Precancerous lesions of the gallbladder in 150 consecutive cholecystectomy specimens resected from the patients with cholelithiasis or cholecystitis were studied. Of these specimens, 80% had simple epithelial hyperpla...Precancerous lesions of the gallbladder in 150 consecutive cholecystectomy specimens resected from the patients with cholelithiasis or cholecystitis were studied. Of these specimens, 80% had simple epithelial hyperplasia, 16% atypical hyperplasia, 1.3% carcinoma in situ and 2.7% invasive carcinoma. Atypical hyperplasia was observed in the mucosa abjacent to carcinoma in situ which, in turn, was found in the mucosa adjacent to invasive carcinoma. This finding suggests that some of simple hyperplasia of the gallbladder evolve towards atypical hyperplasia, carcinoma in situ which finally becomes invasive carcinoma. In addition, the authors provide a morphologic criteria for grading the atypical hyperplasia of the gallbladder.展开更多
The environmental and health impacts from the massive discharge of chemicals and subsequent pollution have been gaining increasing public concern.The unintended exposure to different pollutants,such as heavy metals,ai...The environmental and health impacts from the massive discharge of chemicals and subsequent pollution have been gaining increasing public concern.The unintended exposure to different pollutants,such as heavy metals,air pollutants and organic chemicals,may cause diverse deleterious effects on human bodies,resulting in the incidence and progression of different diseases.The article reviewed the outbreak of environmental pollution-related public health emergencies,the epidemiological evidence on certain pollution-correlated health effects,and the pathological studies on specific pollutant exposure.By recalling the notable historical life-threatening disasters incurred by local chemical pollution,the damning evidence was presented to criminate certain pollutants as the main culprit for the given health issues.The epidemiological data on the prevalence of some common diseases revealed a variety of environmental pollutants to blame,such as endocrine-disrupting chemicals(EDCs),fine particulate matters(PMs)and heavy metals.The retrospection of toxicological studies provided illustrative clues for evaluating ambient pollutant-induced health risks.Overall,environmental pollution,as the hidden culprit,should answer for the increasing public health burden,and more efforts are highly encouraged to strive to explore the cause-and-effect relationships through extensive epidemiological and pathological studies.展开更多
文摘Precancerous lesions of the gallbladder in 150 consecutive cholecystectomy specimens resected from the patients with cholelithiasis or cholecystitis were studied. Of these specimens, 80% had simple epithelial hyperplasia, 16% atypical hyperplasia, 1.3% carcinoma in situ and 2.7% invasive carcinoma. Atypical hyperplasia was observed in the mucosa abjacent to carcinoma in situ which, in turn, was found in the mucosa adjacent to invasive carcinoma. This finding suggests that some of simple hyperplasia of the gallbladder evolve towards atypical hyperplasia, carcinoma in situ which finally becomes invasive carcinoma. In addition, the authors provide a morphologic criteria for grading the atypical hyperplasia of the gallbladder.
基金supported by the National Key R&D Program of China(2018YFA0901101)the National Natural Science Foundation of China(22193050,92143301,22176203).
文摘The environmental and health impacts from the massive discharge of chemicals and subsequent pollution have been gaining increasing public concern.The unintended exposure to different pollutants,such as heavy metals,air pollutants and organic chemicals,may cause diverse deleterious effects on human bodies,resulting in the incidence and progression of different diseases.The article reviewed the outbreak of environmental pollution-related public health emergencies,the epidemiological evidence on certain pollution-correlated health effects,and the pathological studies on specific pollutant exposure.By recalling the notable historical life-threatening disasters incurred by local chemical pollution,the damning evidence was presented to criminate certain pollutants as the main culprit for the given health issues.The epidemiological data on the prevalence of some common diseases revealed a variety of environmental pollutants to blame,such as endocrine-disrupting chemicals(EDCs),fine particulate matters(PMs)and heavy metals.The retrospection of toxicological studies provided illustrative clues for evaluating ambient pollutant-induced health risks.Overall,environmental pollution,as the hidden culprit,should answer for the increasing public health burden,and more efforts are highly encouraged to strive to explore the cause-and-effect relationships through extensive epidemiological and pathological studies.
