The Message Passing Interface (MPI) is a widely accepted standard for parallel computing on distributed memorysystems.However, MPI implementations can contain defects that impact the reliability and performance of par...The Message Passing Interface (MPI) is a widely accepted standard for parallel computing on distributed memorysystems.However, MPI implementations can contain defects that impact the reliability and performance of parallelapplications. Detecting and correcting these defects is crucial, yet there is a lack of published models specificallydesigned for correctingMPI defects. To address this, we propose a model for detecting and correcting MPI defects(DC_MPI), which aims to detect and correct defects in various types of MPI communication, including blockingpoint-to-point (BPTP), nonblocking point-to-point (NBPTP), and collective communication (CC). The defectsaddressed by the DC_MPI model include illegal MPI calls, deadlocks (DL), race conditions (RC), and messagemismatches (MM). To assess the effectiveness of the DC_MPI model, we performed experiments on a datasetconsisting of 40 MPI codes. The results indicate that the model achieved a detection rate of 37 out of 40 codes,resulting in an overall detection accuracy of 92.5%. Additionally, the execution duration of the DC_MPI modelranged from 0.81 to 1.36 s. These findings show that the DC_MPI model is useful in detecting and correctingdefects in MPI implementations, thereby enhancing the reliability and performance of parallel applications. TheDC_MPImodel fills an important research gap and provides a valuable tool for improving the quality ofMPI-basedparallel computing systems.展开更多
Highly evolved granite is an important sign of the mature continent crust and closely associated with deposits of rare metals.In this work,the authors undertake systematically zircon U-Pb ages and whole rock elemental...Highly evolved granite is an important sign of the mature continent crust and closely associated with deposits of rare metals.In this work,the authors undertake systematically zircon U-Pb ages and whole rock elemental data for highly evolved granitic intrusions from the Great Xing’an Range(GXR),NE China,to elucidate their discriminant criteria,spatial-temporal distribution,differentiation and geodynamic mecha-nism.Geochemical data of these highly evolved granites suggest that high w(SiO_(2))(>70%)and differentiation index(DI>88)could be quantified indicators,while strong Eu depletion,high TE_(1,3),lowΣREE and low Zr/Hf,Nb/Ta,K/Rb could only be qualitative indicators.Zircon U-Pb ages suggest that the highly evolved gran-ites in the GXR were mainly formed in Late Mesozoic,which can be divided into two major stages:Late Ju-rassic-early Early Cretaceous(162-136 Ma,peak at 138 Ma),and late Early Cretaceous(136-106 Ma,peak at 126 Ma).The highly evolved granites are mainly distributed in the central-southern GXR,and display a weakly trend of getting younger from northwest to southeast,meanwhile indicating the metallogenic potential of rare metals within the central GXR.The spatial-temporal distribution,combined with regional geological data,indicates the highly evolved Mesozoic granites in the GXR were emplaced in an extensional environ-ment,of which the Late Jurassic-early Early Cretaceous extension was related to the closure of the Mongol-Okhotsk Ocean and roll-back of the Paleo-Pacific Plate,while the late Early Cretaceous extension was mainly related to the roll-back of the Paleo-Pacific Plate.展开更多
This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst inte...This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst interference may occur only on data symbols but not on pilot symbols, which means that interference information cannot be premeasured. To cancel the burst interference, we first revisit the uplink multi-user system and develop a matrixform system model, where the covariance pattern and the low-rank property of the interference matrix is discussed. Then, we propose a turbo message passing based burst interference cancellation(TMP-BIC) algorithm to solve the data detection problem, where the constellation information of target data is fully exploited to refine its estimate. Furthermore, in the TMP-BIC algorithm, we design one module to cope with the interference matrix by exploiting its lowrank property. Numerical results demonstrate that the proposed algorithm can effectively mitigate the adverse effects of burst interference and approach the interference-free bound.展开更多
During the war between Liao Dynasty(907-1125)and Northern Song Dynasty(960-1127),there was a classic battle that happened in Yanmen Pass(located in today’s Dai County,Xinzhou,Shanxi Province,China).It was a well know...During the war between Liao Dynasty(907-1125)and Northern Song Dynasty(960-1127),there was a classic battle that happened in Yanmen Pass(located in today’s Dai County,Xinzhou,Shanxi Province,China).It was a well known battle of ancient China because a commander of the Song army named Yang Ye(?-986)was really famous in both classical Chinese fictions and Chinese war history.He is the early protagonist of a famous Chinese classic fiction named The Romance of the Yang family’s generals(written in the 16th century,Ming Dynasty of China).The story of his family also appears in other novels.Besides,in history,he was a general who was active in the early stages of the war between Liao Dynasty and Northern Song Dynasty.The battle of Yanmen Pass(980)was one of the most important battles of Yang’s military career.His combat style especially his cavalry tactic can be summarized through researching this battle.展开更多
Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients di...Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.展开更多
Compressed sensing(CS)aims for seeking appropriate algorithms to recover a sparse vector from noisy linear observations.Currently,various Bayesian-based algorithms such as sparse Bayesian learning(SBL)and approximate ...Compressed sensing(CS)aims for seeking appropriate algorithms to recover a sparse vector from noisy linear observations.Currently,various Bayesian-based algorithms such as sparse Bayesian learning(SBL)and approximate message passing(AMP)based algorithms have been proposed.For SBL,it has accurate performance with robustness while its computational complexity is high due to matrix inversion.For AMP,its performance is guaranteed by the severe restriction of the measurement matrix,which limits its application in solving CS problem.To overcome the drawbacks of the above algorithms,in this paper,we present a low complexity algorithm for the single linear model that incorporates the vector AMP(VAMP)into the SBL structure with expectation maximization(EM).Specifically,we apply the variance auto-tuning into the VAMP to implement the E step in SBL,which decrease the iterations that require to converge compared with VAMP-EM algorithm when using a Gaussian mixture(GM)prior.Simulation results show that the proposed algorithm has better performance with high robustness under various cases of difficult measurement matrices.展开更多
On January 20,2021,the new-generation isodewaxing catalyst RIW-30 developed by the SINOPEC Research Institute of Petroleum Processing(RIPP)has passed the technical review organized by the SINOPEC Science and Technolog...On January 20,2021,the new-generation isodewaxing catalyst RIW-30 developed by the SINOPEC Research Institute of Petroleum Processing(RIPP)has passed the technical review organized by the SINOPEC Science and Technology Division.The experts attending the technical review meeting have unanimously recognized that this catalytic materials for isodewaxing of petroleum products has achieved a great leap type progress to attain an outstanding catalytic performance,which has reached the internationally advanced level.展开更多
Background: In linear accelerators, the treatment field’s uniform intensity is achieved by including a flattening filter in the beam. However, to produce more conformal dose distributions, contemporary radiotherapy p...Background: In linear accelerators, the treatment field’s uniform intensity is achieved by including a flattening filter in the beam. However, to produce more conformal dose distributions, contemporary radiotherapy practice now frequently uses fluence and aperture modifying techniques, such as volumetric modulated arc therapy. In these circumstances, the flattening filter in the beam manufacturing process is no longer required. It is therefore necessary to compare the monitor units of 6 MV and flattening filter free plans and how it influences the gamma pass rates to determine which is best for treating cervical cancer with pelvic lymph node metastasis. Methods: VMAT plans for fifteen patients with cervical cancer with pathological pelvic lymph node metastasis were included in this study. Each patient had two VMAT plans using conventional 6 MV beam with flattening filter and one with flattening filter free beam (FFF). The VMAT plans were made using two arcs, and then recalculated to give the planned dose distribution to the detectors in a Delta4 phantom. The VMAT plans were irradiated on the Delta4 phantom using an Elekta linear accelerator (6 MV). Results: The mean monitor unit for the 6 MV plans was 506.3 MU and a standard deviation of 48.6 while that of the FFF plans had a mean MU of 701.5 with a standard deviation of 87.6. The total monitor units (MUs) for the FFF plans were significantly greater than the 6 MV plans (p = 6.1 × 10<sup>-5</sup>). Conclusion: Flattening filter free (FFF) plans require more numbers of monitor units in comparison to conventional 6 MV filtered beams for external radiation of cervical cancer with pelvic lymph nodes involvement.展开更多
High-order harmonics q(ψ_(s))=1 energetic particle modes(EPMs)have been observed in toroidal plasmas experiments with neutral beam injection.To investigate these phenomena,linear properties and nonlinear dynamics of ...High-order harmonics q(ψ_(s))=1 energetic particle modes(EPMs)have been observed in toroidal plasmas experiments with neutral beam injection.To investigate these phenomena,linear properties and nonlinear dynamics of these EPMs driven by passing energetic particles(EPs)are studied via the global hybrid kinetic-magnetohydrodynamic code M3D-K.Simulation results demonstrate that passing EPs'effects on high mode-number harmonics(q(ψ_(s))=m/n=2/2,3/3,4/4)instability are more obvious than the q(ψ_(s))=1/1 mode,especially when q-profile is sufficiently flat in the core region.Furthermore,the effects of the pitch angleΛ_0 and beam ion pressure P_(hot)/P_(total)on the features of high n components are also analyzed specifically.It is found that there exists only one resonant condition for these EPMs.In the nonlinear phase,these high mode-number harmonics can induce significant energetic ions redistribution and chirping up phenomena,which differs from the classical fishbone excited by passing EPs.These discoveries are conducive to better apprehend the underlying physical mechanisms of the highorder harmonics driven by passing EPs.展开更多
Background Genotype-by-sequencing has been proposed as an alternative to SNP genotyping arrays in genomic selection to obtain a high density of markers along the genome.It requires a low sequencing depth to be cost ef...Background Genotype-by-sequencing has been proposed as an alternative to SNP genotyping arrays in genomic selection to obtain a high density of markers along the genome.It requires a low sequencing depth to be cost effective,which may increase the error at the genotype assigment.Third generation nanopore sequencing technology offers low cost sequencing and the possibility to detect genome methylation,which provides added value to genotype-by-sequencing.The aim of this study was to evaluate the performance of genotype-by-low pass nanopore sequencing for estimating the direct genomic value in dairy cattle,and the possibility to obtain methylation marks simultaneously.Results Latest nanopore chemistry(LSK14 and Q20)achieved a modal base calling accuracy of 99.55%,whereas previous kit(LSK109)achieved slightly lower accuracy(99.1%).The direct genomic value accuracy from genotype-by-low pass sequencing ranged between 0.79 and 0.99,depending on the trait(milk,fat or protein yield),with a sequencing depth as low as 2×and using the latest chemistry(LSK114).Lower sequencing depth led to biased estimates,yet with high rank correlations.The LSK109 and Q20 achieved lower accuracies(0.57-0.93).More than one million high reliable methylated sites were obtained,even at low sequencing depth,located mainly in distal intergenic(87%)and promoter(5%)regions.Conclusions This study showed that the latest nanopore technology in useful in a LowPass sequencing framework to estimate direct genomic values with high reliability.It may provide advantages in populations with no available SNP chip,or when a large density of markers with a wide range of allele frequencies is needed.In addition,low pass sequencing provided nucleotide methylation status of>1 million nucleotides at≥10×,which is an added value for epigenetic studies.展开更多
Zircon U-Pb isotope dating and whole-rock geochemical analyses were undertaken for the rhyolite,rhyolitic lithic crystal tuff and dacitic tuff from the Manketouebo Formation in the Keyihe area,in order to constrain th...Zircon U-Pb isotope dating and whole-rock geochemical analyses were undertaken for the rhyolite,rhyolitic lithic crystal tuff and dacitic tuff from the Manketouebo Formation in the Keyihe area,in order to constrain their genesis and tectonic significance.Zircon LA-ICP-MS U-Pb data indicate that the rhyolite and rhyolitic lithic crystal tuff were formed during 137±5 Ma and 143±1 Ma,respectively.These volcanic rocks have high SiO2(70.03%–76.46%)and K2O+Na2O(8.10%–9.52%)contents,but low CaO(0.03%–0.95%)and MgO(0.07%–0.67%)contents,which belong to the peraluminous and high-K calc-alkaline rocks.They are enriched in light rare earth elements(REEs),and exhibit fractionation of light over heavy REEs,withδEu values of 0.37–0.83.The volcanic rocks are enriched in LILEs(e.g.,Rb,U and K)and depleted in HFSEs(e.g.,Nb,Ti,P and Ta).The chemical composition suggests that these volcanic rocks formed by partial melting of crust material.Combined with previous regional research results,the authors consider that the volcanic rocks of the Manketouebo Formation in the Keyihe area were formed under an extensional environment related to the closure of the Mongolia–Okhotsk Ocean.展开更多
A memorial for Jiang Zemin,who passed away on November 30,2022,at the age of 96,was held on December 6,2022,at the Great Hall of the People in Beijing.President Xi Jinping addressed the meeting.In a eulogy delivered a...A memorial for Jiang Zemin,who passed away on November 30,2022,at the age of 96,was held on December 6,2022,at the Great Hall of the People in Beijing.President Xi Jinping addressed the meeting.In a eulogy delivered at the memorial,Xi attributed the tremendous achievements of the Party and the nation between 1989 and 2002 to the late Chinese leader’s eminence and bold vision,the key role he played,and his superb political leadership.展开更多
基金the Deanship of Scientific Research at King Abdulaziz University,Jeddah,Saudi Arabia under the Grant No.RG-12-611-43.
文摘The Message Passing Interface (MPI) is a widely accepted standard for parallel computing on distributed memorysystems.However, MPI implementations can contain defects that impact the reliability and performance of parallelapplications. Detecting and correcting these defects is crucial, yet there is a lack of published models specificallydesigned for correctingMPI defects. To address this, we propose a model for detecting and correcting MPI defects(DC_MPI), which aims to detect and correct defects in various types of MPI communication, including blockingpoint-to-point (BPTP), nonblocking point-to-point (NBPTP), and collective communication (CC). The defectsaddressed by the DC_MPI model include illegal MPI calls, deadlocks (DL), race conditions (RC), and messagemismatches (MM). To assess the effectiveness of the DC_MPI model, we performed experiments on a datasetconsisting of 40 MPI codes. The results indicate that the model achieved a detection rate of 37 out of 40 codes,resulting in an overall detection accuracy of 92.5%. Additionally, the execution duration of the DC_MPI modelranged from 0.81 to 1.36 s. These findings show that the DC_MPI model is useful in detecting and correctingdefects in MPI implementations, thereby enhancing the reliability and performance of parallel applications. TheDC_MPImodel fills an important research gap and provides a valuable tool for improving the quality ofMPI-basedparallel computing systems.
基金Supported by projects of the National Natural Science Foundation of China(Nos.92062216,41888101).
文摘Highly evolved granite is an important sign of the mature continent crust and closely associated with deposits of rare metals.In this work,the authors undertake systematically zircon U-Pb ages and whole rock elemental data for highly evolved granitic intrusions from the Great Xing’an Range(GXR),NE China,to elucidate their discriminant criteria,spatial-temporal distribution,differentiation and geodynamic mecha-nism.Geochemical data of these highly evolved granites suggest that high w(SiO_(2))(>70%)and differentiation index(DI>88)could be quantified indicators,while strong Eu depletion,high TE_(1,3),lowΣREE and low Zr/Hf,Nb/Ta,K/Rb could only be qualitative indicators.Zircon U-Pb ages suggest that the highly evolved gran-ites in the GXR were mainly formed in Late Mesozoic,which can be divided into two major stages:Late Ju-rassic-early Early Cretaceous(162-136 Ma,peak at 138 Ma),and late Early Cretaceous(136-106 Ma,peak at 126 Ma).The highly evolved granites are mainly distributed in the central-southern GXR,and display a weakly trend of getting younger from northwest to southeast,meanwhile indicating the metallogenic potential of rare metals within the central GXR.The spatial-temporal distribution,combined with regional geological data,indicates the highly evolved Mesozoic granites in the GXR were emplaced in an extensional environ-ment,of which the Late Jurassic-early Early Cretaceous extension was related to the closure of the Mongol-Okhotsk Ocean and roll-back of the Paleo-Pacific Plate,while the late Early Cretaceous extension was mainly related to the roll-back of the Paleo-Pacific Plate.
基金supported by the National Key Laboratory of Wireless Communications Foundation,China (IFN20230204)。
文摘This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst interference may occur only on data symbols but not on pilot symbols, which means that interference information cannot be premeasured. To cancel the burst interference, we first revisit the uplink multi-user system and develop a matrixform system model, where the covariance pattern and the low-rank property of the interference matrix is discussed. Then, we propose a turbo message passing based burst interference cancellation(TMP-BIC) algorithm to solve the data detection problem, where the constellation information of target data is fully exploited to refine its estimate. Furthermore, in the TMP-BIC algorithm, we design one module to cope with the interference matrix by exploiting its lowrank property. Numerical results demonstrate that the proposed algorithm can effectively mitigate the adverse effects of burst interference and approach the interference-free bound.
文摘During the war between Liao Dynasty(907-1125)and Northern Song Dynasty(960-1127),there was a classic battle that happened in Yanmen Pass(located in today’s Dai County,Xinzhou,Shanxi Province,China).It was a well known battle of ancient China because a commander of the Song army named Yang Ye(?-986)was really famous in both classical Chinese fictions and Chinese war history.He is the early protagonist of a famous Chinese classic fiction named The Romance of the Yang family’s generals(written in the 16th century,Ming Dynasty of China).The story of his family also appears in other novels.Besides,in history,he was a general who was active in the early stages of the war between Liao Dynasty and Northern Song Dynasty.The battle of Yanmen Pass(980)was one of the most important battles of Yang’s military career.His combat style especially his cavalry tactic can be summarized through researching this battle.
文摘Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.
基金supported by NSFC projects(61960206005,61803211,61871111,62101275,62171127,61971136,and 62001056)Jiangsu NSF project(BK20200820)+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX210106)Research Fund of National Mobile Communications Research Laboratory.
文摘Compressed sensing(CS)aims for seeking appropriate algorithms to recover a sparse vector from noisy linear observations.Currently,various Bayesian-based algorithms such as sparse Bayesian learning(SBL)and approximate message passing(AMP)based algorithms have been proposed.For SBL,it has accurate performance with robustness while its computational complexity is high due to matrix inversion.For AMP,its performance is guaranteed by the severe restriction of the measurement matrix,which limits its application in solving CS problem.To overcome the drawbacks of the above algorithms,in this paper,we present a low complexity algorithm for the single linear model that incorporates the vector AMP(VAMP)into the SBL structure with expectation maximization(EM).Specifically,we apply the variance auto-tuning into the VAMP to implement the E step in SBL,which decrease the iterations that require to converge compared with VAMP-EM algorithm when using a Gaussian mixture(GM)prior.Simulation results show that the proposed algorithm has better performance with high robustness under various cases of difficult measurement matrices.
文摘On January 20,2021,the new-generation isodewaxing catalyst RIW-30 developed by the SINOPEC Research Institute of Petroleum Processing(RIPP)has passed the technical review organized by the SINOPEC Science and Technology Division.The experts attending the technical review meeting have unanimously recognized that this catalytic materials for isodewaxing of petroleum products has achieved a great leap type progress to attain an outstanding catalytic performance,which has reached the internationally advanced level.
文摘Background: In linear accelerators, the treatment field’s uniform intensity is achieved by including a flattening filter in the beam. However, to produce more conformal dose distributions, contemporary radiotherapy practice now frequently uses fluence and aperture modifying techniques, such as volumetric modulated arc therapy. In these circumstances, the flattening filter in the beam manufacturing process is no longer required. It is therefore necessary to compare the monitor units of 6 MV and flattening filter free plans and how it influences the gamma pass rates to determine which is best for treating cervical cancer with pelvic lymph node metastasis. Methods: VMAT plans for fifteen patients with cervical cancer with pathological pelvic lymph node metastasis were included in this study. Each patient had two VMAT plans using conventional 6 MV beam with flattening filter and one with flattening filter free beam (FFF). The VMAT plans were made using two arcs, and then recalculated to give the planned dose distribution to the detectors in a Delta4 phantom. The VMAT plans were irradiated on the Delta4 phantom using an Elekta linear accelerator (6 MV). Results: The mean monitor unit for the 6 MV plans was 506.3 MU and a standard deviation of 48.6 while that of the FFF plans had a mean MU of 701.5 with a standard deviation of 87.6. The total monitor units (MUs) for the FFF plans were significantly greater than the 6 MV plans (p = 6.1 × 10<sup>-5</sup>). Conclusion: Flattening filter free (FFF) plans require more numbers of monitor units in comparison to conventional 6 MV filtered beams for external radiation of cervical cancer with pelvic lymph nodes involvement.
基金supported by National Key R&D Program of China(Nos.2019YFE03050002,2018YFE0310400,and 2022YFE03040002)National Natural Science Foundation of China(Nos.12005003 and 11975270)Science Foundation of Institute of Plasma Physics,Chinese Academy of Sciences(No.DSJJ-2022-04)。
文摘High-order harmonics q(ψ_(s))=1 energetic particle modes(EPMs)have been observed in toroidal plasmas experiments with neutral beam injection.To investigate these phenomena,linear properties and nonlinear dynamics of these EPMs driven by passing energetic particles(EPs)are studied via the global hybrid kinetic-magnetohydrodynamic code M3D-K.Simulation results demonstrate that passing EPs'effects on high mode-number harmonics(q(ψ_(s))=m/n=2/2,3/3,4/4)instability are more obvious than the q(ψ_(s))=1/1 mode,especially when q-profile is sufficiently flat in the core region.Furthermore,the effects of the pitch angleΛ_0 and beam ion pressure P_(hot)/P_(total)on the features of high n components are also analyzed specifically.It is found that there exists only one resonant condition for these EPMs.In the nonlinear phase,these high mode-number harmonics can induce significant energetic ions redistribution and chirping up phenomena,which differs from the classical fishbone excited by passing EPs.These discoveries are conducive to better apprehend the underlying physical mechanisms of the highorder harmonics driven by passing EPs.
文摘Background Genotype-by-sequencing has been proposed as an alternative to SNP genotyping arrays in genomic selection to obtain a high density of markers along the genome.It requires a low sequencing depth to be cost effective,which may increase the error at the genotype assigment.Third generation nanopore sequencing technology offers low cost sequencing and the possibility to detect genome methylation,which provides added value to genotype-by-sequencing.The aim of this study was to evaluate the performance of genotype-by-low pass nanopore sequencing for estimating the direct genomic value in dairy cattle,and the possibility to obtain methylation marks simultaneously.Results Latest nanopore chemistry(LSK14 and Q20)achieved a modal base calling accuracy of 99.55%,whereas previous kit(LSK109)achieved slightly lower accuracy(99.1%).The direct genomic value accuracy from genotype-by-low pass sequencing ranged between 0.79 and 0.99,depending on the trait(milk,fat or protein yield),with a sequencing depth as low as 2×and using the latest chemistry(LSK114).Lower sequencing depth led to biased estimates,yet with high rank correlations.The LSK109 and Q20 achieved lower accuracies(0.57-0.93).More than one million high reliable methylated sites were obtained,even at low sequencing depth,located mainly in distal intergenic(87%)and promoter(5%)regions.Conclusions This study showed that the latest nanopore technology in useful in a LowPass sequencing framework to estimate direct genomic values with high reliability.It may provide advantages in populations with no available SNP chip,or when a large density of markers with a wide range of allele frequencies is needed.In addition,low pass sequencing provided nucleotide methylation status of>1 million nucleotides at≥10×,which is an added value for epigenetic studies.
基金Supported by Project of National Natural Science Foundation of China(No.41872234)。
文摘Zircon U-Pb isotope dating and whole-rock geochemical analyses were undertaken for the rhyolite,rhyolitic lithic crystal tuff and dacitic tuff from the Manketouebo Formation in the Keyihe area,in order to constrain their genesis and tectonic significance.Zircon LA-ICP-MS U-Pb data indicate that the rhyolite and rhyolitic lithic crystal tuff were formed during 137±5 Ma and 143±1 Ma,respectively.These volcanic rocks have high SiO2(70.03%–76.46%)and K2O+Na2O(8.10%–9.52%)contents,but low CaO(0.03%–0.95%)and MgO(0.07%–0.67%)contents,which belong to the peraluminous and high-K calc-alkaline rocks.They are enriched in light rare earth elements(REEs),and exhibit fractionation of light over heavy REEs,withδEu values of 0.37–0.83.The volcanic rocks are enriched in LILEs(e.g.,Rb,U and K)and depleted in HFSEs(e.g.,Nb,Ti,P and Ta).The chemical composition suggests that these volcanic rocks formed by partial melting of crust material.Combined with previous regional research results,the authors consider that the volcanic rocks of the Manketouebo Formation in the Keyihe area were formed under an extensional environment related to the closure of the Mongolia–Okhotsk Ocean.
文摘A memorial for Jiang Zemin,who passed away on November 30,2022,at the age of 96,was held on December 6,2022,at the Great Hall of the People in Beijing.President Xi Jinping addressed the meeting.In a eulogy delivered at the memorial,Xi attributed the tremendous achievements of the Party and the nation between 1989 and 2002 to the late Chinese leader’s eminence and bold vision,the key role he played,and his superb political leadership.