Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being.By merely broadening the setpoint of indoor temperatures,we could significantly slash energy usage in building hea...Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being.By merely broadening the setpoint of indoor temperatures,we could significantly slash energy usage in building heating,ventilation,and air-conditioning systems.In recent years,there has been a surge in advancements in personal thermal management(PTM),aiming to regulate heat and moisture transfer within our immediate surroundings,clothing,and skin.The advent of PTM is driven by the rapid development in nano/micro-materials and energy science and engineering.An emerging research area in PTM is personal radiative thermal management(PRTM),which demonstrates immense potential with its high radiative heat transfer efficiency and ease of regulation.However,it is less taken into account in traditional textiles,and there currently lies a gap in our knowledge and understanding of PRTM.In this review,we aim to present a thorough analysis of advanced textile materials and technologies for PRTM.Specifically,we will introduce and discuss the underlying radiation heat transfer mechanisms,fabrication methods of textiles,and various indoor/outdoor applications in light of their different regulation functionalities,including radiative cooling,radiative heating,and dual-mode thermoregulation.Furthermore,we will shine a light on the current hurdles,propose potential strategies,and delve into future technology trends for PRTM with an emphasis on functionalities and applications.展开更多
BACKGROUND The Cariostat caries activity test(CAT)was used to evaluate the effectiveness of personalized oral hygiene management combining oral health education and professional mechanical tooth cleaning on the oral h...BACKGROUND The Cariostat caries activity test(CAT)was used to evaluate the effectiveness of personalized oral hygiene management combining oral health education and professional mechanical tooth cleaning on the oral health status of pregnant women.AIM To investigate whether personalized oral hygiene management enhances the oral health status of pregnant women.METHODS A total of 114 pregnant women who were examined at Dalian Women’s and Children’s Medical Center were divided into four groups:High-risk experimental group(n=29;CAT score≥2;received personalized oral hygiene management training),low-risk experimental group(n=29;CAT score≤1;received oral health education),high-risk control group(n=28;CAT score≥2),and low-risk control group(n=28;CAT score≤1).No hygiene intervention was provided to control groups.CAT scores at different times were compared using independent samples t-test and least significant difference t-test.RESULTS No significant difference in baseline CAT scores was observed between the experimental and control groups,either in the high-risk or low-risk groups.CAT scores were reduced significantly after 3(1.74±0.47 vs 2.50±0.38,P<0.0001)and 6 months(0.53±0.50 vs 2.45±0.42,P<0.0001)of personalized oral hygiene management intervention but not after oral health education alone(0.43±0.39 vs 0.46±0.33,P>0.05 and 0.45±0.36 vs 0.57±0.32,P>0.05,respectively).Within groups,the decrease in CAT scores was significant(2.43±0.44 vs 1.74±0.47 vs 0.53±0.50,P<0.0001)for only the high-risk experimental group.CONCLUSION Personalized oral hygiene management is effective in improving the oral health of pregnant women and can improve pregnancy outcomes and the oral health of the general population.展开更多
Mobile SNS popular topics of mobile is one of the most Internet. In order to fulfill the user demand for self-maintained independent social network and ensure the privacy of their personal information and resources, t...Mobile SNS popular topics of mobile is one of the most Internet. In order to fulfill the user demand for self-maintained independent social network and ensure the privacy of their personal information and resources, the paper proposes system architecture of decentralized mobile SNS.In the temporary scenarios, the system makes use of the existent specification of FOAF (Friend- of-a-Friend) to describe users' personal information and act as a certificate to be identified by SNS sites. Ticket-based Access Authorization System (TAAS) is provided to grant permission to acquire resources on personal portal. Meanwhile, the mechanism and algorithm are devised for user profile complete deletion when users are going to quit the service for the temporary scenarios.展开更多
Personal thermal management is emerging as a promising strategy to provide thermal comfort for the human body while conserving energy.By improving control over the heat dissipating from the human body,personal thermal...Personal thermal management is emerging as a promising strategy to provide thermal comfort for the human body while conserving energy.By improving control over the heat dissipating from the human body,personal thermal management can provide effective personal cooling and warming.Here,we propose a facile surface modification approach to tailor the thermal conduction and radiation properties based on commercially available fabrics,to realize better management of the whole heat transport pathway from the human body to the ambient.A bifunctional asymmetric fabric(BAF)offering both a cooling and a warming effect is demonstrated.Due to the advantages of roughness asymmetry and surface modification,the BAF demonstrates an effective cooling effect through enhanced heat conduction and radiation in the cooling mode;in the warming mode,heat dissipation along both routes is reduced for personal warming.As a result,a 4.6℃ skin temperature difference is measured between the cooling and warming BAF modes,indicating that the thermal comfort zone of the human body can be enlarged with one piece of BAF clothing.We expect this work to present new insights for the design of personal thermal management textiles as well as a novel solution for the facile modification of available fabrics for both personal cooling and warming.展开更多
Smart textiles with high sensitivity and rapid response for various external stimuli have gained tremendous attentions in human healthcare monitoring,personal heat management,and wearable electronics.However,the curre...Smart textiles with high sensitivity and rapid response for various external stimuli have gained tremendous attentions in human healthcare monitoring,personal heat management,and wearable electronics.However,the current smart textiles only acquire desired signal passively,regularly lacking subsequent on-demand therapy actively.Herein,a robust,breathable,and flexible smart textiles as multi-function sensor and wearable heater for human health monitoring and gentle thermotherapy in real time is constructed.The composite fiber as strain sensor(CFY@PU)was fabricated via warping carbon fiber yarns(CFY)onto polyurethane fibers(PU),which endowed composite fiber with high conductivity,excellent sensitivity(GF=76.2),and fantastic dynamic durability(7500 cycles)in strain sensing.In addition,CFY@PU can detect various degrees of human movements such as elbow bending,swallowing and pulse,which can provide effective information for disease diagnosis.More surprisingly,weaving CFY@PU into a fabric can assemble highly sensitive pressure sensor for remote communication and information encryption.Warping CFY onto Kevlar would obtain temperature-sensitive composite fiber(CFY@Kevlar)as temperature sensor and wearable heater for on-demand thermotherapy,which provided unique opportunities in designing smart textiles with ultrahigh sensitivity,rapid response,and great dynamic durability.展开更多
A large of energy consumption is required for indoor and outdoor personal heating to ameliorate the comfortable and healthy conditions.Main personal thermal management strategy is to reflect mid-infrared human body ra...A large of energy consumption is required for indoor and outdoor personal heating to ameliorate the comfortable and healthy conditions.Main personal thermal management strategy is to reflect mid-infrared human body radiation for human surface temperature(THS)regulation.We demonstrate a visible Janus light absorbent/reflective air-layer fabric(Janus A/R fabric)that can passively reflect radiative heating meanwhile can actively capture the solar energy.A series of azobenzene derivatives functionalized with alkyl tails are reported to co-harvest the solar and phase-change energy.The THS covered by Janus A/R fabric can be heated up to~3.7°C higher than that covered by air-layer fabric in cold environment(5°C).Besides,integrating the thermo-and photo-chromic properties is capable of monitoring comfort THS and residue energy storage enthalpy,respectively.According to the colour monitors,intermittent irradiation approach is proposed to prolong comfortable-THS holding time for managing energy efficiently.展开更多
People could potentially mitigate heat discomfort when outdoors by combining passive radiative cooling(PRC)strategies with personal thermal management techniques.However,most current PRC materials lack wearing comfort...People could potentially mitigate heat discomfort when outdoors by combining passive radiative cooling(PRC)strategies with personal thermal management techniques.However,most current PRC materials lack wearing comfort and durability.In this study,a microarray technique is applied to fabricate the tailoring photonic-engineered textiles with intriguing PRC capability and appealing wearability.The developed radiative cooling textiles(RCTs)demonstrate appropriate air-moisture permeability,structural stability,and extended spectroscopic response with high sunlight reflectivity(91.7%)and robust heat emissivity(95.8%)through the atmospheric transparent spectral window(ATSW).In a hot outdoor cooling test,a skin simulator covered by the RCTs displays a temperature drop of approximately 4.4℃at noon compared with cotton textiles.The evolution of our mimetic structures may provide new insights into the generation of wearable,thermal-wet comfortable,and robust textiles for exploring PRC techniques in personal thermal management applications.展开更多
In China,cardiovascular disease has become the leading killer in recent years,and mortality from cardiovascular disease is continuing to rapidly increase.Extant medical research has proven that personal health managem...In China,cardiovascular disease has become the leading killer in recent years,and mortality from cardiovascular disease is continuing to rapidly increase.Extant medical research has proven that personal health management(prevention,intervention,and recuperation)of chronic diseases,such as cardiovascular diseases,is the best strategy for their prevention and treatment.Currently,the public can obtain health management knowledge through the Internet,newspapers,books,and other channels.However,with the explosive growth of available information,the public is limited to obtain effective health management guidance due to the characteristics of multiple sources,uneven accuracy(even some contradictory knowledge)and a major paucity of personalization,especially for the general public who lack professional medical knowledge.To address these problems,this paper proposes a knowledge base framework(i.e.domain ontology library)of health management programs based on the cardiovascular disease domain,which can standardize knowledge of health management programs both logically and structurally.In order to satisfy the needs of personalized health management,the core ontology of the domain ontology library is health-management-program ontology.In addition to common ontologies(e.g.disease ontology,drug ontology,etc.),basic ontologies include the ontology of individual health characteristics(e.g.individual-healthcharacteristics and environmental-characteristics ontology),and ontologies comprising diet and sport(e.g.ingredients,recipes,physical exercise,etc.).We then construct the ontology library through the professional ontology tool,Protégé.With a case study,we translate a piece of text health management knowledge into instances of an ontology library.At the same time,we present a personalized health management program recommendation algorithm based on the ontology library,and a recommendation case is realized according to this algorithm.As a basic research,the results of this paper can also support other health management applications in the future.展开更多
This paper presents a survey of technologies for personal data self-management interfacing with administrative and territorial public service providers.It classifies a selection of scientific technologies into four ca...This paper presents a survey of technologies for personal data self-management interfacing with administrative and territorial public service providers.It classifies a selection of scientific technologies into four categories of solutions:Personal Data Store(PDS),Identity Manager(IdM),Anonymous Certificate System and Access Control Delegation Architecture.Each category,along with its technological approach,is analyzed thanks to 18 identified functional criteria that encompass architectural and communication aspects,as well as user data lifecycle considerations.The originality of the survey is multifold.First,as far as we know,there is no such thorough survey covering such a panel of a dozen of existing solutions.Second,it is the first survey addressing Personally Identifiable Information(PII)management for both administrative and private service providers.Third,this paper achieves a functional comparison of solutions of very different technical natures.The outcome of this paper is the clear identification of functional gaps of each solution.As a result,this paper establishes the research directions to follow in order to fill these functional gaps.展开更多
Various systems and technologies have been developed in recent years to fulfil the growing needs of high-performance HVAC systems with better performance of energy efficiency,thermal comfort,and occupancy health.Inten...Various systems and technologies have been developed in recent years to fulfil the growing needs of high-performance HVAC systems with better performance of energy efficiency,thermal comfort,and occupancy health.Intensified conditioning of human occupied areas and less intensified conditioning of surrounding areas are able to effectively improve the overall satisfaction by individual control of personalized micro-environments and also,achieve maximum energy efficiency.Four main concepts have been identified chronologically through the devel-opment of personal environmental conditioning,changing the intensified conditioning area closer to the human body and enhancing conditioning efforts,namely the task ambient conditioning(TAC)system,personal envi-ronmental control system(PECS),personal comfort system(PCS),and the personal thermal management(PTM)system.This review follows a clue of the concept progress and system evaluation,summarizes important findings and feasible applications,current gaps as well as future research needs.展开更多
Autoimmune hepatitis has been considered as a relatively rare immunological liver disease,especially in the Asia-Pacific area.Although the diagnosis criteria and immunosuppressive treatment regimens have been establis...Autoimmune hepatitis has been considered as a relatively rare immunological liver disease,especially in the Asia-Pacific area.Although the diagnosis criteria and immunosuppressive treatment regimens have been established,there are still some challenges.According to the different presentations,the personalized management of patients who suffer from this disease,including those with chronic or acute severe onset,the autoantibody-negative phenotype and cirrhosis are necessarily descriptive.Each subgroup of patients should receive an individualized therapy.Here,we review the recent studies of autoimmune hepatitis,mainly focusing on the epidemiology and genetics,personalized diagnostics,individualized treatment strategies,special subgroups and outcomes.Most of the research in the literature is based on Japanese and Chinese populations.展开更多
基金support from the Research Grants Council of the Hong Kong Special Administrative Region,China(PolyU152052/21E)Green Tech Fund of Hong Kong(Project No.:GTF202220106)+1 种基金Innovation and Technology Fund of the Hong Kong Special Administrative Region,China(ITP/018/21TP)PolyU Endowed Young Scholars Scheme(Project No.:84CC).
文摘Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being.By merely broadening the setpoint of indoor temperatures,we could significantly slash energy usage in building heating,ventilation,and air-conditioning systems.In recent years,there has been a surge in advancements in personal thermal management(PTM),aiming to regulate heat and moisture transfer within our immediate surroundings,clothing,and skin.The advent of PTM is driven by the rapid development in nano/micro-materials and energy science and engineering.An emerging research area in PTM is personal radiative thermal management(PRTM),which demonstrates immense potential with its high radiative heat transfer efficiency and ease of regulation.However,it is less taken into account in traditional textiles,and there currently lies a gap in our knowledge and understanding of PRTM.In this review,we aim to present a thorough analysis of advanced textile materials and technologies for PRTM.Specifically,we will introduce and discuss the underlying radiation heat transfer mechanisms,fabrication methods of textiles,and various indoor/outdoor applications in light of their different regulation functionalities,including radiative cooling,radiative heating,and dual-mode thermoregulation.Furthermore,we will shine a light on the current hurdles,propose potential strategies,and delve into future technology trends for PRTM with an emphasis on functionalities and applications.
基金Dalian Science and Technology Plan Project,No 2022080102.
文摘BACKGROUND The Cariostat caries activity test(CAT)was used to evaluate the effectiveness of personalized oral hygiene management combining oral health education and professional mechanical tooth cleaning on the oral health status of pregnant women.AIM To investigate whether personalized oral hygiene management enhances the oral health status of pregnant women.METHODS A total of 114 pregnant women who were examined at Dalian Women’s and Children’s Medical Center were divided into four groups:High-risk experimental group(n=29;CAT score≥2;received personalized oral hygiene management training),low-risk experimental group(n=29;CAT score≤1;received oral health education),high-risk control group(n=28;CAT score≥2),and low-risk control group(n=28;CAT score≤1).No hygiene intervention was provided to control groups.CAT scores at different times were compared using independent samples t-test and least significant difference t-test.RESULTS No significant difference in baseline CAT scores was observed between the experimental and control groups,either in the high-risk or low-risk groups.CAT scores were reduced significantly after 3(1.74±0.47 vs 2.50±0.38,P<0.0001)and 6 months(0.53±0.50 vs 2.45±0.42,P<0.0001)of personalized oral hygiene management intervention but not after oral health education alone(0.43±0.39 vs 0.46±0.33,P>0.05 and 0.45±0.36 vs 0.57±0.32,P>0.05,respectively).Within groups,the decrease in CAT scores was significant(2.43±0.44 vs 1.74±0.47 vs 0.53±0.50,P<0.0001)for only the high-risk experimental group.CONCLUSION Personalized oral hygiene management is effective in improving the oral health of pregnant women and can improve pregnancy outcomes and the oral health of the general population.
基金supported by the National Natural Science Foundation of China under Grant No.61272521the Specialized Research Fund for the Doctoral Program of Higher Education under Grant No.20110005130001
文摘Mobile SNS popular topics of mobile is one of the most Internet. In order to fulfill the user demand for self-maintained independent social network and ensure the privacy of their personal information and resources, the paper proposes system architecture of decentralized mobile SNS.In the temporary scenarios, the system makes use of the existent specification of FOAF (Friend- of-a-Friend) to describe users' personal information and act as a certificate to be identified by SNS sites. Ticket-based Access Authorization System (TAAS) is provided to grant permission to acquire resources on personal portal. Meanwhile, the mechanism and algorithm are devised for user profile complete deletion when users are going to quit the service for the temporary scenarios.
文摘Personal thermal management is emerging as a promising strategy to provide thermal comfort for the human body while conserving energy.By improving control over the heat dissipating from the human body,personal thermal management can provide effective personal cooling and warming.Here,we propose a facile surface modification approach to tailor the thermal conduction and radiation properties based on commercially available fabrics,to realize better management of the whole heat transport pathway from the human body to the ambient.A bifunctional asymmetric fabric(BAF)offering both a cooling and a warming effect is demonstrated.Due to the advantages of roughness asymmetry and surface modification,the BAF demonstrates an effective cooling effect through enhanced heat conduction and radiation in the cooling mode;in the warming mode,heat dissipation along both routes is reduced for personal warming.As a result,a 4.6℃ skin temperature difference is measured between the cooling and warming BAF modes,indicating that the thermal comfort zone of the human body can be enlarged with one piece of BAF clothing.We expect this work to present new insights for the design of personal thermal management textiles as well as a novel solution for the facile modification of available fabrics for both personal cooling and warming.
基金supported by Outstanding Youth Project of Zhejiang Provincial Natural Science Foundation(LR22E030002)the Key Research and Development Program of Zhejiang Province(2022C01049)+1 种基金Zhejiang Provincial Natural Science Key Foundation of China(LZ20E030003)National Natural Science Foundation of China(52273095).
文摘Smart textiles with high sensitivity and rapid response for various external stimuli have gained tremendous attentions in human healthcare monitoring,personal heat management,and wearable electronics.However,the current smart textiles only acquire desired signal passively,regularly lacking subsequent on-demand therapy actively.Herein,a robust,breathable,and flexible smart textiles as multi-function sensor and wearable heater for human health monitoring and gentle thermotherapy in real time is constructed.The composite fiber as strain sensor(CFY@PU)was fabricated via warping carbon fiber yarns(CFY)onto polyurethane fibers(PU),which endowed composite fiber with high conductivity,excellent sensitivity(GF=76.2),and fantastic dynamic durability(7500 cycles)in strain sensing.In addition,CFY@PU can detect various degrees of human movements such as elbow bending,swallowing and pulse,which can provide effective information for disease diagnosis.More surprisingly,weaving CFY@PU into a fabric can assemble highly sensitive pressure sensor for remote communication and information encryption.Warping CFY onto Kevlar would obtain temperature-sensitive composite fiber(CFY@Kevlar)as temperature sensor and wearable heater for on-demand thermotherapy,which provided unique opportunities in designing smart textiles with ultrahigh sensitivity,rapid response,and great dynamic durability.
基金support of National Natural Science Foundation of China(21975107)Natural Science Foundation of Jiangsu Province(SBK2019020945)+2 种基金National First-Class Discipline Program of Light Industry Technology and Engineering(LITE2018-21)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_1783)China Scholarship Council(202006790096).
文摘A large of energy consumption is required for indoor and outdoor personal heating to ameliorate the comfortable and healthy conditions.Main personal thermal management strategy is to reflect mid-infrared human body radiation for human surface temperature(THS)regulation.We demonstrate a visible Janus light absorbent/reflective air-layer fabric(Janus A/R fabric)that can passively reflect radiative heating meanwhile can actively capture the solar energy.A series of azobenzene derivatives functionalized with alkyl tails are reported to co-harvest the solar and phase-change energy.The THS covered by Janus A/R fabric can be heated up to~3.7°C higher than that covered by air-layer fabric in cold environment(5°C).Besides,integrating the thermo-and photo-chromic properties is capable of monitoring comfort THS and residue energy storage enthalpy,respectively.According to the colour monitors,intermittent irradiation approach is proposed to prolong comfortable-THS holding time for managing energy efficiently.
基金supported by the Ministry of Industry and Information Technologythe National Development and Reform Commission of the People’s Republic of China+2 种基金the Fundamental Research Funds for the Central Universities(2232020A-06)the Science and Technology Commission of Shanghai Municipality(20QA1400500,21130750100,and 22dz1200102)Huo Yingdong Education Foundation(171065)。
文摘People could potentially mitigate heat discomfort when outdoors by combining passive radiative cooling(PRC)strategies with personal thermal management techniques.However,most current PRC materials lack wearing comfort and durability.In this study,a microarray technique is applied to fabricate the tailoring photonic-engineered textiles with intriguing PRC capability and appealing wearability.The developed radiative cooling textiles(RCTs)demonstrate appropriate air-moisture permeability,structural stability,and extended spectroscopic response with high sunlight reflectivity(91.7%)and robust heat emissivity(95.8%)through the atmospheric transparent spectral window(ATSW).In a hot outdoor cooling test,a skin simulator covered by the RCTs displays a temperature drop of approximately 4.4℃at noon compared with cotton textiles.The evolution of our mimetic structures may provide new insights into the generation of wearable,thermal-wet comfortable,and robust textiles for exploring PRC techniques in personal thermal management applications.
基金This research was supported by the National Natural Science Foundation of China with grants(71421002,71471064,and 91646205).
文摘In China,cardiovascular disease has become the leading killer in recent years,and mortality from cardiovascular disease is continuing to rapidly increase.Extant medical research has proven that personal health management(prevention,intervention,and recuperation)of chronic diseases,such as cardiovascular diseases,is the best strategy for their prevention and treatment.Currently,the public can obtain health management knowledge through the Internet,newspapers,books,and other channels.However,with the explosive growth of available information,the public is limited to obtain effective health management guidance due to the characteristics of multiple sources,uneven accuracy(even some contradictory knowledge)and a major paucity of personalization,especially for the general public who lack professional medical knowledge.To address these problems,this paper proposes a knowledge base framework(i.e.domain ontology library)of health management programs based on the cardiovascular disease domain,which can standardize knowledge of health management programs both logically and structurally.In order to satisfy the needs of personalized health management,the core ontology of the domain ontology library is health-management-program ontology.In addition to common ontologies(e.g.disease ontology,drug ontology,etc.),basic ontologies include the ontology of individual health characteristics(e.g.individual-healthcharacteristics and environmental-characteristics ontology),and ontologies comprising diet and sport(e.g.ingredients,recipes,physical exercise,etc.).We then construct the ontology library through the professional ontology tool,Protégé.With a case study,we translate a piece of text health management knowledge into instances of an ontology library.At the same time,we present a personalized health management program recommendation algorithm based on the ontology library,and a recommendation case is realized according to this algorithm.As a basic research,the results of this paper can also support other health management applications in the future.
文摘This paper presents a survey of technologies for personal data self-management interfacing with administrative and territorial public service providers.It classifies a selection of scientific technologies into four categories of solutions:Personal Data Store(PDS),Identity Manager(IdM),Anonymous Certificate System and Access Control Delegation Architecture.Each category,along with its technological approach,is analyzed thanks to 18 identified functional criteria that encompass architectural and communication aspects,as well as user data lifecycle considerations.The originality of the survey is multifold.First,as far as we know,there is no such thorough survey covering such a panel of a dozen of existing solutions.Second,it is the first survey addressing Personally Identifiable Information(PII)management for both administrative and private service providers.Third,this paper achieves a functional comparison of solutions of very different technical natures.The outcome of this paper is the clear identification of functional gaps of each solution.As a result,this paper establishes the research directions to follow in order to fill these functional gaps.
文摘Various systems and technologies have been developed in recent years to fulfil the growing needs of high-performance HVAC systems with better performance of energy efficiency,thermal comfort,and occupancy health.Intensified conditioning of human occupied areas and less intensified conditioning of surrounding areas are able to effectively improve the overall satisfaction by individual control of personalized micro-environments and also,achieve maximum energy efficiency.Four main concepts have been identified chronologically through the devel-opment of personal environmental conditioning,changing the intensified conditioning area closer to the human body and enhancing conditioning efforts,namely the task ambient conditioning(TAC)system,personal envi-ronmental control system(PECS),personal comfort system(PCS),and the personal thermal management(PTM)system.This review follows a clue of the concept progress and system evaluation,summarizes important findings and feasible applications,current gaps as well as future research needs.
基金the National Natural Science Foundation of China(No.81325002,81620108002 to X Ma,81570511,81770564 to QX Wang)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.81421001)the Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai(No.2017YQ037 to QX Wang)
文摘Autoimmune hepatitis has been considered as a relatively rare immunological liver disease,especially in the Asia-Pacific area.Although the diagnosis criteria and immunosuppressive treatment regimens have been established,there are still some challenges.According to the different presentations,the personalized management of patients who suffer from this disease,including those with chronic or acute severe onset,the autoantibody-negative phenotype and cirrhosis are necessarily descriptive.Each subgroup of patients should receive an individualized therapy.Here,we review the recent studies of autoimmune hepatitis,mainly focusing on the epidemiology and genetics,personalized diagnostics,individualized treatment strategies,special subgroups and outcomes.Most of the research in the literature is based on Japanese and Chinese populations.