BACKGROUND Perimenopausal syndrome(PMS)is a chronic disease associated with estrogen deficiency.Because of the unsatisfactory outcomes of current conventional treatments for this condition,its treatment must be contin...BACKGROUND Perimenopausal syndrome(PMS)is a chronic disease associated with estrogen deficiency.Because of the unsatisfactory outcomes of current conventional treatments for this condition,its treatment must be continuously explored and optimized.AIM To assess the clinical effectiveness ofγ-oryzanol in combination with Femoston for PMS.METHODS A total of 119 patients with PMS were selected from June 2023 to December 2023,which included 59 and 60 patients in the control and observation group,respectively.The control and observation groups were treated with Femoston andγ-oryzanol+Femoston,respectively.Comparative analyses were performed in terms of clinical effectiveness,safety(dizziness and headache,nausea and vomiting,and breast tenderness),sex hormones[estradiol(E2),luteinizing hormone(LH),and follicle-stimulating hormone(FSH)],lumbar spine(L1-4)and bilateral femoral bone mineral density(BMD),and sleep quality(sleeping time and frequency of awakenings from sleep).RESULTS Compared with the control group,the observation group had statistically higher total effective rates of treatment;lower overall incidence of adverse events;higher post-treatment E2 levels and L1-4 and bilateral femoral BMD;and lower LH and FSH levels,sleeping time,and frequency of awakenings from sleep after treatment.CONCLUSION Therefore,for the treatment of PMS,γ-oryzanol combined with Femoston is significantly better than Femoston alone in terms of clinical effectiveness,exhibiting more pronounced clinical advantages in improving safety,sex hormone levels,BMD,and sleep quality.展开更多
[Objectives]This study was conducted to explore the intervention mechanism of Danggui Buxue Decoction in perimenopausal syndrome based on network pharmacology and molecular docking.[Methods]The chemical components and...[Objectives]This study was conducted to explore the intervention mechanism of Danggui Buxue Decoction in perimenopausal syndrome based on network pharmacology and molecular docking.[Methods]The chemical components and targets of Danggui Buxue Decoction were acquired through the TCMSP database,and the main targets of perimenopausal syndrome were obtained through the GeneCards database.The component targets and disease targets were intersected,and combining with active components and Chinese herbs in the decoction,a traditional Chinese medicine-component-target network was constructed using Cytoscape 3.7.1 software.The STRING platform was employed for protein-protein interaction analysis.The DAVID analysis platform was used to conduct target GO and KEGG enrichment analysis,so as to predict the action mechanism Danggui Buxue Decoction.Finally,an active component-disease target-signal pathway network diagram was constructed.[Results]Twenty two components in Danggui Buxue Decoction related to perimenopausal syndrome and 120 corresponding targets were obtained,including active components such as 1,7-dihydroxy-3,9-dimquercetin and kaempferol,and key targets such as TNF,ESR1 and PPARG.The results of GO analysis and KEEG analysis indicated that Danggui Buxue Decoction might regulate the transcription of RNA polymerase II promoter,DNA templating,gene expression,signal transduction,hypoxia response and other biological processes by regulating multiple signal pathways such as chemical carcinogenesis-receptor activation,cancer pathways,lipid and atherosclerosis,tryptophan metabolism,malaria,steroid hormone biosynthesis and chemical carcinogenesis-DNA adduct.[Conclusions]Danggui Buxue Decoction intervenes in perimenopausal syndrome through multiple components,targets and pathways,providing a basis for elucidating the intervention mechanism of Danggui Buxue Decoction and expanding its clinical application.展开更多
Objective:To study the effects of the ethnic medicine Polygala fallax Hemsl with Guangxi characteristics on the sex hormones andβ-EP in research objective perimenopausal rat models.Methods:40 female SPF rats were ran...Objective:To study the effects of the ethnic medicine Polygala fallax Hemsl with Guangxi characteristics on the sex hormones andβ-EP in research objective perimenopausal rat models.Methods:40 female SPF rats were randomly divided into 4 groups,including the normal,model,high-dose and lowdose groups.Rats of three groups except for the normal one were treated with perimenopausal modelling through the method of subcutaneous injection of compound 4-VCD for 15 consecutive days.Rats of the normal and model group were normally fed without any treatment.Rats of the high-dose and low-dose groups were administered by high-and low-dose intragastric administration of the extract of Polygala fallax Hemsl.According to the menstrual cycle of the vaginal smear of the rat,each menstrual cycle is a course of treatment and 6 consecutive courses of treatment would be given.The indexes of serum sex hormones(E2,FSH,LH)andβ-EP of rats in each group were observed after treatment.Results:After the treatment of 6 cycles,for the levels ofβ-EP and E2,the model group was lowest(P<0.05),the normal group was highest(P<0.05);and the high-dose group was higher than the low-dose group;For the levels of FSH and LH,the normal group was lowest(P<0.05),the model group was highest(P<0.05),and the high-dose group was lower than the low-dose group.Conclusion:Guangxi characteristic national medicine Polygala fallax Hemsl can effectively improve the levels of serum sex hormones andβ-EP in perimenopausal rat models and relieve the related symptoms with a certain dose-effect relationship.展开更多
Objective: To evaluate the efficacy and safety of Heyan Kuntai Capsule(和颜坤泰胶囊, HYKT) and hormone therapy(HT) on perimenopausal syndromes(PMSs). Methods: From 2005 to 2008, 390 women with PMSs were recrui...Objective: To evaluate the efficacy and safety of Heyan Kuntai Capsule(和颜坤泰胶囊, HYKT) and hormone therapy(HT) on perimenopausal syndromes(PMSs). Methods: From 2005 to 2008, 390 women with PMSs were recruited from 4 clinic centers. The inclusion criteria included ages 40 to 60 years, estradiol(E2) below 30 ng/L, and follicle stimulating hormone(FSH) above 40 IU/L, etc. The patients were randomly assigned to HYKT group or HT group by random number table method, administrated HYKT or conjugated estrogen with/without medroxyprogesterone acetate tablets for 12 months. During treatment, the patients were interviewed quarterly, Kupperman Menopausal Index(KMI) scores, hot flush scores, insomnia scores, Menopause-Specific Quality of Life(MENQOL) scores and adverse effects were used for evaluating drug efficacy and safety respectively. The last interview was made at the end of 12-month treatment. Results: After treatment, KMI scores of HYKT group and HT group were both significantly decreased compared with baseline(P〈0.01) and there was no significant difference between groups(P〉0.05), except that KMI of HYKT group was higher after 3-month treatment(P〈0.05). After treatment, hot flush and insomnia scores were both improved significantly in two groups(P〈0.01); and HT had a better performance than HYKT in improving hot flush(P〈0.05). MENQOL were significantly improved in both groups after treatment(P〈0.01); but there was no significant difference between two groups(P〉0.05). The incidence of adverse event in the HYKT group was much lower than that in the HT group(P〈0.01). Conclusions: HYKT could effectively relieve PMSs and improve patient quality of life without severe adverse reactions. Although HYKT exerted curative effects more slowly than hormone, it possessed better safety profile than hormone.展开更多
Objective:To evaluate the clinical effect of scraping therapy in the treatment of perimenopausal syndrome(PMS).Methods:Thirty recruited PMS subjects were treated with scraping therapy in the Outpatient Department,Acup...Objective:To evaluate the clinical effect of scraping therapy in the treatment of perimenopausal syndrome(PMS).Methods:Thirty recruited PMS subjects were treated with scraping therapy in the Outpatient Department,Acupuncture-Moxibustion Hospital,China Academy of Chinese Medical Sciences,at the areas including Shéntíng(神庭GV24)-Běihuì(百会GV20),Qìhǎi(气海CV6)-Guānyuán(关元CV4),Zǐgōng(子宫EXCA1),Zúsānlǐ(足三里ST36)-Xiàjùxū(下巨虚ST39),Dìjī(地机SP8)-Sányīnjiāo(三阴交SP6),Tàichōng(太冲LR3)-Xíngjiān(行间LR2),Gānshū(肝俞BL18)-Dǎnshū(胆俞BL19),Píshū(脾俞BL20)-Wèishū(胃俞BL21),and Sānjiāoshū(三焦俞BL 22)-Shènshū(肾俞BL 23),with an even reinforcing-reducing method.Before and after treatment,the serum follicle-stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E_(2)) were tested.And before treatment and at the 4 th week,8 th week,and 12 th week of treatment,the Kupperman index(KI) and menopause-specific quality of life questionnaire(MENQOL) symptom scores were recorded for evaluating the clinical efficacy.Results:Comparing with before treatment,the modified Kupperman symptom scores were all decreased after treatment,the difference was statistically significant(P<0.05);all symptoms were relieved significantly after treatment,the difference was statistically significant(all P<0.05).There was no significant difference in serum E_(2),FSH,and LH levels after treatment(all P>0.05);the total effective rate was 85.71%after the 4 weeks’ treatment,96.42% after the 8 weeks’ treatment,and 96.42% after the 12 weeks’ treatment.Conclusion:Scraping therapy can relieve the PMS symptoms to some extent.It can improve the life quality of PMS subjects.Its influence on the estrogen levels of PMS subjects was not obvious.展开更多
文摘BACKGROUND Perimenopausal syndrome(PMS)is a chronic disease associated with estrogen deficiency.Because of the unsatisfactory outcomes of current conventional treatments for this condition,its treatment must be continuously explored and optimized.AIM To assess the clinical effectiveness ofγ-oryzanol in combination with Femoston for PMS.METHODS A total of 119 patients with PMS were selected from June 2023 to December 2023,which included 59 and 60 patients in the control and observation group,respectively.The control and observation groups were treated with Femoston andγ-oryzanol+Femoston,respectively.Comparative analyses were performed in terms of clinical effectiveness,safety(dizziness and headache,nausea and vomiting,and breast tenderness),sex hormones[estradiol(E2),luteinizing hormone(LH),and follicle-stimulating hormone(FSH)],lumbar spine(L1-4)and bilateral femoral bone mineral density(BMD),and sleep quality(sleeping time and frequency of awakenings from sleep).RESULTS Compared with the control group,the observation group had statistically higher total effective rates of treatment;lower overall incidence of adverse events;higher post-treatment E2 levels and L1-4 and bilateral femoral BMD;and lower LH and FSH levels,sleeping time,and frequency of awakenings from sleep after treatment.CONCLUSION Therefore,for the treatment of PMS,γ-oryzanol combined with Femoston is significantly better than Femoston alone in terms of clinical effectiveness,exhibiting more pronounced clinical advantages in improving safety,sex hormone levels,BMD,and sleep quality.
基金Supported by Project of Science and Technology Department of Guizhou Province(ZK[2021]-546)Project of Science and Technology Department of Guizhou Province([2019]1401)+1 种基金Guizhou Administration of Traditional Chinese Medicine(QZYY-2021-03)Guizhou Provincial Health Commission(gzwkj2021-464).
文摘[Objectives]This study was conducted to explore the intervention mechanism of Danggui Buxue Decoction in perimenopausal syndrome based on network pharmacology and molecular docking.[Methods]The chemical components and targets of Danggui Buxue Decoction were acquired through the TCMSP database,and the main targets of perimenopausal syndrome were obtained through the GeneCards database.The component targets and disease targets were intersected,and combining with active components and Chinese herbs in the decoction,a traditional Chinese medicine-component-target network was constructed using Cytoscape 3.7.1 software.The STRING platform was employed for protein-protein interaction analysis.The DAVID analysis platform was used to conduct target GO and KEGG enrichment analysis,so as to predict the action mechanism Danggui Buxue Decoction.Finally,an active component-disease target-signal pathway network diagram was constructed.[Results]Twenty two components in Danggui Buxue Decoction related to perimenopausal syndrome and 120 corresponding targets were obtained,including active components such as 1,7-dihydroxy-3,9-dimquercetin and kaempferol,and key targets such as TNF,ESR1 and PPARG.The results of GO analysis and KEEG analysis indicated that Danggui Buxue Decoction might regulate the transcription of RNA polymerase II promoter,DNA templating,gene expression,signal transduction,hypoxia response and other biological processes by regulating multiple signal pathways such as chemical carcinogenesis-receptor activation,cancer pathways,lipid and atherosclerosis,tryptophan metabolism,malaria,steroid hormone biosynthesis and chemical carcinogenesis-DNA adduct.[Conclusions]Danggui Buxue Decoction intervenes in perimenopausal syndrome through multiple components,targets and pathways,providing a basis for elucidating the intervention mechanism of Danggui Buxue Decoction and expanding its clinical application.
基金Project for Improving Basic Capabilities of Middle-aged and Young Teachers in Guangxi Institutions of Higher Learning(No.KY2016YB835)National Natural Science Foundation of China(No.81660830)+3 种基金Open Project for Guangxi Key Laboratory of Chinese Medicine Foundation Research of Guangxi(No.15-140-32-06)Open Project for Guangxi First-class Discipline Construction of Guangxi University of Chinese Medicine(No.2019XK038)Funded by Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine(No.2018005)Traditional Chinese Medicine-Guangxi first-class discipline construction project(No.Gui Jiao Ke Yan[2018]12).
文摘Objective:To study the effects of the ethnic medicine Polygala fallax Hemsl with Guangxi characteristics on the sex hormones andβ-EP in research objective perimenopausal rat models.Methods:40 female SPF rats were randomly divided into 4 groups,including the normal,model,high-dose and lowdose groups.Rats of three groups except for the normal one were treated with perimenopausal modelling through the method of subcutaneous injection of compound 4-VCD for 15 consecutive days.Rats of the normal and model group were normally fed without any treatment.Rats of the high-dose and low-dose groups were administered by high-and low-dose intragastric administration of the extract of Polygala fallax Hemsl.According to the menstrual cycle of the vaginal smear of the rat,each menstrual cycle is a course of treatment and 6 consecutive courses of treatment would be given.The indexes of serum sex hormones(E2,FSH,LH)andβ-EP of rats in each group were observed after treatment.Results:After the treatment of 6 cycles,for the levels ofβ-EP and E2,the model group was lowest(P<0.05),the normal group was highest(P<0.05);and the high-dose group was higher than the low-dose group;For the levels of FSH and LH,the normal group was lowest(P<0.05),the model group was highest(P<0.05),and the high-dose group was lower than the low-dose group.Conclusion:Guangxi characteristic national medicine Polygala fallax Hemsl can effectively improve the levels of serum sex hormones andβ-EP in perimenopausal rat models and relieve the related symptoms with a certain dose-effect relationship.
基金Supported by the"Tenth-Five"National Medical Science and Technique Foundation,China(No.2004BA720A08)
文摘Objective: To evaluate the efficacy and safety of Heyan Kuntai Capsule(和颜坤泰胶囊, HYKT) and hormone therapy(HT) on perimenopausal syndromes(PMSs). Methods: From 2005 to 2008, 390 women with PMSs were recruited from 4 clinic centers. The inclusion criteria included ages 40 to 60 years, estradiol(E2) below 30 ng/L, and follicle stimulating hormone(FSH) above 40 IU/L, etc. The patients were randomly assigned to HYKT group or HT group by random number table method, administrated HYKT or conjugated estrogen with/without medroxyprogesterone acetate tablets for 12 months. During treatment, the patients were interviewed quarterly, Kupperman Menopausal Index(KMI) scores, hot flush scores, insomnia scores, Menopause-Specific Quality of Life(MENQOL) scores and adverse effects were used for evaluating drug efficacy and safety respectively. The last interview was made at the end of 12-month treatment. Results: After treatment, KMI scores of HYKT group and HT group were both significantly decreased compared with baseline(P〈0.01) and there was no significant difference between groups(P〉0.05), except that KMI of HYKT group was higher after 3-month treatment(P〈0.05). After treatment, hot flush and insomnia scores were both improved significantly in two groups(P〈0.01); and HT had a better performance than HYKT in improving hot flush(P〈0.05). MENQOL were significantly improved in both groups after treatment(P〈0.01); but there was no significant difference between two groups(P〉0.05). The incidence of adverse event in the HYKT group was much lower than that in the HT group(P〈0.01). Conclusions: HYKT could effectively relieve PMSs and improve patient quality of life without severe adverse reactions. Although HYKT exerted curative effects more slowly than hormone, it possessed better safety profile than hormone.
基金Supported by National Natural Science Foundation of China:NO.81674079Natural Science Foundation of Beijing:NO.71721491.
文摘Objective:To evaluate the clinical effect of scraping therapy in the treatment of perimenopausal syndrome(PMS).Methods:Thirty recruited PMS subjects were treated with scraping therapy in the Outpatient Department,Acupuncture-Moxibustion Hospital,China Academy of Chinese Medical Sciences,at the areas including Shéntíng(神庭GV24)-Běihuì(百会GV20),Qìhǎi(气海CV6)-Guānyuán(关元CV4),Zǐgōng(子宫EXCA1),Zúsānlǐ(足三里ST36)-Xiàjùxū(下巨虚ST39),Dìjī(地机SP8)-Sányīnjiāo(三阴交SP6),Tàichōng(太冲LR3)-Xíngjiān(行间LR2),Gānshū(肝俞BL18)-Dǎnshū(胆俞BL19),Píshū(脾俞BL20)-Wèishū(胃俞BL21),and Sānjiāoshū(三焦俞BL 22)-Shènshū(肾俞BL 23),with an even reinforcing-reducing method.Before and after treatment,the serum follicle-stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E_(2)) were tested.And before treatment and at the 4 th week,8 th week,and 12 th week of treatment,the Kupperman index(KI) and menopause-specific quality of life questionnaire(MENQOL) symptom scores were recorded for evaluating the clinical efficacy.Results:Comparing with before treatment,the modified Kupperman symptom scores were all decreased after treatment,the difference was statistically significant(P<0.05);all symptoms were relieved significantly after treatment,the difference was statistically significant(all P<0.05).There was no significant difference in serum E_(2),FSH,and LH levels after treatment(all P>0.05);the total effective rate was 85.71%after the 4 weeks’ treatment,96.42% after the 8 weeks’ treatment,and 96.42% after the 12 weeks’ treatment.Conclusion:Scraping therapy can relieve the PMS symptoms to some extent.It can improve the life quality of PMS subjects.Its influence on the estrogen levels of PMS subjects was not obvious.