Background: Highly Active Antiretroviral Therapy (HAART) has changed the clinical picture of HIV infection by reducing morbidity and mortality rates in the population. However, alterations in lipid metabolism leading ...Background: Highly Active Antiretroviral Therapy (HAART) has changed the clinical picture of HIV infection by reducing morbidity and mortality rates in the population. However, alterations in lipid metabolism leading to hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia and redistribution of body fat, which are risk factors for cardiovascular diseases, have emerged. Metabolic Syndrome (MS) is a complex disorder represented by a set of cardiovascular risk factors commonly associated with central adiposity and insulin resistance. Aim: Current paper evaluates the prevalence of MS in patients with HIV/AIDS using HAART from a reference Center in southern Brazil. Methods: Samples comprised patients who had the infection for at least five years and were undergoing antiretroviral therapy. Metabolic syndrome was identified according to the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII). A physical examination was performed by evaluating percentage of body fat by bio-impedance and measuring blood pressure, determination of Body Mass Index and Waist-Hip Ratio, glycaemia, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: 184 patients were evaluated. MS prevalence was 30% (55 patients), with 30 (16.3%) males and 25 (13.7%) females. Conclusions: Brazil was among the first country profoundly impacted by the HIV/AIDS epidemic but today, Brazil has less than 1% adult HIV prevalence, implemented treatment and prevention programs early in the epidemic. Whereas there is currently a significant increase in the survival of HIV patients by HAART, the patients reveal a higher prevalence of Metabolic Syndrome in this specific population requiring political strategy of care to this population.展开更多
Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to 2021.It also aimed to recommend targeted interventions for the prevention and treatment of HIV/A...Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to 2021.It also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly patients.Methods Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the CRIMS.Trend tests and spatial analyses were also conducted.Results Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in China.The main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in women.The proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for CHC.The spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern provinces.Conclusion In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual transmission.The primary modes of infection were CHC and NMNCHC.There were variations in the sex ratio among different age groups,infected through various sexual behaviors.HIV/AIDS cases exhibited spatial clustering.Based on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.展开更多
文摘Background: Highly Active Antiretroviral Therapy (HAART) has changed the clinical picture of HIV infection by reducing morbidity and mortality rates in the population. However, alterations in lipid metabolism leading to hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia and redistribution of body fat, which are risk factors for cardiovascular diseases, have emerged. Metabolic Syndrome (MS) is a complex disorder represented by a set of cardiovascular risk factors commonly associated with central adiposity and insulin resistance. Aim: Current paper evaluates the prevalence of MS in patients with HIV/AIDS using HAART from a reference Center in southern Brazil. Methods: Samples comprised patients who had the infection for at least five years and were undergoing antiretroviral therapy. Metabolic syndrome was identified according to the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII). A physical examination was performed by evaluating percentage of body fat by bio-impedance and measuring blood pressure, determination of Body Mass Index and Waist-Hip Ratio, glycaemia, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: 184 patients were evaluated. MS prevalence was 30% (55 patients), with 30 (16.3%) males and 25 (13.7%) females. Conclusions: Brazil was among the first country profoundly impacted by the HIV/AIDS epidemic but today, Brazil has less than 1% adult HIV prevalence, implemented treatment and prevention programs early in the epidemic. Whereas there is currently a significant increase in the survival of HIV patients by HAART, the patients reveal a higher prevalence of Metabolic Syndrome in this specific population requiring political strategy of care to this population.
文摘Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to 2021.It also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly patients.Methods Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the CRIMS.Trend tests and spatial analyses were also conducted.Results Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in China.The main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in women.The proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for CHC.The spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern provinces.Conclusion In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual transmission.The primary modes of infection were CHC and NMNCHC.There were variations in the sex ratio among different age groups,infected through various sexual behaviors.HIV/AIDS cases exhibited spatial clustering.Based on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.
