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Clinical presentation and management of drug-induced gingival overgrowth: A case series 被引量:1
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作者 Li Fang Bao-Chun Tan 《World Journal of Clinical Cases》 SCIE 2021年第32期9926-9934,共9页
BACKGROUND We report three patients with drug-induced gingiva overgrowth(DIGO)caused by nifedipine,a calcium channel blocker,who were treated and followed up for 1–3 years.We discussed their symptoms,treatment proces... BACKGROUND We report three patients with drug-induced gingiva overgrowth(DIGO)caused by nifedipine,a calcium channel blocker,who were treated and followed up for 1–3 years.We discussed their symptoms,treatment process,treatment prognosis,and follow-up results.CASE SUMMARY All the patients had a history of nifedipine treatment to control hypertension.Besides nifedipine,Patient 1 was prescribed immunosuppressant cyclosporine A to control nephritis,which is also implicated in GO.Thus,we assumed that a synergistic effect between the drugs contributed to the severity of Patient 1’s condition.This condition has been reported to be more pronounced in patients with periodontitis.In the course of treatment,Patients 1 and 2 did not stop or change drugs.After initial periodontal treatment,periodontal surgery,and later periodontal support and better plaque control,their gingival hyperplasia was well managed and controlled.Under the guidance of a physician,Patient 3 replaced her calcium-channel blocker drug with losartan potassium and hydrochlorothiazide tablets.She received initial treatment without surgery,obtaining a good curative effect.CONCLUSION Patients’compliance,self-plaque control,and professional periodontal therapy have a vital role in treating and preventing the recurrence of DIGO. 展开更多
关键词 Drug-induced gingiva overgrowth NIFEDIPINE Periodontal surgery Treatment prognosis Case report
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Gingival enlargement induced by cyclosporine in Medullary aplasia:A case report
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作者 Giovanna Victory Rodríguez Alondra del Carmen Ruiz Gutiérrez +1 位作者 Juan Ramón Gómez Sandoval Sarah Monserrat LomelíMartínez 《World Journal of Clinical Cases》 SCIE 2022年第34期12750-12760,共11页
BACKGROUND Cyclosporine is an immunosuppressive agent used effectively for treatment of a rare haematological disorder known as medullary aplasia.This drug prevents several side effects,including gingival enlargement(... BACKGROUND Cyclosporine is an immunosuppressive agent used effectively for treatment of a rare haematological disorder known as medullary aplasia.This drug prevents several side effects,including gingival enlargement(GE)which compromises aesthetics,phonetics and chewing,and also predisposes patients to periodontitis.CASE SUMMARY This clinical case reports a 41-year-old woman who presented with cyclosporineinduced GE with underlying periodontitis and medullary aplasia.The management of the disease was approached through multidisciplinary strategy which allowed for accurate diagnosis and a strategic treatment based on the systemic condition and severity of oral pathology.The diagnosis was confirmed through histopathological analysis.The treatment was carried out in phases:Initial(oral hygiene motivation,mechanical supragingival plaque control,and non-surgical therapy);systemic treatment,corrective treatment,and maintenance.CONCLUSION Multidisciplinary management of cyclosporine-induced GE and medullary aplasia allows for correct diagnosis and effective treatment of this pathological expression through a phased therapeutic approach. 展开更多
关键词 CYCLOSPORINE Gingival enlargement Medullary aplasia Periodontal surgery Case report
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Heparan-mimetics:Potential agents of tissue regeneration for bone and periodontal therapies
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作者 Maroun Bou Karam Joe El Khoury +7 位作者 Carole Chakar Sylvie Changotade Didier Lutomski Nada Naaman Gaston Godeau Abdellatif Elm’selmi Ronald Younes Karim Senni 《Medicine in Novel Technology and Devices》 2021年第3期1-10,共10页
Heparan sulfate glycosaminoglycans are key players of tissue repair and can be regarded as useful compounds for regenerative medicines.Unfortunately,their therapeutic uses face many technical,industrial,and regulatory... Heparan sulfate glycosaminoglycans are key players of tissue repair and can be regarded as useful compounds for regenerative medicines.Unfortunately,their therapeutic uses face many technical,industrial,and regulatory hurdles due to their animal origin.So,some non-animal sulfated polysaccharides mimic heparan sulfate properties and offer interesting solutions to replace them.Among them,dextran derivatives,seaweed polysaccharides,or marine bacterial polysaccharides are the best known and have demonstrated their pro-regenerative capabilities by promoting both extracellular matrix structuring and angiogenesis and limiting degenerative processes such as inflammatory cell migration or tissue proteolysis.These polysaccharides have also shown their ability to specifically promote osteoblastic differentiation and bone wound healing.Furthermore,recent works shows that heparan-mimetics can be used as an additive to improve the cytocompatibility of bone substitutes commonly used in periodontal surgery.The use of these polysaccharides can be regarded as a clever approach to improve the biointegration of bone substitutes. 展开更多
关键词 Bone biomaterials Periodontal surgery Heparan-mimetics Marine biotechnology Dextran derivatives Bacterial exopolysaccharides FUCOIDANS
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