Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets.Peperomia dindygulensis,belonging to Piperaceae family,was proved to b...Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets.Peperomia dindygulensis,belonging to Piperaceae family,was proved to be effective to the treatment of cancer,but the action mechanism is incomprehensive.In this study,we employed molecular docking and network pharmacology methods to predict the effective compositions,potential target proteins and potential biological pathways.Six compounds were predicted to have potential activity for liver-cancer target proteins.Meanwhile,we analyzed the biological pathways based on compounds-target network,which may be play an important role in liver cancer.This article is presented to explore the active ingredients of P.dindygulensis and provide crucial material for the further research and development of the plant.展开更多
文摘Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets.Peperomia dindygulensis,belonging to Piperaceae family,was proved to be effective to the treatment of cancer,but the action mechanism is incomprehensive.In this study,we employed molecular docking and network pharmacology methods to predict the effective compositions,potential target proteins and potential biological pathways.Six compounds were predicted to have potential activity for liver-cancer target proteins.Meanwhile,we analyzed the biological pathways based on compounds-target network,which may be play an important role in liver cancer.This article is presented to explore the active ingredients of P.dindygulensis and provide crucial material for the further research and development of the plant.
