[Objectives]This study was conducted to explore the intervention mechanism of Danggui Buxue Decoction in perimenopausal syndrome based on network pharmacology and molecular docking.[Methods]The chemical components and...[Objectives]This study was conducted to explore the intervention mechanism of Danggui Buxue Decoction in perimenopausal syndrome based on network pharmacology and molecular docking.[Methods]The chemical components and targets of Danggui Buxue Decoction were acquired through the TCMSP database,and the main targets of perimenopausal syndrome were obtained through the GeneCards database.The component targets and disease targets were intersected,and combining with active components and Chinese herbs in the decoction,a traditional Chinese medicine-component-target network was constructed using Cytoscape 3.7.1 software.The STRING platform was employed for protein-protein interaction analysis.The DAVID analysis platform was used to conduct target GO and KEGG enrichment analysis,so as to predict the action mechanism Danggui Buxue Decoction.Finally,an active component-disease target-signal pathway network diagram was constructed.[Results]Twenty two components in Danggui Buxue Decoction related to perimenopausal syndrome and 120 corresponding targets were obtained,including active components such as 1,7-dihydroxy-3,9-dimquercetin and kaempferol,and key targets such as TNF,ESR1 and PPARG.The results of GO analysis and KEEG analysis indicated that Danggui Buxue Decoction might regulate the transcription of RNA polymerase II promoter,DNA templating,gene expression,signal transduction,hypoxia response and other biological processes by regulating multiple signal pathways such as chemical carcinogenesis-receptor activation,cancer pathways,lipid and atherosclerosis,tryptophan metabolism,malaria,steroid hormone biosynthesis and chemical carcinogenesis-DNA adduct.[Conclusions]Danggui Buxue Decoction intervenes in perimenopausal syndrome through multiple components,targets and pathways,providing a basis for elucidating the intervention mechanism of Danggui Buxue Decoction and expanding its clinical application.展开更多
Objective:To explore the clinical experience in using Zishui Qinggan decoction in the treatment of perimenopausal gall disease.Methods:By comparing the clinical effects of two groups of patients under different method...Objective:To explore the clinical experience in using Zishui Qinggan decoction in the treatment of perimenopausal gall disease.Methods:By comparing the clinical effects of two groups of patients under different methods of treatment,100 patients with perimenopausal gall disease who visited the hospital from January 2022 to February 2022 were selected as the research subjects of this study.According to the methods of treatment,the patients were divided into two groups:the conventional group comprised of 50 patients who received conventional medication,whereas the Zishui Qinggan decoction group comprised of the other 50 patients who received Zishui Qinggan decoction.The overall clinical effects of the two groups were compared along with the time required for symptom relief Results:The time required for symptom relief in the Zishui Qinggan decoction group was significantly shorter than that in the conventional group(p<0.05).Conclusion:Zishui Qinggan decoction can effectively treat perimenopausal gall disease and reduce the time required for symptom(pain)relief.展开更多
基金Supported by Project of Science and Technology Department of Guizhou Province(ZK[2021]-546)Project of Science and Technology Department of Guizhou Province([2019]1401)+1 种基金Guizhou Administration of Traditional Chinese Medicine(QZYY-2021-03)Guizhou Provincial Health Commission(gzwkj2021-464).
文摘[Objectives]This study was conducted to explore the intervention mechanism of Danggui Buxue Decoction in perimenopausal syndrome based on network pharmacology and molecular docking.[Methods]The chemical components and targets of Danggui Buxue Decoction were acquired through the TCMSP database,and the main targets of perimenopausal syndrome were obtained through the GeneCards database.The component targets and disease targets were intersected,and combining with active components and Chinese herbs in the decoction,a traditional Chinese medicine-component-target network was constructed using Cytoscape 3.7.1 software.The STRING platform was employed for protein-protein interaction analysis.The DAVID analysis platform was used to conduct target GO and KEGG enrichment analysis,so as to predict the action mechanism Danggui Buxue Decoction.Finally,an active component-disease target-signal pathway network diagram was constructed.[Results]Twenty two components in Danggui Buxue Decoction related to perimenopausal syndrome and 120 corresponding targets were obtained,including active components such as 1,7-dihydroxy-3,9-dimquercetin and kaempferol,and key targets such as TNF,ESR1 and PPARG.The results of GO analysis and KEEG analysis indicated that Danggui Buxue Decoction might regulate the transcription of RNA polymerase II promoter,DNA templating,gene expression,signal transduction,hypoxia response and other biological processes by regulating multiple signal pathways such as chemical carcinogenesis-receptor activation,cancer pathways,lipid and atherosclerosis,tryptophan metabolism,malaria,steroid hormone biosynthesis and chemical carcinogenesis-DNA adduct.[Conclusions]Danggui Buxue Decoction intervenes in perimenopausal syndrome through multiple components,targets and pathways,providing a basis for elucidating the intervention mechanism of Danggui Buxue Decoction and expanding its clinical application.
文摘Objective:To explore the clinical experience in using Zishui Qinggan decoction in the treatment of perimenopausal gall disease.Methods:By comparing the clinical effects of two groups of patients under different methods of treatment,100 patients with perimenopausal gall disease who visited the hospital from January 2022 to February 2022 were selected as the research subjects of this study.According to the methods of treatment,the patients were divided into two groups:the conventional group comprised of 50 patients who received conventional medication,whereas the Zishui Qinggan decoction group comprised of the other 50 patients who received Zishui Qinggan decoction.The overall clinical effects of the two groups were compared along with the time required for symptom relief Results:The time required for symptom relief in the Zishui Qinggan decoction group was significantly shorter than that in the conventional group(p<0.05).Conclusion:Zishui Qinggan decoction can effectively treat perimenopausal gall disease and reduce the time required for symptom(pain)relief.
