The possibility of an infectious origin in inflammatory bowel disease(IBD)has been postulated since the first description of Crohn’s disease(CD).Many observations implicate bacteria as a trigger for the development o...The possibility of an infectious origin in inflammatory bowel disease(IBD)has been postulated since the first description of Crohn’s disease(CD).Many observations implicate bacteria as a trigger for the development of CD:lesions occur in regions with higher bacterial concentrations;aphthous ulcers occur in Peyer’s patches;inflammation resolves when the fecal stream is diverted and is reactivated following reinfusion ofbowel contents;severity of the disease is correlated with bacterial density in the mucosa;granulomas can contain bacteria;and susceptible mice raised in germfree conditions develop inflammation when bacteria are introduced in the 1990’s,several studies sought to establish a relationship with viral infections and the onset of IBD,finally concluding that no direct link had been demonstrated.In the past fifteen years,evidence relating IBD pathogenesis to Mycobacterium avium paratuberculosis,salmonella,campylobacter,etc.,has been found.The tendency now under discussion to regard microbiota as the primary catalyst has led to the latest studies on microbiota as pathogens,focusing on Escherichia coli,mainly in ileal CD.The present review discusses the literature available on these"bugs".展开更多
To evaluate the clinical signification of coagulation factors(Ⅱ Ⅴ Ⅶ Ⅷ Ⅸ Ⅹ),Fibrinogen(Fib),PT and APTT in patients with hepatit is and cirrhosis.Method: 108 patients′ plasmas and 30 plasmas from normal subjec t...To evaluate the clinical signification of coagulation factors(Ⅱ Ⅴ Ⅶ Ⅷ Ⅸ Ⅹ),Fibrinogen(Fib),PT and APTT in patients with hepatit is and cirrhosis.Method: 108 patients′ plasmas and 30 plasmas from normal subjec ts were determined.Results: The lengthed PT and APTT were found in samples from 80. 56% and 71.30% patients with hepatitis and cirrhosis.Plasmas levels of Fib incre ased in patients with acute hepatitis,remained normal in patients with chronic p ersistent hepatitis,but decreased significantly in patients with chronic active hepatitis,cirrhosis and severe hepatitis( P< 0.05 ).The activity of coagula tion factors Ⅱ Ⅴ Ⅶ Ⅸ Ⅹ were lower than that in control group( P<0.05～0.001 ) ;but the activity of coagulation factor Ⅷ was higher than that in control group ( P<0.01 ).Conclusion: The studies indicated that the quantitative determin ation of coagulation activity had diagnostic and prognositc value in hepatitis a nd cirrhosis.展开更多
Selective coronary angiography and intervention with injection of contrast medium into the coronary arteries has become very common in dealing with coronary cardiac diseases. The excretion of contrast medium through k...Selective coronary angiography and intervention with injection of contrast medium into the coronary arteries has become very common in dealing with coronary cardiac diseases. The excretion of contrast medium through kidneys may lead to acute renal functional insufficiency,especially for those suffering from chronic nephropathy,diabetes and cardiac functional disorder to form the so called"contrast medium nephropathy"which is considered as the number second drug induced acute renal functional failure. Although routine preventive measure including low osmotic contrast mediun and fine hydrotherapy have been taken,14% incidenes still occur with renal functional damage. The majority could be reversible but the minority needs emergent hemodialysis or even with persistant renal functional damage in a few ones. (J Intervent Radiol,2006,15: 382-384)展开更多
To study the role of interleukin(IL)-10 in acute-graft-versus-host disease (aGVHD) and graft rejection Methods Serum concentrations of IL-10 in 28 patients who underwent allogeneic hematopoietic stem cell transpla...To study the role of interleukin(IL)-10 in acute-graft-versus-host disease (aGVHD) and graft rejection Methods Serum concentrations of IL-10 in 28 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) were measured by enzymed-linked immunosorbent assay (ELISA) IL-10 gene expression in peripheral mononuclear cells was measured by reverse-transcriptase polymerase chain reaction (RT-PCR) after transplantation Results Seven patients developed grade Ⅰ GVHD, 7 patients developed grade Ⅱ-Ⅳ GVHD, 4 patients had graft rejection Before transplantation, the concentrations of IL-10 were higher in patients who later did not developed aGVHD After transplantation, IL-10 levels increased in patients without aGVHD, but decreased in patients with aGVHD or graft rejection And IL-10mRNA was more frequent in patients without aGVHD compared to those with aGVHD Conclusions IL-10 plays a negative role in the development of aGVHD and graft rejection展开更多
文摘The possibility of an infectious origin in inflammatory bowel disease(IBD)has been postulated since the first description of Crohn’s disease(CD).Many observations implicate bacteria as a trigger for the development of CD:lesions occur in regions with higher bacterial concentrations;aphthous ulcers occur in Peyer’s patches;inflammation resolves when the fecal stream is diverted and is reactivated following reinfusion ofbowel contents;severity of the disease is correlated with bacterial density in the mucosa;granulomas can contain bacteria;and susceptible mice raised in germfree conditions develop inflammation when bacteria are introduced in the 1990’s,several studies sought to establish a relationship with viral infections and the onset of IBD,finally concluding that no direct link had been demonstrated.In the past fifteen years,evidence relating IBD pathogenesis to Mycobacterium avium paratuberculosis,salmonella,campylobacter,etc.,has been found.The tendency now under discussion to regard microbiota as the primary catalyst has led to the latest studies on microbiota as pathogens,focusing on Escherichia coli,mainly in ileal CD.The present review discusses the literature available on these"bugs".
文摘To evaluate the clinical signification of coagulation factors(Ⅱ Ⅴ Ⅶ Ⅷ Ⅸ Ⅹ),Fibrinogen(Fib),PT and APTT in patients with hepatit is and cirrhosis.Method: 108 patients′ plasmas and 30 plasmas from normal subjec ts were determined.Results: The lengthed PT and APTT were found in samples from 80. 56% and 71.30% patients with hepatitis and cirrhosis.Plasmas levels of Fib incre ased in patients with acute hepatitis,remained normal in patients with chronic p ersistent hepatitis,but decreased significantly in patients with chronic active hepatitis,cirrhosis and severe hepatitis( P< 0.05 ).The activity of coagula tion factors Ⅱ Ⅴ Ⅶ Ⅸ Ⅹ were lower than that in control group( P<0.05～0.001 ) ;but the activity of coagulation factor Ⅷ was higher than that in control group ( P<0.01 ).Conclusion: The studies indicated that the quantitative determin ation of coagulation activity had diagnostic and prognositc value in hepatitis a nd cirrhosis.
文摘Selective coronary angiography and intervention with injection of contrast medium into the coronary arteries has become very common in dealing with coronary cardiac diseases. The excretion of contrast medium through kidneys may lead to acute renal functional insufficiency,especially for those suffering from chronic nephropathy,diabetes and cardiac functional disorder to form the so called"contrast medium nephropathy"which is considered as the number second drug induced acute renal functional failure. Although routine preventive measure including low osmotic contrast mediun and fine hydrotherapy have been taken,14% incidenes still occur with renal functional damage. The majority could be reversible but the minority needs emergent hemodialysis or even with persistant renal functional damage in a few ones. (J Intervent Radiol,2006,15: 382-384)
基金ThisstudywassupportedbyagrantfromNationalNaturalSciencesFoundationofChina (No 39870 71 0 )
文摘To study the role of interleukin(IL)-10 in acute-graft-versus-host disease (aGVHD) and graft rejection Methods Serum concentrations of IL-10 in 28 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) were measured by enzymed-linked immunosorbent assay (ELISA) IL-10 gene expression in peripheral mononuclear cells was measured by reverse-transcriptase polymerase chain reaction (RT-PCR) after transplantation Results Seven patients developed grade Ⅰ GVHD, 7 patients developed grade Ⅱ-Ⅳ GVHD, 4 patients had graft rejection Before transplantation, the concentrations of IL-10 were higher in patients who later did not developed aGVHD After transplantation, IL-10 levels increased in patients without aGVHD, but decreased in patients with aGVHD or graft rejection And IL-10mRNA was more frequent in patients without aGVHD compared to those with aGVHD Conclusions IL-10 plays a negative role in the development of aGVHD and graft rejection
