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Dysfunction of synaptic endocytic trafficking in Parkinson's disease
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作者 Xin Yi Ng Mian Cao 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2649-2660,共12页
Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of t... Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of these dopamine neurons remain largely elusive.Genetic investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's disease.Notably,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis pathway.This suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"mechanism.Recently,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively characterized.These models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical studies.In this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic effect.Subsequently,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease pathogenesis.We will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK8))in synaptic endocytic trafficking.Additionally,we will discuss the emerging novel functions of these endocytic proteins in downstream membrane traffic pathways,particularly autophagy.Given that synaptic dysfunction is considered as an early event in Parkinson's disease,a deeper understanding of the cellular mechanisms underlying synaptic vesicle endocytic trafficking may unveil novel to rgets for early diagnosis and the development of interventional therapies for Parkinson's disease.Future research should aim to elucidate why generalized synaptic endocytic dysfunction leads to the selective degeneration of nigrostriatal dopamine neurons in Parkinson's disease. 展开更多
关键词 AUTOPHAGY auxilin/park19 clathrin-mediated endocytosis dopamine neurons NEURODEGENERATION nigrostriatal pathway parkinson's disease synaptic vesicle recycling synaptojanin1/park20
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Path Planning and Tracking Control for Parking via Soft Actor-Critic Under Non-Ideal Scenarios
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作者 Xiaolin Tang Yuyou Yang +3 位作者 Teng Liu Xianke Lin Kai Yang Shen Li 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期181-195,共15页
Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adja... Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adjacent parking lots, which poses a safety threat to vehicles parked in these parking lots. However, previous studies have not addressed this issue. In this paper, we aim to evaluate the impact of parking deviation of existing vehicles next to the target parking lot(PDEVNTPL) on the automatic ego vehicle(AEV) parking, in terms of safety, comfort, accuracy, and efficiency of parking. A segmented parking training framework(SPTF) based on soft actor-critic(SAC) is proposed to improve parking performance. In the proposed method, the SAC algorithm incorporates strategy entropy into the objective function, to enable the AEV to learn parking strategies based on a more comprehensive understanding of the environment. Additionally, the SPTF simplifies complex parking tasks to maintain the high performance of deep reinforcement learning(DRL). The experimental results reveal that the PDEVNTPL has a detrimental influence on the AEV parking in terms of safety, accuracy, and comfort, leading to reductions of more than 27%, 54%, and 26%respectively. However, the SAC-based SPTF effectively mitigates this impact, resulting in a considerable increase in the parking success rate from 71% to 93%. Furthermore, the heading angle deviation is significantly reduced from 2.25 degrees to 0.43degrees. 展开更多
关键词 Automatic parking control strategy parking deviation(APS) soft actor-critic(SAC)
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Practical Experience of Management of Urban Parks at Home and Abroad
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作者 Wenqian LING Yong ZHU Qinhuai XU 《Meteorological and Environmental Research》 2024年第1期30-37,共8页
By systematically reviewing the practical experience of management of urban parks at home and abroad,the advanced experience in organization,management system,operation mechanism and social participation were summariz... By systematically reviewing the practical experience of management of urban parks at home and abroad,the advanced experience in organization,management system,operation mechanism and social participation were summarized,and the optimization and improvement measures for the construction and management of urban parks in Chengdu were proposed to provide reference for the high-level construction,high-quality experience and efficient management of urban parks in the construction of park city demonstration zone in Chengdu. 展开更多
关键词 Urban parks Management and operation Domestic and foreign experience Chengdu park city
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高分辨MRI在肛瘘诊断及Parks分型中的应用价值
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作者 罗项超 周永进 +3 位作者 程淑芳 应海峰 陈玲 王祖飞 《医学影像学杂志》 2024年第4期159-161,共3页
目的 探讨高分辨MRI在肛瘘诊断及Parks分型中的应用价值。方法 选取肛瘘接受手术治疗患者108例,均行MRI检查,以手术结果为金标准,分析患者MRI特征及Parks分型。结果 108例中总计检出内口112个、瘘管124个、外口112个、肛周脓肿35个,与... 目的 探讨高分辨MRI在肛瘘诊断及Parks分型中的应用价值。方法 选取肛瘘接受手术治疗患者108例,均行MRI检查,以手术结果为金标准,分析患者MRI特征及Parks分型。结果 108例中总计检出内口112个、瘘管124个、外口112个、肛周脓肿35个,与手术确诊结果对比差异无统计学意义(P>0.05),其中括约肌间型64例、经括约肌型30例、括约肌上型11例、括约肌外型3例,与手术确诊结果对比差异无统计学意义(P>0.05)。结论 MRI应用于肛瘘诊断并进行Parks分型,能清晰显示出内口、外口、瘘管、脓肿位置以及数目信息。 展开更多
关键词 肛瘘 parks分型 磁共振成像
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PARK2介导的帕金森病中帕金蛋白对α-突触核蛋白的作用
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作者 肖琪 樊慧杰 +8 位作者 李艳荣 范丽珊 和璐璐 谢良骐 贾璐 王青 肖保国 马存根 柴智 《中国老年学杂志》 CAS 北大核心 2024年第4期999-1005,共7页
帕金森病(PD)是常见的神经退行性疾病之一,主要表现为运动障碍,伴有主要运动症状,如运动迟缓、僵直性和静息性震颤,还可能表现为多种非运动症状,如自主神经功能障碍、认知障碍、睡眠障碍和神经精神症状〔1〕。
关键词 帕金森病 帕金蛋白 Α-突触核蛋白 park2基因突变
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显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视患儿的效果及其对泪膜功能的影响
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作者 高锦展 王素萍 何利 《实用防盲技术》 2024年第1期41-43,F0003,共4页
目的探探讨显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视患儿的效果及其对泪膜功能的影响。方法选取我科2017年6月至2019年11月期间95例水平共同性斜视患儿作为研究对象,按照随机数字表法分成两组,均行斜视矫正术,对照组47例给... 目的探探讨显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视患儿的效果及其对泪膜功能的影响。方法选取我科2017年6月至2019年11月期间95例水平共同性斜视患儿作为研究对象,按照随机数字表法分成两组,均行斜视矫正术,对照组47例给予术中作角膜缘梯形结膜瓣切口,观察组48例给予显微镜下改良Parks切口,1个月后对比两组患儿视功能改善效果、手术效果、泪膜功能。结果观察组治疗后总有效率95.83%高于对照组89.36%(χ^(2)=0.6632,P=0.4154);观察组水平共同性斜视患儿手术时间明显短于对照组(t=11.9892,P=0.0000);观察组患儿治疗后泪液分泌量高于对照组(t=15.0051,P=0.0000),泪膜破裂时间较对照组上升(t=9.2228,P=0.0000),角膜荧光染色评分较对照组降低(t=10.7815,P=0.0000)。结论显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视效果确切,能够显著矫正眼部,改善患儿视功能及泪膜功能,安全可靠,值得应用。 展开更多
关键词 微镜下改良parks切口斜视矫正术 水平共同性斜视 泪膜功能
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改良Park法重睑成形术与传统切开重睑术用于单睑伴内眦赘皮的疗效和安全性对比研究
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作者 黄积荣 李守春 +2 位作者 赵丽丽 陈树 洪丽容 《大医生》 2024年第7期39-41,共3页
目的探讨改良Park法重睑成形术与传统切开重睑术用于单睑伴内眦赘皮的疗效和安全性,为临床提供参考。方法选取2021年11月至2023年1月贵港市人民医院收治的80例行重睑成形术的单睑伴内眦赘皮患者,按照随机数字表法分为对照组与观察组,各4... 目的探讨改良Park法重睑成形术与传统切开重睑术用于单睑伴内眦赘皮的疗效和安全性,为临床提供参考。方法选取2021年11月至2023年1月贵港市人民医院收治的80例行重睑成形术的单睑伴内眦赘皮患者,按照随机数字表法分为对照组与观察组,各40例。给予对照组患者传统切开重睑术进行治疗,给予观察组患者改良Park法重睑成形术进行治疗。比较两组患者临床效果、手术相关指标、温哥华瘢痕评分量表(VSS)评分和并发症发生情况。结果观察组患者整体疗效优于对照组,总有效率较对照组更高(均P<0.05)。观察组患者手术时间、拆线时间和术后恢复时间比对照组更短,术中出血量比对照组更少(均P<0.05)。两组VSS评分具有时间、组间、交互效应差异;两组术后6个月低于术后3个月和术后1个月,术后3个月低于术后1个月,且观察组低于对照组(P<0.05)。观察组患者并发症总发生率比对照组更低(P<0.05)。结论与传统切开重睑术比较,改良Park法重睑成形术治疗单睑伴内眦赘皮效果更好,同时手术时间、拆线时间和术后恢复时间均更短,术中出血量更少,同时可改善患者术后的瘢痕情况,安全性好。 展开更多
关键词 改良park法重睑成形术 传统切开重睑术 单睑伴内眦赘皮 安全性
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Recreational Behavior and Spatial Characteristics of Urban Parks Based on Multi-Source Information: A Case Study of Xiaohong Stone Carving Park in Nanjing
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作者 XIANG Linkang WANG Xiaojun 《Journal of Landscape Research》 2024年第2期6-14,共9页
Urban parks are an important part of urban recreational spaces,and the development of analysis framework of recreational behavior and space is helpful for the design of urban parks to better meet the activity and usag... Urban parks are an important part of urban recreational spaces,and the development of analysis framework of recreational behavior and space is helpful for the design of urban parks to better meet the activity and usage requirements of visitors.In this paper,Xiaohong Stone Carving Park in Nanjing was taken as the research object to explore the relationship between landscape space and user behavior for design feedback.The orthographic image technology of unmanned aerial vehicle(UAV)and machine deep learning were used to analyze users behavior activities in the park,and the spatial characteristics of each node in the park were evaluated by semantic differential scale to explore the potential causes of behavior activities.The results showed that①there were significant differences in the number of visitors on holidays and working days,and young people and children were the main users.②The users activity of the park differed greatly on the inner and outer tour roads,and the users showed stronger willingness to stay on the inner tour roads.Recreational activities received more attention than cultural ones.③The overall distribution of users was significantly affected by hydrophilicity,and the recreational behavior and activity type were affected by multiple factors which include the hydrophilicity,safety,accessibility of cultural relics and the amount of recreational facilities.Finally,the enhanced strategies such as improving the cultural tour system,establishing hydrophilic safety belts and optimizing recreational facilities were put forward. 展开更多
关键词 Urban park Recreational behavior Landscape space Machine learning UAV
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Low-Density Microplastics in Recreational Parks of Al Ain, United Arab Emirates: Abundance, Composition, and Potential Effects on Soil Health
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作者 Rener De Jesus Ahmed Abuibaid +1 位作者 Bassam Al-Hindawi Ruwaya AlKendi 《Journal of Environmental Protection》 2024年第2期109-123,共15页
Microplastics (MPs) have been an emerging concern due to their harmful effects on the ecosystem and are ubiquitous in various habitats, from marine to terrestrial environments. However, studies on the presence of MPs ... Microplastics (MPs) have been an emerging concern due to their harmful effects on the ecosystem and are ubiquitous in various habitats, from marine to terrestrial environments. However, studies on the presence of MPs in recreational areas are limited. One of the previous works has reported that urban recreational parks are considered “sinks” for plastic debris, including MPs. In this study, low-density MPs (LD-MPs) in soil samples collected from recreational parks of Al Ain, United Arab Emirates (UAE) were isolated by density flotation method. Results showed that these parks have varying levels of LD-MPs caused by various anthropogenic activities, such as sludge use and application of reclaimed water from wastewater treatment facilities in those areas. These plastic particles were isolated in 87% of the soil samples, with an average concentration of 1550 ± 340 MPs/kg. Predominantly, these comprised large LD-MPs (300 - 5000 μm), with red and blue being the most common colors. Fourier transform infrared (FTIR) spectroscopy identified possible synthetic polymers, including polyethylene and polypropylene. Additionally, a negative correlation was observed between LD-MP concentration and soil pH and moisture content, indicating potential adverse effects on soil health. These findings highlight the need for monitoring and managing microplastic pollution in urban recreational areas to mitigate its ecological impacts. 展开更多
关键词 Plastic Particles FTIR Analysis MICROFIBERS Soil Pollutants Urban parks
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Influence of Human Activity Intensity on Habitat Quality in Hainan Tropical Rainforest National Park,China
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作者 HAN Nianlong YU Miao +2 位作者 JIA Peihong ZHANG Yucheng HU Ke 《Chinese Geographical Science》 SCIE CSCD 2024年第3期519-532,共14页
Due to long-term human activity interference,the Hainan Tropical Rainforest National Park(HTRNP)of China has experienced ecological problems such as habitat fragmentation and biodiversity loss,and with the expanding s... Due to long-term human activity interference,the Hainan Tropical Rainforest National Park(HTRNP)of China has experienced ecological problems such as habitat fragmentation and biodiversity loss,and with the expanding scope and intensity of human activity impact,the regional ecological security is facing serious challenges.A scientific assessment of the interrelationship between human activity intensity and habitat quality in the HTRNP is a prerequisite for achieving effective management of ecological disturbances caused by human activities and can also provide scientific strategies for the sustainable development of the region.Based on the land use change data in 2000,2010,and 2020,the spatial and temporal variations and the relationship between habitat quality(HQ)and human activity intensity(HAI)in the HTRNP were explored using the integrated valuation of ecosystem services and trade-offs(InVEST)model.System dynamics and land use simulation models were also combined to conduct multi-scenario simulations of their relationships.The results showed that during 2000–2020,the habitat quality of the HTRNP improved,the intensity of human activities decreased each year,and there was a negative correlation between the two.Second,the system dynamic model could be well coupled with the land use simulation model by combining socio-economic and natural factors.The simulation scenarios of the coupling model showed that the harmonious development(HD)scenario is effective in curbing the increasing trend of human activity intensity and decreasing trend of habitat quality,with a weaker trade-off between the two compared with the baseline development(BD)and investment priority oriented(IPO)scenarios.To maintain the authenticity and integrity of the HTRNP,effective measures such as ecological corridor construction,ecological restoration,and the implementation of ecological compensation policies need to be strengthened. 展开更多
关键词 human activity intensity(HAI) habitat quality(HQ) bivariate spatial autocorrelation system dynamics model integrated valuation of ecosystem services and trade-offs(InVEST)model Hainan Tropical Rainforest National park(HTRNP)of China
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Exploration of Child-friendly Urban Park Design Strategies Based on Child Behavioral Psychology
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作者 WANG Youxuan ZENG Junfeng 《Journal of Landscape Research》 2024年第1期7-11,共5页
By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly... By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly parks,so as to provide a practical basis for the construction of child-friendly cities. 展开更多
关键词 Landscape architecture Child-friendly cities Child behavioral psychology Urban public space park planning and design
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内眦开大术联合改良Park法重睑成形术在双侧单睑伴内眦赘皮患者中的应用效果观察
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作者 杜兴隆 张远其 《中国医疗美容》 2024年第2期11-15,共5页
目的观察内眦开大术联合改良Park法重睑成形术在双侧单睑伴内眦赘皮患者中的应用效果。方法选取82例于2020年9月至2023年9月在贵州医科大学附属乌当医院就诊的有求美需求的双侧单睑伴内眦赘皮患者,均为女性,按照治疗方式不同分为研究组... 目的观察内眦开大术联合改良Park法重睑成形术在双侧单睑伴内眦赘皮患者中的应用效果。方法选取82例于2020年9月至2023年9月在贵州医科大学附属乌当医院就诊的有求美需求的双侧单睑伴内眦赘皮患者,均为女性,按照治疗方式不同分为研究组和对照组,各41例(82只眼)。对照组采取内眦开大术联合传统Park重睑成形术,研究组采取内眦开大术联合改良Park法重睑成形术。比较两组患者术中出血量、瘢痕消失时间、术后满意度和临床疗效。结果研究组术中出血量少于对照组,手术时间短于对照组,瘢痕消失时间早于对照组,术后总满意度高于对照组患者,术后7天眼睑宽度小于对照组,眼裂高度大于对照组,术后半年上睑提肌肌力大于对照组,临床疗效总有效率高于对照组,并发症总发生率小于对照组,差异有统计学意义(P均<0.05)。结论内眦开大术联合改良Park法重睑成形术用于治疗双侧单睑伴内眦赘皮临床疗效较好,术中出血量少,术后并发症少,瘢痕消失时间早,恢复速度快,重睑形态对称自然,患者满意度高,值得临床应用。 展开更多
关键词 改良park 重睑成形术 内眦开大术 单睑 内眦赘皮
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改良Park法重睑术与传统切开法重睑术治疗上睑松弛伴臃肿患者的效果对比
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作者 史迅 周彦鹏 李九旭 《临床医学工程》 2024年第4期431-432,共2页
目的探讨改良Park法重睑术与传统切开法重睑术治疗上睑松弛伴臃肿患者的效果。方法45例上睑松弛伴臃肿患者按治疗方法的不同分为对照组(传统切开法重睑术)和观察组(改良Park法重睑术),比较两组的手术情况、眼睑形态、修复满意度及并发... 目的探讨改良Park法重睑术与传统切开法重睑术治疗上睑松弛伴臃肿患者的效果。方法45例上睑松弛伴臃肿患者按治疗方法的不同分为对照组(传统切开法重睑术)和观察组(改良Park法重睑术),比较两组的手术情况、眼睑形态、修复满意度及并发症。结果观察组的手术时间、拆线时间及术后恢复时间均短于对照组,术后3个月的眼睑形态评分及修复满意度评分均高于对照组(P<0.05)。两组的并发症总发生率相比,差异无统计学意义(P>0.05)。结论与传统切开法重睑术相比,改良Park法重睑术治疗上睑松弛伴臃肿的效果更显著,安全性更高,可改善患者眼睑形态,提高修复满意度。 展开更多
关键词 上睑松弛 臃肿 改良park法重睑术 眼睑形态
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Characterisation of Human-Wildlife Conflicts around the Kahuzi-Biega National Park, Eastern Democratic Republic of Congo
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作者 Basubi Muke Matthieu Vwima Stany +3 位作者 Ayagirwe Basengere Rodrigue Mushagalusa Freddy Benjamin-Fink Nicole Bobo Kadiri Serge 《Journal of Environmental Protection》 2024年第3期343-356,共14页
The history of mankind contains so many illustrations of well-classified and violent struggles against various animals over crop production in agricultural fields, attacks on human life or competition in order to have... The history of mankind contains so many illustrations of well-classified and violent struggles against various animals over crop production in agricultural fields, attacks on human life or competition in order to have access to certain natural resources. The aim of this study is to characterise the human-wildlife conflicts that occur around the KBNP, especially with regard to primates. Surveys were carried out in 260 households selected using the snowball method. The results showed that human-wildlife conflicts around the KBNP are characterised by the destruction of crops in riparian fields by monkeys, chimpanzees and gorillas, the destruction of houses, physical attacks and zoonoses. Despite the conservation and protection measures for wildlife and local populations put in place by the Park’s managers, conflicts between local populations and the Park’s wild animals are still visible. These conflicts lead to the detention of wild animals by local people roaming in the villages and to poaching on the Park’s boundaries. The weakness of the community management policy on the part of the park managers and the resentment of the indigenous peoples towards the restriction of their access to natural resources are the major constraints on the sustainable management of conflicts between the local populations and the wild animals in the KBNP. The strategies for the sustainable resolution of human-wildlife conflicts around the KBNP must be geared towards and integrated into a community conservation approach. 展开更多
关键词 Community Conservation Human-Wildlife Conflict Kahuzi-Biega National park
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The Research on Open Sharing of Higher Education Park Based on Intelligent Security System
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作者 Yan Dong 《Journal of Computer and Communications》 2024年第3期101-106,共6页
The intelligent security system is a series of systems that use modern information technology means such as artificial intelligence, cloud computing, big data, face recognition to carry out comprehensive monitoring, e... The intelligent security system is a series of systems that use modern information technology means such as artificial intelligence, cloud computing, big data, face recognition to carry out comprehensive monitoring, early warning, prevention and control, disposal, etc, for security protection. It is the development trend of security system in the future, and it is also the basis for open sharing between higher education parks and universities. By using content analysis, unstructured interviews and other research methods, this paper deeply studies the feasibility and basic ideas of the construction of intelligent security system in Shahe Higher Education Park, and forms basic experience and typical practices through the project construction, which further promotes the more intelligent, standardized and scientific safety management in colleges and universities. It really provides an important theoretical basis and practical guidance for the opening and sharing between higher education parks and universities. 展开更多
关键词 Intelligent Security System Higher Education park Open Sharing
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基于障碍物和车位检测的单阶段多任务YOLO-Parking算法研究
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作者 张炳力 王焱辉 +3 位作者 潘泽昊 王怿昕 杨程磊 王欣雨 《合肥工业大学学报(自然科学版)》 CAS 北大核心 2024年第1期1-6,61,共7页
文章提出一种基于YOLOv4的端到端多任务网络模型用于自动泊车系统中的感知任务,以环视图像(around view monitor, AVM)作为网络输入,基于卷积网络提取图像特征信息,通过YOLO和DMPR-PS(directional marking-point regression-parking sl... 文章提出一种基于YOLOv4的端到端多任务网络模型用于自动泊车系统中的感知任务,以环视图像(around view monitor, AVM)作为网络输入,基于卷积网络提取图像特征信息,通过YOLO和DMPR-PS(directional marking-point regression-parking slot)检测头实现停车位与障碍物并行检测。在PS 2.0公开数据集上进行验证的结果表明,所提出的多任务检测方法能够同时检测停车位和障碍物,障碍物识别平均精度均值达到89.72%,车位识别查准率达到93.53%,网络检测速率为34.0帧/s,在满足自动泊车感知任务需求的同时提升了系统的检测效率。该文研究成果对自动泊车感知技术的发展具有一定的意义。 展开更多
关键词 自动泊车 环视图像(AVM) 多任务网络 障碍物识别 停车位识别
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基于Park变换和Teager能量算子的晶闸管逆变器保护新方法 被引量:1
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作者 金恩淑 耿梦炜 《东北电力大学学报》 2023年第3期8-15,共8页
在高压直流输电系统中,晶闸管逆变器直流差动保护误动于区外故障,以晶闸管逆变器作为研究对象,提出了基于Park变换和Teager能量算子的晶闸管逆变器保护新方法。首先,利用Park变换分析逆变器交流侧电流,建立和直流侧电流的平衡关系,提出... 在高压直流输电系统中,晶闸管逆变器直流差动保护误动于区外故障,以晶闸管逆变器作为研究对象,提出了基于Park变换和Teager能量算子的晶闸管逆变器保护新方法。首先,利用Park变换分析逆变器交流侧电流,建立和直流侧电流的平衡关系,提出主判据;其次,采用逆变器交流侧接地故障的零序电流和逆变器交流侧电流的Teager能量算子作为辅助判据;最后,通过PSCAD仿真将该保护和传统直流差动保护进行比较。结果表明:该保护可有效解决传统直流差动保护误动于区外故障的问题,对于直流差动保护不能动作区内的相间短路故障,该保护方法可正确动作。 展开更多
关键词 晶闸管逆变器 park变换 零序电流 TEAGER能量算子
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老年帕金森病患者血清PARK2、GFAP和BDNF表达对疾病分期和认知功能的评估
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作者 周小燕 杨丹 +2 位作者 张敏 雷蓉 任丽君 《中国老年学杂志》 CAS 北大核心 2023年第9期2142-2145,共4页
目的分析老年帕金森病患者血清人帕金森病蛋白(PARK)2、神经胶质纤维酸性蛋白(GFAP)和脑源性神经营养因子(BDNF)表达对患者疾病分期和认知功能的诊断意义。方法采用前瞻性研究方法,选取老年帕金森病患者80例为观察组,其中认知功能障碍... 目的分析老年帕金森病患者血清人帕金森病蛋白(PARK)2、神经胶质纤维酸性蛋白(GFAP)和脑源性神经营养因子(BDNF)表达对患者疾病分期和认知功能的诊断意义。方法采用前瞻性研究方法,选取老年帕金森病患者80例为观察组,其中认知功能障碍组45例,认知功能正常组35例;早期组26例,中期组21例,晚期组33例。另选取同期进行健康体检的志愿者80例为对照组,比较观察组及对照组、不同分级、不同认知功能障碍患者血清PARK2、GFAP和BDNF表达水平的差异,研究血清PARK2、GFAP和BDNF表达对疾病分期和认知功能的诊断意义。结果观察组PARK2水平显著低于对照组,GFAP和BDNF水平显著高于对照组(P<0.05);不同疾病进展患者血清PARK2、GFAP和BDNF水平差异有统计学意义(P<0.05),随着疾病进展,患者血清PARK2水平显著降低,GFAP和BDNF水平显著升高;认知障碍组血清PARK2显著低于对照组,GFAP和BDNF水平显著高于对照组(P<0.05);通过联合诊断效能进行分析,血清PARK2、GFAP和BDNF水平联合检测特异度显著高于单独检测;针对疾病进展患者,血清PARK2、GFAP和BDNF水平的临界值为0.77、2.05及1609.33 pg/ml。针对认知障碍患者,血清PARK2、GFAP和BDNF水平的临界值为0.85、1.71及1458.85 pg/ml。结论老年帕金森病患者血清PARK2、GFAP和BDNF表达对患者疾病分期和认知功能具有显著意义。 展开更多
关键词 帕金森病 人帕金森病蛋白(park)2 神经胶质纤维酸性蛋白(GFAP) 脑源性神经营养因子(BDNF)
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The Role of Deep Learning in Parking Space Identification and Prediction Systems
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作者 Faizan Rasheed Yasir Saleem +2 位作者 Kok-Lim Alvin Yau Yung-Wey Chong Sye Loong Keoh 《Computers, Materials & Continua》 SCIE EI 2023年第4期761-784,共24页
In today’s smart city transportation,traffic congestion is a vexing issue,and vehicles seeking parking spaces have been identified as one of the causes leading to approximately 40%of traffic congestion.Identifying pa... In today’s smart city transportation,traffic congestion is a vexing issue,and vehicles seeking parking spaces have been identified as one of the causes leading to approximately 40%of traffic congestion.Identifying parking spaces alone is insufficient because an identified available parking space may have been taken by another vehicle when it arrives,resulting in the driver’s frustration and aggravating traffic jams while searching for another parking space.This explains the need to predict the availability of parking spaces.Recently,deep learning(DL)has been shown to facilitate drivers to find parking spaces efficiently,leading to a promising performance enhancement in parking identification and prediction systems.However,no work reviews DL approaches applied to solve parking identification and prediction problems.Inspired by this gap,the purpose of this work is to investigate,highlight,and report on recent advances inDLapproaches applied to predict and identify the availability of parking spaces.Ataxonomy of DL-based parking identification and prediction systems is established as a methodology by classifying and categorizing existing literature,and by doing so,the salient and supportive features of different DL techniques for providing parking solutions are presented.Moreover,several open research challenges are outlined.This work identifies that there are various DL architectures,datasets,and performance measures used to address parking identification and prediction problems.Moreover,there are some open-source implementations available that can be used directly either to extend existing works or explore a new domain.This is the first short survey article that focuses on the use of DL-based techniques in parking identification and prediction systems for smart cities.This study concludes that although the deployment of DL in parking identification and prediction systems provides various benefits,the convergence of these two types of systems and DL brings about new issues that must be resolved in the near future. 展开更多
关键词 Convolutional neural network deep learning neural networks parking identification parking prediction smart city
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Transformation Design of Old Parks Based on Behavior Psychology: A Case Study of Hefei Xiaoyaojin Park
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作者 GE Juan CAO Menghan +3 位作者 CHEN Jiaxin HU Yueyue LI Quanjun LI Yinan 《Journal of Landscape Research》 2023年第5期35-40,共6页
City park undertakes the function of urban core green island. Hefei Xiaoyaojin Park providesa leisure and entertainment place for Hefei citizens. Although it has been continuously transformed andupgraded, there are st... City park undertakes the function of urban core green island. Hefei Xiaoyaojin Park providesa leisure and entertainment place for Hefei citizens. Although it has been continuously transformed andupgraded, there are still many places to be improved. Through behavior observation and questionnaire,the usage and satisfaction evaluation of tourists in Xiaoyaojin Park were obtained, and the transformationdesign of Xiaoyaojin Park was analyzed from the perspective of behavior psychology by analyzing thebehavior of tourists in different zones of Xiaoyaojin. Based on the premise of exploring the behaviorof tourists in different spaces, a city park environment that meets the needs of tourists can be created bypromoting the cultural context of the Three Kingdoms, improving the plant landscape and infrastructureof the site, optimizing the spatial function, and exploring the park design and transformation strategy that ismore in line with the needs of people, in order to provide new ideas for the future landscape transformationof Xiaoyaojin park, and offer reference suggestions for the future transformation design of old city parks. 展开更多
关键词 Behavior psychology Old park City park Environmental optimization
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