The clinical symptoms of a disorder which is known locally as ＂wool-eating ailment＂ in Guizhou semi-fine wool sheep in the Weining County of Guizhou Province, China, are poor weight gain, lost appetite, pica, emacia...The clinical symptoms of a disorder which is known locally as ＂wool-eating ailment＂ in Guizhou semi-fine wool sheep in the Weining County of Guizhou Province, China, are poor weight gain, lost appetite, pica, emaciation, and wool-eating. The mineral composition of forage, and samples of blood, liver and wool from Guizhou semi-fine wool sheep in affected ranches were compared with those from the unaffected areas. The mean concentration of iron in forage from affected pasture was significantly higher than that from the unaffected pasture. The mean concentration of sulfur in forage from the affected and unaffected pasture was similar and within normal ranges. The mean concentration of sulfur in blood, liver and wool from the affected Guizhou semi-fine wool sheep was significantly lower than that from the unaffected sheep while the content of iron in blood, liver and wool from the affected sheep was significantly higher than that from the unaffected sheep. Oral administration of calcium sulfate prevented and cured the disease. We concluded that the disease of Guizhou semi-fine wool sheep in the Weining County is due to S deficiency caused by the high Fe in forages.展开更多
BMP15基因(bone morphogenetic protein 15,BMP15)和BMPR-IB基因(bone morphogenetic protein 1beta,BMPR-IB)是影响绵羊排卵率和产羔数的主效基因,对绵羊多羔性状有明显加性效应,可作为检测绵羊繁殖力的主要辅助标记.利用操作简便、灵...BMP15基因(bone morphogenetic protein 15,BMP15)和BMPR-IB基因(bone morphogenetic protein 1beta,BMPR-IB)是影响绵羊排卵率和产羔数的主效基因,对绵羊多羔性状有明显加性效应,可作为检测绵羊繁殖力的主要辅助标记.利用操作简便、灵敏度高等特点的高分辨率熔解曲线分析(High resolution melting curve,HRM),并结合测序技术,对63只彭波半细毛羊(产单羔羊56只、产双羔羊7只)BMP15和BMPR-IB基因的常见突变区域进行突变分析.结果表明:所有样本BMP15基因第718位、第747位、第755位、第871位和第896位,BMPR-IB基因233位和746位均未见DNA突变;仅23个样本的BMPR-IB基因1 078位发现T到C的杂合性突变.但经相关性检验分析,发现该杂合性突变与彭波半细毛羊的双羔性无关.展开更多
基金supported financially by the National Natural Science Foundation of China (40930533/ D011004)the China Agriculture Research System (CARS-40-30)+2 种基金the Science Foundation of Bijie District Grant, China (200905)the Guizhou Provincial Key Technologies R&D Program, China (NY[2010]3041)the Guizhou Governor Foundation, China (2009129)
文摘The clinical symptoms of a disorder which is known locally as ＂wool-eating ailment＂ in Guizhou semi-fine wool sheep in the Weining County of Guizhou Province, China, are poor weight gain, lost appetite, pica, emaciation, and wool-eating. The mineral composition of forage, and samples of blood, liver and wool from Guizhou semi-fine wool sheep in affected ranches were compared with those from the unaffected areas. The mean concentration of iron in forage from affected pasture was significantly higher than that from the unaffected pasture. The mean concentration of sulfur in forage from the affected and unaffected pasture was similar and within normal ranges. The mean concentration of sulfur in blood, liver and wool from the affected Guizhou semi-fine wool sheep was significantly lower than that from the unaffected sheep while the content of iron in blood, liver and wool from the affected sheep was significantly higher than that from the unaffected sheep. Oral administration of calcium sulfate prevented and cured the disease. We concluded that the disease of Guizhou semi-fine wool sheep in the Weining County is due to S deficiency caused by the high Fe in forages.
