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Isolated Right Pulmonary Agenesis in a 2-Month-Old Infant in the Pediatric Ward of Hospital of Mali
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作者 Bourama Kané Mody Abdoulaye Camara +3 位作者 Seydou Togo Mohame Maba Traoré Boubacar Mami Touré Moussa Abdoulaye Ouattara 《Open Journal of Pediatrics》 2020年第2期274-279,共6页
<strong><span style="font-family:Verdana;">Introduction: </span></strong><span style="font-family:;" "=""><span style="font-family:Verdana;"... <strong><span style="font-family:Verdana;">Introduction: </span></strong><span style="font-family:;" "=""><span style="font-family:Verdana;">Pulmonary agenesis is a rare congenital abnormality defined by the absence of parenchyma, bronchi and pulmonary vessels, frequently associated with other malformations. We describe a case of isolated right pulmonary agenesis diagnosed in the pediatric ward of the Mali Hospital. </span><b><span style="font-family:Verdana;">Clinical case</span></b><span style="font-family:Verdana;">: He was a month-old baby boy, born at term by cesarean section of a well-followed pregnancy. He was not resuscitated. He developed dyspnea after a cold. An emergency chest X-ray revealed a right opaque lung. He was referred to the hospital for the exploration of this opacity. At the entrance, it weighed 3910 g, size: 54 cm and the temperature was 36.9<span style="white-space:nowrap;">°</span>C. He had a polypnea, an intercostal print. The sounds of the heart were diverted to the right. The rest of the clinical examination was without much particularity. The chest CT scan confirmed the right pulmonary agenesis. Abdominal and cardiac ultrasound w</span></span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> normal. </span><span style="font-family:Verdana;">A healing includ</span><span style="font-family:Verdana;">es</span><span style="font-family:Verdana;"> oxygenotherapy, serum glucose 10% minding 100 ml/ Kg/day and amoxicillin</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">minding 100 mg/ Kg/day</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">at 3 times by oral way</span><span style="font-family:Verdana;">. After 24 hours of treatment</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> we observed an improvement in dyspnea. On D2</span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> he was weaned off oxygen and resumed feeding. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Pulmonary agenesis is a rare congenital anomaly that is frequently associated with other malformations, thus making its prognosis poor. The search for malformative abnormalities should be systematic in right pulmonary agenesis.</span></span> 展开更多
关键词 pulmonary Isolated Agenesis pediatric Hospital of Mali
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Utility of flexible fiberoptic bronchoscopy for critically ill pediatric patients:A systematic review 被引量:13
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作者 Aida Field-Ridley Viyeka Sethi +2 位作者 Shweta Murthi Kiran Nandalike Su-Ting T Li 《World Journal of Critical Care Medicine》 2015年第1期77-88,共12页
AIM: To investigate the diagnostic yield, therapeutic efficacy, and rate of adverse events related to flexible fiberoptic bronchoscopy(FFB) in critically ill children. METHODS: We searched Pub Med, SCOPUS, OVID, and E... AIM: To investigate the diagnostic yield, therapeutic efficacy, and rate of adverse events related to flexible fiberoptic bronchoscopy(FFB) in critically ill children. METHODS: We searched Pub Med, SCOPUS, OVID, and EMBASE databases through July 2014 for English language publications studying FFB performed in the intensive care unit in children < 18 years old. We identified 666 studies, of which 89 full-text studies were screened for further review. Two reviewers independently determined that 27 of these studies met inclusion criteria and extracted data. We examined the diagnostic yield of FFB among upper and lower airway evaluations, as well as the utility of bronchoalveolar lavage(BAL). RESULTS: We found that FFB led to a change in medical management in 28.9%(range 21.9%-69.2%) of critically ill children. The diagnostic yield of FFB was 82%(range 45.2%-100%). Infectious organisms were identified in 25.7%(17.6%-75%) of BALs performed, resulting in a change of antimicrobial management in 19.1%(range: 12.2%-75%). FFB successfully reexpanded atelectasis or removed mucus plugs in 60.3%(range: 23.8%-100%) of patients with atelectasis. Adverse events were reported in 12.9%(range: 0.5%-71.4%) of patients. The most common adverse effects of FFB were transient hypotension, hypoxia and/or bradycardia that resolved with minimal intervention, such as oxygen supplementation or removal of the bronchoscope. Serious adverse events were uncommon; 2.1% of adverse events required intervention such as bag-mask ventilation or intubation and atropine for hypoxia and bradycardia, normal saline boluses for hypotension, or lavage and suctioning for hemorrhage. CONCLUSION: FFB is safe and effective for diagnostic and therapeutic use in critically ill pediatric patients. 展开更多
关键词 BRONCHOSCOPY CRITICAL illness pediatricS Bronchoalveolar LAVAGE pulmonary disease
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Improving antibiotic prescribing in the emergency department for uncomplicated community-acquired pneumonia 被引量:1
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作者 Rebekah Shaw Erica Popovsky +4 位作者 Alyssa Abo Marni Jacobs Nicole Herrera James Chamberlain AndreaHahn 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2020年第4期199-205,共7页
BACKGROUND:The Pediatric Infectious Disease Society(PIDS)and Infectious Disease Society of America(IDSA)published an evidence-based guideline for the treatment of uncomplicated communityacquired pneumonia(CAP)in child... BACKGROUND:The Pediatric Infectious Disease Society(PIDS)and Infectious Disease Society of America(IDSA)published an evidence-based guideline for the treatment of uncomplicated communityacquired pneumonia(CAP)in children,recommending aminopenicillins as the first-line therapy.Poor guideline compliance with 10%–50%of patients admitted to the hospital receiving narrow-spectrum antibiotics has been reported.A new clinical practice guideline(CPG)was implemented in our emergency department(ED)for uncomplicated CAP.The aim of this study was to examine baseline knowledge and ED provider prescribing patterns pre-and post-CPG implementation.METHODS:Prior to CPG-implementation,an anonymous case-based survey was distributed to evaluate knowledge of the current PIDS/IDSA guideline.A retrospective chart review of patients treated in the ED for CAP from January 2015 to February 2017 was performed to assess prescribing patterns for intravenous(IV)antibiotics in the ED at Children’s National Health System pre-and post-CPG implementation.RESULTS:ED providers were aware of the PIDS/IDSA guideline recommendations,with 86.4%of survey responders selecting ampicillin as the initial antibiotic of choice.However,only 41.2%of patients admitted to the hospital with uncomplicated CAP pre-CPG received ampicillin(P<0.01).There was no statistically signifi cant increase in ampicillin prescribing post-CPG(P=0.40).CONCLUSIONS:Providers in the ED are aware of the PIDS/IDSA guideline regarding the first-line therapy for uncomplicated CAP;however,this knowledge does not translate into clinical practice.Implementation of a CPG in isolation did not significantly change prescribing patterns for uncomplicated CAP. 展开更多
关键词 ANTIBIOTICS community-acquired pneumonia Emergency department pediatricS
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Time Course of Elevations in Plasma Olprinone Concentration during Pediatric Cardiac Surgery
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作者 Satoshi Kurokawa Minoru Nomura 《Open Journal of Anesthesiology》 2013年第2期80-83,共4页
Purpose: Little research has been reported to date on the usefulness of olprinone in pediatric cardiac surgery, and no standard pediatric infusion protocol is currently established. Our study sought to confirm that th... Purpose: Little research has been reported to date on the usefulness of olprinone in pediatric cardiac surgery, and no standard pediatric infusion protocol is currently established. Our study sought to confirm that the regimen described herein rapidly achieves the requisite plasma olprinone concentrations. Methods: For the purposes of our study, we enrolled 13 patients: 7 biventricular repair candidates and 6 Fontan-type operation candidates. We administered a continuous infusion of olprinone to our study subjects at 0.3 μg/kg/min with no loading dose starting approximately 30 minutes (min) before weaning from cardiopulmonary bypass (CPB). We performed blood sampling at 15, 30, 45, 60, 90, and 120 min after the start of infusion and at the same elapsed intervals after separation from CPB. We measured plasma olprinone concentrations using ultra-fast liquid chromatography. Results: We observed effective plasma olpri-none concentrations (>20 ng/ml) at 30 min after weaning from CPB, or at 60 min after the start of infusion. Conclusion: We conclude that continuous olprinone infusion at 0.3 μg/kg/min without a loading dose initiated immediately after the release of aortic cross-clamping or immediately after the completion of all surgical procedures quickly and reliably achieves effective plasma concentrations. 展开更多
关键词 OLPRINONE Phosphodiesterase-3 Inhibitor PLASMA CONCENTRATION pediatric Cardiac Surgery WEANING from Cardio-pulmonary Bypass
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Medium-Term Results of Balloon Valvuloplasty of Native Pulmonary Valve Stenosis with and without Supravalvular Obstruction in Childhood
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作者 Olivia Lenoir Daniel Quandt +1 位作者 Oliver Kretschmar Walter Knirsch 《Congenital Heart Disease》 SCIE 2022年第2期161-172,共12页
Objectives:Factors influencing results of balloon valvuloplasty(BVP)of pulmonary valve stenosis(PS)in children are investigated.Background:BVP has become the standard of care for PS,medium-term results are not uniform... Objectives:Factors influencing results of balloon valvuloplasty(BVP)of pulmonary valve stenosis(PS)in children are investigated.Background:BVP has become the standard of care for PS,medium-term results are not uniform and depend on various preconditions.Methods:We analysed the medium-term results of BVP of PS in children in an observational,single centre study.Need for additional procedure was defined as outcome after initial BVP.Results:We included 143 children(83 female)at a median(IQR)age of 2.6(0.26–9.24)months and body weight of 5(3.4–8)kg at BVP with a follow–up of 5.04(1.6–10.2)years.We used balloon size of 10(9–14)mm and maximal balloon pressure of 4(3.5–10)atm,resulting in balloon–to–pulmonary annulus ratio of 1.28(1.2–1.4).Systolic pressure gradient of PS was reduced with BVP(43.5 mmHg vs.14.0 mmHg,p<0.001)and confirmed by echocardiography(68.0 mmHg vs.25.0 mmHg,p<0.001)day 1 post procedure.Pulmonary BVP with associated supravalvular PS resulted in a relevant reduction of systolic pressure gradient in 23 of 31 patients(74.2%).Early additional procedure was necessary in 14 patients(9.8%)after 0.2(0.1–0.7)years due to residual PS(n=13)and infective endocarditis(n=1).Factors for additional procedures were associated supravalvular PS with a higher residual pressure gradient,but not genetic syndrome.During further follow–up of 5.04(1.6–10.2)years no further additional procedures were needed.Conclusions:Pulmonary BVP of native pulmonary valve stenosis leads to excellent medium-term results,even in 3 of 4 infants with associated supravalvular obstruction sufficient pressure relief can be obtained. 展开更多
关键词 pediatric CATHETER CONGENITAL pulmonary balloon valvuloplasty
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Prediction of Pulmonary Arterial Pressure Level after Repair of Congenital Cardiac Communications and Discharge from the Hospital: Role of Down Syndrome and Early Postoperative Hemodynamics
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作者 Eloisa Sassa Carvalho Maria Francilene SSouza +5 位作者 Kelly Cristina O.Abud Claudia R.P.Castro Juliano G.Penha Ana Maria Thomaz Vanessa A.Guimaraes Antonio Augusto Lopes 《Congenital Heart Disease》 SCIE 2022年第3期351-363,共13页
Background:Postoperative pulmonary hypertension limits the success of surgical treatment in some patients with unrestrictive congenital cardiac communications.Identifying patients at risk of developing postoperative p... Background:Postoperative pulmonary hypertension limits the success of surgical treatment in some patients with unrestrictive congenital cardiac communications.Identifying patients at risk of developing postoperative pulmonary hypertension is important to individualize follow-up strategies.Methods:We analyzed a prospective cohort of 52 pediatric patients(age 3 to 35 months)looking for perioperative predictors of mildly elevated pulmonary arterial pressure 6 months after surgery,defined as a systolic pressure greater than 30 mmHg by transthoracic echocardiography.This corresponds to a mean pulmonary arterial pressure of>20 mmHg.Clinical,echocardiographic and hemodynamic parameters were investigated.Perioperative hemodynamics was assessed by directly measuring pulmonary and systemic arterial pressures using indwelling catheters.Early postoperative pulmonary hemodynamics was defined as the mean pulmonary/systemic mean arterial pressure ratio(PAP/SAP)obtained per patient during the first 6 h of postoperative care.Results:Among the factors that were investigated as possible predictors,perioperative hemodynamics and the presence of Down syndrome were initially selected using univariate analysis(p<0.030).Early postoperative PAP/SAP was correlated with PAP/SAP obtained in the operating room just after cardiopulmonary bypass(r=0.70,p<0.001),and it was higher in subjects with Down syndrome than in nonsyndromic individuals(p=0.003).Early postoperative PAP/SAP was the only predictor selected using multivariate analysis.It was characterized as an independent predictor after adjustments for possible confounders.An early postoperative PAP/SAP of>0.35 was 76%sensitive and 74%specific at predicting a systolic pulmonary arterial pressure of>30 mmHg 6 months after surgery(hazard ratio with 95%CI 8.972[2.428–33.158],p=0.002).Conclusion:The hypertensive early postoperative behavior of the pulmonary circulation was strongly but not exclusively associated with Down syndrome,and it was characterized as an independent predictor of altered pulmonary arterial pressure after discharge from the hospital. 展开更多
关键词 pulmonary hypertension congenital heart disease Down syndrome pediatric cardiac surgery
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Massive pulmonary embolism in Klippel-Trenaunay syndrome after leg raising:A case report
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作者 Chih-Yu Lo Kuen-Bao Chen +1 位作者 Li-Kuei Chen Chiuan-Shiou Chiou 《World Journal of Clinical Cases》 SCIE 2023年第17期4133-4141,共9页
BACKGROUND Klippel-Trenaunay syndrome(KTS)is a rare congenital disorder characterized by a combination of capillary malformations,soft-tissue or bone hypertrophy,and varicose veins or venous malformations.The syndrome... BACKGROUND Klippel-Trenaunay syndrome(KTS)is a rare congenital disorder characterized by a combination of capillary malformations,soft-tissue or bone hypertrophy,and varicose veins or venous malformations.The syndrome predisposes patients to hypercoagulable states,including venous thromboembolism and pulmonary embolism(PE).CASE SUMMARY A 12-year-old girl with KTS was scheduled excision of verrucous hyperkeratosis in the left foot and posterior aspect of the left leg and left thigh and excision of a cutaneous hemangioma in the right buttock.After induction,the surgeon elevated the patient’s leg for sterilization,whereupon she experienced a massive PE and refractory cardiac arrest.Extracorporeal membrane oxygenation(ECMO)was performed after prolonged resuscitation,and she had a return of spontaneous circulation.After this episode,the patient was discharged without any neurologic complications.CONCLUSION The mechanism of PE,a lethal disease,involves a preexisting deep vein thrombosis that is mechanically dislodged by compression or changing positions and travels to the pulmonary artery.Therefore,patients predisposed to PE should be prescribed prophylactic anticoagulants.If the patient has unstable vital signs,resuscitation should be started immediately,and extracorporeal cardiopulmonary resuscitation should be considered in settings with existing ECMO protocols,expertise,and equipment.Awareness of PE in patients with KTS while leg raising for sterilization is critical. 展开更多
关键词 Klippel-Trenaunay syndrome pediatric pulmonary embolism ANESTHESIA Case report
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陈华教授传承浙派中医儿科学术特色治疗小儿肺系疾病经验探析
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作者 杨伟吉 吴蔚波 +2 位作者 彭甜 章家菡 陈华 《浙江中医药大学学报》 CAS 2024年第4期452-455,共4页
[目的]总结陈华教授传承浙派中医儿科学术特色治疗小儿肺系疾病的经验。[方法]通过随师临证,研究浙派儿科学术特点,从病因病机、遣方用药等方面阐释陈师治疗小儿肺系疾病的临床经验及方药特色,并通过临床验案加以佐证。[结果]陈师诊疗... [目的]总结陈华教授传承浙派中医儿科学术特色治疗小儿肺系疾病的经验。[方法]通过随师临证,研究浙派儿科学术特点,从病因病机、遣方用药等方面阐释陈师治疗小儿肺系疾病的临床经验及方药特色,并通过临床验案加以佐证。[结果]陈师诊疗小儿肺系疾病的经验可概括为融通中西,谨守病机;四望一听,尤重望诊;分期论治,善用和清;用药轻灵,顾护脾胃。所列案例为小儿急性上呼吸道感染的典型案例,急性感染期解表清里,迁延反复期益气养阴,缓解恢复期补肺健脾,疗效显著。[结论]陈师小儿肺系疾病的诊治经验,不仅有较高临床实用价值,更是对浙派中医儿科学术特色的传承和发展。 展开更多
关键词 肺系疾病 浙派中医儿科 小儿 临床经验 医案 陈华
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PBL联合CBL教学法在儿童肺功能临床见习教学中的应用
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作者 刘芳君 林颖 +2 位作者 龚财惠 秦江蛟 刘莎 《中国高等医学教育》 2024年第5期94-96,共3页
目的:探索PBL联合CBL教学法在儿童肺功能临床见习教学中的应用效果。方法:将呼吸专科护士培训班45名学员随机分为对照组和试验组,在临床见习中分别实施CBL教学法和PBL联合CBL的教学法,比较两组学员考试成绩及教学效果主观评价情况。结果... 目的:探索PBL联合CBL教学法在儿童肺功能临床见习教学中的应用效果。方法:将呼吸专科护士培训班45名学员随机分为对照组和试验组,在临床见习中分别实施CBL教学法和PBL联合CBL的教学法,比较两组学员考试成绩及教学效果主观评价情况。结果:试验组学员考试成绩及教学效果的总体主观评价均明显高于对照组(P<0.05)。结论:在理论课时较少且学员学习基础较薄弱的肺功能临床见习教学实践中,PBL联合CBL教学法更有利于学员对难点内容的理解和掌握,可有效提高教学质量,得到学员的认可和喜爱。 展开更多
关键词 儿童肺功能检查 临床见习 PBL联合CBL教学法 呼吸专科护士
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Current Status of Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease 被引量:18
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作者 De-Shun Liu Xiu-Di Han Xue-Dong Liu 《Chinese Medical Journal》 SCIE CAS CSCD 2018年第9期1086-1091,共6页
Objective:Worldwide,community-acquired pneumonia (CAP) is a common infection that occurs in older adults,who may have pulmonary comorbidities,including chronic obstructive pulmonary disease (COPD).Although there ... Objective:Worldwide,community-acquired pneumonia (CAP) is a common infection that occurs in older adults,who may have pulmonary comorbidities,including chronic obstructive pulmonary disease (COPD).Although there have been clinical studies on the coexistence of CAP with COPD,there remain some controversial findings.This review presents the current status of COPD in CAP patients,including the disease burden,clinical characteristics,risk factors,microbial etiology,and antibiotic treatment.Data Sources:A literature review included full peer-reviewed publications up to January 2018 derived from the PubMed database,using the keywords "community-acquired pneumonia" and "chronic obstructive pulmonary disease".Study Selection:Papers in English were reviewed,with no restriction on study design.Results:COPD patients who are treated with inhaled corticosteroids are at an increased risk of CAP and have a worse prognosis,but data regarding the increased mortality remains unclear.Although Streptococcus pneumoniae is still regarded as the most common bacteria isolated from patients with CAP and COPD,Pseudomonas aeruginosa is also important,and physicians should pay close attention to the occurrence of antimicrobial resistance,particularly in these two organisms.Conclusions:COPD is a common and important predisposing comorbidity in patients who develop CAP.COPD often aggravates the clinical symptoms of patients with CAP,complicating treatment,but generally does not appear to affect prognosis. 展开更多
关键词 Chronic Obstructive pulmonary Disease community-acquired Pneumonia MORBIDITY TREATMENT
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肺部超声在小儿肺部疾病中的应用进展
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作者 栗雯霏 张捷 栗建辉 《医学综述》 CAS 2024年第14期1765-1771,共7页
超声在诊断实性脏器、含液性脏器及浅表组织等疾病方面具有准确、经济、非侵入性等优点。既往认为超声仅用于诊断胸膜炎、胸腔积液等肺部疾病,近年认为超声在其他肺部疾病(气胸、肺炎、肺间质病变、呼吸窘迫综合征、先天性肺畸形等)诊... 超声在诊断实性脏器、含液性脏器及浅表组织等疾病方面具有准确、经济、非侵入性等优点。既往认为超声仅用于诊断胸膜炎、胸腔积液等肺部疾病,近年认为超声在其他肺部疾病(气胸、肺炎、肺间质病变、呼吸窘迫综合征、先天性肺畸形等)诊断方面也具有潜力。由于气体的存在和胸廓的干扰,肺脏不适用超声检查,而小儿胸腔的特殊解剖结构使其可通过超声检查时肺表面产生的超声伪像(B线)诊断肺部疾病,因此肺部超声被认为是诊断肺部疾病的有效方法之一,特别是小儿,基本上可以替代X线,以防电离辐射。 展开更多
关键词 肺部疾病 肺部超声 小儿
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优化个体护理对支气管哮喘患儿生理健康状况的影响
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作者 沈琴 卢欢欢 《中西医结合护理(中英文)》 2024年第1期9-12,共4页
目的探讨优化个体护理应用于支气管哮喘患儿对其生理健康状况的影响。方法收集2021年1月至2022年12月苏州大学附属儿童医院收治的348例支气管哮喘患儿的一般资料并开展回顾性分析,依据不同的护理方式分为对照组(173例)和观察组(175例)... 目的探讨优化个体护理应用于支气管哮喘患儿对其生理健康状况的影响。方法收集2021年1月至2022年12月苏州大学附属儿童医院收治的348例支气管哮喘患儿的一般资料并开展回顾性分析,依据不同的护理方式分为对照组(173例)和观察组(175例)。对照组行常规护理,观察组行优化个体护理。比较2组患儿的生理健康状况,包括肺功能指标、血气分析指标、临床相关指标及炎症因子水平。结果观察组的肺部啰音及喘憋消失时间均较对照组更早,住院时间较对照组更短(P均<0.05)。出院时及出院2周后,观察组的用力肺活量、一秒率、呼气高峰流量和动脉血氧分压均明显较同期对照组更高,动脉血二氧化碳分压、白介素-6、白介素-10和超敏C反应蛋白水平均明显较同期对照组更低(P均<0.05);2组的上述指标均较入院时更优(P均<0.05)。结论在支气管哮喘患儿中实施优化个体护理,可有效改善患儿的临床症状、肺功能及血气分析指标,降低其机体炎症水平,促进患儿康复。 展开更多
关键词 小儿支气管哮喘 优化个体护理 肺功能 炎症因子
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阿奇霉素联合孟鲁司特钠片对小儿支原体肺炎症状、肺功能及免疫功能的影响 被引量:1
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作者 王旭颖 《中国处方药》 2024年第7期88-90,共3页
目的探讨阿奇霉素联合孟鲁司特钠片对小儿支原体肺炎症状、肺功能及免疫功能的影响。方法选择2021年1月~2023年8月某院接诊的98例支原体肺炎患儿,采用抽签法随机分为两组。对照组49例,给予阿奇霉素治疗,观察组49例,在对照组基础上给予... 目的探讨阿奇霉素联合孟鲁司特钠片对小儿支原体肺炎症状、肺功能及免疫功能的影响。方法选择2021年1月~2023年8月某院接诊的98例支原体肺炎患儿,采用抽签法随机分为两组。对照组49例,给予阿奇霉素治疗,观察组49例,在对照组基础上给予孟鲁司特钠片治疗。比较两组的症状改善时间、肺功能及免疫功能。结果观察组的体温恢复正常时间、X线阴影消失时间、肺部啰音消失时间和咳嗽停止时间短于对照组(P<0.05);治疗前,两组的最大呼气中期流速(MMF)、最大肺活量(VC_(max))、呼气峰值流量(PEF)、最大自主通气量(MVV)和第1秒用力呼气容积占预计值百分比(FEV_(1)%)比较,差异无统计学意义(P>0.05),治疗后,两组的MMF、VC_(max)、PEF、MVV和FEV_(1)%均明显升高,且观察组更高(P<0.05);治疗前,两组的免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及免疫球蛋白M(IgM)水平比较,差异无统计学意义(P>0.05),治疗后,两组的IgA、IgM和IgG水平均明显升高,且观察组更高(P<0.05);两组患儿的恶心、肝功能异常、皮疹及腹部不适发生率比较,差异无统计学意义(P>0.05)。结论阿奇霉素与孟鲁司特钠片联用能明显改善小儿支原体肺炎的症状、肺功能及免疫功能。 展开更多
关键词 阿奇霉素 孟鲁司特钠片 小儿支原体肺炎 免疫功能 肺功能
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小儿肺咳颗粒联合阿奇霉素对小儿肺炎的治疗作用及对患者炎性因子水平的影响 被引量:1
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作者 张贵州 《临床研究》 2024年第2期102-105,共4页
目的分析小儿肺咳颗粒联合阿奇霉素在小儿肺炎中疗效及对炎性因子水平的影响。方法将南阳市中心医院在2022年2月至2023年2月期间收治的肺炎患儿(72例)作为研究对象,依据区间随机法将其分为对照组、研究组,各纳入36例,对照组药物治疗方... 目的分析小儿肺咳颗粒联合阿奇霉素在小儿肺炎中疗效及对炎性因子水平的影响。方法将南阳市中心医院在2022年2月至2023年2月期间收治的肺炎患儿(72例)作为研究对象,依据区间随机法将其分为对照组、研究组,各纳入36例,对照组药物治疗方案为单纯阿奇霉素,研究组药物治疗方案为阿奇霉素联合小儿肺咳颗粒。比较两组治疗有效率、基础症状消失时间、治疗前后炎性因子指标[C反应蛋白(CRP)、降钙素原(PCT)、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)]变化情况及治疗前后肺部感染评分(CPIS)变化情况。结果研究组治疗有效率(97.22%)高于对照组(80.56%),差异有统计学意义(P<0.05)。研究组发热、咳嗽、气促、湿啰音消失时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组间各炎症因子水平对比,差异无统计学意义(P>0.05);治疗后,两组CRP、PCT、TNF-α、IL-6较治疗前均有明显降低,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组间CPIS评分对比,差异无统计学意义(P>0.05);治疗后,两组CPIS评分较治疗前均有明显降低,且研究组低于对照组,差异有统计学意义(P<0.05)。结论小儿肺咳颗粒联合阿奇霉素在小儿肺炎中疗效理想,可有效控制肺部感染、炎性因子水平,值得应用。 展开更多
关键词 小儿肺咳颗粒 阿奇霉素 小儿肺炎 炎性因子 肺部感染评分
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常克教授运用“开郁顺气”治疗小儿肺系疾病举隅
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作者 车昭 杨钰潇 +2 位作者 罗慧 张静祎 常克 《成都中医药大学学报》 2024年第3期23-26,共4页
本文旨在介绍常克教授治疗小儿肺系疾病的经验。常克教授认为“肺气郁闭”是小儿肺系疾病的常见病机,病邪在少阳经脉,与肺、脾、肝三脏关系密切,与小儿生理病理特点相关。治疗当以“开郁顺气”为总原则,促使人体气机运行快速恢复正常,... 本文旨在介绍常克教授治疗小儿肺系疾病的经验。常克教授认为“肺气郁闭”是小儿肺系疾病的常见病机,病邪在少阳经脉,与肺、脾、肝三脏关系密切,与小儿生理病理特点相关。治疗当以“开郁顺气”为总原则,促使人体气机运行快速恢复正常,教授临床上还注重辨病与辨证相结合,常用自拟柴府汤加减,调气开郁,祛火通腑,复肺脾肝之气机,临床反应良好。 展开更多
关键词 开郁顺气 肺系疾病 儿科 医家经验
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肺动脉环缩术治疗小儿心力衰竭二例
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作者 窦铮 马凯 +12 位作者 张本青 芮璐 林野 王旭 曾敏 逄坤静 张惠丽 毛凤群 袁建辉 何奇彧 吴冬冬 刘禹泽 李守军 《中国循环杂志》 CSCD 北大核心 2024年第5期511-515,共5页
本文报道2例于2021年12月至2022年1月期间在中国医学科学院阜外医院接受肺动脉环缩术治疗的小儿心力衰竭病例。1例患儿8个月大,术前超声心动图及心脏磁共振成像提示左心室心肌致密化不全、左心功能不全、室间隔缺损、房间隔缺损。另1例... 本文报道2例于2021年12月至2022年1月期间在中国医学科学院阜外医院接受肺动脉环缩术治疗的小儿心力衰竭病例。1例患儿8个月大,术前超声心动图及心脏磁共振成像提示左心室心肌致密化不全、左心功能不全、室间隔缺损、房间隔缺损。另1例患儿4个月大,超声心动图考虑左心室心肌致密化不全、左心功能不全、主动脉弓缩窄。经肺动脉环缩术治疗后,两例患儿左心功能及形态均显著改善,未发生严重手术相关并发症。肺动脉环缩术在小儿心力衰竭治疗的个例经验中表现出比药物治疗更满意的疗效和安全性,尤其对于药物无法控制的小儿心力衰竭,具有一定的推广价值,但仍需更多临床数据支持。 展开更多
关键词 肺动脉环缩术 小儿心力衰竭 先天性心脏病 病例报告
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儿童心脏外科手术体外循环与非体外循环围术期血糖及乳酸变化的比较分析
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作者 陈静 孙军 +1 位作者 张思成 李传应 《分子诊断与治疗杂志》 2024年第7期1195-1199,共5页
目的 探讨体外循环(CPB)儿童心脏外科手术患者围术期血糖水平变化以及术后乳酸水平相关影响因素分析。方法 选取2022年01月至2022年12月在安徽省儿童医院行心脏外科手术共103例患者,按手术方式分为CPB组和非CPB组。比较两组的术前术后... 目的 探讨体外循环(CPB)儿童心脏外科手术患者围术期血糖水平变化以及术后乳酸水平相关影响因素分析。方法 选取2022年01月至2022年12月在安徽省儿童医院行心脏外科手术共103例患者,按手术方式分为CPB组和非CPB组。比较两组的术前术后血糖水平、术后乳酸水平及相关影响因素。结果 CPB组患者术后血糖水平平均值高于术前血糖水平平均值,差异有统计学意义(t=13.37, P<0.001)。非CPB组为患者术后血糖水平高于术前血糖水平,差异有统计学意义(t=3.60,P=0.001)。两组患者术前血糖比较无明显差异(t=0.11, P=0.91),CPB组术后血糖水平明显高于非CPB血糖水平,差异有显著统计学意义(t=7.55, P<0.0001)。CPB组患者术后乳酸水平明显高于非CPB组,差异有统计学意义(t=4.16, P<0.001),且两组患者中乳酸水平与术后血糖水平明显正相关(P=0.042),与总体外转流时间和主肺动脉阻断时间明显相关(P=0.049)。结论 CPB儿童心脏外科手术患者的术后血糖水平升高更加明显,术后血糖水平与乳酸水平明显相关。 展开更多
关键词 儿童心脏外科手术 体外循环 血糖 乳酸
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分析整体干预对小儿支气管肺炎患儿睡眠质量的应用效果
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作者 张丽珍 周宝萍 《世界睡眠医学杂志》 2024年第3期588-590,共3页
目的:分析整体干预对小儿支气管肺炎患儿睡眠质量的应用效果。方法:选取2022年1月至2023年9月厦门大学附属妇女儿童医院收治的小儿支气管肺炎患儿100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例。对照组给予常规护理干... 目的:分析整体干预对小儿支气管肺炎患儿睡眠质量的应用效果。方法:选取2022年1月至2023年9月厦门大学附属妇女儿童医院收治的小儿支气管肺炎患儿100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例。对照组给予常规护理干预,观察组给予整体护理干预,采用匹兹堡睡眠质量指数(PSQI)比较2组患儿睡眠质量的差异。结果:干预后,观察组小儿支气管肺炎患儿PSQI评分显著低于对照组,差异有统计学意义(P<0.05)。结论:小儿支气管肺炎患儿实施整体干预效果确切,可有效改善患儿的睡眠质量,值得临床推广应用。 展开更多
关键词 整体干预 小儿支气管肺炎 应用效果 睡眠质量 肺部疾病
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痰热清注射液联合注射用阿莫西林钠克拉维酸钾治疗小儿支气管肺炎的效果及安全性
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作者 范宴燕 张倩倩 《临床合理用药杂志》 2024年第15期33-35,39,共4页
目的 观察痰热清注射液联合注射用阿莫西林钠克拉维酸钾治疗小儿支气管肺炎的临床效果及安全性。方法 回顾性选取2020年1月—2022年12月鹰潭市中医院收治的支气管肺炎患儿70例,根据用药方法分为西药组与中药联合组,各35例。西药组患儿... 目的 观察痰热清注射液联合注射用阿莫西林钠克拉维酸钾治疗小儿支气管肺炎的临床效果及安全性。方法 回顾性选取2020年1月—2022年12月鹰潭市中医院收治的支气管肺炎患儿70例,根据用药方法分为西药组与中药联合组,各35例。西药组患儿予注射用阿莫西林钠克拉维酸钾,中药联合组患儿在西药组基础上予痰热清注射液,2组均持续用药1周。比较2组临床疗效,症状及体征消失时间,用药前后肺功能指标、免疫指标、血清炎性因子及不良反应。结果 中药联合组总有效率高于西药组(97.14%vs. 77.14%,χ^(2)=4.590,P=0.032)。中药联合组体温恢复正常时间、呼吸功能改善时间及咳嗽、肺部啰音、肺部病灶消失时间均短于西药组(P<0.05)。用药1周后,2组第1秒用力呼气容积、用力肺活量、呼气流量峰值及免疫球蛋白A、免疫球蛋白G、免疫球蛋白M、血清白介素-2、白介素-10水平高于用药前,血清肿瘤坏死因子-α水平低于用药前,且中药联合组高/低于西药组(P<0.01)。中药联合组与西药组不良反应总发生率比较,差异无统计学意义(5.71%vs. 8.57%,P=1.000)。结论 小儿支气管肺炎采用痰热清注射液联合注射用阿莫西林钠克拉维酸钾治疗的临床效果显著,能够明显改善患儿的肺功能,提高免疫功能,减轻炎性反应,进而促进症状及体征快速消失,且安全性较高。 展开更多
关键词 小儿支气管肺炎 痰热清注射液 注射用阿莫西林钠克拉维酸钾 肺功能 免疫功能 不良反应
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肺脏超声与SAA/hs-CRP、PCT诊断小儿感染性肺炎的价值
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作者 王小晔 余秀华 +3 位作者 蔡海丽 宋欣欣 赵宇薇 孟婷婷 《中国现代医生》 2024年第24期21-24,49,共5页
目的探究小儿感染性肺炎肺脏超声表现及与血清淀粉样蛋白A(serum amyloid protein A,SAA)/超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、降钙素原(procalcitonin,PCT)的联合诊断价值。方法选取中国人民解放军联勤保障部... 目的探究小儿感染性肺炎肺脏超声表现及与血清淀粉样蛋白A(serum amyloid protein A,SAA)/超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、降钙素原(procalcitonin,PCT)的联合诊断价值。方法选取中国人民解放军联勤保障部队第九〇三医院2019年1月至2023年6月收治的107例感染性肺炎患儿作为研究组,选取同期入院体检的50名健康儿童作为对照组。两组儿童均行肺脏超声检查,分析感染性肺炎患儿的超声表现;比较SAA/hs-CRP、PCT,并分析肺脏超声与SAA/hs-CRP、PCT联合检测对小儿感染性肺炎的诊断价值。结果107例感染性肺炎患儿经肺脏超声诊断阳性104例,阳性率97.20%。研究组患儿肺脏超声评分、SAA/hs-CRP、PCT高于对照组(P<0.05)。重症感染性肺炎患儿肺脏超声评分、SAA/hs-CRP、PCT高于轻症患儿(P<0.05)。肺脏超声与SAA/hs-CRP、PCT联合检测对小儿感染性肺炎的诊断效能优于单独检测,曲线下面积为0.923,敏感度、特异性分别为92.30%、87.98%。肺脏超声评分与SAA/hs-CRP、PCT呈正相关(P<0.05)。结论肺脏超声可显示感染性肺炎患儿的肺部病变特征,患儿超声表现多为胸膜线异常、B线增多、肺实变,与SAA/hs-CRP、PCT联合检测可进一步提高对小儿感染性肺炎的诊断效能。 展开更多
关键词 小儿感染性肺炎 肺脏超声 超声表现 血清淀粉样蛋白A 超敏C反应蛋白 降钙素原
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