03-3.31, P= 0.016) were associated with moderate or non-compliance with oral analgesic treatment. In conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with chronic pain and compliance was negatively associated with family income and degree of pain of patients. 展开更多
关键词 chronic pain INPATIENT oral paregoric drugs COMPLIANCE
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