Circular RNA(circRNA)is a novel class of single-stranded RNAs with a closed loop structure.The majority of circRNAs are formed by a back-splicing process in pre-mRNA splicing.Their expression is dynamically regulated ...Circular RNA(circRNA)is a novel class of single-stranded RNAs with a closed loop structure.The majority of circRNAs are formed by a back-splicing process in pre-mRNA splicing.Their expression is dynamically regulated and shows spatiotemporal patterns among cell types,tissues and developmental stages.CircRNAs have important biological functions in many physiological processes,and their aberrant expression is implicated in many human diseases.Due to their high stability,circRNAs are becoming promising biomarkers in many human diseases,such as cardiovascular diseases,autoimmune diseases and human cancers.In this review,we focus on the translational potential of using human blood circRNAs as liquid biopsy biomarkers for human diseases.We highlight their abundant expression,essential biological functions and significant correlations to human diseases in various components of peripheral blood,including whole blood,blood cells and extracellular vesicles.In addition,we summarize the current knowledge of blood circRNA biomarkers for disease diagnosis or prognosis.展开更多
基金This work was funded by Grants from National Key R&D Program of China(2018YFC1314900,2018YFC1314902)National Natural Science Foundation of China(61571109)the Fundamental Research Funds for the Central Universities(2242017K3DN04).
文摘Circular RNA(circRNA)is a novel class of single-stranded RNAs with a closed loop structure.The majority of circRNAs are formed by a back-splicing process in pre-mRNA splicing.Their expression is dynamically regulated and shows spatiotemporal patterns among cell types,tissues and developmental stages.CircRNAs have important biological functions in many physiological processes,and their aberrant expression is implicated in many human diseases.Due to their high stability,circRNAs are becoming promising biomarkers in many human diseases,such as cardiovascular diseases,autoimmune diseases and human cancers.In this review,we focus on the translational potential of using human blood circRNAs as liquid biopsy biomarkers for human diseases.We highlight their abundant expression,essential biological functions and significant correlations to human diseases in various components of peripheral blood,including whole blood,blood cells and extracellular vesicles.In addition,we summarize the current knowledge of blood circRNA biomarkers for disease diagnosis or prognosis.
