The double moral hazard of "company + farmer" and the time preference cost of company and farmer was analyzed. According to static game model, it re-vealed that the reason for low compliance rate of "company + fa...The double moral hazard of "company + farmer" and the time preference cost of company and farmer was analyzed. According to static game model, it re-vealed that the reason for low compliance rate of "company + farmer" model was the existence of market risk, namely, the fluctuation of market price, and the stable market price in contracts was actualy a kind of interval, instead of a specific value. Furthermore, the effect of default penalty, market transaction cost and time prefer-ence cost on the stability of contract was studied. The results showed that default penalty, market transaction cost and time preference cost had positive influence on the price interval range of a contract.展开更多
The photodissociation dynamics of 2-iodotoluene following excitation at 266 nm have been investigated employing femtosecond time-resolved mass spectrometry. The photofragments are detected by multiphoton ionization us...The photodissociation dynamics of 2-iodotoluene following excitation at 266 nm have been investigated employing femtosecond time-resolved mass spectrometry. The photofragments are detected by multiphoton ionization using an intense laser field centered at 800 nm. A dissociation time of 3804-50 fs was measured from the rising time of the co-fragments of toluene radical (C7H7) and iodine atom (I), which is attributed to the averaged time needed for the C-I bond breaking for the simultaneously excited nσ and ππ* states by 266 nm pump light. In addition, a probe light centered at 298.23 nm corresponding to resonance wavelength of ground-state iodine atom is used to selectively ionize ground-state iodine atoms generated from the dissociation of initially populated hσ* and ππ* states. And a rise time of 4004-50 fs is extracted from the fitting of time-dependent I+ transient, which is in agreement with the dissociation time obtained by multiphoton ionization with 800 nm, suggesting that the main dissociative products are ground-state iodine atoms.展开更多
Recently, canopy transpiration (Ec) has been often estimated by xylem sap-flow measurements. However, there is a significant time lag between sap flow measured at the base of the stem and canopy transpiration due to...Recently, canopy transpiration (Ec) has been often estimated by xylem sap-flow measurements. However, there is a significant time lag between sap flow measured at the base of the stem and canopy transpiration due to the capacitive exchange between the transpiration stream and stem water storage. Significant errors will be introduced in canopy conductance (gc) and canopy transpiration estimation if the time lag is neglected. In this study, a cross-correlation analysis was used to quantify the time lag, and the sap flowbased transpiration was measured to pararneterize Jarvistype models of gc and thus to simulate Ec of Populus cathayana using the Penman-Monteith equation. The results indicate that solar radiation (Rs) and vapor pressure deficit (VPD) are not fully coincident with sap flow and have an obvious lag effect; the sap flow lags behind Rs and precedes VPD, and there is a 1-h time shift between Eo and sap flow in the 30-min interval data set. A parameterized Jarvis-type gc model is suitable to predict P. cathayana transpiration and explains more than 80% of the variation observed in go, and the relative error was less than 25%, which shows a preferable simulation effect. The root mean square error (RMSEs) between the predicted and measured Ec were 1.91×10^-3 (with the time lag) and 3.12×10^-3cm h^-1 (without the time lag). More importantly, Ec simulation precision that incorporates time lag is improved by 6% compared to the results without the time lag, with the mean relative error (MRE) of only 8.32% and the mean absolute error (MAE) of 1.48 × 10^-3 cm h^-1.展开更多
Recent advances in intelligent transportation system allow traffic safety studies to extend from historic data-based analyses to real-time applications. The study presents a new method to predict crash likelihood with...Recent advances in intelligent transportation system allow traffic safety studies to extend from historic data-based analyses to real-time applications. The study presents a new method to predict crash likelihood with traffic data collected by discrete loop detectors as well as the web-crawl weather data. Matched case-control method and support vector machines (SVMs) technique were employed to identify the risk status. The adaptive synthetic over-sampling technique was applied to solve the imbalanced dataset issues. Random forest technique was applied to select the contributing factors and avoid the over-fitting issues. The results indicate that the SVMs classifier could successfully classify 76.32% of the crashes on the test dataset and 87.52% of the crashes on the overall dataset, which were relatively satisfactory compared with the results of the previous studies. Compared with the SVMs classifier without the data, the SVMs classifier with the web-crawl weather data increased the crash prediction accuracy by 1.32% and decreased the false alarm rate by 1.72%, showing the potential value of the massive web weather data. Mean impact value method was employed to evaluate the variable effects, and the results are identical with the results of most of previous studies. The emerging technique based on the discrete traffic data and web weather data proves to be more applicable on real- time safety management on freeways.展开更多
In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-d...In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-dimensional nonlinear time fractional thermal diffusion model.The time Caputo fractional derivative is approximated by using the L2-1formula,the first-order derivative and nonlinear term are discretized by some second-order approximation formulas,and the quadratic finite element is used to approximate the spatial direction.The error accuracy O(h3+t2)is obtained,which is verified by the numerical results.展开更多
It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventual...It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventually blow up or explode in finite time. If the drift and diffusion functions are globally Lipschitz, linear growth may still be experienced, as well as a possible blow-up of solutions in finite time. In this paper, a nonlinear scalar delay differential equation with a constant time lag is perturbed by a multiplicative Ito-type time - space white noise to form a stochastic Fokker-Planck delay differential equation. It is established that no explosion is possible in the presence of any intrinsically slow time - space white noise of Ito - type as manifested in the resulting stochastic Fokker- Planck delay differential equation. Time - space white noise has a role to play since the solution of the classical nonlinear equation without it still exhibits explosion.展开更多
Based on the research technology of scholars' prediction of farmers' income and the data of per capita annual net income in rural households in Henan Statistical Yearbook from 1979 to 2009,it is found that tim...Based on the research technology of scholars' prediction of farmers' income and the data of per capita annual net income in rural households in Henan Statistical Yearbook from 1979 to 2009,it is found that time series of farmers' income is in accordance with I(2)non-stationary process.The order-determination and identification of the model are achieved by adopting the correlogram-based analytical method of Box-Jenkins.On the basis of comparing a group of model properties with different parameters,model ARIMA(4,2,2)is built up.The testing result shows that the residual error of the selected model is white noise and accords with the normal distribution,which can be used to predict farmers' income.The model prediction indicates that income in rural households will continue to increase from 2009 to 2012 and will reach the value of 2 282.4,2 502.9,2 686.9 and 2 884.5 respectively.The growth speed will go down from fast to slow with weak sustainability.展开更多
Shaw's method used to correlate 40 sections across the Permo-Triassic boundary in South China is applied in the paper. Two steps are adopted to get an Integral Composite Section (ICS) by synthesizing these data : ...Shaw's method used to correlate 40 sections across the Permo-Triassic boundary in South China is applied in the paper. Two steps are adopted to get an Integral Composite Section (ICS) by synthesizing these data : First , South China is divided into five areas and composite section developed for each area . Then the second step . the Changxing composite section is regarded as a composite standard (CSRS) while the ICS is produced by matching the CSRS with composite sections of the other areas. Three biozones in the Changxingian and two biozones in the Griesbachian can be discerned on the basis of computing Z values in the ICS. These biozones are marked by the Z values which quantitatively represent their time ranges ; therefore , they may increase accuracy of stratigraphic time correlation . The mass extinction at the end of the Permian is an abrupt event that is supported by the relative rate of extinction near the P/T boundary . About 90% of invertebrate species died out by the end of the Permian . The duration of the mass extinction is rather short ,approximately 0.018Ma .展开更多
Forest losses or gains have long been recognized as critical processes modulating the carbon flux between the biosphere and the atmosphere. Timely, accurate and spatially explicit information on forest disturbance and...Forest losses or gains have long been recognized as critical processes modulating the carbon flux between the biosphere and the atmosphere. Timely, accurate and spatially explicit information on forest disturbance and recovery history is required for assessing the effectiveness of existing forest management. The major objectives of our research focused on testing the mapping efficacy of the vegetation change tracker (VCT) model over a forested area in China. We used a new version of VCT algorithm built upon the Landsat time series stacks (LTSS). The LTSS consisted of yearly image acquisitions to map forest disturbance history from 1987 to 2011 over the Ning-Zhen Mountains, Jiangsu Province of east China. The LTSS consisted of TM and ETM+ scenes with different projec- tions due to distinct data sources (Beijing remote sensing ground station and the USGS EROS Center). The valida- tion results of the disturbance year maps showed that most spatial agreement measures ranged from 70 to 86 %, comparable with the VCT accuracies reported for many places in USA. Very low accuracies were identified in 1995 (38.3 %) and 1992 (56.2 %) in the current analysis. These resulted from the insensitivity of the VCT algorithm to detect low intensity disturbances and also from the mis- registration errors of the image pairs. Major forest distur- bance types existing in our study area were identified as agricultural expansion (39.8 %), urbanization (24.9 %), forest management practice (19.3 %), and mining (12.8 %). In general, there was a gradual decreasing trend in forest cover throughout this region, caused principally by China's economic, demographic, environmental and political policies and decisions, as well as some weather events. While VCT has largely been used to assess long term changes and trends in the USA, it has great potential for assessing landscape level change elsewhere throughout the world.展开更多
We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin(2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immed...We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin(2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou Medical University in China received right middle cerebral artery occlusion for 120 minutes, and were treated with 2-BFI(3 mg/kg) through the caudal vein at 0, 1, 3, 5, 7, and 9 hours after reperfusion. Neurological function was assessed using the Longa's method. Infarct volume was measured by 2,3,5-triphenyltetrazolium chloride assay. Morphological changes in the cortical penumbra were observed by hematoxylin-eosin staining under transmission electron microscopy. The apoptosis levels in the ipsilateral cortex were examined with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL) assay. The protein expression of Bcl-2 and BAX was detected using immunohistochemistry. We found the following: Treatment with 2-BFI within 5 hours after reperfusion obviously improved neurological function. Administering 2-BFI within 9 hours after ischemia/reperfusion decreased infarct volume and alleviated apoptosis. 2-BFI administration at different time points after reperfusion alleviated the pathological damage of the ischemic penumbra and reduced the number of apoptotic neurons, but the protective effect was more obvious when administered within 5 hours. Administration of 2-BFI within 5 hours after reperfusion remarkably increased Bcl-2 expression and decreased BAX expression. To conclude, 2-BFI shows potent neuroprotective effects when administered within 5 hours after reperfusion, seemingly by up-regulating Bcl-2 and down-regulating BAX expression. The time window provided clinical potential for ischemic stroke by 2-BFI.展开更多
A Farmer ion chamber with an air cavity volume is the most widely used dosimeter for accurate dose determinations in radiotherapy. The quantity of ionization in the cavity volume occurred a given radiation dose has to...A Farmer ion chamber with an air cavity volume is the most widely used dosimeter for accurate dose determinations in radiotherapy. The quantity of ionization in the cavity volume occurred a given radiation dose has to be corrected to the cavity air temperature according to a dosimetry protocol because the mass of air in the cavity volume is subject to atmospheric variations. In the present study, we aim to measure the thermal equilibration time in the cavity volume of a Farmer ion chamber for the routine dosimetry. The Farmer ion chamber’s electrode was replaced by a thin thermocouple and coated by the PMMA for a waterproofing so that the measurement of the temperature in the cavity performed in water. As a result of the measurement, A Farmer ion chamber in thermal equilibrium with waterproofing equilibrates rapidly, followed by an exponential fall-off. In water, equilibration to less than 10% of the initial temperature difference required only a few minutes. Thermal equilibrium time is hardly affected by the room temperature change.展开更多
This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition is...This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition isobtained for each subsystem and overall system to be sta-bilizable via linear memoryless state feedback robust de-centralized controllers.The results depend on the size of the delays and are given in terms of linear matrix ine-qualities,so they are less conservative than those of delay-independent.Moreover,matching condition is not a necessary condition.Finally,an example is presented to illustrative the effectiveness of the proposed method.展开更多
The non-stationary buffeting response of long span suspension bridge in time domain under strong wind loading is computed. Modeling method for generating non-stationary fluctuating winds with probabilistic model for n...The non-stationary buffeting response of long span suspension bridge in time domain under strong wind loading is computed. Modeling method for generating non-stationary fluctuating winds with probabilistic model for non-stationary strong wind fields is first presented. Non-stationary wind forces induced by strong winds on bridge deck and tower are then given a brief introduction. Finally,Non-stationary buffeting response of Pulite Bridge in China,a long span suspension bridge,is computed by using ANSYS software under four working conditions with different combination of time-varying mean wind and time-varying variance. The case study further confirms that it is necessity of considering non-stationary buffeting response for long span suspension bridge under strong wind loading,rather than only stationary buffeting response.展开更多
基金Supported by Humanities and Social Sciences of Ministry of Education(12YJC630050)Soft Science Bidding Project of Ministry of Agriculture(20140203)+1 种基金Jiangxi Soft Science Fund(20141BBA10065)Jiangxi’s Jiangxi Provincial Education Department(GJJ13727)~~
文摘The double moral hazard of "company + farmer" and the time preference cost of company and farmer was analyzed. According to static game model, it re-vealed that the reason for low compliance rate of "company + farmer" model was the existence of market risk, namely, the fluctuation of market price, and the stable market price in contracts was actualy a kind of interval, instead of a specific value. Furthermore, the effect of default penalty, market transaction cost and time prefer-ence cost on the stability of contract was studied. The results showed that default penalty, market transaction cost and time preference cost had positive influence on the price interval range of a contract.
基金This work was supported by the National Basic Research Program of China (973 Program) (No.2013CB922200) and the National Natural Science Foundation of China (No.91121006, No.21273274, No.21173256, and No.21303255).
文摘The photodissociation dynamics of 2-iodotoluene following excitation at 266 nm have been investigated employing femtosecond time-resolved mass spectrometry. The photofragments are detected by multiphoton ionization using an intense laser field centered at 800 nm. A dissociation time of 3804-50 fs was measured from the rising time of the co-fragments of toluene radical (C7H7) and iodine atom (I), which is attributed to the averaged time needed for the C-I bond breaking for the simultaneously excited nσ and ππ* states by 266 nm pump light. In addition, a probe light centered at 298.23 nm corresponding to resonance wavelength of ground-state iodine atom is used to selectively ionize ground-state iodine atoms generated from the dissociation of initially populated hσ* and ππ* states. And a rise time of 4004-50 fs is extracted from the fitting of time-dependent I+ transient, which is in agreement with the dissociation time obtained by multiphoton ionization with 800 nm, suggesting that the main dissociative products are ground-state iodine atoms.
基金supported by the Qinghai province natural science foundation project(2015-ZJ-902)the Qinghai province science and technology plan program(2014-NK-A4-4)
文摘Recently, canopy transpiration (Ec) has been often estimated by xylem sap-flow measurements. However, there is a significant time lag between sap flow measured at the base of the stem and canopy transpiration due to the capacitive exchange between the transpiration stream and stem water storage. Significant errors will be introduced in canopy conductance (gc) and canopy transpiration estimation if the time lag is neglected. In this study, a cross-correlation analysis was used to quantify the time lag, and the sap flowbased transpiration was measured to pararneterize Jarvistype models of gc and thus to simulate Ec of Populus cathayana using the Penman-Monteith equation. The results indicate that solar radiation (Rs) and vapor pressure deficit (VPD) are not fully coincident with sap flow and have an obvious lag effect; the sap flow lags behind Rs and precedes VPD, and there is a 1-h time shift between Eo and sap flow in the 30-min interval data set. A parameterized Jarvis-type gc model is suitable to predict P. cathayana transpiration and explains more than 80% of the variation observed in go, and the relative error was less than 25%, which shows a preferable simulation effect. The root mean square error (RMSEs) between the predicted and measured Ec were 1.91×10^-3 (with the time lag) and 3.12×10^-3cm h^-1 (without the time lag). More importantly, Ec simulation precision that incorporates time lag is improved by 6% compared to the results without the time lag, with the mean relative error (MRE) of only 8.32% and the mean absolute error (MAE) of 1.48 × 10^-3 cm h^-1.
基金supported by the National Natural Science Foundation (71301119)the Shanghai Natural Science Foundation (12ZR1434100)
文摘Recent advances in intelligent transportation system allow traffic safety studies to extend from historic data-based analyses to real-time applications. The study presents a new method to predict crash likelihood with traffic data collected by discrete loop detectors as well as the web-crawl weather data. Matched case-control method and support vector machines (SVMs) technique were employed to identify the risk status. The adaptive synthetic over-sampling technique was applied to solve the imbalanced dataset issues. Random forest technique was applied to select the contributing factors and avoid the over-fitting issues. The results indicate that the SVMs classifier could successfully classify 76.32% of the crashes on the test dataset and 87.52% of the crashes on the overall dataset, which were relatively satisfactory compared with the results of the previous studies. Compared with the SVMs classifier without the data, the SVMs classifier with the web-crawl weather data increased the crash prediction accuracy by 1.32% and decreased the false alarm rate by 1.72%, showing the potential value of the massive web weather data. Mean impact value method was employed to evaluate the variable effects, and the results are identical with the results of most of previous studies. The emerging technique based on the discrete traffic data and web weather data proves to be more applicable on real- time safety management on freeways.
基金the National Natural Science Fund(11661058,11761053)Natural Science Fund of Inner Mongolia Autonomous Region(2016MS0102,2017MS0107)+1 种基金Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT-17-A07)National Undergraduate Innovative Training Project of Inner Mongolia University(201710126026).
文摘In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-dimensional nonlinear time fractional thermal diffusion model.The time Caputo fractional derivative is approximated by using the L2-1formula,the first-order derivative and nonlinear term are discretized by some second-order approximation formulas,and the quadratic finite element is used to approximate the spatial direction.The error accuracy O(h3+t2)is obtained,which is verified by the numerical results.
文摘It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventually blow up or explode in finite time. If the drift and diffusion functions are globally Lipschitz, linear growth may still be experienced, as well as a possible blow-up of solutions in finite time. In this paper, a nonlinear scalar delay differential equation with a constant time lag is perturbed by a multiplicative Ito-type time - space white noise to form a stochastic Fokker-Planck delay differential equation. It is established that no explosion is possible in the presence of any intrinsically slow time - space white noise of Ito - type as manifested in the resulting stochastic Fokker- Planck delay differential equation. Time - space white noise has a role to play since the solution of the classical nonlinear equation without it still exhibits explosion.
基金Supported by the Planned Project of"Studies on Institutional Innovation of Farml and Property Rights in the Core Area of Grain Production"Launched by Philosophy and Social Sciences in Henan Province
文摘Based on the research technology of scholars' prediction of farmers' income and the data of per capita annual net income in rural households in Henan Statistical Yearbook from 1979 to 2009,it is found that time series of farmers' income is in accordance with I(2)non-stationary process.The order-determination and identification of the model are achieved by adopting the correlogram-based analytical method of Box-Jenkins.On the basis of comparing a group of model properties with different parameters,model ARIMA(4,2,2)is built up.The testing result shows that the residual error of the selected model is white noise and accords with the normal distribution,which can be used to predict farmers' income.The model prediction indicates that income in rural households will continue to increase from 2009 to 2012 and will reach the value of 2 282.4,2 502.9,2 686.9 and 2 884.5 respectively.The growth speed will go down from fast to slow with weak sustainability.
文摘Shaw's method used to correlate 40 sections across the Permo-Triassic boundary in South China is applied in the paper. Two steps are adopted to get an Integral Composite Section (ICS) by synthesizing these data : First , South China is divided into five areas and composite section developed for each area . Then the second step . the Changxing composite section is regarded as a composite standard (CSRS) while the ICS is produced by matching the CSRS with composite sections of the other areas. Three biozones in the Changxingian and two biozones in the Griesbachian can be discerned on the basis of computing Z values in the ICS. These biozones are marked by the Z values which quantitatively represent their time ranges ; therefore , they may increase accuracy of stratigraphic time correlation . The mass extinction at the end of the Permian is an abrupt event that is supported by the relative rate of extinction near the P/T boundary . About 90% of invertebrate species died out by the end of the Permian . The duration of the mass extinction is rather short ,approximately 0.018Ma .
基金funded by the following grants:the Forestry Public Welfare Project(201304208)the‘‘948’’Project sponsored by the State Forestry Administration(SFA)of China(2014-4-25)+4 种基金the National Natural Science Foundation of China(31270587,31100414)the PAPD(Priority Academic Program Development)of Jiangsu provincial universitiesperformed while the lead author held a scholarship sponsored the CSC(China Scholarship Council)(201208320553)at the department of Geographical Sciences,University of Marylandawardee of the 2012 Youth Backbone Teachers Support Plan of Jiangsu Provincethe 2012 Youth Talents Support Plan of Nanjing Forestry University
文摘Forest losses or gains have long been recognized as critical processes modulating the carbon flux between the biosphere and the atmosphere. Timely, accurate and spatially explicit information on forest disturbance and recovery history is required for assessing the effectiveness of existing forest management. The major objectives of our research focused on testing the mapping efficacy of the vegetation change tracker (VCT) model over a forested area in China. We used a new version of VCT algorithm built upon the Landsat time series stacks (LTSS). The LTSS consisted of yearly image acquisitions to map forest disturbance history from 1987 to 2011 over the Ning-Zhen Mountains, Jiangsu Province of east China. The LTSS consisted of TM and ETM+ scenes with different projec- tions due to distinct data sources (Beijing remote sensing ground station and the USGS EROS Center). The valida- tion results of the disturbance year maps showed that most spatial agreement measures ranged from 70 to 86 %, comparable with the VCT accuracies reported for many places in USA. Very low accuracies were identified in 1995 (38.3 %) and 1992 (56.2 %) in the current analysis. These resulted from the insensitivity of the VCT algorithm to detect low intensity disturbances and also from the mis- registration errors of the image pairs. Major forest distur- bance types existing in our study area were identified as agricultural expansion (39.8 %), urbanization (24.9 %), forest management practice (19.3 %), and mining (12.8 %). In general, there was a gradual decreasing trend in forest cover throughout this region, caused principally by China's economic, demographic, environmental and political policies and decisions, as well as some weather events. While VCT has largely been used to assess long term changes and trends in the USA, it has great potential for assessing landscape level change elsewhere throughout the world.
基金supported by the National Natural Science Foundation of China,No.81571114 and 81771267(to ZH)the National Science Funds for Distinguished Youth Scholars of China,No.81325007(to XMJ)+2 种基金the Distinguished Professor of Cheung Kong Scholars Program in China,No.T2014251(to XMJ)the Wenzhou Municipal Sci-Tec Bureau Programs in China,No.Y20120154(to ZZ) and Y20140686(to ZH)the Projects of International Cooperation and Exchanges National Natural Science Foundation of China,No.81620108011(to XMJ)
文摘We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin(2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou Medical University in China received right middle cerebral artery occlusion for 120 minutes, and were treated with 2-BFI(3 mg/kg) through the caudal vein at 0, 1, 3, 5, 7, and 9 hours after reperfusion. Neurological function was assessed using the Longa's method. Infarct volume was measured by 2,3,5-triphenyltetrazolium chloride assay. Morphological changes in the cortical penumbra were observed by hematoxylin-eosin staining under transmission electron microscopy. The apoptosis levels in the ipsilateral cortex were examined with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL) assay. The protein expression of Bcl-2 and BAX was detected using immunohistochemistry. We found the following: Treatment with 2-BFI within 5 hours after reperfusion obviously improved neurological function. Administering 2-BFI within 9 hours after ischemia/reperfusion decreased infarct volume and alleviated apoptosis. 2-BFI administration at different time points after reperfusion alleviated the pathological damage of the ischemic penumbra and reduced the number of apoptotic neurons, but the protective effect was more obvious when administered within 5 hours. Administration of 2-BFI within 5 hours after reperfusion remarkably increased Bcl-2 expression and decreased BAX expression. To conclude, 2-BFI shows potent neuroprotective effects when administered within 5 hours after reperfusion, seemingly by up-regulating Bcl-2 and down-regulating BAX expression. The time window provided clinical potential for ischemic stroke by 2-BFI.
文摘A Farmer ion chamber with an air cavity volume is the most widely used dosimeter for accurate dose determinations in radiotherapy. The quantity of ionization in the cavity volume occurred a given radiation dose has to be corrected to the cavity air temperature according to a dosimetry protocol because the mass of air in the cavity volume is subject to atmospheric variations. In the present study, we aim to measure the thermal equilibration time in the cavity volume of a Farmer ion chamber for the routine dosimetry. The Farmer ion chamber’s electrode was replaced by a thin thermocouple and coated by the PMMA for a waterproofing so that the measurement of the temperature in the cavity performed in water. As a result of the measurement, A Farmer ion chamber in thermal equilibrium with waterproofing equilibrates rapidly, followed by an exponential fall-off. In water, equilibration to less than 10% of the initial temperature difference required only a few minutes. Thermal equilibrium time is hardly affected by the room temperature change.
基金China Postdoctotral Foundation and Shanghai Postdoctoral Foundation
文摘This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition isobtained for each subsystem and overall system to be sta-bilizable via linear memoryless state feedback robust de-centralized controllers.The results depend on the size of the delays and are given in terms of linear matrix ine-qualities,so they are less conservative than those of delay-independent.Moreover,matching condition is not a necessary condition.Finally,an example is presented to illustrative the effectiveness of the proposed method.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51408174)Anhui Provincial Natural Science Foundation(Grant No.1408085QE95)+1 种基金China Postdoctoral Science Foundation(Grant No.2013M540511 and 2015T80652)Key University Science Research Project of Anhui Province(Grant No.KJ2016A294)
文摘The non-stationary buffeting response of long span suspension bridge in time domain under strong wind loading is computed. Modeling method for generating non-stationary fluctuating winds with probabilistic model for non-stationary strong wind fields is first presented. Non-stationary wind forces induced by strong winds on bridge deck and tower are then given a brief introduction. Finally,Non-stationary buffeting response of Pulite Bridge in China,a long span suspension bridge,is computed by using ANSYS software under four working conditions with different combination of time-varying mean wind and time-varying variance. The case study further confirms that it is necessity of considering non-stationary buffeting response for long span suspension bridge under strong wind loading,rather than only stationary buffeting response.