BACKGROUND Cardiovascular disease has been the leading cause of morbidity and mortality for type 2 diabetes mellitus(T2DM)patients over the last decade.AIM To determine whether layer-specific global longitudinal strai...BACKGROUND Cardiovascular disease has been the leading cause of morbidity and mortality for type 2 diabetes mellitus(T2DM)patients over the last decade.AIM To determine whether layer-specific global longitudinal strain(GLS)combined with peak strain dispersion(PSD)can be used to assess left ventricle(LV)myocardium systolic dysfunction in T2DM patients or without hypertension(HP).METHODS We enrolled 97 T2DM patients,70 T2DM+HP patients and 101 healthy subjects.Layer-specific GLS and PSD were calculated by EchoPAC software in apical three-,four-and two-chamber views.GLS of the epimyocardial,middle-layer and endomyocardial(GLSepi,GLSmid,and GLSendo)were measured and recorded.Receiver operating characteristic analysis was performed to detect LV myocardium systolic dysfunction in T2DM patients.RESULTS There were significant differences in GLSepi,GLSmid,GLSendo,and PSD between healthy subjects,T2DM patients and T2DM patients with HP(P<0.001).Trend tests yielded the ranking of healthy subjects>T2DM patients>T2DM with HP patients in the absolute values of GLSepi,GLSmid and GLSendo(P<0.001),while PSD was ranked healthy subjects<T2DM<T2DM with HP(P<0.001).Layer-specific GLS and PSD had high diagnostic efficiency for detecting LV myocardium systolic dysfunction in T2DM patients,however,the area under the curve(AUC)for layer-specific GLS and PSD combined was significantly higher than the AUCs for the individual indices(P<0.05).CONCLUSION Layer-specific GLS and PSD were associated with LV myocardium systolic dysfunction in T2DM patients,T2DM patients with HP.T2DM patients with HP have more severe LV myocardium systolic dysfunction than T2DM patients without HP and normal control patients.The combination of layer-specific GLS and PSD may provide additional prognostic information for T2DM patients with or without HP.展开更多
BACKGROUND Peripheral vascular disease(PVD)is a common complication of type 2 diabetes mellitus(T2DM).Patients with T2DM have twice the risk of PVD as nondiabetic patients.AIM To evaluate left ventricular(LV)systolic ...BACKGROUND Peripheral vascular disease(PVD)is a common complication of type 2 diabetes mellitus(T2DM).Patients with T2DM have twice the risk of PVD as nondiabetic patients.AIM To evaluate left ventricular(LV)systolic function by layer-specific global longitudinal strain(GLS)and peak strain dispersion(PSD)in T2DM patients with and without PVD.METHODS Sixty-five T2DM patients without PVD,57 T2DM patients with PVD and 63 normal controls were enrolled in the study.Layer-specific GLS[GLS of the epimyocardium(GLSepi),GLS of the middle myocardium(GLSmid)and GLS of the endocardium(GLSendo)]and PSD were calculated.Receiver operating characteristic(ROC)analysis was performed to calculate the sensitivity and specificity of LV systolic dysfunction in T2DM patients with PVD.We calculated Pearson’s correlation coefficients between biochemical data,echocardiographic characteristics,and layer-specific GLS and PSD.RESULTS There were significant differences in GLSepi,GLSmid and GLSendo between normal controls,T2DM patients without PVD and T2DM patients with PVD(P<0.001).Trend tests revealed a ranking of normal controls>T2DM patients without PVD>T2DM patients with PVD in the absolute value of GLS(P<0.001).PSD differed significantly between the three groups,and the trend ranking was as follows:normal controls<T2DM patients without PVD<T2DM patients with PVD(P<0.001).ROC analysis revealed that the combination of layer-specific GLS and PSD had high diagnostic efficiency for detecting LV systolic dysfunction in T2DM patients with PVD.Lowdensity lipoprotein cholesterol was positively correlated with GLSepi,GLSmid and PSD(P<0.05),while LV ejection fraction was negatively correlated with GLSepi,GLSmid and GLSendo in T2DM patients with PVD(P<0.01).CONCLUSION PVD may aggravate the deterioration of LV systolic dysfunction in T2DM patients.Layer-specific GLS and PSD can be used to detect LV systolic dysfunction accurately and conveniently in T2DM patients with or without PVD.展开更多
颗粒混凝土材料在建筑结构中应用比较常见,但其冲击下的动力学性能研究欠缺.为得到颗粒混凝土的动力学特性,借助MTS实验机得出其静力学强度,其后使用直径为75 mm SHPB系统对颗粒混凝土试样做了多种加载速度下的冲击试验.结果表明,颗粒...颗粒混凝土材料在建筑结构中应用比较常见,但其冲击下的动力学性能研究欠缺.为得到颗粒混凝土的动力学特性,借助MTS实验机得出其静力学强度,其后使用直径为75 mm SHPB系统对颗粒混凝土试样做了多种加载速度下的冲击试验.结果表明,颗粒混凝土试样的毁坏模式是非脆性碎裂,呈现出延性特点;随着冲击速度的增大,破坏后的形状由试样被压扁(形态基本完整,表现出明显的可压缩性)过渡到絮状.应变率在103.88~464.71 s^(-1)时,试样的峰值应力随着应变率的变大而增大,表现出明显的应变率效应.根据实验现象和实验数据进行分析,推导建立了颗粒混凝土峰值应力前和峰值应力后应力-应变的等效本构方程,将实验数据与拟合数据进行对比,具有较为明显的一致性,验证了本构方程的准确性.展开更多
目的:应用斑点追踪成像技术对左束支起搏(left bundle branch pacing,LBBP)与希氏束起搏(His bundle pacing,HBP)患者起搏器植入1年后左心室收缩功能及同步性进行评价。方法:获取LBBP患者(40例)、HBP患者(40例)、对照组(40例)标准心尖...目的:应用斑点追踪成像技术对左束支起搏(left bundle branch pacing,LBBP)与希氏束起搏(His bundle pacing,HBP)患者起搏器植入1年后左心室收缩功能及同步性进行评价。方法:获取LBBP患者(40例)、HBP患者(40例)、对照组(40例)标准心尖四腔、三腔、两腔和短轴二尖瓣、心尖水平图像;分别测量和比较LBBP、HBP患者与对照组纵向、圆周和径向应变、纵向应变达峰时间弥散度(peak strain dispersion,PSD)、左室扭转、心室间机械延迟时间(interventricular mechanical delay time,IVMD);计算和比较圆周应变达峰时间标准差(standard deviation of time to peak circumferential strain,T-sd-CS)、径向应变达峰时间标准差(standard deviation of time to peak radial strain,T-sd-RS)。结果:HBP组短轴心尖平面T-sd-CS大于对照组,其余心室电活动及机械同步性参数与对照组无显著差异;LBBP组QRS波宽度大于HBP组和对照组(P<0.05);LBBP组短轴心尖平面T-sd-CS大于HBP组和对照组(P<0.05);LBBP组左室纵向PSD大于HBP组和对照组(P<0.05);各组间左心室短轴径向应变、T-sd-RS、纵向应变、扭转角度及IVMD比较均无统计学差异。结论:LBBP组与HBP组、对照组相比,左心室内同步性稍延迟;LBBP组与HBP组、对照组心肌收缩功能基本相近。展开更多
An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Int...An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Introducing the variation of dynamic grain size and the heterogeneous distribution of disolo- cation densities densities under DRX,a simple method for modeling and simulating DRX processes is developed by using Laplace transformation theory. The results derived from the present model agree well with the experimental results in literatures. This simulation can reproduce a number of features in DRX flow behaviors, for example,single and multiple peak flow behaviors followed by a steady state flow, the transition between them, and so on.展开更多
基金Supported by the Science and Technology Project of Changzhou Health Commission,No.ZD202342.
文摘BACKGROUND Cardiovascular disease has been the leading cause of morbidity and mortality for type 2 diabetes mellitus(T2DM)patients over the last decade.AIM To determine whether layer-specific global longitudinal strain(GLS)combined with peak strain dispersion(PSD)can be used to assess left ventricle(LV)myocardium systolic dysfunction in T2DM patients or without hypertension(HP).METHODS We enrolled 97 T2DM patients,70 T2DM+HP patients and 101 healthy subjects.Layer-specific GLS and PSD were calculated by EchoPAC software in apical three-,four-and two-chamber views.GLS of the epimyocardial,middle-layer and endomyocardial(GLSepi,GLSmid,and GLSendo)were measured and recorded.Receiver operating characteristic analysis was performed to detect LV myocardium systolic dysfunction in T2DM patients.RESULTS There were significant differences in GLSepi,GLSmid,GLSendo,and PSD between healthy subjects,T2DM patients and T2DM patients with HP(P<0.001).Trend tests yielded the ranking of healthy subjects>T2DM patients>T2DM with HP patients in the absolute values of GLSepi,GLSmid and GLSendo(P<0.001),while PSD was ranked healthy subjects<T2DM<T2DM with HP(P<0.001).Layer-specific GLS and PSD had high diagnostic efficiency for detecting LV myocardium systolic dysfunction in T2DM patients,however,the area under the curve(AUC)for layer-specific GLS and PSD combined was significantly higher than the AUCs for the individual indices(P<0.05).CONCLUSION Layer-specific GLS and PSD were associated with LV myocardium systolic dysfunction in T2DM patients,T2DM patients with HP.T2DM patients with HP have more severe LV myocardium systolic dysfunction than T2DM patients without HP and normal control patients.The combination of layer-specific GLS and PSD may provide additional prognostic information for T2DM patients with or without HP.
基金Supported by The Science and Technology Project of Changzhou Health Commission,No.ZD202342.
文摘BACKGROUND Peripheral vascular disease(PVD)is a common complication of type 2 diabetes mellitus(T2DM).Patients with T2DM have twice the risk of PVD as nondiabetic patients.AIM To evaluate left ventricular(LV)systolic function by layer-specific global longitudinal strain(GLS)and peak strain dispersion(PSD)in T2DM patients with and without PVD.METHODS Sixty-five T2DM patients without PVD,57 T2DM patients with PVD and 63 normal controls were enrolled in the study.Layer-specific GLS[GLS of the epimyocardium(GLSepi),GLS of the middle myocardium(GLSmid)and GLS of the endocardium(GLSendo)]and PSD were calculated.Receiver operating characteristic(ROC)analysis was performed to calculate the sensitivity and specificity of LV systolic dysfunction in T2DM patients with PVD.We calculated Pearson’s correlation coefficients between biochemical data,echocardiographic characteristics,and layer-specific GLS and PSD.RESULTS There were significant differences in GLSepi,GLSmid and GLSendo between normal controls,T2DM patients without PVD and T2DM patients with PVD(P<0.001).Trend tests revealed a ranking of normal controls>T2DM patients without PVD>T2DM patients with PVD in the absolute value of GLS(P<0.001).PSD differed significantly between the three groups,and the trend ranking was as follows:normal controls<T2DM patients without PVD<T2DM patients with PVD(P<0.001).ROC analysis revealed that the combination of layer-specific GLS and PSD had high diagnostic efficiency for detecting LV systolic dysfunction in T2DM patients with PVD.Lowdensity lipoprotein cholesterol was positively correlated with GLSepi,GLSmid and PSD(P<0.05),while LV ejection fraction was negatively correlated with GLSepi,GLSmid and GLSendo in T2DM patients with PVD(P<0.01).CONCLUSION PVD may aggravate the deterioration of LV systolic dysfunction in T2DM patients.Layer-specific GLS and PSD can be used to detect LV systolic dysfunction accurately and conveniently in T2DM patients with or without PVD.
文摘颗粒混凝土材料在建筑结构中应用比较常见,但其冲击下的动力学性能研究欠缺.为得到颗粒混凝土的动力学特性,借助MTS实验机得出其静力学强度,其后使用直径为75 mm SHPB系统对颗粒混凝土试样做了多种加载速度下的冲击试验.结果表明,颗粒混凝土试样的毁坏模式是非脆性碎裂,呈现出延性特点;随着冲击速度的增大,破坏后的形状由试样被压扁(形态基本完整,表现出明显的可压缩性)过渡到絮状.应变率在103.88~464.71 s^(-1)时,试样的峰值应力随着应变率的变大而增大,表现出明显的应变率效应.根据实验现象和实验数据进行分析,推导建立了颗粒混凝土峰值应力前和峰值应力后应力-应变的等效本构方程,将实验数据与拟合数据进行对比,具有较为明显的一致性,验证了本构方程的准确性.
文摘目的:应用斑点追踪成像技术对左束支起搏(left bundle branch pacing,LBBP)与希氏束起搏(His bundle pacing,HBP)患者起搏器植入1年后左心室收缩功能及同步性进行评价。方法:获取LBBP患者(40例)、HBP患者(40例)、对照组(40例)标准心尖四腔、三腔、两腔和短轴二尖瓣、心尖水平图像;分别测量和比较LBBP、HBP患者与对照组纵向、圆周和径向应变、纵向应变达峰时间弥散度(peak strain dispersion,PSD)、左室扭转、心室间机械延迟时间(interventricular mechanical delay time,IVMD);计算和比较圆周应变达峰时间标准差(standard deviation of time to peak circumferential strain,T-sd-CS)、径向应变达峰时间标准差(standard deviation of time to peak radial strain,T-sd-RS)。结果:HBP组短轴心尖平面T-sd-CS大于对照组,其余心室电活动及机械同步性参数与对照组无显著差异;LBBP组QRS波宽度大于HBP组和对照组(P<0.05);LBBP组短轴心尖平面T-sd-CS大于HBP组和对照组(P<0.05);LBBP组左室纵向PSD大于HBP组和对照组(P<0.05);各组间左心室短轴径向应变、T-sd-RS、纵向应变、扭转角度及IVMD比较均无统计学差异。结论:LBBP组与HBP组、对照组相比,左心室内同步性稍延迟;LBBP组与HBP组、对照组心肌收缩功能基本相近。
文摘An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Introducing the variation of dynamic grain size and the heterogeneous distribution of disolo- cation densities densities under DRX,a simple method for modeling and simulating DRX processes is developed by using Laplace transformation theory. The results derived from the present model agree well with the experimental results in literatures. This simulation can reproduce a number of features in DRX flow behaviors, for example,single and multiple peak flow behaviors followed by a steady state flow, the transition between them, and so on.
