Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzhei...Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease development.To do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of age.Twelve-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 mice.Notably,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 mice.These findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.展开更多
With the transformation of society and the deepening of reform, the government＇s emphasis on public service level gradually increased, arises at the historic moment of women in social organization to participate in s...With the transformation of society and the deepening of reform, the government＇s emphasis on public service level gradually increased, arises at the historic moment of women in social organization to participate in social management and service ofgrassroots women play an important role on the stage. Women social organizations in jiangsu province to grow faster, quantity stability has increased year by year, widely participate in social services, in the ease of social contradictions, providing public services, safeguard women＇s rights has played a unique role. But at the same time also face the system is not sound, management is not standard, and all kinds of resources are scarce, etc. Women social organizations must through the standardization of the management and operation, actively integrating the resource of inside and outside the organization improve the survival and development environment, so as to promote their own development and perfection, a greater extent play a positive role in social and public services.展开更多
The BRICS political parties,think tanks and civil society organizations Forum was held in Fuzhou,capital of southeast China’s Fujian Province,June 11-12,2017.The forum drew over 400 participants from BRICS and other ...The BRICS political parties,think tanks and civil society organizations Forum was held in Fuzhou,capital of southeast China’s Fujian Province,June 11-12,2017.The forum drew over 400 participants from BRICS and other developing countries.Heads of political parties,think tanks and civil society organiza-展开更多
Single-atom catalysts(SACs)have received enormous attention in the field of catalysis due to their inherent mer-its,such as nearly 100%atomic efficiency,environmental friendliness,and unique physicochemical properties...Single-atom catalysts(SACs)have received enormous attention in the field of catalysis due to their inherent mer-its,such as nearly 100%atomic efficiency,environmental friendliness,and unique physicochemical properties.The emerging SACs have facilitated the development and advancement of catalysis.The rapidly increasing ap-plications of SACs in various fields,including oxygen evolution reaction,organic synthesis,hydrogen evolution reaction,and CO_(2) reduction,reflect their enormous potential.Recently,SACs have been extensively used in per-sulfate(PS)activation for refractory organic pollutants degradation in the aqueous environment.SACs exhibit distinct advantages of both homogeneous and heterogeneous catalysis,demonstrating a prospective application in PS activation.This review first introduces the synthesis and characterization schemes of SACs in PS activa-tion.Second,the factors influencing PS activation by SACs,including coordination numbers,type of coordination atoms,the spin state of metal sites,type of carriers,and the loading amount of metal atoms,are described.Third,the applications and activation mechanisms of SACs are summarized.Finally,the opportunities and challenges confronted by SACs and their future development prospects in advanced oxidation processes(AOPs)are put forward.展开更多
Amine modification is an effective strategy to improve the H_(2)S removal performance of Cu-BTC.In order to avoid the problem of pore blockage after amine modification in post synthesis impregnation,herein a series of...Amine modification is an effective strategy to improve the H_(2)S removal performance of Cu-BTC.In order to avoid the problem of pore blockage after amine modification in post synthesis impregnation,herein a series of Cu-BTC modified with organic amine adsorbents were prepared via an in-situ one-pot method and the H_(2)S removal performance under ambient conditions was tested.It is found that the introduced organic amines,depending on the types of amine selected,have a significant influence on the growth of Cu-BTC and its textural properties.The H_(2)S removal performance on the as-prepared materials suggested that the amine modified samples remarkably improved the H_(2)S removal capacities with an order of BA-Cu-BTC>TEA-Cu-BTC>TEOA-Cu-BTC>Cu-BTC.Besides the enlarged surface area and the increased mesopores volumes,BA has the advantages of smaller steric hindrance and-NH_(2)groups,among which the former increased the accessibility of Cu active sites while the latter acted as additional active sites for H_(2)S capturing,thus affording BA-Cu-BTC highest breakthrough capacity of 77.3 mg S/g.Overall,this study elaborates the effect of organic amines in-situ modification on the Cu-BTC structure and desulfurization.展开更多
Objective To study the characteristics, specific functions and policy improvement process of the Group Purchasing Organizations (GPOs) in the U.S. and to provide references for drug group purchasing practices in China...Objective To study the characteristics, specific functions and policy improvement process of the Group Purchasing Organizations (GPOs) in the U.S. and to provide references for drug group purchasing practices in China. Methods Domestic and foreign relevant literatures, websites were reviewed or searched to analyze the functions and policy improvement process of the GPOs in the U.S. so as to provide references for drug group purchasing practices in China. Results and Conclusion As a third party in the U.S. GPOs has formed a relatively integrated business process and projects service system after long-term development. Supported by corresponding policies and industrial regulations, GPOs have made a great contribution to control the growth of medical and healthcare expenses and improve the efficiency of medical institutions, and its development experience can enlighten the practices in China.展开更多
The nature of farmer cooperative economy organization( known as FCEO) determines the fact that the economic effects of farmer cooperative economy organization are as important as its social effects. Many experts,howev...The nature of farmer cooperative economy organization( known as FCEO) determines the fact that the economic effects of farmer cooperative economy organization are as important as its social effects. Many experts,however,now would only focus on its economic function, and either neglect or weaken its social influence. Therefore,this paper introduces the theoretical foundation of the farmer cooperative economy organization,and studies the nature of cooperative economics. Based on those typical cases,the future of cooperative organization and four supporting elements were put forward in this paper.展开更多
This study examined the spatiotemporal dynamics of colored dissolved organic matter （CDOM） and spectral slope （S）, and further to analyze its sources in three productive water supplies （Eagle Creek, Geist and Mor...This study examined the spatiotemporal dynamics of colored dissolved organic matter （CDOM） and spectral slope （S）, and further to analyze its sources in three productive water supplies （Eagle Creek, Geist and Morse reservoirs） from Indiana, USA. The re- sults showed that he absorption coefficient aCDOM（440） ranged from 0.37 m-1 to 3.93 m-1 with an average of 1.89 ± 0.76 m-1 （±SD） for the aggregated dataset, and S varied from 0.0048 nm -1 to 0.0239 nm-1 with an average of 0.0108 ±0.0040 nmI. A significant relation- ship between S and aCDOM（440） can be fitted with a power equation （S = 0.013 × aCDOM（440）-0.42, R2 = 0.612）, excluding data from Geist Reservoir during high flow （12 April 2010） and the Morse Reservoir on 25 June 2010 due to a T-storm achieves even higher determina- tion coefficient （R2 = 0.842）. Correlation analysis indicated that aCDOM（440） has strong association with inorganic suspended matter （ISM） concentration （0.231 〈 R2 〈 0.786） for each of the field surveys, and this trend followed the aggregated datasets （R2 = 0.447, p 〈 0.001）. In contrast, chlorophyll-a was only correlated with aCDOM（440） in summer and autumn （0.081 〈 R2 〈 0.763）, indicating that CDOM is mainly from terrigenous sources in early spring and that phytoplankton contributed during the algal blooming season. The S value was used to characterize CDOM origin. The results indicate that the CDOM source is mainly controlled by hydrological varia- tions, while phytoplankton originated organic matter also closely linked with CDOM dynamics in three productive reservoirs.展开更多
BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index ...BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score.展开更多
Global carbon cycling is a significant factor that controls climate change.The centennial-scale variations in total organic carbon(TOC)contents and its sources in marginal sea sediments may reflect the influence of hu...Global carbon cycling is a significant factor that controls climate change.The centennial-scale variations in total organic carbon(TOC)contents and its sources in marginal sea sediments may reflect the influence of human activities on global climate change.In this study,two fine-grained sediment cores from the Yellow Sea Cold Water Mass of the South Yellow Sea were used to systematically determine TOC contents and stable carbon isotope ratios.These results were combined with previous data of black carbon and (210)~Pb dating from which we reconstructed the centennial-scale initial sequences of TOC,terrigenous TOC(TOC_(ter))and marine autogenous TOC(TOC_(mar))after selecting suitable models to correct the measured TOC(TOC_(cor)).These sequences showed that the TOC_(ter) decreased with time in the both cores while the TOC_(mar) increased,particularly the rapid growth in core H43 since the late 1960s.According to the correlation between the Huanghe(Yellow)River discharge and the TOC_(cor),TOC_(ter),or TOC_(mar),we found that the TOC_(ter) in the two cores mainly derived from the Huanghe River and was transported by it,and that higher Huanghe River discharge could strengthen the decomposition of TOC_(mar).The newly obtained initial TOC sequences provide important insights into the interaction between human activities and natural processes.展开更多
基金financially supported by the National Natural Science Foundation of China,No.823 74552 (to WP)the Science and Technology Innovation Program of Hunan Province,No.2022RC1220 (to WP)+1 种基金the Natural Science Foundation of Hunan Province of China,Nos.2020JJ4803 (to WP),2022JJ40723 (to MY)the Scientific Research Launch Project for New Employees of the Second Xiangya Hospital of Central South University (to MY)
文摘Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease development.To do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of age.Twelve-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 mice.Notably,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 mice.These findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.
文摘With the transformation of society and the deepening of reform, the government＇s emphasis on public service level gradually increased, arises at the historic moment of women in social organization to participate in social management and service ofgrassroots women play an important role on the stage. Women social organizations in jiangsu province to grow faster, quantity stability has increased year by year, widely participate in social services, in the ease of social contradictions, providing public services, safeguard women＇s rights has played a unique role. But at the same time also face the system is not sound, management is not standard, and all kinds of resources are scarce, etc. Women social organizations must through the standardization of the management and operation, actively integrating the resource of inside and outside the organization improve the survival and development environment, so as to promote their own development and perfection, a greater extent play a positive role in social and public services.
文摘The BRICS political parties,think tanks and civil society organizations Forum was held in Fuzhou,capital of southeast China’s Fujian Province,June 11-12,2017.The forum drew over 400 participants from BRICS and other developing countries.Heads of political parties,think tanks and civil society organiza-
基金supported by the General Project of Liaoning Provin-cial Education Department(LQ2019015)Open Fund Project of Key Lab-oratory of Industrial Ecology and Environmental Engineering of Min-istry of Education,Dalian University of Technology(KLIEEE-19-08).
文摘Single-atom catalysts(SACs)have received enormous attention in the field of catalysis due to their inherent mer-its,such as nearly 100%atomic efficiency,environmental friendliness,and unique physicochemical properties.The emerging SACs have facilitated the development and advancement of catalysis.The rapidly increasing ap-plications of SACs in various fields,including oxygen evolution reaction,organic synthesis,hydrogen evolution reaction,and CO_(2) reduction,reflect their enormous potential.Recently,SACs have been extensively used in per-sulfate(PS)activation for refractory organic pollutants degradation in the aqueous environment.SACs exhibit distinct advantages of both homogeneous and heterogeneous catalysis,demonstrating a prospective application in PS activation.This review first introduces the synthesis and characterization schemes of SACs in PS activa-tion.Second,the factors influencing PS activation by SACs,including coordination numbers,type of coordination atoms,the spin state of metal sites,type of carriers,and the loading amount of metal atoms,are described.Third,the applications and activation mechanisms of SACs are summarized.Finally,the opportunities and challenges confronted by SACs and their future development prospects in advanced oxidation processes(AOPs)are put forward.
基金Supported by National Natural Science Foundation of China[Grant No.21878209,Grant No.22078223 and Grant No.22208233]Basic Research Project of Shanxi Province[Grant No.20210302123065].
文摘Amine modification is an effective strategy to improve the H_(2)S removal performance of Cu-BTC.In order to avoid the problem of pore blockage after amine modification in post synthesis impregnation,herein a series of Cu-BTC modified with organic amine adsorbents were prepared via an in-situ one-pot method and the H_(2)S removal performance under ambient conditions was tested.It is found that the introduced organic amines,depending on the types of amine selected,have a significant influence on the growth of Cu-BTC and its textural properties.The H_(2)S removal performance on the as-prepared materials suggested that the amine modified samples remarkably improved the H_(2)S removal capacities with an order of BA-Cu-BTC>TEA-Cu-BTC>TEOA-Cu-BTC>Cu-BTC.Besides the enlarged surface area and the increased mesopores volumes,BA has the advantages of smaller steric hindrance and-NH_(2)groups,among which the former increased the accessibility of Cu active sites while the latter acted as additional active sites for H_(2)S capturing,thus affording BA-Cu-BTC highest breakthrough capacity of 77.3 mg S/g.Overall,this study elaborates the effect of organic amines in-situ modification on the Cu-BTC structure and desulfurization.
文摘Objective To study the characteristics, specific functions and policy improvement process of the Group Purchasing Organizations (GPOs) in the U.S. and to provide references for drug group purchasing practices in China. Methods Domestic and foreign relevant literatures, websites were reviewed or searched to analyze the functions and policy improvement process of the GPOs in the U.S. so as to provide references for drug group purchasing practices in China. Results and Conclusion As a third party in the U.S. GPOs has formed a relatively integrated business process and projects service system after long-term development. Supported by corresponding policies and industrial regulations, GPOs have made a great contribution to control the growth of medical and healthcare expenses and improve the efficiency of medical institutions, and its development experience can enlighten the practices in China.
基金Supported by the Youth Program of Chongqing Social Science Plan(No.2012QNGL047)West Program of Humanistic and Social Science of Education Department(No.13XJC630006)+1 种基金Education and Teaching Program of Southwest University(No.2012JY037)Chongqing Science Committee Decision-making Subject(No.2013KXKT07)
文摘The nature of farmer cooperative economy organization( known as FCEO) determines the fact that the economic effects of farmer cooperative economy organization are as important as its social effects. Many experts,however,now would only focus on its economic function, and either neglect or weaken its social influence. Therefore,this paper introduces the theoretical foundation of the farmer cooperative economy organization,and studies the nature of cooperative economics. Based on those typical cases,the future of cooperative organization and four supporting elements were put forward in this paper.
基金Under the auspices of National Aeronautics and Space Administration of US(NASA)(No.NNG06GA92G)National Natural Science Foundation of China(No.41171293)
文摘This study examined the spatiotemporal dynamics of colored dissolved organic matter （CDOM） and spectral slope （S）, and further to analyze its sources in three productive water supplies （Eagle Creek, Geist and Morse reservoirs） from Indiana, USA. The re- sults showed that he absorption coefficient aCDOM（440） ranged from 0.37 m-1 to 3.93 m-1 with an average of 1.89 ± 0.76 m-1 （±SD） for the aggregated dataset, and S varied from 0.0048 nm -1 to 0.0239 nm-1 with an average of 0.0108 ±0.0040 nmI. A significant relation- ship between S and aCDOM（440） can be fitted with a power equation （S = 0.013 × aCDOM（440）-0.42, R2 = 0.612）, excluding data from Geist Reservoir during high flow （12 April 2010） and the Morse Reservoir on 25 June 2010 due to a T-storm achieves even higher determina- tion coefficient （R2 = 0.842）. Correlation analysis indicated that aCDOM（440） has strong association with inorganic suspended matter （ISM） concentration （0.231 〈 R2 〈 0.786） for each of the field surveys, and this trend followed the aggregated datasets （R2 = 0.447, p 〈 0.001）. In contrast, chlorophyll-a was only correlated with aCDOM（440） in summer and autumn （0.081 〈 R2 〈 0.763）, indicating that CDOM is mainly from terrigenous sources in early spring and that phytoplankton contributed during the algal blooming season. The S value was used to characterize CDOM origin. The results indicate that the CDOM source is mainly controlled by hydrological varia- tions, while phytoplankton originated organic matter also closely linked with CDOM dynamics in three productive reservoirs.
文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score.
基金Supported by the National Basic Research Program of China(973 Program)(No.2012CB956004)the Fundamental Research Funds for the Central Universities(No.16lgjc22)
文摘Global carbon cycling is a significant factor that controls climate change.The centennial-scale variations in total organic carbon(TOC)contents and its sources in marginal sea sediments may reflect the influence of human activities on global climate change.In this study,two fine-grained sediment cores from the Yellow Sea Cold Water Mass of the South Yellow Sea were used to systematically determine TOC contents and stable carbon isotope ratios.These results were combined with previous data of black carbon and (210)~Pb dating from which we reconstructed the centennial-scale initial sequences of TOC,terrigenous TOC(TOC_(ter))and marine autogenous TOC(TOC_(mar))after selecting suitable models to correct the measured TOC(TOC_(cor)).These sequences showed that the TOC_(ter) decreased with time in the both cores while the TOC_(mar) increased,particularly the rapid growth in core H43 since the late 1960s.According to the correlation between the Huanghe(Yellow)River discharge and the TOC_(cor),TOC_(ter),or TOC_(mar),we found that the TOC_(ter) in the two cores mainly derived from the Huanghe River and was transported by it,and that higher Huanghe River discharge could strengthen the decomposition of TOC_(mar).The newly obtained initial TOC sequences provide important insights into the interaction between human activities and natural processes.
